Putative pumillio protein 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

pumillio protein 3, putative

Species:

Leishmania braziliensis

UniProt:

A4HC32_LEIBR

TriTrypDb:

LbrM.21.1990 , LBRM2903_210025600

Length:

573

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC32

Function

Biological processes
Term	Name	Level	Count
GO:0010468	regulation of gene expression	5	1
GO:0010608	post-transcriptional regulation of gene expression	6	1
GO:0019222	regulation of metabolic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003729	mRNA binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	189	193	PF00656	0.396
CLV_NRD_NRD_1	11	13	PF00675	0.440
CLV_NRD_NRD_1	116	118	PF00675	0.457
CLV_NRD_NRD_1	515	517	PF00675	0.554
CLV_PCSK_KEX2_1	11	13	PF00082	0.440
CLV_PCSK_KEX2_1	136	138	PF00082	0.538
CLV_PCSK_PC1ET2_1	136	138	PF00082	0.556
CLV_PCSK_SKI1_1	120	124	PF00082	0.623
CLV_PCSK_SKI1_1	164	168	PF00082	0.474
CLV_PCSK_SKI1_1	315	319	PF00082	0.313
CLV_PCSK_SKI1_1	374	378	PF00082	0.307
DEG_SCF_FBW7_1	279	286	PF00400	0.256
DEG_SCF_FBW7_1	567	572	PF00400	0.463
DEG_SCF_FBW7_1	90	97	PF00400	0.472
DOC_CDC14_PxL_1	415	423	PF14671	0.298
DOC_CKS1_1	48	53	PF01111	0.527
DOC_CKS1_1	91	96	PF01111	0.569
DOC_CYCLIN_yCln2_LP_2	59	65	PF00134	0.729
DOC_MAPK_MEF2A_6	408	417	PF00069	0.276
DOC_PP4_FxxP_1	48	51	PF00568	0.569
DOC_PP4_FxxP_1	523	526	PF00568	0.608
DOC_USP7_MATH_1	32	36	PF00917	0.626
DOC_USP7_MATH_1	404	408	PF00917	0.393
DOC_USP7_UBL2_3	36	40	PF12436	0.643
DOC_USP7_UBL2_3	506	510	PF12436	0.360
DOC_WW_Pin1_4	128	133	PF00397	0.615
DOC_WW_Pin1_4	166	171	PF00397	0.544
DOC_WW_Pin1_4	279	284	PF00397	0.262
DOC_WW_Pin1_4	367	372	PF00397	0.335
DOC_WW_Pin1_4	47	52	PF00397	0.549
DOC_WW_Pin1_4	522	527	PF00397	0.698
DOC_WW_Pin1_4	536	541	PF00397	0.645
DOC_WW_Pin1_4	544	549	PF00397	0.609
DOC_WW_Pin1_4	565	570	PF00397	0.471
DOC_WW_Pin1_4	58	63	PF00397	0.542
DOC_WW_Pin1_4	74	79	PF00397	0.476
DOC_WW_Pin1_4	90	95	PF00397	0.545
LIG_14-3-3_CanoR_1	106	112	PF00244	0.460
LIG_14-3-3_CanoR_1	343	352	PF00244	0.439
LIG_Actin_WH2_2	426	441	PF00022	0.274
LIG_AP2alpha_2	391	393	PF02296	0.274
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BIR_III_4	319	323	PF00653	0.256
LIG_BRCT_BRCA1_1	44	48	PF00533	0.554
LIG_EH1_1	286	294	PF00400	0.256
LIG_FHA_1	284	290	PF00498	0.256
LIG_FHA_1	345	351	PF00498	0.432
LIG_FHA_1	410	416	PF00498	0.273
LIG_FHA_2	2	8	PF00498	0.538
LIG_FHA_2	204	210	PF00498	0.343
LIG_FHA_2	220	226	PF00498	0.388
LIG_FHA_2	296	302	PF00498	0.366
LIG_FHA_2	53	59	PF00498	0.628
LIG_LIR_Apic_2	367	371	PF02991	0.216
LIG_LIR_Apic_2	45	51	PF02991	0.570
LIG_LIR_Apic_2	522	526	PF02991	0.465
LIG_LIR_Gen_1	13	22	PF02991	0.589
LIG_LIR_Gen_1	245	256	PF02991	0.274
LIG_LIR_Gen_1	83	92	PF02991	0.627
LIG_LIR_Nem_3	109	114	PF02991	0.678
LIG_LIR_Nem_3	13	18	PF02991	0.544
LIG_LIR_Nem_3	245	251	PF02991	0.274
LIG_LIR_Nem_3	339	345	PF02991	0.279
LIG_LIR_Nem_3	391	396	PF02991	0.259
LIG_LIR_Nem_3	465	470	PF02991	0.256
LIG_MAD2	436	444	PF02301	0.300
LIG_PCNA_yPIPBox_3	318	330	PF02747	0.256
LIG_PTB_Apo_2	497	504	PF02174	0.356
LIG_PTB_Phospho_1	497	503	PF10480	0.362
LIG_Rb_pABgroove_1	251	259	PF01858	0.256
LIG_SH2_CRK	342	346	PF00017	0.315
LIG_SH2_CRK	368	372	PF00017	0.216
LIG_SH2_GRB2like	15	18	PF00017	0.589
LIG_SH2_GRB2like	248	251	PF00017	0.256
LIG_SH2_NCK_1	368	372	PF00017	0.216
LIG_SH2_NCK_1	92	96	PF00017	0.622
LIG_SH2_STAP1	248	252	PF00017	0.256
LIG_SH2_STAP1	503	507	PF00017	0.347
LIG_SH2_STAP1	550	554	PF00017	0.472
LIG_SH2_STAT3	24	27	PF00017	0.380
LIG_SH2_STAT3	396	399	PF00017	0.256
LIG_SH2_STAT3	470	473	PF00017	0.256
LIG_SH2_STAT5	128	131	PF00017	0.475
LIG_SH2_STAT5	215	218	PF00017	0.388
LIG_SH2_STAT5	24	27	PF00017	0.544
LIG_SH2_STAT5	340	343	PF00017	0.398
LIG_SH2_STAT5	396	399	PF00017	0.256
LIG_SH2_STAT5	400	403	PF00017	0.256
LIG_SH2_STAT5	41	44	PF00017	0.470
LIG_SH2_STAT5	449	452	PF00017	0.230
LIG_SH2_STAT5	470	473	PF00017	0.256
LIG_SH2_STAT5	92	95	PF00017	0.673
LIG_SH3_3	126	132	PF00018	0.735
LIG_SH3_3	268	274	PF00018	0.297
LIG_SH3_3	386	392	PF00018	0.379
LIG_SH3_3	490	496	PF00018	0.340
LIG_SH3_3	88	94	PF00018	0.587
LIG_SUMO_SIM_par_1	277	282	PF11976	0.335
LIG_SUMO_SIM_par_1	411	416	PF11976	0.199
LIG_SUMO_SIM_par_1	52	58	PF11976	0.463
LIG_TRAF2_1	526	529	PF00917	0.467
LIG_TRFH_1	128	132	PF08558	0.566
MOD_CDC14_SPxK_1	61	64	PF00782	0.539
MOD_CDK_SPK_2	522	527	PF00069	0.447
MOD_CDK_SPxK_1	58	64	PF00069	0.547
MOD_CDK_SPxxK_3	367	374	PF00069	0.335
MOD_CDK_SPxxK_3	536	543	PF00069	0.695
MOD_CDK_SPxxK_3	94	101	PF00069	0.688
MOD_CK1_1	186	192	PF00069	0.569
MOD_CK1_1	35	41	PF00069	0.682
MOD_CK1_1	49	55	PF00069	0.590
MOD_CK1_1	536	542	PF00069	0.665
MOD_CK1_1	77	83	PF00069	0.587
MOD_CK2_1	1	7	PF00069	0.621
MOD_CK2_1	295	301	PF00069	0.273
MOD_CK2_1	52	58	PF00069	0.620
MOD_CK2_1	522	528	PF00069	0.492
MOD_GlcNHglycan	138	142	PF01048	0.713
MOD_GlcNHglycan	180	184	PF01048	0.627
MOD_GlcNHglycan	535	538	PF01048	0.725
MOD_GlcNHglycan	555	558	PF01048	0.420
MOD_GSK3_1	179	186	PF00069	0.659
MOD_GSK3_1	188	195	PF00069	0.520
MOD_GSK3_1	279	286	PF00069	0.271
MOD_GSK3_1	344	351	PF00069	0.378
MOD_GSK3_1	35	42	PF00069	0.619
MOD_GSK3_1	409	416	PF00069	0.347
MOD_GSK3_1	54	61	PF00069	0.434
MOD_GSK3_1	565	572	PF00069	0.563
MOD_GSK3_1	77	84	PF00069	0.582
MOD_GSK3_1	90	97	PF00069	0.538
MOD_N-GLC_1	107	112	PF02516	0.636
MOD_N-GLC_1	183	188	PF02516	0.598
MOD_N-GLC_1	409	414	PF02516	0.369
MOD_N-GLC_1	80	85	PF02516	0.630
MOD_NEK2_1	1	6	PF00069	0.641
MOD_NEK2_1	107	112	PF00069	0.732
MOD_NEK2_1	292	297	PF00069	0.268
MOD_NEK2_1	487	492	PF00069	0.347
MOD_PIKK_1	186	192	PF00454	0.554
MOD_PIKK_1	42	48	PF00454	0.557
MOD_PKA_1	11	17	PF00069	0.412
MOD_PKA_2	11	17	PF00069	0.412
MOD_Plk_1	107	113	PF00069	0.590
MOD_Plk_1	409	415	PF00069	0.411
MOD_Plk_1	80	86	PF00069	0.627
MOD_Plk_4	413	419	PF00069	0.208
MOD_ProDKin_1	128	134	PF00069	0.615
MOD_ProDKin_1	166	172	PF00069	0.541
MOD_ProDKin_1	279	285	PF00069	0.262
MOD_ProDKin_1	367	373	PF00069	0.335
MOD_ProDKin_1	47	53	PF00069	0.544
MOD_ProDKin_1	522	528	PF00069	0.701
MOD_ProDKin_1	536	542	PF00069	0.643
MOD_ProDKin_1	544	550	PF00069	0.610
MOD_ProDKin_1	565	571	PF00069	0.470
MOD_ProDKin_1	58	64	PF00069	0.543
MOD_ProDKin_1	74	80	PF00069	0.474
MOD_ProDKin_1	90	96	PF00069	0.549
MOD_SUMO_rev_2	110	119	PF00179	0.611
MOD_SUMO_rev_2	403	409	PF00179	0.337
TRG_DiLeu_BaLyEn_6	458	463	PF01217	0.209
TRG_DiLeu_BaLyEn_6	493	498	PF01217	0.471
TRG_ENDOCYTIC_2	15	18	PF00928	0.589
TRG_ENDOCYTIC_2	248	251	PF00928	0.256
TRG_ENDOCYTIC_2	342	345	PF00928	0.313
TRG_ER_diArg_1	10	12	PF00400	0.446
TRG_ER_diArg_1	199	202	PF00400	0.458
TRG_Pf-PMV_PEXEL_1	461	465	PF00026	0.169

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P473	Leptomonas seymouri	30%	100%
A0A0N1PC50	Leptomonas seymouri	72%	99%
A0A0S4JMB8	Bodo saltans	32%	82%
A0A1X0NHM5	Trypanosomatidae	57%	100%
A0A3S7WWX7	Leishmania donovani	84%	100%
A0A422N8V0	Trypanosoma rangeli	53%	100%
A4HNL0	Leishmania braziliensis	31%	100%
A4HZH4	Leishmania infantum	84%	100%
D0A0Z9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	98%
E9AVG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
P0DN95	Arabidopsis thaliana	23%	100%
P39016	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	67%
Q4QC15	Leishmania major	83%	100%
Q9LDW3	Arabidopsis thaliana	33%	100%
V5B1W9	Trypanosoma cruzi	55%	100%