RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Zinc finger, C3HC4 type (RING finger), putative

Species:

Leishmania braziliensis

UniProt:

A4HC42_LEIBR

TriTrypDb:

LbrM.21.2090 , LBRM2903_080017800

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	13
GO:0110165	cellular anatomical entity	1	13

Expansion

Sequence features

A4HC42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC42

Function

Biological processes
Term	Name	Level	Count
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010468	regulation of gene expression	5	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0045893	positive regulation of DNA-templated transcription	7	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0045944	positive regulation of transcription by RNA polymerase II	8	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051252	regulation of RNA metabolic process	5	1
GO:0051254	positive regulation of RNA metabolic process	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1902680	positive regulation of RNA biosynthetic process	7	1
GO:1903506	regulation of nucleic acid-templated transcription	7	1
GO:1903508	positive regulation of nucleic acid-templated transcription	8	1
GO:2001141	regulation of RNA biosynthetic process	6	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	13
GO:0043167	ion binding	2	13
GO:0043169	cation binding	3	13
GO:0046872	metal ion binding	4	13
GO:0000976	transcription cis-regulatory region binding	5	1
GO:0001067	transcription regulatory region nucleic acid binding	4	1
GO:0003676	nucleic acid binding	3	1
GO:0003677	DNA binding	4	1
GO:0003690	double-stranded DNA binding	5	1
GO:0043565	sequence-specific DNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1
GO:1990837	sequence-specific double-stranded DNA binding	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.577
CLV_NRD_NRD_1	163	165	PF00675	0.415
CLV_NRD_NRD_1	189	191	PF00675	0.506
CLV_NRD_NRD_1	210	212	PF00675	0.427
CLV_NRD_NRD_1	379	381	PF00675	0.467
CLV_NRD_NRD_1	427	429	PF00675	0.530
CLV_NRD_NRD_1	563	565	PF00675	0.706
CLV_NRD_NRD_1	9	11	PF00675	0.581
CLV_NRD_NRD_1	94	96	PF00675	0.497
CLV_PCSK_KEX2_1	189	191	PF00082	0.474
CLV_PCSK_KEX2_1	201	203	PF00082	0.309
CLV_PCSK_KEX2_1	210	212	PF00082	0.386
CLV_PCSK_KEX2_1	379	381	PF00082	0.554
CLV_PCSK_KEX2_1	427	429	PF00082	0.537
CLV_PCSK_KEX2_1	508	510	PF00082	0.648
CLV_PCSK_KEX2_1	64	66	PF00082	0.325
CLV_PCSK_KEX2_1	9	11	PF00082	0.597
CLV_PCSK_KEX2_1	94	96	PF00082	0.526
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.438
CLV_PCSK_PC1ET2_1	508	510	PF00082	0.648
CLV_PCSK_PC1ET2_1	64	66	PF00082	0.310
CLV_PCSK_SKI1_1	314	318	PF00082	0.739
CLV_PCSK_SKI1_1	345	349	PF00082	0.509
CLV_PCSK_SKI1_1	403	407	PF00082	0.507
CLV_PCSK_SKI1_1	410	414	PF00082	0.536
CLV_PCSK_SKI1_1	535	539	PF00082	0.490
CLV_PCSK_SKI1_1	64	68	PF00082	0.455
CLV_PCSK_SKI1_1	94	98	PF00082	0.405
DEG_APCC_DBOX_1	76	84	PF00400	0.558
DEG_APCC_DBOX_1	93	101	PF00400	0.308
DEG_SCF_FBW7_2	246	253	PF00400	0.524
DEG_SCF_FBW7_2	315	322	PF00400	0.716
DOC_CKS1_1	172	177	PF01111	0.523
DOC_CKS1_1	247	252	PF01111	0.533
DOC_CYCLIN_yCln2_LP_2	172	178	PF00134	0.517
DOC_MAPK_gen_1	379	390	PF00069	0.420
DOC_MAPK_gen_1	94	102	PF00069	0.541
DOC_PP2B_LxvP_1	404	407	PF13499	0.522
DOC_PP2B_LxvP_1	481	484	PF13499	0.680
DOC_PP4_FxxP_1	217	220	PF00568	0.381
DOC_USP7_MATH_1	28	32	PF00917	0.646
DOC_USP7_MATH_1	533	537	PF00917	0.699
DOC_USP7_UBL2_3	557	561	PF12436	0.736
DOC_WW_Pin1_4	117	122	PF00397	0.517
DOC_WW_Pin1_4	171	176	PF00397	0.550
DOC_WW_Pin1_4	216	221	PF00397	0.591
DOC_WW_Pin1_4	246	251	PF00397	0.540
DOC_WW_Pin1_4	305	310	PF00397	0.584
DOC_WW_Pin1_4	315	320	PF00397	0.592
DOC_WW_Pin1_4	460	465	PF00397	0.603
DOC_WW_Pin1_4	538	543	PF00397	0.557
DOC_WW_Pin1_4	575	580	PF00397	0.759
LIG_14-3-3_CanoR_1	137	145	PF00244	0.390
LIG_14-3-3_CanoR_1	210	217	PF00244	0.524
LIG_14-3-3_CanoR_1	314	319	PF00244	0.742
LIG_14-3-3_CanoR_1	39	46	PF00244	0.617
LIG_14-3-3_CanoR_1	447	454	PF00244	0.629
LIG_14-3-3_CanoR_1	535	542	PF00244	0.659
LIG_Actin_WH2_2	339	356	PF00022	0.522
LIG_Actin_WH2_2	51	66	PF00022	0.484
LIG_AP2alpha_2	214	216	PF02296	0.555
LIG_APCC_ABBA_1	326	331	PF00400	0.510
LIG_BIR_II_1	1	5	PF00653	0.589
LIG_deltaCOP1_diTrp_1	458	462	PF00928	0.697
LIG_FHA_1	361	367	PF00498	0.490
LIG_FHA_1	376	382	PF00498	0.419
LIG_FHA_1	473	479	PF00498	0.707
LIG_FHA_1	84	90	PF00498	0.550
LIG_FHA_2	118	124	PF00498	0.470
LIG_FHA_2	315	321	PF00498	0.722
LIG_FHA_2	363	369	PF00498	0.345
LIG_Integrin_RGD_1	456	458	PF01839	0.475
LIG_Integrin_RGD_1	526	528	PF01839	0.743
LIG_LIR_Apic_2	122	127	PF02991	0.414
LIG_LIR_Apic_2	214	220	PF02991	0.356
LIG_LIR_Apic_2	48	52	PF02991	0.652
LIG_LIR_Gen_1	322	330	PF02991	0.545
LIG_LIR_Gen_1	477	484	PF02991	0.684
LIG_LIR_Nem_3	322	328	PF02991	0.467
LIG_LIR_Nem_3	438	444	PF02991	0.522
LIG_LIR_Nem_3	477	483	PF02991	0.642
LIG_MYND_1	309	313	PF01753	0.629
LIG_PTAP_UEV_1	132	137	PF05743	0.435
LIG_PTB_Apo_2	68	75	PF02174	0.341
LIG_SH2_CRK	124	128	PF00017	0.463
LIG_SH2_CRK	145	149	PF00017	0.372
LIG_SH2_CRK	49	53	PF00017	0.735
LIG_SH2_SRC	329	332	PF00017	0.415
LIG_SH2_STAP1	258	262	PF00017	0.511
LIG_SH2_STAT5	145	148	PF00017	0.330
LIG_SH2_STAT5	176	179	PF00017	0.459
LIG_SH2_STAT5	245	248	PF00017	0.385
LIG_SH2_STAT5	325	328	PF00017	0.457
LIG_SH2_STAT5	338	341	PF00017	0.406
LIG_SH2_STAT5	444	447	PF00017	0.520
LIG_SH2_STAT5	480	483	PF00017	0.687
LIG_SH3_2	185	190	PF14604	0.498
LIG_SH3_3	130	136	PF00018	0.387
LIG_SH3_3	179	185	PF00018	0.380
LIG_SH3_3	307	313	PF00018	0.603
LIG_SH3_3	493	499	PF00018	0.612
LIG_SH3_3	517	523	PF00018	0.652
LIG_SUMO_SIM_par_1	78	86	PF11976	0.603
LIG_TRAF2_1	120	123	PF00917	0.522
LIG_TRAF2_1	365	368	PF00917	0.338
LIG_TRFH_1	176	180	PF08558	0.495
LIG_TYR_ITIM	478	483	PF00017	0.713
LIG_UBA3_1	150	158	PF00899	0.390
LIG_UBA3_1	286	295	PF00899	0.537
LIG_WW_3	523	527	PF00397	0.482
MOD_CDK_SPK_2	575	580	PF00069	0.704
MOD_CK1_1	240	246	PF00069	0.424
MOD_CK1_1	31	37	PF00069	0.706
MOD_CK1_1	41	47	PF00069	0.696
MOD_CK1_1	449	455	PF00069	0.705
MOD_CK1_1	463	469	PF00069	0.607
MOD_CK1_1	472	478	PF00069	0.595
MOD_CK1_1	485	491	PF00069	0.457
MOD_CK1_1	536	542	PF00069	0.546
MOD_CK2_1	117	123	PF00069	0.460
MOD_CK2_1	275	281	PF00069	0.520
MOD_CK2_1	314	320	PF00069	0.725
MOD_CK2_1	362	368	PF00069	0.317
MOD_Cter_Amidation	7	10	PF01082	0.676
MOD_GlcNHglycan	33	36	PF01048	0.709
MOD_GlcNHglycan	451	454	PF01048	0.624
MOD_GlcNHglycan	487	490	PF01048	0.671
MOD_GlcNHglycan	528	531	PF01048	0.708
MOD_GSK3_1	216	223	PF00069	0.580
MOD_GSK3_1	358	365	PF00069	0.471
MOD_GSK3_1	368	375	PF00069	0.480
MOD_GSK3_1	38	45	PF00069	0.662
MOD_GSK3_1	536	543	PF00069	0.632
MOD_GSK3_1	75	82	PF00069	0.504
MOD_LATS_1	37	43	PF00433	0.509
MOD_N-GLC_2	205	207	PF02516	0.495
MOD_NEK2_1	1	6	PF00069	0.512
MOD_NEK2_1	102	107	PF00069	0.502
MOD_NEK2_1	446	451	PF00069	0.656
MOD_NEK2_1	516	521	PF00069	0.718
MOD_NEK2_1	81	86	PF00069	0.641
MOD_PIKK_1	83	89	PF00454	0.639
MOD_PKA_1	9	15	PF00069	0.526
MOD_PKA_2	136	142	PF00069	0.390
MOD_PKA_2	203	209	PF00069	0.473
MOD_PKA_2	31	37	PF00069	0.720
MOD_PKA_2	38	44	PF00069	0.719
MOD_PKA_2	446	452	PF00069	0.636
MOD_PKA_2	504	510	PF00069	0.644
MOD_PKA_2	9	15	PF00069	0.599
MOD_Plk_1	437	443	PF00069	0.555
MOD_Plk_1	469	475	PF00069	0.669
MOD_Plk_4	102	108	PF00069	0.496
MOD_Plk_4	111	117	PF00069	0.316
MOD_Plk_4	300	306	PF00069	0.687
MOD_Plk_4	511	517	PF00069	0.754
MOD_Plk_4	9	15	PF00069	0.599
MOD_ProDKin_1	117	123	PF00069	0.526
MOD_ProDKin_1	171	177	PF00069	0.545
MOD_ProDKin_1	216	222	PF00069	0.596
MOD_ProDKin_1	246	252	PF00069	0.534
MOD_ProDKin_1	305	311	PF00069	0.586
MOD_ProDKin_1	315	321	PF00069	0.586
MOD_ProDKin_1	460	466	PF00069	0.604
MOD_ProDKin_1	538	544	PF00069	0.559
MOD_SUMO_for_1	560	563	PF00179	0.742
MOD_SUMO_rev_2	292	300	PF00179	0.601
TRG_DiLeu_BaEn_2	280	286	PF01217	0.534
TRG_DiLeu_BaLyEn_6	92	97	PF01217	0.327
TRG_ENDOCYTIC_2	325	328	PF00928	0.490
TRG_ENDOCYTIC_2	338	341	PF00928	0.412
TRG_ENDOCYTIC_2	382	385	PF00928	0.437
TRG_ENDOCYTIC_2	480	483	PF00928	0.694
TRG_ER_diArg_1	188	190	PF00400	0.520
TRG_ER_diArg_1	209	211	PF00400	0.452
TRG_ER_diArg_1	379	381	PF00400	0.552
TRG_ER_diArg_1	427	430	PF00400	0.535
TRG_ER_diArg_1	94	96	PF00400	0.526
TRG_NLS_Bipartite_1	189	205	PF00514	0.490
TRG_Pf-PMV_PEXEL_1	269	273	PF00026	0.556
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWK4	Leptomonas seymouri	68%	99%
A0A0S4IP20	Bodo saltans	28%	74%
A0A1X0NGG7	Trypanosomatidae	40%	100%
A0A3S5H6A1	Leishmania donovani	84%	100%
A0A3S7WQF9	Leishmania donovani	86%	100%
A0A422NFU0	Trypanosoma rangeli	39%	100%
C9ZPG2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AG88	Leishmania infantum	86%	100%
E9AMJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q32NQ8	Xenopus laevis	23%	77%
Q4QI41	Leishmania major	85%	98%
V5DAD1	Trypanosoma cruzi	41%	100%