Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC43_LEIBR

TriTrypDb:

LbrM.21.2100 , LBRM2903_080017900

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC43

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC43

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	344	346	PF00675	0.569
CLV_NRD_NRD_1	496	498	PF00675	0.686
CLV_PCSK_KEX2_1	344	346	PF00082	0.609
CLV_PCSK_KEX2_1	495	497	PF00082	0.758
CLV_PCSK_PC7_1	492	498	PF00082	0.752
CLV_PCSK_SKI1_1	262	266	PF00082	0.583
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DOC_CKS1_1	363	368	PF01111	0.470
DOC_CYCLIN_yCln2_LP_2	70	73	PF00134	0.511
DOC_PP2B_LxvP_1	70	73	PF13499	0.511
DOC_PP4_FxxP_1	42	45	PF00568	0.626
DOC_USP7_MATH_1	155	159	PF00917	0.512
DOC_USP7_MATH_1	206	210	PF00917	0.446
DOC_USP7_MATH_1	239	243	PF00917	0.636
DOC_USP7_MATH_1	272	276	PF00917	0.526
DOC_USP7_MATH_1	286	290	PF00917	0.703
DOC_USP7_MATH_1	294	298	PF00917	0.522
DOC_USP7_MATH_1	335	339	PF00917	0.658
DOC_USP7_MATH_1	439	443	PF00917	0.728
DOC_USP7_MATH_1	477	481	PF00917	0.625
DOC_USP7_MATH_1	84	88	PF00917	0.763
DOC_WW_Pin1_4	105	110	PF00397	0.753
DOC_WW_Pin1_4	150	155	PF00397	0.695
DOC_WW_Pin1_4	208	213	PF00397	0.720
DOC_WW_Pin1_4	362	367	PF00397	0.460
DOC_WW_Pin1_4	437	442	PF00397	0.636
LIG_14-3-3_CanoR_1	205	215	PF00244	0.635
LIG_14-3-3_CanoR_1	344	348	PF00244	0.616
LIG_14-3-3_CanoR_1	403	409	PF00244	0.603
LIG_14-3-3_CanoR_1	74	79	PF00244	0.775
LIG_BIR_III_2	418	422	PF00653	0.767
LIG_Clathr_ClatBox_1	368	372	PF01394	0.743
LIG_FHA_1	127	133	PF00498	0.752
LIG_FHA_1	293	299	PF00498	0.638
LIG_FHA_1	363	369	PF00498	0.588
LIG_FHA_1	65	71	PF00498	0.666
LIG_FHA_2	145	151	PF00498	0.729
LIG_FHA_2	205	211	PF00498	0.581
LIG_GBD_Chelix_1	400	408	PF00786	0.548
LIG_LIR_Gen_1	193	202	PF02991	0.459
LIG_LIR_Nem_3	193	199	PF02991	0.458
LIG_NRBOX	131	137	PF00104	0.765
LIG_NRBOX	302	308	PF00104	0.563
LIG_SH2_NCK_1	196	200	PF00017	0.461
LIG_SH2_SRC	196	199	PF00017	0.461
LIG_SH2_STAT5	316	319	PF00017	0.505
LIG_SH2_STAT5	329	332	PF00017	0.568
LIG_SH2_STAT5	396	399	PF00017	0.522
LIG_SH3_1	360	366	PF00018	0.442
LIG_SH3_3	112	118	PF00018	0.694
LIG_SH3_3	29	35	PF00018	0.641
LIG_SH3_3	293	299	PF00018	0.716
LIG_SH3_3	360	366	PF00018	0.532
LIG_SH3_3	435	441	PF00018	0.637
LIG_SH3_3	443	449	PF00018	0.767
LIG_SH3_3	488	494	PF00018	0.532
LIG_SUMO_SIM_par_1	304	310	PF11976	0.596
LIG_SUMO_SIM_par_1	367	373	PF11976	0.724
LIG_TRAF2_1	275	278	PF00917	0.710
LIG_WW_3	71	75	PF00397	0.511
MOD_CK1_1	131	137	PF00069	0.765
MOD_CK1_1	22	28	PF00069	0.651
MOD_CK1_1	225	231	PF00069	0.538
MOD_CK1_1	310	316	PF00069	0.440
MOD_CK1_1	480	486	PF00069	0.543
MOD_CK1_1	66	72	PF00069	0.615
MOD_CK2_1	150	156	PF00069	0.606
MOD_CK2_1	272	278	PF00069	0.708
MOD_CK2_1	392	398	PF00069	0.392
MOD_CK2_1	439	445	PF00069	0.565
MOD_CK2_1	466	472	PF00069	0.725
MOD_CK2_1	84	90	PF00069	0.650
MOD_DYRK1A_RPxSP_1	208	212	PF00069	0.471
MOD_GlcNHglycan	147	150	PF01048	0.765
MOD_GlcNHglycan	217	220	PF01048	0.710
MOD_GlcNHglycan	230	233	PF01048	0.538
MOD_GlcNHglycan	24	27	PF01048	0.620
MOD_GlcNHglycan	274	277	PF01048	0.677
MOD_GlcNHglycan	337	340	PF01048	0.713
MOD_GlcNHglycan	423	426	PF01048	0.611
MOD_GlcNHglycan	441	444	PF01048	0.729
MOD_GlcNHglycan	46	49	PF01048	0.756
MOD_GlcNHglycan	467	471	PF01048	0.723
MOD_GlcNHglycan	478	482	PF01048	0.582
MOD_GlcNHglycan	85	89	PF01048	0.791
MOD_GSK3_1	141	148	PF00069	0.743
MOD_GSK3_1	16	23	PF00069	0.792
MOD_GSK3_1	204	211	PF00069	0.524
MOD_GSK3_1	294	301	PF00069	0.578
MOD_GSK3_1	333	340	PF00069	0.494
MOD_GSK3_1	59	66	PF00069	0.730
MOD_N-GLC_1	376	381	PF02516	0.678
MOD_NEK2_1	189	194	PF00069	0.614
MOD_NEK2_1	265	270	PF00069	0.660
MOD_NEK2_1	307	312	PF00069	0.504
MOD_NEK2_1	404	409	PF00069	0.583
MOD_NEK2_1	59	64	PF00069	0.745
MOD_NEK2_1	65	70	PF00069	0.739
MOD_NEK2_2	343	348	PF00069	0.600
MOD_PIKK_1	16	22	PF00454	0.678
MOD_PKA_1	496	502	PF00069	0.739
MOD_PKA_2	126	132	PF00069	0.736
MOD_PKA_2	141	147	PF00069	0.724
MOD_PKA_2	204	210	PF00069	0.579
MOD_PKA_2	343	349	PF00069	0.609
MOD_PKA_2	496	502	PF00069	0.706
MOD_PKB_1	331	339	PF00069	0.421
MOD_Plk_1	155	161	PF00069	0.580
MOD_Plk_1	190	196	PF00069	0.368
MOD_Plk_1	392	398	PF00069	0.351
MOD_Plk_2-3	392	398	PF00069	0.438
MOD_Plk_4	131	137	PF00069	0.765
MOD_Plk_4	211	217	PF00069	0.751
MOD_Plk_4	404	410	PF00069	0.605
MOD_Plk_4	66	72	PF00069	0.734
MOD_ProDKin_1	105	111	PF00069	0.753
MOD_ProDKin_1	150	156	PF00069	0.688
MOD_ProDKin_1	208	214	PF00069	0.725
MOD_ProDKin_1	362	368	PF00069	0.462
MOD_ProDKin_1	437	443	PF00069	0.635
TRG_DiLeu_BaEn_1	156	161	PF01217	0.582
TRG_DiLeu_LyEn_5	156	161	PF01217	0.628
TRG_ENDOCYTIC_2	196	199	PF00928	0.461
TRG_ER_diArg_1	11	14	PF00400	0.680
TRG_ER_diArg_1	254	257	PF00400	0.384
TRG_ER_diArg_1	494	497	PF00400	0.756
TRG_ER_diArg_1	500	503	PF00400	0.717
TRG_Pf-PMV_PEXEL_1	178	182	PF00026	0.555
TRG_Pf-PMV_PEXEL_1	345	349	PF00026	0.545

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK83	Leptomonas seymouri	43%	100%
A0A3S5H6A2	Leishmania donovani	74%	100%
A0A422NFT6	Trypanosoma rangeli	30%	100%
E9AG89	Leishmania infantum	70%	100%
E9AMJ3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QI40	Leishmania major	73%	99%
V5AUD8	Trypanosoma cruzi	30%	100%