Proteasome subunit alpha type

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome alpha 2 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HC34_LEIBR

TriTrypDb:

LbrM.21.2010 , LBRM2903_210025800

Length:

231

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 10

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	12
GO:0005737	cytoplasm	2	12
GO:0005839	proteasome core complex	3	1
GO:0019773	proteasome core complex, alpha-subunit complex	2	12
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0043229	intracellular organelle	3	12
GO:0043231	intracellular membrane-bounded organelle	4	12
GO:0110165	cellular anatomical entity	1	12

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Expansion

Sequence features

A4HC34

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC34

PDB structure(s): 6qm7_B , 6qm7_P , 6qm8_B , 6qm8_P , 6tcz_b , 6td5_b

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	12
GO:0006511	ubiquitin-dependent protein catabolic process	7	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	12
GO:0010498	proteasomal protein catabolic process	5	1
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	12

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0016787	hydrolase activity	2	8

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	53	57	PF00656	0.640
CLV_NRD_NRD_1	109	111	PF00675	0.426
CLV_PCSK_KEX2_1	174	176	PF00082	0.354
CLV_PCSK_PC1ET2_1	174	176	PF00082	0.354
CLV_PCSK_SKI1_1	169	173	PF00082	0.354
DEG_SCF_FBW7_1	201	206	PF00400	0.478
DOC_CKS1_1	200	205	PF01111	0.478
DOC_MAPK_gen_1	174	182	PF00069	0.565
DOC_SPAK_OSR1_1	215	219	PF12202	0.746
DOC_WW_Pin1_4	199	204	PF00397	0.478

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2I1	Leptomonas seymouri	40%	95%
A0A0N0P4E6	Leptomonas seymouri	32%	97%
A0A0N0P7F8	Leptomonas seymouri	25%	76%
A0A0N1I173	Leptomonas seymouri	93%	100%
A0A0N1I278	Leptomonas seymouri	38%	94%
A0A0N1I2E0	Leptomonas seymouri	29%	92%
A0A0N1ILS9	Leptomonas seymouri	40%	87%
A0A0N1PBJ3	Leptomonas seymouri	37%	81%
A0A0S4INC9	Bodo saltans	31%	98%
A0A0S4IQU5	Bodo saltans	37%	87%

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