Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC37_LEIBR

TriTrypDb:

LbrM.21.2040 , LBRM2903_210026100

Length:

170

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC37

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC37

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	160	164	PF00656	0.612
CLV_C14_Caspase3-7	97	101	PF00656	0.695
CLV_NRD_NRD_1	11	13	PF00675	0.598
CLV_NRD_NRD_1	129	131	PF00675	0.539
CLV_NRD_NRD_1	25	27	PF00675	0.491
CLV_NRD_NRD_1	66	68	PF00675	0.481
CLV_PCSK_KEX2_1	111	113	PF00082	0.555
CLV_PCSK_KEX2_1	120	122	PF00082	0.611
CLV_PCSK_KEX2_1	129	131	PF00082	0.515
CLV_PCSK_KEX2_1	55	57	PF00082	0.554
CLV_PCSK_KEX2_1	68	70	PF00082	0.430
CLV_PCSK_PC1ET2_1	111	113	PF00082	0.555
CLV_PCSK_PC1ET2_1	120	122	PF00082	0.611
CLV_PCSK_PC1ET2_1	55	57	PF00082	0.554
CLV_PCSK_PC1ET2_1	68	70	PF00082	0.430
CLV_PCSK_SKI1_1	112	116	PF00082	0.548
CLV_PCSK_SKI1_1	120	124	PF00082	0.637
CLV_PCSK_SKI1_1	150	154	PF00082	0.661
CLV_PCSK_SKI1_1	31	35	PF00082	0.636
DEG_APCC_KENBOX_2	40	44	PF00400	0.377
DOC_CYCLIN_RxL_1	147	154	PF00134	0.432
DOC_PP1_RVXF_1	29	36	PF00149	0.636
DOC_PP2B_LxvP_1	122	125	PF13499	0.672
DOC_PP4_FxxP_1	59	62	PF00568	0.492
DOC_USP7_MATH_1	80	84	PF00917	0.435
DOC_USP7_MATH_1	94	98	PF00917	0.712
DOC_USP7_UBL2_3	13	17	PF12436	0.730
DOC_USP7_UBL2_3	131	135	PF12436	0.740
DOC_USP7_UBL2_3	27	31	PF12436	0.538
DOC_USP7_UBL2_3	34	38	PF12436	0.546
DOC_WW_Pin1_4	92	97	PF00397	0.777
LIG_Actin_WH2_2	40	57	PF00022	0.618
LIG_BIR_II_1	1	5	PF00653	0.731
LIG_BRCT_BRCA1_1	10	14	PF00533	0.737
LIG_FHA_1	139	145	PF00498	0.433
LIG_FHA_1	34	40	PF00498	0.624
LIG_FHA_1	93	99	PF00498	0.724
LIG_FHA_2	113	119	PF00498	0.611
LIG_Pex14_2	165	169	PF04695	0.434
LIG_REV1ctd_RIR_1	106	116	PF16727	0.648
LIG_WRC_WIRS_1	162	167	PF05994	0.688
MOD_CK1_1	110	116	PF00069	0.556
MOD_CK1_1	4	10	PF00069	0.500
MOD_CK2_1	112	118	PF00069	0.728
MOD_GlcNHglycan	1	4	PF01048	0.548
MOD_GSK3_1	1	8	PF00069	0.523
MOD_GSK3_1	134	141	PF00069	0.472
MOD_GSK3_1	161	168	PF00069	0.690
MOD_GSK3_1	33	40	PF00069	0.591
MOD_GSK3_1	94	101	PF00069	0.640
MOD_NEK2_1	1	6	PF00069	0.666
MOD_NEK2_1	107	112	PF00069	0.537
MOD_NEK2_1	165	170	PF00069	0.685
MOD_PIKK_1	138	144	PF00454	0.597
MOD_PKA_1	134	140	PF00069	0.475
MOD_PKA_2	138	144	PF00069	0.442
MOD_Plk_2-3	100	106	PF00069	0.748
MOD_Plk_4	161	167	PF00069	0.692
MOD_Plk_4	94	100	PF00069	0.535
MOD_ProDKin_1	92	98	PF00069	0.774
MOD_SUMO_rev_2	117	122	PF00179	0.705
MOD_SUMO_rev_2	127	137	PF00179	0.435
MOD_SUMO_rev_2	77	86	PF00179	0.697
TRG_DiLeu_BaEn_1	66	71	PF01217	0.492
TRG_ER_diArg_1	128	130	PF00400	0.519
TRG_ER_diArg_1	56	59	PF00400	0.615
TRG_ER_diArg_1	67	70	PF00400	0.465
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	73	77	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NH88	Trypanosomatidae	34%	97%
A0A3S7WWT3	Leishmania donovani	74%	99%
A0A422N8U7	Trypanosoma rangeli	34%	97%
A4HZH9	Leishmania infantum	74%	99%
D0A0Y3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	81%
E9AVG9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4QC10	Leishmania major	72%	100%