Thyroid adenoma-associated protein homolog

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC29_LEIBR

TriTrypDb:

LbrM.21.1960 , LBRM2903_210025500

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC29

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC29

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	4	8	PF00656	0.554
CLV_PCSK_KEX2_1	256	258	PF00082	0.277
CLV_PCSK_KEX2_1	31	33	PF00082	0.448
CLV_PCSK_PC1ET2_1	256	258	PF00082	0.277
CLV_PCSK_PC1ET2_1	31	33	PF00082	0.448
CLV_PCSK_SKI1_1	122	126	PF00082	0.255
CLV_PCSK_SKI1_1	344	348	PF00082	0.463
CLV_PCSK_SKI1_1	362	366	PF00082	0.253
CLV_PCSK_SKI1_1	402	406	PF00082	0.423
CLV_PCSK_SKI1_1	410	414	PF00082	0.416
CLV_PCSK_SKI1_1	56	60	PF00082	0.331
CLV_Separin_Metazoa	35	39	PF03568	0.448
DEG_APCC_DBOX_1	361	369	PF00400	0.418
DEG_APCC_DBOX_1	55	63	PF00400	0.265
DEG_MDM2_SWIB_1	174	182	PF02201	0.374
DOC_CYCLIN_RxL_1	405	417	PF00134	0.399
DOC_CYCLIN_RxL_1	53	63	PF00134	0.269
DOC_PP2B_LxvP_1	93	96	PF13499	0.513
DOC_PP4_FxxP_1	140	143	PF00568	0.362
DOC_PP4_FxxP_1	82	85	PF00568	0.465
DOC_USP7_MATH_1	115	119	PF00917	0.531
DOC_USP7_MATH_1	162	166	PF00917	0.539
DOC_USP7_MATH_1	215	219	PF00917	0.449
DOC_USP7_MATH_1	24	28	PF00917	0.519
DOC_USP7_MATH_1	261	265	PF00917	0.463
DOC_USP7_MATH_1	436	440	PF00917	0.579
DOC_WW_Pin1_4	353	358	PF00397	0.487
LIG_14-3-3_CanoR_1	177	182	PF00244	0.280
LIG_14-3-3_CanoR_1	321	326	PF00244	0.344
LIG_Actin_WH2_2	306	323	PF00022	0.424
LIG_BRCT_BRCA1_1	337	341	PF00533	0.263
LIG_CtBP_PxDLS_1	441	447	PF00389	0.425
LIG_deltaCOP1_diTrp_1	176	184	PF00928	0.385
LIG_FHA_1	123	129	PF00498	0.236
LIG_FHA_1	177	183	PF00498	0.353
LIG_FHA_1	211	217	PF00498	0.404
LIG_FHA_1	278	284	PF00498	0.526
LIG_FHA_1	28	34	PF00498	0.514
LIG_FHA_1	299	305	PF00498	0.511
LIG_FHA_1	306	312	PF00498	0.510
LIG_FHA_1	322	328	PF00498	0.259
LIG_FHA_1	341	347	PF00498	0.244
LIG_FHA_1	50	56	PF00498	0.417
LIG_FHA_2	2	8	PF00498	0.445
LIG_FHA_2	228	234	PF00498	0.324
LIG_FHA_2	353	359	PF00498	0.413
LIG_FHA_2	415	421	PF00498	0.483
LIG_LIR_Apic_2	79	85	PF02991	0.449
LIG_LIR_Gen_1	176	186	PF02991	0.450
LIG_LIR_Gen_1	218	228	PF02991	0.340
LIG_LIR_Gen_1	281	291	PF02991	0.335
LIG_LIR_Gen_1	68	78	PF02991	0.354
LIG_LIR_Nem_3	176	181	PF02991	0.460
LIG_LIR_Nem_3	281	287	PF02991	0.343
LIG_LIR_Nem_3	68	74	PF02991	0.397
LIG_NRBOX	32	38	PF00104	0.482
LIG_NRBOX	54	60	PF00104	0.266
LIG_PCNA_yPIPBox_3	168	177	PF02747	0.314
LIG_PCNA_yPIPBox_3	67	76	PF02747	0.358
LIG_Pex14_2	100	104	PF04695	0.438
LIG_Pex14_2	174	178	PF04695	0.385
LIG_Rb_pABgroove_1	180	188	PF01858	0.232
LIG_REV1ctd_RIR_1	339	348	PF16727	0.469
LIG_SH2_SRC	203	206	PF00017	0.313
LIG_SH2_STAT5	203	206	PF00017	0.319
LIG_SH2_STAT5	239	242	PF00017	0.366
LIG_SH3_3	211	217	PF00018	0.393
LIG_SUMO_SIM_anti_2	245	250	PF11976	0.440
LIG_SUMO_SIM_par_1	212	219	PF11976	0.417
LIG_TRAF2_1	394	397	PF00917	0.392
LIG_UBA3_1	403	410	PF00899	0.251
LIG_WRC_WIRS_1	386	391	PF05994	0.253
MOD_CK1_1	118	124	PF00069	0.393
MOD_CK1_1	27	33	PF00069	0.468
MOD_CK1_1	289	295	PF00069	0.447
MOD_CK1_1	314	320	PF00069	0.453
MOD_CK1_1	330	336	PF00069	0.270
MOD_CK1_1	340	346	PF00069	0.319
MOD_CK1_1	388	394	PF00069	0.463
MOD_CK1_1	440	446	PF00069	0.624
MOD_CK1_1	86	92	PF00069	0.530
MOD_CK2_1	414	420	PF00069	0.487
MOD_Cter_Amidation	254	257	PF01082	0.256
MOD_GlcNHglycan	107	110	PF01048	0.438
MOD_GlcNHglycan	206	209	PF01048	0.326
MOD_GlcNHglycan	263	266	PF01048	0.354
MOD_GlcNHglycan	288	291	PF01048	0.478
MOD_GlcNHglycan	313	316	PF01048	0.359
MOD_GlcNHglycan	337	340	PF01048	0.271
MOD_GlcNHglycan	439	442	PF01048	0.597
MOD_GSK3_1	111	118	PF00069	0.434
MOD_GSK3_1	122	129	PF00069	0.508
MOD_GSK3_1	144	151	PF00069	0.239
MOD_GSK3_1	23	30	PF00069	0.443
MOD_GSK3_1	286	293	PF00069	0.383
MOD_GSK3_1	316	323	PF00069	0.466
MOD_GSK3_1	327	334	PF00069	0.278
MOD_GSK3_1	385	392	PF00069	0.359
MOD_GSK3_1	436	443	PF00069	0.591
MOD_N-GLC_1	16	21	PF02516	0.443
MOD_N-GLC_1	167	172	PF02516	0.540
MOD_N-GLC_1	397	402	PF02516	0.374
MOD_NEK2_1	1	6	PF00069	0.519
MOD_NEK2_1	286	291	PF00069	0.512
MOD_NEK2_1	313	318	PF00069	0.440
MOD_NEK2_1	320	325	PF00069	0.339
MOD_NEK2_1	327	332	PF00069	0.280
MOD_NEK2_1	337	342	PF00069	0.265
MOD_NEK2_1	374	379	PF00069	0.421
MOD_NEK2_1	385	390	PF00069	0.280
MOD_NEK2_1	404	409	PF00069	0.385
MOD_NEK2_1	413	418	PF00069	0.471
MOD_NEK2_1	46	51	PF00069	0.394
MOD_PIKK_1	122	128	PF00454	0.241
MOD_PIKK_1	290	296	PF00454	0.385
MOD_PIKK_1	376	382	PF00454	0.262
MOD_PIKK_1	424	430	PF00454	0.475
MOD_PIKK_1	80	86	PF00454	0.456
MOD_PK_1	242	248	PF00069	0.423
MOD_PKA_2	176	182	PF00069	0.330
MOD_PKA_2	311	317	PF00069	0.465
MOD_PKA_2	320	326	PF00069	0.355
MOD_PKA_2	424	430	PF00069	0.363
MOD_PKA_2	86	92	PF00069	0.579
MOD_Plk_1	167	173	PF00069	0.546
MOD_Plk_1	186	192	PF00069	0.239
MOD_Plk_1	397	403	PF00069	0.328
MOD_Plk_4	177	183	PF00069	0.360
MOD_Plk_4	216	222	PF00069	0.362
MOD_Plk_4	327	333	PF00069	0.338
MOD_Plk_4	337	343	PF00069	0.323
MOD_Plk_4	385	391	PF00069	0.343
MOD_ProDKin_1	353	359	PF00069	0.487
MOD_SUMO_rev_2	161	171	PF00179	0.481
MOD_SUMO_rev_2	271	280	PF00179	0.341
TRG_DiLeu_BaEn_2	135	141	PF01217	0.467
TRG_DiLeu_BaLyEn_6	153	158	PF01217	0.329
TRG_DiLeu_BaLyEn_6	399	404	PF01217	0.340
TRG_DiLeu_LyEn_5	194	199	PF01217	0.422
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	56	61	PF00026	0.413

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1III8	Leptomonas seymouri	57%	100%
A0A1X0NJ75	Trypanosomatidae	34%	100%
A0A3Q8IC10	Leishmania donovani	82%	100%
A0A3S5IQQ3	Trypanosoma rangeli	32%	100%
A4HZH2	Leishmania infantum	82%	100%
D0A102	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	31%	100%
E9AVG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QC17	Leishmania major	82%	100%
V5BRG3	Trypanosoma cruzi	33%	100%