Putative mitochondrial structure specific endonuclease I (SSE-1)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial structure specific endonuclease I (SSE-1), putative

Species:

Leishmania braziliensis

UniProt:

A4HC28_LEIBR

TriTrypDb:

LbrM.21.1950 , LBRM2903_210025400

Length:

297

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC28

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0033567	DNA replication, Okazaki fragment processing	5	12
GO:0034641	cellular nitrogen compound metabolic process	3	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044237	cellular metabolic process	2	12
GO:0044238	primary metabolic process	2	12
GO:0044260	obsolete cellular macromolecule metabolic process	3	12
GO:0046483	heterocycle metabolic process	3	12
GO:0071704	organic substance metabolic process	2	12
GO:0090304	nucleic acid metabolic process	4	12
GO:1901360	organic cyclic compound metabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003677	DNA binding	4	12
GO:0003824	catalytic activity	1	12
GO:0004518	nuclease activity	4	12
GO:0004519	endonuclease activity	5	12
GO:0004520	DNA endonuclease activity	5	12
GO:0004536	DNA nuclease activity	4	12
GO:0005488	binding	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0016888	endodeoxyribonuclease activity, producing 5'-phosphomonoesters	6	12
GO:0016893	endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters	6	12
GO:0017108	5'-flap endonuclease activity	7	12
GO:0048256	flap endonuclease activity	6	12
GO:0097159	organic cyclic compound binding	2	12
GO:0140097	catalytic activity, acting on DNA	3	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:1901363	heterocyclic compound binding	2	12
GO:0004527	exonuclease activity	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	220	224	PF00656	0.255
CLV_C14_Caspase3-7	85	89	PF00656	0.240
CLV_MEL_PAP_1	200	206	PF00089	0.288
CLV_NRD_NRD_1	162	164	PF00675	0.377
CLV_NRD_NRD_1	181	183	PF00675	0.119
CLV_NRD_NRD_1	91	93	PF00675	0.248
CLV_PCSK_KEX2_1	162	164	PF00082	0.369
CLV_PCSK_KEX2_1	91	93	PF00082	0.255
CLV_PCSK_SKI1_1	116	120	PF00082	0.259
CLV_PCSK_SKI1_1	212	216	PF00082	0.413
CLV_PCSK_SKI1_1	252	256	PF00082	0.271
CLV_PCSK_SKI1_1	270	274	PF00082	0.371
CLV_PCSK_SKI1_1	286	290	PF00082	0.444
DEG_APCC_DBOX_1	126	134	PF00400	0.305
DOC_CKS1_1	31	36	PF01111	0.185
DOC_MAPK_gen_1	28	37	PF00069	0.218
DOC_MAPK_gen_1	4	11	PF00069	0.367
DOC_MAPK_gen_1	76	84	PF00069	0.255
DOC_MAPK_MEF2A_6	76	84	PF00069	0.255
DOC_PP2B_LxvP_1	131	134	PF13499	0.300
DOC_SPAK_OSR1_1	46	50	PF12202	0.312
DOC_USP7_MATH_1	100	104	PF00917	0.201
DOC_USP7_MATH_1	126	130	PF00917	0.386
DOC_USP7_MATH_1	181	185	PF00917	0.386
DOC_USP7_MATH_1	218	222	PF00917	0.312
DOC_WW_Pin1_4	105	110	PF00397	0.361
DOC_WW_Pin1_4	30	35	PF00397	0.222
DOC_WW_Pin1_4	63	68	PF00397	0.289
DOC_WW_Pin1_4	71	76	PF00397	0.298
LIG_14-3-3_CanoR_1	105	109	PF00244	0.163
LIG_14-3-3_CanoR_1	182	186	PF00244	0.163
LIG_14-3-3_CanoR_1	23	27	PF00244	0.284
LIG_eIF4E_1	172	178	PF01652	0.300
LIG_FHA_1	189	195	PF00498	0.247
LIG_FHA_1	256	262	PF00498	0.356
LIG_FHA_2	105	111	PF00498	0.163
LIG_FHA_2	31	37	PF00498	0.365
LIG_LIR_Apic_2	29	34	PF02991	0.184
LIG_LIR_Gen_1	173	181	PF02991	0.255
LIG_LIR_LC3C_4	128	133	PF02991	0.305
LIG_LIR_Nem_3	108	114	PF02991	0.372
LIG_LIR_Nem_3	169	175	PF02991	0.259
LIG_LIR_Nem_3	213	217	PF02991	0.265
LIG_NRBOX	260	266	PF00104	0.386
LIG_PTB_Apo_2	41	48	PF02174	0.334
LIG_SH2_CRK	31	35	PF00017	0.185
LIG_SH2_STAT5	26	29	PF00017	0.255
LIG_SH3_3	201	207	PF00018	0.377
LIG_SUMO_SIM_anti_2	128	135	PF11976	0.371
LIG_SUMO_SIM_par_1	128	135	PF11976	0.279
LIG_SUMO_SIM_par_1	7	12	PF11976	0.241
MOD_CDK_SPK_2	71	76	PF00069	0.245
MOD_CDK_SPxxK_3	105	112	PF00069	0.361
MOD_CK1_1	196	202	PF00069	0.269
MOD_CK1_1	66	72	PF00069	0.386
MOD_CK2_1	104	110	PF00069	0.163
MOD_CK2_1	196	202	PF00069	0.214
MOD_Cter_Amidation	89	92	PF01082	0.255
MOD_DYRK1A_RPxSP_1	105	109	PF00069	0.163
MOD_GSK3_1	100	107	PF00069	0.163
MOD_GSK3_1	158	165	PF00069	0.294
MOD_N-GLC_1	100	105	PF02516	0.163
MOD_NEK2_1	150	155	PF00069	0.304
MOD_NEK2_1	48	53	PF00069	0.381
MOD_PKA_1	162	168	PF00069	0.251
MOD_PKA_2	104	110	PF00069	0.163
MOD_PKA_2	126	132	PF00069	0.305
MOD_PKA_2	162	168	PF00069	0.305
MOD_PKA_2	181	187	PF00069	0.119
MOD_PKA_2	22	28	PF00069	0.284
MOD_Plk_1	196	202	PF00069	0.207
MOD_Plk_4	126	132	PF00069	0.301
MOD_Plk_4	162	168	PF00069	0.255
MOD_Plk_4	290	296	PF00069	0.449
MOD_ProDKin_1	105	111	PF00069	0.361
MOD_ProDKin_1	30	36	PF00069	0.222
MOD_ProDKin_1	63	69	PF00069	0.289
MOD_ProDKin_1	71	77	PF00069	0.298
MOD_SUMO_for_1	254	257	PF00179	0.386
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.464
TRG_ENDOCYTIC_2	175	178	PF00928	0.255
TRG_ENDOCYTIC_2	243	246	PF00928	0.250
TRG_ER_diArg_1	162	164	PF00400	0.318
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.274

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAT2	Leptomonas seymouri	71%	100%
A0A0S4JC26	Bodo saltans	42%	95%
A0A1X0NHU7	Trypanosomatidae	67%	100%
A0A3Q8IC31	Leishmania donovani	92%	100%
A0A3R7MFS0	Trypanosoma rangeli	70%	100%
A0KHE3	Aeromonas hydrophila subsp. hydrophila (strain ATCC 7966 / DSM 30187 / BCRC 13018 / CCUG 14551 / JCM 1027 / KCTC 2358 / NCIMB 9240 / NCTC 8049)	29%	100%
A0KZ94	Shewanella sp. (strain ANA-3)	29%	100%
A1JP96	Yersinia enterocolitica serotype O:8 / biotype 1B (strain NCTC 13174 / 8081)	30%	100%
A1RLT6	Shewanella sp. (strain W3-18-1)	29%	100%
A1S8B8	Shewanella amazonensis (strain ATCC BAA-1098 / SB2B)	28%	100%
A1SYB8	Psychromonas ingrahamii (strain 37)	30%	100%
A3D2C6	Shewanella baltica (strain OS155 / ATCC BAA-1091)	28%	100%
A4HZH1	Leishmania infantum	92%	100%
A4SQK3	Aeromonas salmonicida (strain A449)	28%	100%
A4TLA4	Yersinia pestis (strain Pestoides F)	27%	100%
A4Y4Y4	Shewanella putrefaciens (strain CN-32 / ATCC BAA-453)	29%	100%
A6WL18	Shewanella baltica (strain OS185)	29%	100%
A7FFF8	Yersinia pseudotuberculosis serotype O:1b (strain IP 31758)	27%	100%
A8FYJ2	Shewanella sediminis (strain HAW-EB3)	29%	100%
A8GIF8	Serratia proteamaculans (strain 568)	29%	100%
A9KTM9	Shewanella baltica (strain OS195)	29%	100%
B0TPG7	Shewanella halifaxensis (strain HAW-EB4)	29%	100%
B1JQE9	Yersinia pseudotuberculosis serotype O:3 (strain YPIII)	27%	100%
B1KQX1	Shewanella woodyi (strain ATCC 51908 / MS32)	31%	100%
B2JZ46	Yersinia pseudotuberculosis serotype IB (strain PB1/+)	27%	100%
B8EAT2	Shewanella baltica (strain OS223)	29%	100%
C4L9Z0	Tolumonas auensis (strain DSM 9187 / TA4)	30%	100%
D0A103	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	64%	100%
E9AVG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
P54161	Bacillus subtilis (strain 168)	29%	100%
P57506	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	28%	100%
P75403	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	30%	100%
P9WNU2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	26%	93%
P9WNU3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	26%	93%
Q07ZE8	Shewanella frigidimarina (strain NCIMB 400)	27%	100%
Q0HGN0	Shewanella sp. (strain MR-4)	30%	100%
Q0HSY6	Shewanella sp. (strain MR-7)	30%	100%
Q12L39	Shewanella denitrificans (strain OS217 / ATCC BAA-1090 / DSM 15013)	33%	100%
Q1CFD3	Yersinia pestis bv. Antiqua (strain Nepal516)	27%	100%
Q3ICC5	Pseudoalteromonas translucida (strain TAC 125)	32%	100%
Q47YA8	Colwellia psychrerythraea (strain 34H / ATCC BAA-681)	27%	100%
Q49406	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	26%	100%
Q4QC18	Leishmania major	92%	100%
Q667H8	Yersinia pseudotuberculosis serotype I (strain IP32953)	27%	100%
Q6D8F6	Pectobacterium atrosepticum (strain SCRI 1043 / ATCC BAA-672)	29%	100%
Q7CH07	Yersinia pestis	27%	100%
Q7N8Q9	Photorhabdus laumondii subsp. laumondii (strain DSM 15139 / CIP 105565 / TT01)	27%	100%
Q89AD1	Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp)	29%	98%
Q8EGP9	Shewanella oneidensis (strain MR-1)	30%	100%
Q8K9D0	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	26%	100%
Q98PK2	Mycoplasmopsis pulmonis (strain UAB CTIP)	29%	100%
Q9KAV6	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	28%	98%
Q9PQ75	Ureaplasma parvum serovar 3 (strain ATCC 700970)	27%	100%
V5BLX0	Trypanosoma cruzi	71%	100%