Putative centromere/microtubule binding protein cbf5

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

centromere/microtubule binding protein cbf5, putative (fragment)

Species:

Leishmania braziliensis

UniProt:

A4HC31_LEIBR

TriTrypDb:

LbrM.21.1980 , LBRM2903_210026300

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 1
NetGPI	no	yes: 0, no: 1

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC31

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC31

Function

Biological processes
Term	Name	Level	Count
GO:0001522	pseudouridine synthesis	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009451	RNA modification	5	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003824	catalytic activity	1	2
GO:0005488	binding	1	2
GO:0009982	pseudouridine synthase activity	4	2
GO:0016853	isomerase activity	2	2
GO:0016866	intramolecular transferase activity	3	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	19	21	PF00675	0.600
CLV_PCSK_KEX2_1	19	21	PF00082	0.600
CLV_PCSK_KEX2_1	49	51	PF00082	0.500
CLV_PCSK_PC1ET2_1	49	51	PF00082	0.500
CLV_PCSK_SKI1_1	49	53	PF00082	0.500
CLV_PCSK_SKI1_1	80	84	PF00082	0.500
DEG_Nend_UBRbox_3	1	3	PF02207	0.600
DOC_USP7_UBL2_3	49	53	PF12436	0.700
DOC_WW_Pin1_4	13	18	PF00397	0.600
LIG_14-3-3_CanoR_1	19	28	PF00244	0.337
LIG_14-3-3_CanoR_1	4	11	PF00244	0.600
LIG_BRCT_BRCA1_1	4	8	PF00533	0.600
LIG_FHA_1	66	72	PF00498	0.700
LIG_FHA_1	77	83	PF00498	0.562
LIG_FHA_2	7	13	PF00498	0.600
LIG_GBD_Chelix_1	44	52	PF00786	0.600
LIG_LIR_Gen_1	5	12	PF02991	0.600
LIG_LIR_Nem_3	12	18	PF02991	0.477
LIG_LIR_Nem_3	23	28	PF02991	0.284
LIG_LIR_Nem_3	5	11	PF02991	0.600
LIG_LIR_Nem_3	91	95	PF02991	0.700
LIG_PDZ_Class_2	90	95	PF00595	0.700
LIG_SH2_CRK	28	32	PF00017	0.600
LIG_SH2_PTP2	92	95	PF00017	0.804
LIG_SH2_STAT5	25	28	PF00017	0.600
LIG_SH2_STAT5	92	95	PF00017	0.804
LIG_SH3_3	33	39	PF00018	0.600
LIG_TYR_ITIM	26	31	PF00017	0.600
LIG_UBA3_1	30	35	PF00899	0.600
MOD_CDC14_SPxK_1	16	19	PF00782	0.600
MOD_CDK_SPxK_1	13	19	PF00069	0.600
MOD_CDK_SPxxK_3	13	20	PF00069	0.600
MOD_CK1_1	37	43	PF00069	0.600
MOD_CK2_1	37	43	PF00069	0.600
MOD_CK2_1	6	12	PF00069	0.600
MOD_GSK3_1	2	9	PF00069	0.600
MOD_GSK3_1	34	41	PF00069	0.600
MOD_GSK3_1	72	79	PF00069	0.700
MOD_NEK2_1	81	86	PF00069	0.700
MOD_PIKK_1	81	87	PF00454	0.700
MOD_PKA_2	3	9	PF00069	0.600
MOD_PKA_2	76	82	PF00069	0.700
MOD_Plk_4	43	49	PF00069	0.600
MOD_Plk_4	88	94	PF00069	0.700
MOD_ProDKin_1	13	19	PF00069	0.600
TRG_ENDOCYTIC_2	28	31	PF00928	0.600
TRG_ENDOCYTIC_2	92	95	PF00928	0.804
TRG_ER_diArg_1	18	20	PF00400	0.600
TRG_Pf-PMV_PEXEL_1	20	24	PF00026	0.600
TRG_Pf-PMV_PEXEL_1	50	55	PF00026	0.500

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0AIC9	LISW6	42%	31%
A0JUU8	ARTS2	44%	31%
A0LHM2	SYNFM	41%	31%
A0PQD9	MYCUA	42%	32%
A0Q7W5	FRATN	39%	31%
A0QIX1	MYCA1	42%	31%
A0RHI1	BACAH	42%	31%
A1AG71	ECOK1	38%	30%
A1B5U1	PARDP	40%	32%
A1K7B7	AZOSB	35%	32%
A1KMD6	MYCBP	44%	32%
A1R520	PAEAT	44%	31%
A1S464	SHEAM	38%	30%
A1ST47	PSYIN	40%	31%
A1U5Z8	MARN8	35%	31%
A1UET1	MYCSK	47%	32%
A1WXU9	HALHL	37%	31%
A2BSS0	PROMS	43%	31%
A2BY54	PROM5	46%	31%
A2C4C0	PROM1	43%	30%
A2RE90	STRPG	42%	32%
A3CMF2	STRSV	48%	33%
A3MJW6	BURM7	39%	31%
A3N007	ACTP2	37%	31%
A3N8W0	BURP6	39%	31%
A3NUL2	BURP0	39%	31%
A3PEI1	PROM0	43%	31%
A3PNF6	CERS1	41%	32%
A3PY88	MYCSJ	47%	32%
A3QGU3	SHELP	36%	30%
A4IME0	GEOTN	44%	31%
A4IWL0	FRATW	39%	31%
A4QEY6	CORGB	42%	32%
A4VPN8	PSEU5	35%	31%
A4WEY1	ENT38	37%	30%
A4WWP4	CERS5	41%	32%
A4XL67	CALS8	39%	33%
A4XYD8	PSEMY	36%	31%
A5D2S3	PELTS	45%	30%
A5F928	VIBC3	38%	30%
A5FQR4	DEHMB	36%	32%
A5GF89	GEOUR	40%	31%
A5GN82	SYNPW	46%	32%
A5IIS7	THEP1	40%	31%
A5ISF5	STAA9	42%	31%
A5N845	CLOK5	39%	33%
A5U6E6	MYCTA	44%	32%
A5UBU2	HAEIE	38%	31%
A5UF28	HAEIG	38%	31%
A5VJE2	LIMRD	44%	32%
A6KZJ9	PHOV8	42%	40%
A6LLV6	THEM4	41%	31%
A6QGH0	STAAE	42%	31%
A6TEI5	KLEP7	38%	30%
A6U190	STAA2	42%	31%
A6UF31	SINMW	42%	31%
A6VCJ9	PSEA7	35%	31%
A6VNE2	ACTSZ	38%	31%
A6VU31	MARMS	34%	31%
A7GG03	CLOBL	45%	33%
A7GRE0	BACCN	42%	31%
A7MQD9	CROS8	37%	30%
A7MZI3	VIBC1	38%	30%
A7NAR1	FRATF	39%	31%
A7X1Q5	STAA1	42%	31%
A7Z4T7	BACVZ	45%	31%
A7ZS63	ECO24	36%	30%
A8A4Y2	ECOHS	38%	30%
A8AQ55	CITK8	38%	30%
A8AX28	STRGC	45%	33%
A8EYU0	RICCK	44%	32%
A8FDD4	BACP2	42%	31%
A8G6F8	PROM2	41%	31%
A8G909	SERP5	35%	30%
A8GNM0	RICAH	45%	32%
A8GWV0	RICB8	44%	32%
A8H738	SHEPA	36%	30%
A8LL26	DINSH	44%	31%
A8MFB1	ALKOO	41%	32%
A8Z3V1	STAAT	42%	31%
A9HF26	GLUDA	42%	31%
A9KBM3	COXBN	36%	31%
A9KNW1	LACP7	39%	31%
A9MP38	SALAR	38%	30%
A9N730	SALPB	38%	30%
A9N8V4	COXBR	36%	31%
B0CCH1	ACAM1	44%	33%
B0JJJ5	MICAN	45%	32%
B0R686	HALS3	42%	32%
B0RRB6	XANCB	36%	31%
B0T173	CAUSK	42%	31%
B0THR7	HELMI	42%	31%
B0TQA0	SHEHH	36%	30%
B0TXH9	FRAP2	38%	31%
B0UU15	HISS2	38%	31%
B1AIZ3	UREP2	38%	42%
B1GZN9	ENDTX	40%	41%
B1IQV5	ECOLC	38%	30%
B1MD72	MYCA9	44%	32%
B1VYN2	STRGG	42%	32%
B1ZX46	OPITP	39%	39%
B3R1E2	CUPTR	41%	30%
B4RMB1	NEIG2	33%	31%
B5FA81	ALIFM	39%	30%
B5ZBG4	UREU1	41%	41%
B7KGX7	GLOC7	48%	31%
B8CKH5	SHEPW	36%	30%
C1D1L3	DEIDV	38%	31%
C3LSQ0	VIBCM	38%	30%
C3PH13	CORA7	38%	32%
C4K3E8	HAMD5	41%	30%
O34273	YEREN	38%	31%
O66922	AQUAE	47%	33%
P0DD48	STRP3	42%	32%
P0DD49	STRPQ	42%	32%
P32732	BACSU	45%	31%
P45142	HAEIN	38%	30%
P58063	CAUVC	42%	31%
P59873	BACAN	42%	31%
P59874	BORPA	42%	39%
P59877	BLOFL	38%	37%
P59878	HAEDU	41%	31%
P59880	PROMA	43%	30%
P59882	PROMP	46%	31%
P59884	PARMW	44%	33%
P60340	ECOLI	38%	30%
P60341	ECOL6	38%	30%
P60342	ECO57	38%	30%
P60343	CORDI	42%	32%
P60344	GEOSL	38%	31%
P62189	MYCBO	44%	32%
P65852	BORPE	42%	39%
P65853	BORBR	42%	39%
P65854	STAAM	42%	31%
P65855	STAAN	42%	31%
P65856	STRA3	42%	32%
P65857	STRA5	42%	32%
P65858	STRP1	42%	32%
P65859	STRP8	42%	32%
P72154	PSEAE	35%	31%
P74696	SYNY3	40%	32%
P9WHP6	MYCTO	44%	32%
P9WHP7	MYCTU	44%	32%
Q01SZ5	SOLUE	46%	32%
Q02FT0	PSEAB	35%	31%
Q03FS1	PEDPA	45%	32%
Q03QT7	LEVBA	41%	31%
Q044B5	LACGA	41%	32%
Q049V7	LACDB	45%	32%
Q04ED7	OENOB	41%	32%
Q04KA7	STRP2	45%	33%
Q0BN06	FRATO	39%	31%
Q0I3P3	HAES1	38%	31%
Q0I7Z1	SYNS3	48%	32%
Q0S212	RHOJR	40%	31%
Q0SSD7	CLOPS	38%	32%
Q0T0B5	SHIF8	38%	30%
Q0TCU3	ECOL5	38%	30%
Q0TPS0	CLOP1	38%	32%
Q112N2	TRIEI	44%	32%
Q11BC6	CHESB	41%	30%
Q14G67	FRAT1	39%	31%
Q16CE8	ROSDO	41%	31%
Q18BH7	CLOD6	44%	32%
Q1BA81	MYCSS	47%	32%
Q1G9Q1	LACDA	45%	32%
Q1GKJ9	RUEST	39%	31%
Q1GXD4	METFK	38%	31%
Q1J0C1	DEIGD	40%	30%
Q1J6C1	STRPF	42%	32%
Q1JBI5	STRPB	42%	32%
Q1JGK3	STRPD	42%	32%
Q1JLG7	STRPC	42%	32%
Q1LLR8	CUPMC	39%	30%
Q1MN41	RHIL3	42%	31%
Q1QSZ2	CHRSD	38%	31%
Q1R6H2	ECOUT	38%	30%
Q1RIG2	RICBR	44%	32%
Q1WUF2	LIGS1	39%	31%
Q21H63	SACD2	38%	30%
Q2A4N1	FRATH	39%	31%
Q2FHG7	STAA3	42%	31%
Q2G2Q3	STAA8	42%	31%
Q2GGA2	EHRCR	44%	32%
Q2GJV3	ANAPZ	45%	32%
Q2KDZ7	RHIEC	41%	31%
Q2KXZ0	BORA1	45%	39%
Q2LWU1	SYNAS	49%	30%
Q2NIZ2	AYWBP	44%	34%
Q2NW21	SODGM	38%	31%
Q2P0X3	XANOM	36%	31%
Q2RJM2	MOOTA	42%	31%
Q2SML1	HAHCH	35%	31%
Q2SSF2	MYCCT	36%	33%
Q2Y7W4	NITMU	43%	30%
Q2YXP5	STAAB	42%	31%
Q319E0	PROM9	43%	31%
Q31GK3	HYDCU	33%	31%
Q31W45	SHIBS	38%	30%
Q32BG7	SHIDS	38%	30%
Q38W87	LATSS	42%	31%
Q39VA3	GEOMG	39%	31%
Q3A4A3	SYNC1	42%	31%
Q3ABA1	CARHZ	43%	33%
Q3AQK9	CHLCH	40%	37%
Q3B200	CHLL3	42%	33%
Q3BRP7	XANC5	36%	31%
Q3IYU1	CERS4	41%	32%
Q3J9B8	NITOC	40%	31%
Q3JSY7	BURP1	39%	31%
Q3K189	STRA1	42%	32%
Q3M356	TRIV2	47%	32%
Q3YSC6	EHRCJ	44%	32%
Q3YX75	SHISS	38%	30%
Q3Z7U5	DEHM1	38%	32%
Q3ZXU5	DEHMC	38%	32%
Q46JB9	PROMT	43%	30%
Q46ZP3	CUPPJ	40%	30%
Q47D96	DECAR	37%	32%
Q47RU8	THEFY	44%	32%
Q48TB3	STRPM	42%	32%
Q493T5	BLOPB	41%	37%
Q49X59	STAS1	44%	31%
Q4AAX7	COXBU	36%	31%
Q4JV56	CORJK	38%	31%
Q4L5X4	STAHJ	42%	31%
Q4QK43	HAEI8	38%	31%
Q4UWA0	XANC8	36%	31%
Q57JI1	SALCH	38%	30%
Q5E7L3	ALIF1	39%	30%
Q5F8W8	NEIG1	33%	31%
Q5FHK7	EHRRG	48%	32%
Q5FJN8	LACAC	44%	32%
Q5GXV1	XANOR	36%	31%
Q5HBH8	EHRRW	48%	32%
Q5HGG0	STAAC	42%	31%
Q5HPS0	STAEQ	44%	31%
Q5L0I5	GEOKA	42%	33%
Q5LLT4	RUEPO	42%	31%
Q5LZV2	STRT1	45%	32%
Q5M4G2	STRT2	45%	32%
Q5N5A0	SYNP6	48%	32%
Q5NER4	FRATT	39%	31%
Q5PAY2	ANAMM	44%	31%
Q5PLB2	SALPA	38%	30%
Q5QTZ0	IDILO	36%	31%
Q5SLS6	THET8	42%	30%
Q5UXH1	HALMA	42%	30%
Q5WFU5	ALKCK	44%	31%
Q5XBX7	STRP6	42%	32%
Q5YSE0	NOCFA	43%	31%
Q62KL1	BURMA	39%	31%
Q636L6	BACCZ	42%	31%
Q63TQ0	BURPS	39%	31%
Q65JH8	BACLD	45%	31%
Q65SL2	MANSM	40%	31%
Q67P83	SYMTH	45%	32%
Q68WN3	RICTY	41%	33%
Q6A7P0	CUTAK	44%	32%
Q6AG41	LEIXX	42%	31%
Q6AJY7	DESPS	47%	39%
Q6D9A3	PECAS	38%	30%
Q6F1I4	MESFL	38%	33%
Q6G0P4	BARQU	42%	35%
Q6G9U2	STAAS	42%	31%
Q6GHG4	STAAR	42%	31%
Q6HF05	BACHK	42%	31%
Q6LUJ0	PHOPR	39%	30%
Q6MMS4	BDEBA	39%	31%
Q6MTR0	MYCMS	38%	33%
Q6YQY6	ONYPE	45%	34%
Q71ZZ4	LISMF	42%	31%
Q72ER4	DESVH	45%	31%
Q72GS9	THET2	42%	30%
Q732R2	BACC1	41%	31%
Q73VW3	MYCPA	42%	32%
Q74IT0	LACJO	41%	32%
Q7MAY1	PHOLL	37%	30%
Q7MBB8	GLOVI	42%	33%
Q7MI11	VIBVY	39%	30%
Q812X9	BACCR	42%	31%
Q820P2	NITEU	42%	31%
Q82K56	STRAW	41%	32%
Q83MJ8	SHIFL	38%	30%
Q87EV2	XYLFT	36%	31%
Q87M04	VIBPA	38%	30%
Q88VL5	LACPL	41%	31%
Q895J5	CLOTE	47%	33%
Q89AF6	BUCBP	48%	31%
Q8CMM6	STAES	44%	31%
Q8CWM3	THEVB	40%	33%
Q8CWR2	STRR6	45%	33%
Q8CXG9	OCEIH	40%	31%
Q8CXQ2	MALP2	43%	41%
Q8DBV8	VIBVU	39%	30%
Q8DU15	STRMU	45%	32%
Q8FPB3	COREF	42%	32%
Q8GB99	HELMO	43%	31%
Q8K9H3	BUCAP	39%	30%
Q8KFS9	CHLTE	42%	40%
Q8KIY0	SYNE7	48%	32%
Q8NP46	CORGL	42%	32%
Q8NWZ0	STAAW	42%	31%
Q8P7U9	XANCP	36%	31%
Q8PJ57	XANAC	37%	31%
Q8R5X8	FUSNN	38%	33%
Q8RA40	CALS4	41%	33%
Q8UJ53	AGRFC	41%	30%
Q8XJS1	CLOPE	38%	32%
Q8XZV4	RALSO	41%	30%
Q8Y7F3	LISMO	42%	31%
Q8YWR1	NOSS1	44%	32%
Q8Z3H9	SALTI	38%	30%
Q8ZLT2	SALTY	38%	30%
Q92C26	LISIN	42%	31%
Q92SW2	RHIME	42%	31%
Q97I48	CLOAB	42%	33%
Q97QJ3	STRPN	45%	33%
Q9CMQ7	PASMU	39%	31%
Q9HPA4	HALSA	42%	32%
Q9JTX5	NEIMA	34%	31%
Q9JYY1	NEIMB	36%	31%
Q9KA80	HALH5	39%	31%
Q9KU78	VIBCH	38%	30%
Q9PGR1	XYLFA	36%	31%
Q9PQD7	UREPA	38%	42%
Q9RB36	FLAJ1	39%	41%
Q9RUQ9	DEIRA	40%	31%
Q9WZW0	THEMA	40%	31%
Q9Z528	STRCO	42%	32%
Q9ZD46	RICPR	41%	55%