RNA polymerase II

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RNA polymerase II

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC38_LEIBR

TriTrypDb:

LbrM.21.2050

Length:

374

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	13
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HC38

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC38

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	13
GO:0006396	RNA processing	6	13
GO:0006725	cellular aromatic compound metabolic process	3	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016070	RNA metabolic process	5	13
GO:0031123	RNA 3'-end processing	7	13
GO:0034641	cellular nitrogen compound metabolic process	3	13
GO:0043170	macromolecule metabolic process	3	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0046483	heterocycle metabolic process	3	13
GO:0071076	RNA 3' uridylation	8	13
GO:0071704	organic substance metabolic process	2	13
GO:0090304	nucleic acid metabolic process	4	13
GO:1901360	organic cyclic compound metabolic process	3	13
GO:0006378	mRNA polyadenylation	7	1
GO:0006397	mRNA processing	7	1
GO:0016071	mRNA metabolic process	6	1
GO:0031124	mRNA 3'-end processing	8	1
GO:0043631	RNA polyadenylation	6	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004652	obsolete polynucleotide adenylyltransferase activity	6	5
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016779	nucleotidyltransferase activity	4	13
GO:0050265	RNA uridylyltransferase activity	4	13
GO:0070566	adenylyltransferase activity	5	5
GO:0070569	uridylyltransferase activity	5	13
GO:0140098	catalytic activity, acting on RNA	3	13
GO:0140640	catalytic activity, acting on a nucleic acid	2	13
GO:0005488	binding	1	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	79	83	PF00656	0.425
CLV_NRD_NRD_1	122	124	PF00675	0.460
CLV_NRD_NRD_1	147	149	PF00675	0.445
CLV_NRD_NRD_1	202	204	PF00675	0.388
CLV_PCSK_KEX2_1	202	204	PF00082	0.384
CLV_PCSK_SKI1_1	274	278	PF00082	0.440
CLV_PCSK_SKI1_1	42	46	PF00082	0.526
DEG_APCC_DBOX_1	180	188	PF00400	0.423
DEG_Nend_Nbox_1	1	3	PF02207	0.578
DOC_CKS1_1	283	288	PF01111	0.416
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.419
DOC_MAPK_gen_1	110	120	PF00069	0.465
DOC_MAPK_gen_1	135	143	PF00069	0.325
DOC_MAPK_gen_1	364	370	PF00069	0.423
DOC_MAPK_MEF2A_6	113	122	PF00069	0.422
DOC_MAPK_MEF2A_6	156	163	PF00069	0.355
DOC_MAPK_MEF2A_6	8	17	PF00069	0.382
DOC_MAPK_NFAT4_5	156	164	PF00069	0.378
DOC_PP1_RVXF_1	342	349	PF00149	0.361
DOC_PP1_RVXF_1	47	54	PF00149	0.332
DOC_USP7_MATH_1	245	249	PF00917	0.449
DOC_USP7_MATH_1	4	8	PF00917	0.522
DOC_USP7_MATH_1	70	74	PF00917	0.479
DOC_USP7_MATH_1	92	96	PF00917	0.467
DOC_WW_Pin1_4	15	20	PF00397	0.318
DOC_WW_Pin1_4	204	209	PF00397	0.350
DOC_WW_Pin1_4	282	287	PF00397	0.411
DOC_WW_Pin1_4	62	67	PF00397	0.528
LIG_14-3-3_CanoR_1	148	154	PF00244	0.492
LIG_14-3-3_CanoR_1	224	228	PF00244	0.508
LIG_14-3-3_CanoR_1	27	34	PF00244	0.398
LIG_14-3-3_CanoR_1	303	310	PF00244	0.458
LIG_14-3-3_CanoR_1	359	364	PF00244	0.289
LIG_Actin_WH2_2	154	169	PF00022	0.390
LIG_AP2alpha_2	335	337	PF02296	0.375
LIG_BRCT_BRCA1_1	115	119	PF00533	0.479
LIG_BRCT_BRCA1_1	344	348	PF00533	0.364
LIG_FHA_2	18	24	PF00498	0.409
LIG_FHA_2	242	248	PF00498	0.480
LIG_LIR_Gen_1	212	219	PF02991	0.332
LIG_LIR_Gen_1	275	283	PF02991	0.361
LIG_LIR_Gen_1	321	331	PF02991	0.286
LIG_LIR_Gen_1	369	374	PF02991	0.413
LIG_LIR_Nem_3	116	122	PF02991	0.423
LIG_LIR_Nem_3	212	218	PF02991	0.297
LIG_LIR_Nem_3	275	280	PF02991	0.328
LIG_LIR_Nem_3	321	326	PF02991	0.293
LIG_LIR_Nem_3	369	374	PF02991	0.413
LIG_NRBOX	43	49	PF00104	0.423
LIG_PCNA_PIPBox_1	273	282	PF02747	0.319
LIG_Pex14_1	205	209	PF04695	0.329
LIG_REV1ctd_RIR_1	346	354	PF16727	0.379
LIG_SH2_CRK	283	287	PF00017	0.499
LIG_SH2_CRK	34	38	PF00017	0.392
LIG_SH2_CRK	71	75	PF00017	0.401
LIG_SH2_NCK_1	283	287	PF00017	0.256
LIG_SH2_STAP1	209	213	PF00017	0.310
LIG_SH2_STAP1	34	38	PF00017	0.473
LIG_SH2_STAT5	146	149	PF00017	0.433
LIG_SH2_STAT5	215	218	PF00017	0.303
LIG_SH2_STAT5	87	90	PF00017	0.449
LIG_SH3_3	333	339	PF00018	0.390
LIG_SH3_3	64	70	PF00018	0.386
LIG_SH3_3	86	92	PF00018	0.410
LIG_SUMO_SIM_anti_2	268	273	PF11976	0.520
LIG_SUMO_SIM_anti_2	329	335	PF11976	0.374
LIG_SUMO_SIM_par_1	294	300	PF11976	0.342
LIG_SUMO_SIM_par_1	329	335	PF11976	0.349
LIG_TRAF2_2	263	268	PF00917	0.416
LIG_TYR_ITIM	69	74	PF00017	0.456
LIG_UBA3_1	118	124	PF00899	0.421
LIG_UBA3_1	213	220	PF00899	0.365
LIG_UBA3_1	44	49	PF00899	0.227
MOD_CK1_1	73	79	PF00069	0.427
MOD_CK1_1	95	101	PF00069	0.567
MOD_CK2_1	147	153	PF00069	0.482
MOD_CK2_1	17	23	PF00069	0.449
MOD_CK2_1	241	247	PF00069	0.406
MOD_CK2_1	310	316	PF00069	0.289
MOD_GlcNHglycan	149	152	PF01048	0.585
MOD_GlcNHglycan	23	27	PF01048	0.503
MOD_GlcNHglycan	359	362	PF01048	0.479
MOD_GlcNHglycan	75	78	PF01048	0.364
MOD_GSK3_1	218	225	PF00069	0.259
MOD_GSK3_1	241	248	PF00069	0.443
MOD_GSK3_1	338	345	PF00069	0.474
MOD_GSK3_1	366	373	PF00069	0.481
MOD_GSK3_1	94	101	PF00069	0.486
MOD_N-GLC_1	15	20	PF02516	0.343
MOD_NEK2_1	166	171	PF00069	0.318
MOD_NEK2_1	218	223	PF00069	0.361
MOD_NEK2_1	291	296	PF00069	0.415
MOD_NEK2_2	310	315	PF00069	0.269
MOD_PIKK_1	232	238	PF00454	0.450
MOD_PIKK_1	250	256	PF00454	0.340
MOD_PIKK_1	27	33	PF00454	0.495
MOD_PK_1	359	365	PF00069	0.416
MOD_PKA_2	147	153	PF00069	0.516
MOD_PKA_2	223	229	PF00069	0.261
MOD_PKA_2	302	308	PF00069	0.519
MOD_PKA_2	32	38	PF00069	0.451
MOD_PKB_1	301	309	PF00069	0.442
MOD_Plk_1	250	256	PF00069	0.480
MOD_Plk_1	267	273	PF00069	0.429
MOD_Plk_1	291	297	PF00069	0.467
MOD_Plk_4	166	172	PF00069	0.319
MOD_Plk_4	209	215	PF00069	0.295
MOD_Plk_4	257	263	PF00069	0.405
MOD_Plk_4	291	297	PF00069	0.452
MOD_Plk_4	366	372	PF00069	0.465
MOD_Plk_4	70	76	PF00069	0.362
MOD_ProDKin_1	15	21	PF00069	0.304
MOD_ProDKin_1	204	210	PF00069	0.346
MOD_ProDKin_1	282	288	PF00069	0.410
MOD_ProDKin_1	62	68	PF00069	0.520
MOD_SUMO_for_1	363	366	PF00179	0.373
TRG_DiLeu_BaEn_1	321	326	PF01217	0.445
TRG_ENDOCYTIC_2	215	218	PF00928	0.304
TRG_ENDOCYTIC_2	34	37	PF00928	0.428
TRG_ENDOCYTIC_2	71	74	PF00928	0.405
TRG_ER_diArg_1	137	140	PF00400	0.406
TRG_ER_diArg_1	180	183	PF00400	0.382
TRG_ER_diArg_1	298	301	PF00400	0.452
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.488

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA71	Leptomonas seymouri	61%	100%
A0A0S4IUE3	Bodo saltans	35%	84%
A0A0S4IXY7	Bodo saltans	21%	100%
A0A1X0NI50	Trypanosomatidae	45%	100%
A0A1X0NT04	Trypanosomatidae	23%	100%
A0A3R7M9K0	Trypanosoma rangeli	45%	100%
A0A3S7WWT5	Leishmania donovani	82%	98%
A4HZI0	Leishmania infantum	82%	98%
D0A0Y4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AVH0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	98%
Q4QC09	Leishmania major	80%	100%