Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HC27_LEIBR

TriTrypDb:

LbrM.21.1940 , LBRM2903_210025300

Length:

499

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC27

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13
GO:0018105	peptidyl-serine phosphorylation	6	1
GO:0018107	peptidyl-threonine phosphorylation	6	1
GO:0018193	peptidyl-amino acid modification	5	1
GO:0018209	peptidyl-serine modification	6	1
GO:0018210	peptidyl-threonine modification	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004713	protein tyrosine kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	190	192	PF00675	0.234
CLV_NRD_NRD_1	282	284	PF00675	0.346
CLV_NRD_NRD_1	51	53	PF00675	0.649
CLV_NRD_NRD_1	56	58	PF00675	0.500
CLV_NRD_NRD_1	89	91	PF00675	0.622
CLV_PCSK_KEX2_1	190	192	PF00082	0.234
CLV_PCSK_KEX2_1	89	91	PF00082	0.590
CLV_PCSK_SKI1_1	17	21	PF00082	0.519
CLV_PCSK_SKI1_1	227	231	PF00082	0.284
CLV_PCSK_SKI1_1	238	242	PF00082	0.281
CLV_PCSK_SKI1_1	304	308	PF00082	0.294
CLV_PCSK_SKI1_1	46	50	PF00082	0.728
CLV_PCSK_SKI1_1	53	57	PF00082	0.473
DEG_APCC_DBOX_1	263	271	PF00400	0.404
DEG_APCC_DBOX_1	303	311	PF00400	0.333
DEG_SPOP_SBC_1	39	43	PF00917	0.449
DOC_CYCLIN_RxL_1	49	59	PF00134	0.486
DOC_CYCLIN_yCln2_LP_2	135	141	PF00134	0.507
DOC_MAPK_FxFP_2	446	449	PF00069	0.284
DOC_MAPK_gen_1	11	18	PF00069	0.516
DOC_MAPK_gen_1	190	198	PF00069	0.264
DOC_MAPK_gen_1	360	369	PF00069	0.256
DOC_MAPK_HePTP_8	357	369	PF00069	0.256
DOC_MAPK_MEF2A_6	190	198	PF00069	0.264
DOC_MAPK_MEF2A_6	360	369	PF00069	0.256
DOC_MAPK_MEF2A_6	372	379	PF00069	0.256
DOC_PP4_FxxP_1	446	449	PF00568	0.284
DOC_USP7_MATH_1	112	116	PF00917	0.496
DOC_USP7_MATH_1	2	6	PF00917	0.705
DOC_USP7_MATH_1	329	333	PF00917	0.404
DOC_USP7_MATH_1	69	73	PF00917	0.604
DOC_USP7_UBL2_3	46	50	PF12436	0.626
LIG_14-3-3_CanoR_1	17	23	PF00244	0.529
LIG_14-3-3_CanoR_1	224	230	PF00244	0.404
LIG_14-3-3_CanoR_1	304	313	PF00244	0.346
LIG_14-3-3_CanoR_1	424	429	PF00244	0.258
LIG_14-3-3_CanoR_1	471	477	PF00244	0.315
LIG_14-3-3_CanoR_1	52	56	PF00244	0.747
LIG_Actin_WH2_2	295	313	PF00022	0.404
LIG_Actin_WH2_2	465	483	PF00022	0.410
LIG_APCC_ABBA_1	163	168	PF00400	0.440
LIG_BRCT_BRCA1_1	225	229	PF00533	0.284
LIG_Clathr_ClatBox_1	395	399	PF01394	0.346
LIG_Clathr_ClatBox_1	458	462	PF01394	0.346
LIG_EH1_1	251	259	PF00400	0.342
LIG_eIF4E_1	252	258	PF01652	0.415
LIG_eIF4E_1	262	268	PF01652	0.398
LIG_eIF4E_1	439	445	PF01652	0.404
LIG_FHA_1	269	275	PF00498	0.284
LIG_FHA_1	348	354	PF00498	0.269
LIG_FHA_1	389	395	PF00498	0.266
LIG_FHA_2	170	176	PF00498	0.422
LIG_FHA_2	383	389	PF00498	0.381
LIG_HCF-1_HBM_1	463	466	PF13415	0.346
LIG_LIR_Apic_2	359	365	PF02991	0.256
LIG_LIR_Gen_1	140	147	PF02991	0.629
LIG_LIR_Gen_1	179	188	PF02991	0.495
LIG_LIR_Gen_1	231	240	PF02991	0.171
LIG_LIR_Gen_1	250	260	PF02991	0.130
LIG_LIR_Gen_1	463	474	PF02991	0.266
LIG_LIR_Nem_3	101	106	PF02991	0.481
LIG_LIR_Nem_3	129	134	PF02991	0.492
LIG_LIR_Nem_3	140	144	PF02991	0.546
LIG_LIR_Nem_3	179	183	PF02991	0.443
LIG_LIR_Nem_3	231	237	PF02991	0.171
LIG_LIR_Nem_3	250	255	PF02991	0.294
LIG_LIR_Nem_3	259	263	PF02991	0.283
LIG_LIR_Nem_3	463	469	PF02991	0.257
LIG_PCNA_yPIPBox_3	298	307	PF02747	0.346
LIG_Rb_pABgroove_1	114	122	PF01858	0.556
LIG_SH2_CRK	252	256	PF00017	0.171
LIG_SH2_NCK_1	106	110	PF00017	0.412
LIG_SH2_SRC	106	109	PF00017	0.413
LIG_SH2_SRC	134	137	PF00017	0.368
LIG_SH2_SRC	279	282	PF00017	0.404
LIG_SH2_STAP1	281	285	PF00017	0.319
LIG_SH2_STAT3	147	150	PF00017	0.550
LIG_SH2_STAT3	210	213	PF00017	0.460
LIG_SH2_STAT5	131	134	PF00017	0.518
LIG_SH2_STAT5	252	255	PF00017	0.324
LIG_SH2_STAT5	260	263	PF00017	0.300
LIG_SH2_STAT5	293	296	PF00017	0.269
LIG_SH2_STAT5	348	351	PF00017	0.241
LIG_SH2_STAT5	356	359	PF00017	0.269
LIG_SH2_STAT5	429	432	PF00017	0.307
LIG_SH2_STAT5	466	469	PF00017	0.284
LIG_SH3_3	191	197	PF00018	0.443
LIG_SH3_3	408	414	PF00018	0.304
LIG_SH3_3	446	452	PF00018	0.364
LIG_SH3_3	68	74	PF00018	0.476
LIG_SH3_5	118	122	PF00018	0.554
LIG_SUMO_SIM_anti_2	265	272	PF11976	0.346
LIG_SUMO_SIM_anti_2	315	320	PF11976	0.171
LIG_SUMO_SIM_par_1	265	272	PF11976	0.364
LIG_SUMO_SIM_par_1	339	346	PF11976	0.404
MOD_CK1_1	140	146	PF00069	0.658
MOD_CK1_1	400	406	PF00069	0.330
MOD_CK1_1	407	413	PF00069	0.275
MOD_CK1_1	59	65	PF00069	0.639
MOD_CK1_1	72	78	PF00069	0.658
MOD_CK2_1	169	175	PF00069	0.399
MOD_CK2_1	230	236	PF00069	0.188
MOD_CK2_1	329	335	PF00069	0.198
MOD_CK2_1	382	388	PF00069	0.404
MOD_Cter_Amidation	188	191	PF01082	0.226
MOD_GlcNHglycan	4	7	PF01048	0.593
MOD_GlcNHglycan	482	485	PF01048	0.342
MOD_GSK3_1	199	206	PF00069	0.313
MOD_GSK3_1	343	350	PF00069	0.257
MOD_GSK3_1	352	359	PF00069	0.258
MOD_GSK3_1	378	385	PF00069	0.404
MOD_GSK3_1	40	47	PF00069	0.585
MOD_GSK3_1	400	407	PF00069	0.404
MOD_GSK3_1	424	431	PF00069	0.439
MOD_GSK3_1	56	63	PF00069	0.647
MOD_GSK3_1	65	72	PF00069	0.579
MOD_N-GLC_1	424	429	PF02516	0.346
MOD_NEK2_1	203	208	PF00069	0.352
MOD_NEK2_1	312	317	PF00069	0.376
MOD_NEK2_1	343	348	PF00069	0.347
MOD_NEK2_1	382	387	PF00069	0.343
MOD_NEK2_1	404	409	PF00069	0.302
MOD_NEK2_1	428	433	PF00069	0.330
MOD_NEK2_1	83	88	PF00069	0.661
MOD_NEK2_1	91	96	PF00069	0.558
MOD_PIKK_1	84	90	PF00454	0.657
MOD_PKA_2	223	229	PF00069	0.269
MOD_PKA_2	423	429	PF00069	0.269
MOD_PKA_2	480	486	PF00069	0.256
MOD_PKA_2	51	57	PF00069	0.659
MOD_PKA_2	59	65	PF00069	0.654
MOD_Plk_1	199	205	PF00069	0.171
MOD_Plk_1	230	236	PF00069	0.179
MOD_Plk_1	424	430	PF00069	0.346
MOD_Plk_4	225	231	PF00069	0.346
MOD_Plk_4	314	320	PF00069	0.253
MOD_Plk_4	352	358	PF00069	0.269
MOD_Plk_4	390	396	PF00069	0.381
MOD_Plk_4	400	406	PF00069	0.294
MOD_Plk_4	424	430	PF00069	0.375
MOD_Plk_4	51	57	PF00069	0.627
MOD_SUMO_for_1	176	179	PF00179	0.305
MOD_SUMO_for_1	323	326	PF00179	0.256
MOD_SUMO_rev_2	108	115	PF00179	0.396
MOD_SUMO_rev_2	317	325	PF00179	0.263
MOD_SUMO_rev_2	332	341	PF00179	0.274
TRG_DiLeu_BaEn_1	265	270	PF01217	0.346
TRG_DiLeu_BaEn_1	440	445	PF01217	0.307
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.346
TRG_ENDOCYTIC_2	252	255	PF00928	0.284
TRG_ENDOCYTIC_2	260	263	PF00928	0.292
TRG_ENDOCYTIC_2	293	296	PF00928	0.261
TRG_ENDOCYTIC_2	466	469	PF00928	0.271
TRG_ER_diArg_1	190	192	PF00400	0.234
TRG_ER_diArg_1	89	91	PF00400	0.559
TRG_ER_diLys_1	495	499	PF00400	0.291
TRG_NES_CRM1_1	265	276	PF08389	0.210
TRG_NLS_MonoExtC_3	48	53	PF00514	0.649
TRG_NLS_MonoExtN_4	46	53	PF00514	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4D6	Leptomonas seymouri	33%	69%
A0A0N1IJ52	Leptomonas seymouri	64%	99%
A0A0N1PBM1	Leptomonas seymouri	32%	68%
A0A0S4IIU2	Bodo saltans	32%	100%
A0A0S4IVF2	Bodo saltans	25%	100%
A0A0S4IYY9	Bodo saltans	25%	100%
A0A0S4J2K6	Bodo saltans	31%	100%
A0A0S4J343	Bodo saltans	47%	89%
A0A0S4J8J4	Bodo saltans	26%	100%
A0A0S4JUY0	Bodo saltans	28%	84%
A0A0S4JZV2	Bodo saltans	26%	100%
A0A1X0NHA6	Trypanosomatidae	47%	95%
A0A1X0NMR5	Trypanosomatidae	25%	100%
A0A1X0NMS0	Trypanosomatidae	25%	100%
A0A1X0NQT9	Trypanosomatidae	26%	100%
A0A1X0P3K5	Trypanosomatidae	33%	100%
A0A3Q8IC55	Leishmania donovani	89%	100%
A0A3Q8IDK8	Leishmania donovani	24%	89%
A0A3R7KRM5	Trypanosoma rangeli	36%	74%
A0A3S5H6C8	Leishmania donovani	26%	100%
A0A3S5H7N7	Leishmania donovani	25%	100%
A0A3S7WQK7	Leishmania donovani	26%	100%
A0A3S7WR45	Leishmania donovani	28%	100%
A0A3S7X9D1	Leishmania donovani	31%	87%
A0A422N7C9	Trypanosoma rangeli	24%	80%
A0A422N878	Trypanosoma rangeli	47%	95%
A0A422P2B2	Trypanosoma rangeli	26%	100%
A3EZ55	Wallemia ichthyophaga (strain EXF-994 / CBS 113033)	26%	100%
A4H5L7	Leishmania braziliensis	26%	100%
A4H641	Leishmania braziliensis	28%	100%
A4H9D1	Leishmania braziliensis	28%	100%
A4HA94	Leishmania braziliensis	24%	100%
A4HG27	Leishmania braziliensis	24%	92%
A4HIM5	Leishmania braziliensis	25%	100%
A4HMK7	Leishmania braziliensis	31%	87%
A4HTV4	Leishmania infantum	26%	100%
A4HTV5	Leishmania infantum	26%	100%
A4HUG1	Leishmania infantum	28%	100%
A4HZH0	Leishmania infantum	89%	100%
A4I349	Leishmania infantum	24%	88%
A4I5X0	Leishmania infantum	25%	100%
A4IB86	Leishmania infantum	31%	87%
B0Y4X4	Neosartorya fumigata (strain CEA10 / CBS 144.89 / FGSC A1163)	27%	100%
C9ZVD8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
D0A105	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	97%
E8NHK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AF07	Leishmania major	30%	87%
E9AMP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9AN59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9AVG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B663	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	87%
G4N374	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	26%	100%
O13352	Magnaporthe oryzae	26%	100%
O35491	Mus musculus	26%	100%
O42099	Cyprinus carpio	29%	100%
O43781	Homo sapiens	32%	85%
O61443	Drosophila melanogaster	28%	100%
O80673	Arabidopsis thaliana	27%	87%
P27361	Homo sapiens	25%	100%
P40417	Drosophila melanogaster	27%	100%
P49760	Homo sapiens	27%	100%
P51566	Arabidopsis thaliana	27%	100%
P51567	Arabidopsis thaliana	27%	100%
P53779	Homo sapiens	27%	100%
Q10156	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	72%
Q39011	Arabidopsis thaliana	24%	100%
Q39012	Arabidopsis thaliana	25%	100%
Q39023	Arabidopsis thaliana	25%	100%
Q40531	Nicotiana tabacum	25%	100%
Q4Q701	Leishmania major	26%	100%
Q4QC19	Leishmania major	88%	100%
Q4QFG6	Leishmania major	33%	96%
Q4QHG6	Leishmania major	28%	100%
Q4QHY3	Leishmania major	26%	100%
Q4QHY4	Leishmania major	26%	100%
Q4R6S5	Macaca fascicularis	32%	88%
Q4V8A3	Rattus norvegicus	29%	85%
Q4WQR3	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	27%	100%
Q501Q9	Xenopus laevis	24%	85%
Q5U4C9	Mus musculus	32%	83%
Q5VP69	Oryza sativa subsp. japonica	27%	100%
Q5ZIU3	Gallus gallus	32%	95%
Q84UI5	Oryza sativa subsp. japonica	26%	100%
Q8SQZ4	Encephalitozoon cuniculi (strain GB-M1)	30%	100%
Q90327	Cyprinus carpio	29%	100%
Q922Y0	Mus musculus	33%	85%
Q99078	Ustilago maydis (strain 521 / FGSC 9021)	25%	100%
Q9DGD9	Danio rerio	29%	100%
Q9P6P3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	93%
Q9V3D5	Drosophila melanogaster	34%	69%
V5DIC3	Trypanosoma cruzi	47%	83%