MYND-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC30_LEIBR

TriTrypDb:

LbrM.21.1970

Length:

155

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC30

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC30

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0043167	ion binding	2	8
GO:0043169	cation binding	3	8
GO:0046872	metal ion binding	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	68	72	PF00656	0.582
CLV_C14_Caspase3-7	91	95	PF00656	0.436
CLV_PCSK_SKI1_1	8	12	PF00082	0.380
DEG_Nend_UBRbox_3	1	3	PF02207	0.400
DOC_CYCLIN_RxL_1	5	14	PF00134	0.332
DOC_PP2B_LxvP_1	96	99	PF13499	0.306
DOC_PP4_FxxP_1	112	115	PF00568	0.470
DOC_USP7_MATH_1	86	90	PF00917	0.670
DOC_USP7_UBL2_3	58	62	PF12436	0.482
DOC_WW_Pin1_4	77	82	PF00397	0.488
LIG_FHA_1	14	20	PF00498	0.450
LIG_FHA_2	19	25	PF00498	0.532
LIG_FHA_2	63	69	PF00498	0.467
LIG_LIR_Apic_2	110	115	PF02991	0.277
LIG_LIR_Gen_1	102	107	PF02991	0.485
LIG_LIR_Nem_3	102	106	PF02991	0.478
LIG_PCNA_yPIPBox_3	6	19	PF02747	0.320
LIG_SH2_CRK	103	107	PF00017	0.450
LIG_SH2_STAT5	103	106	PF00017	0.394
LIG_SH2_STAT5	122	125	PF00017	0.325
LIG_SH2_STAT5	31	34	PF00017	0.315
LIG_SH3_3	139	145	PF00018	0.336
LIG_SH3_5	99	103	PF00018	0.370
MOD_CDC14_SPxK_1	80	83	PF00782	0.485
MOD_CDK_SPxK_1	77	83	PF00069	0.488
MOD_CK1_1	13	19	PF00069	0.438
MOD_CK1_1	64	70	PF00069	0.471
MOD_CK1_1	74	80	PF00069	0.460
MOD_CK1_1	89	95	PF00069	0.508
MOD_CK2_1	18	24	PF00069	0.448
MOD_CK2_1	62	68	PF00069	0.465
MOD_GlcNHglycan	123	126	PF01048	0.552
MOD_GlcNHglycan	91	94	PF01048	0.612
MOD_GSK3_1	144	151	PF00069	0.478
MOD_GSK3_1	18	25	PF00069	0.417
MOD_GSK3_1	67	74	PF00069	0.538
MOD_GSK3_1	84	91	PF00069	0.515
MOD_N-GLC_1	62	67	PF02516	0.464
MOD_N-GLC_1	75	80	PF02516	0.548
MOD_N-GLC_1	89	94	PF02516	0.597
MOD_NEK2_1	105	110	PF00069	0.459
MOD_NEK2_1	18	23	PF00069	0.464
MOD_OFUCOSY	104	111	PF10250	0.268
MOD_PIKK_1	48	54	PF00454	0.381
MOD_Plk_1	75	81	PF00069	0.545
MOD_Plk_4	18	24	PF00069	0.353
MOD_ProDKin_1	77	83	PF00069	0.488
MOD_SUMO_rev_2	43	49	PF00179	0.387
TRG_ENDOCYTIC_2	103	106	PF00928	0.446
TRG_ER_diArg_1	130	133	PF00400	0.429

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU38	Leptomonas seymouri	39%	100%
A0A3Q8IAH7	Leishmania donovani	69%	100%
A0A422N8B7	Trypanosoma rangeli	30%	100%
A4HZH3	Leishmania infantum	68%	100%
D0A101	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	68%
E9AVG3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	100%
Q4QC16	Leishmania major	67%	100%