SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC39_LEIBR

TriTrypDb:

LbrM.21.2060 , LBRM2903_210026200

Length:

385

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC39

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC39

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.610
CLV_NRD_NRD_1	145	147	PF00675	0.411
CLV_NRD_NRD_1	203	205	PF00675	0.474
CLV_NRD_NRD_1	23	25	PF00675	0.443
CLV_NRD_NRD_1	297	299	PF00675	0.512
CLV_PCSK_KEX2_1	145	147	PF00082	0.429
CLV_PCSK_KEX2_1	149	151	PF00082	0.407
CLV_PCSK_KEX2_1	23	25	PF00082	0.480
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.545
CLV_PCSK_PC7_1	145	151	PF00082	0.467
CLV_PCSK_SKI1_1	130	134	PF00082	0.375
CLV_PCSK_SKI1_1	146	150	PF00082	0.484
CLV_PCSK_SKI1_1	252	256	PF00082	0.434
CLV_PCSK_SKI1_1	64	68	PF00082	0.486
DOC_CKS1_1	99	104	PF01111	0.330
DOC_MAPK_gen_1	145	154	PF00069	0.477
DOC_MAPK_gen_1	298	308	PF00069	0.416
DOC_MAPK_MEF2A_6	11	19	PF00069	0.291
DOC_PP4_FxxP_1	194	197	PF00568	0.440
DOC_WW_Pin1_4	134	139	PF00397	0.572
DOC_WW_Pin1_4	193	198	PF00397	0.477
DOC_WW_Pin1_4	273	278	PF00397	0.367
DOC_WW_Pin1_4	72	77	PF00397	0.518
DOC_WW_Pin1_4	98	103	PF00397	0.339
LIG_14-3-3_CanoR_1	302	306	PF00244	0.420
LIG_BRCT_BRCA1_1	198	202	PF00533	0.427
LIG_CtBP_PxDLS_1	2	6	PF00389	0.349
LIG_deltaCOP1_diTrp_1	51	58	PF00928	0.461
LIG_FHA_1	274	280	PF00498	0.367
LIG_FHA_1	28	34	PF00498	0.455
LIG_FHA_1	37	43	PF00498	0.407
LIG_FHA_2	151	157	PF00498	0.520
LIG_FHA_2	174	180	PF00498	0.607
LIG_FHA_2	32	38	PF00498	0.512
LIG_FHA_2	355	361	PF00498	0.461
LIG_FHA_2	46	52	PF00498	0.440
LIG_FHA_2	89	95	PF00498	0.444
LIG_GBD_Chelix_1	162	170	PF00786	0.292
LIG_Integrin_isoDGR_2	300	302	PF01839	0.532
LIG_LIR_Apic_2	192	197	PF02991	0.431
LIG_LIR_Apic_2	351	356	PF02991	0.453
LIG_LIR_Gen_1	266	275	PF02991	0.420
LIG_LIR_Gen_1	52	63	PF02991	0.438
LIG_LIR_Nem_3	128	132	PF02991	0.578
LIG_LIR_Nem_3	266	271	PF02991	0.375
LIG_LIR_Nem_3	273	278	PF02991	0.392
LIG_LIR_Nem_3	318	324	PF02991	0.517
LIG_LIR_Nem_3	362	368	PF02991	0.453
LIG_LIR_Nem_3	52	58	PF02991	0.458
LIG_MYND_1	3	7	PF01753	0.585
LIG_Pex14_1	27	31	PF04695	0.391
LIG_Pex14_2	264	268	PF04695	0.402
LIG_PTB_Apo_2	262	269	PF02174	0.371
LIG_SH2_CRK	321	325	PF00017	0.460
LIG_SH2_GRB2like	263	266	PF00017	0.384
LIG_SH2_NCK_1	258	262	PF00017	0.415
LIG_SH2_SRC	114	117	PF00017	0.538
LIG_SH2_STAP1	114	118	PF00017	0.276
LIG_SH2_STAP1	31	35	PF00017	0.405
LIG_SH2_STAP1	333	337	PF00017	0.435
LIG_SH2_STAT5	235	238	PF00017	0.397
LIG_SH2_STAT5	263	266	PF00017	0.441
LIG_SH2_STAT5	331	334	PF00017	0.474
LIG_SH2_STAT5	368	371	PF00017	0.381
LIG_SH2_STAT5	378	381	PF00017	0.416
LIG_SH2_STAT5	87	90	PF00017	0.404
LIG_SH3_3	129	135	PF00018	0.539
LIG_SH3_3	320	326	PF00018	0.453
LIG_SH3_3	96	102	PF00018	0.569
LIG_SUMO_SIM_anti_2	179	185	PF11976	0.298
LIG_SUMO_SIM_par_1	179	185	PF11976	0.298
LIG_TRAF2_1	357	360	PF00917	0.513
LIG_TYR_ITIM	127	132	PF00017	0.360
LIG_TYR_ITIM	319	324	PF00017	0.453
LIG_UBA3_1	182	187	PF00899	0.491
LIG_WRC_WIRS_1	190	195	PF05994	0.327
MOD_CK1_1	177	183	PF00069	0.462
MOD_CK1_1	196	202	PF00069	0.434
MOD_CK2_1	134	140	PF00069	0.585
MOD_CK2_1	31	37	PF00069	0.512
MOD_CK2_1	354	360	PF00069	0.449
MOD_CK2_1	88	94	PF00069	0.493
MOD_GlcNHglycan	159	162	PF01048	0.307
MOD_GlcNHglycan	20	23	PF01048	0.418
MOD_GlcNHglycan	239	242	PF01048	0.407
MOD_GSK3_1	173	180	PF00069	0.516
MOD_GSK3_1	189	196	PF00069	0.503
MOD_GSK3_1	27	34	PF00069	0.416
MOD_GSK3_1	68	75	PF00069	0.511
MOD_GSK3_1	94	101	PF00069	0.310
MOD_N-GLC_1	177	182	PF02516	0.594
MOD_N-GLC_1	27	32	PF02516	0.425
MOD_N-GLC_1	94	99	PF02516	0.542
MOD_NEK2_1	189	194	PF00069	0.395
MOD_NEK2_1	271	276	PF00069	0.367
MOD_NEK2_2	88	93	PF00069	0.381
MOD_PK_1	68	74	PF00069	0.447
MOD_PKA_2	301	307	PF00069	0.369
MOD_Plk_1	11	17	PF00069	0.406
MOD_Plk_1	177	183	PF00069	0.458
MOD_Plk_1	27	33	PF00069	0.325
MOD_Plk_1	315	321	PF00069	0.491
MOD_Plk_1	36	42	PF00069	0.456
MOD_Plk_2-3	47	53	PF00069	0.504
MOD_Plk_4	177	183	PF00069	0.492
MOD_Plk_4	189	195	PF00069	0.440
MOD_Plk_4	301	307	PF00069	0.369
MOD_Plk_4	348	354	PF00069	0.500
MOD_ProDKin_1	134	140	PF00069	0.573
MOD_ProDKin_1	193	199	PF00069	0.473
MOD_ProDKin_1	273	279	PF00069	0.367
MOD_ProDKin_1	72	78	PF00069	0.522
MOD_ProDKin_1	98	104	PF00069	0.331
MOD_SUMO_rev_2	179	189	PF00179	0.511
MOD_SUMO_rev_2	281	288	PF00179	0.550
MOD_SUMO_rev_2	75	84	PF00179	0.448
TRG_DiLeu_BaEn_1	185	190	PF01217	0.410
TRG_ENDOCYTIC_2	129	132	PF00928	0.585
TRG_ENDOCYTIC_2	235	238	PF00928	0.413
TRG_ENDOCYTIC_2	253	256	PF00928	0.294
TRG_ENDOCYTIC_2	321	324	PF00928	0.464
TRG_ER_diArg_1	23	25	PF00400	0.493
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.553
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVT0	Leptomonas seymouri	68%	99%
A0A0S4IW33	Bodo saltans	51%	94%
A0A1X0P992	Trypanosomatidae	52%	99%
A0A3Q8ILA8	Leishmania donovani	90%	100%
A0A422NY07	Trypanosoma rangeli	50%	99%
A4HZI1	Leishmania infantum	90%	100%
C9ZL06	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	77%
E9AVH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4QC08	Leishmania major	89%	100%
V5C212	Trypanosoma cruzi	50%	100%