Calcium uniporter protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function, DUF607, putative

Species:

Leishmania braziliensis

UniProt:

A4HC33_LEIBR

TriTrypDb:

LbrM.21.2000 , LBRM2903_210025700

Length:

251

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005743	mitochondrial inner membrane	5	13
GO:0016020	membrane	2	13
GO:0019866	organelle inner membrane	4	13
GO:0031090	organelle membrane	3	13
GO:0031966	mitochondrial membrane	4	13
GO:0110165	cellular anatomical entity	1	14
GO:0005737	cytoplasm	2	1
GO:0032991	protein-containing complex	1	1
GO:0034702	monoatomic ion channel complex	4	1
GO:0034703	cation channel complex	5	1
GO:0034704	calcium channel complex	6	1
GO:0098796	membrane protein complex	2	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0098800	inner mitochondrial membrane protein complex	3	1
GO:1902495	transmembrane transporter complex	3	1
GO:1990246	uniplex complex	4	1
GO:1990351	transporter complex	2	1

Expansion

Sequence features

A4HC33

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC33

Function

Biological processes
Term	Name	Level	Count
GO:0006873	intracellular monoatomic ion homeostasis	4	14
GO:0006874	intracellular calcium ion homeostasis	7	14
GO:0006875	obsolete intracellular metal ion homeostasis	6	14
GO:0009987	cellular process	1	14
GO:0019725	cellular homeostasis	2	14
GO:0030003	intracellular monoatomic cation homeostasis	5	14
GO:0042592	homeostatic process	3	14
GO:0048878	chemical homeostasis	4	14
GO:0050801	monoatomic ion homeostasis	5	14
GO:0051560	mitochondrial calcium ion homeostasis	8	14
GO:0055065	obsolete metal ion homeostasis	7	14
GO:0055074	calcium ion homeostasis	8	14
GO:0055080	monoatomic cation homeostasis	6	14
GO:0055082	intracellular chemical homeostasis	3	14
GO:0065007	biological regulation	1	14
GO:0065008	regulation of biological quality	2	14
GO:0072503	obsolete cellular divalent inorganic cation homeostasis	6	14
GO:0072507	obsolete divalent inorganic cation homeostasis	7	14
GO:0098771	inorganic ion homeostasis	6	14
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0006816	calcium ion transport	7	1
GO:0006851	mitochondrial calcium ion transmembrane transport	4	1
GO:0030001	metal ion transport	6	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0036444	calcium import into the mitochondrion	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0070588	calcium ion transmembrane transport	6	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1
GO:1990542	mitochondrial transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	14
GO:0005216	monoatomic ion channel activity	4	14
GO:0005261	monoatomic cation channel activity	5	14
GO:0005262	calcium channel activity	6	14
GO:0008324	monoatomic cation transmembrane transporter activity	4	14
GO:0015075	monoatomic ion transmembrane transporter activity	3	14
GO:0015085	calcium ion transmembrane transporter activity	6	14
GO:0015267	channel activity	4	14
GO:0015291	secondary active transmembrane transporter activity	4	14
GO:0015292	uniporter activity	5	14
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	14
GO:0022803	passive transmembrane transporter activity	3	14
GO:0022804	active transmembrane transporter activity	3	14
GO:0022857	transmembrane transporter activity	2	14
GO:0022890	inorganic cation transmembrane transporter activity	4	14
GO:0046873	metal ion transmembrane transporter activity	5	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	125	127	PF00675	0.258
CLV_NRD_NRD_1	7	9	PF00675	0.394
CLV_PCSK_KEX2_1	125	127	PF00082	0.273
CLV_PCSK_KEX2_1	59	61	PF00082	0.381
CLV_PCSK_PC1ET2_1	59	61	PF00082	0.381
CLV_PCSK_SKI1_1	22	26	PF00082	0.426
CLV_PCSK_SKI1_1	27	31	PF00082	0.369
CLV_PCSK_SKI1_1	59	63	PF00082	0.346
CLV_PCSK_SKI1_1	9	13	PF00082	0.372
DEG_Nend_Nbox_1	1	3	PF02207	0.589
DEG_SPOP_SBC_1	91	95	PF00917	0.393
DOC_MAPK_gen_1	59	67	PF00069	0.536
DOC_MAPK_MEF2A_6	59	67	PF00069	0.561
DOC_USP7_MATH_1	135	139	PF00917	0.352
DOC_USP7_MATH_1	170	174	PF00917	0.418
DOC_USP7_MATH_1	224	228	PF00917	0.666
DOC_USP7_MATH_1	92	96	PF00917	0.516
DOC_USP7_UBL2_3	23	27	PF12436	0.637
DOC_WW_Pin1_4	37	42	PF00397	0.621
LIG_Actin_WH2_2	71	87	PF00022	0.560
LIG_BRCT_BRCA1_1	94	98	PF00533	0.574
LIG_deltaCOP1_diTrp_1	129	133	PF00928	0.468
LIG_FHA_1	132	138	PF00498	0.406
LIG_FHA_1	147	153	PF00498	0.279
LIG_FHA_1	160	166	PF00498	0.394
LIG_HCF-1_HBM_1	183	186	PF13415	0.523
LIG_LIR_Gen_1	173	180	PF02991	0.403
LIG_LIR_Gen_1	183	194	PF02991	0.439
LIG_LIR_Gen_1	28	34	PF02991	0.531
LIG_LIR_Gen_1	69	79	PF02991	0.517
LIG_LIR_Gen_1	95	105	PF02991	0.477
LIG_LIR_Nem_3	127	133	PF02991	0.532
LIG_LIR_Nem_3	149	153	PF02991	0.284
LIG_LIR_Nem_3	173	177	PF02991	0.368
LIG_LIR_Nem_3	183	189	PF02991	0.446
LIG_LIR_Nem_3	28	33	PF02991	0.533
LIG_LIR_Nem_3	69	75	PF02991	0.517
LIG_LIR_Nem_3	95	101	PF02991	0.574
LIG_PCNA_PIPBox_1	141	150	PF02747	0.358
LIG_SH2_NCK_1	186	190	PF00017	0.540
LIG_SH2_STAP1	174	178	PF00017	0.376
LIG_SH2_STAT5	147	150	PF00017	0.343
LIG_SH2_STAT5	176	179	PF00017	0.400
LIG_SH2_STAT5	54	57	PF00017	0.495
LIG_SH2_STAT5	70	73	PF00017	0.487
LIG_SH3_3	154	160	PF00018	0.284
LIG_SH3_3	86	92	PF00018	0.583
LIG_SUMO_SIM_par_1	224	231	PF11976	0.681
LIG_SUMO_SIM_par_1	62	69	PF11976	0.519
LIG_TRAF2_1	218	221	PF00917	0.666
LIG_WRC_WIRS_1	147	152	PF05994	0.343
MOD_CK1_1	185	191	PF00069	0.557
MOD_CK1_1	245	251	PF00069	0.678
MOD_CK2_1	44	50	PF00069	0.559
MOD_Cter_Amidation	20	23	PF01082	0.415
MOD_GlcNHglycan	137	140	PF01048	0.321
MOD_GlcNHglycan	201	205	PF01048	0.313
MOD_GlcNHglycan	85	88	PF01048	0.375
MOD_GSK3_1	131	138	PF00069	0.386
MOD_GSK3_1	159	166	PF00069	0.308
MOD_NEK2_1	105	110	PF00069	0.567
MOD_NEK2_1	163	168	PF00069	0.378
MOD_NEK2_1	2	7	PF00069	0.525
MOD_NEK2_2	54	59	PF00069	0.583
MOD_PIKK_1	32	38	PF00454	0.658
MOD_PIKK_1	39	45	PF00454	0.662
MOD_PKA_1	243	249	PF00069	0.709
MOD_PKA_2	231	237	PF00069	0.694
MOD_Plk_1	114	120	PF00069	0.446
MOD_Plk_1	182	188	PF00069	0.469
MOD_Plk_1	200	206	PF00069	0.475
MOD_Plk_1	237	243	PF00069	0.706
MOD_Plk_4	159	165	PF00069	0.352
MOD_Plk_4	2	8	PF00069	0.656
MOD_Plk_4	245	251	PF00069	0.545
MOD_ProDKin_1	37	43	PF00069	0.623
MOD_SUMO_rev_2	238	246	PF00179	0.526
MOD_SUMO_rev_2	68	78	PF00179	0.579
TRG_ENDOCYTIC_2	147	150	PF00928	0.343
TRG_ENDOCYTIC_2	174	177	PF00928	0.344
TRG_ENDOCYTIC_2	186	189	PF00928	0.435
TRG_ENDOCYTIC_2	72	75	PF00928	0.508
TRG_ER_diArg_1	124	126	PF00400	0.458

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P418	Leptomonas seymouri	58%	89%
A0A0N1I8M7	Leptomonas seymouri	27%	76%
A0A0S4IYH5	Bodo saltans	33%	100%
A0A0S4JRI1	Bodo saltans	30%	94%
A0A1X0NHK2	Trypanosomatidae	41%	93%
A0A3Q8IFA5	Leishmania donovani	83%	100%
A0A422N8V4	Trypanosoma rangeli	34%	96%
A4HZH5	Leishmania infantum	83%	100%
D0A0Z8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	99%
E9AVG5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4QC14	Leishmania major	83%	100%
V5DIC7	Trypanosoma cruzi	43%	84%