EF-hand domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC26_LEIBR

TriTrypDb:

LbrM.21.1930 , LBRM2903_210025200

Length:

245

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC26

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	203	205	PF00675	0.557
CLV_NRD_NRD_1	30	32	PF00675	0.671
CLV_PCSK_KEX2_1	18	20	PF00082	0.723
CLV_PCSK_KEX2_1	202	204	PF00082	0.540
CLV_PCSK_KEX2_1	30	32	PF00082	0.723
CLV_PCSK_PC1ET2_1	18	20	PF00082	0.757
CLV_PCSK_SKI1_1	113	117	PF00082	0.422
CLV_PCSK_SKI1_1	12	16	PF00082	0.754
CLV_PCSK_SKI1_1	222	226	PF00082	0.414
DEG_APCC_DBOX_1	221	229	PF00400	0.333
DEG_Nend_Nbox_1	1	3	PF02207	0.485
DOC_CDC14_PxL_1	7	15	PF14671	0.491
DOC_CYCLIN_RxL_1	71	83	PF00134	0.561
DOC_MAPK_gen_1	202	211	PF00069	0.566
DOC_PP4_FxxP_1	99	102	PF00568	0.303
DOC_USP7_MATH_1	216	220	PF00917	0.566
DOC_USP7_MATH_1	224	228	PF00917	0.455
DOC_USP7_MATH_1	234	238	PF00917	0.247
DOC_USP7_MATH_1	46	50	PF00917	0.568
DOC_USP7_MATH_2	102	108	PF00917	0.522
LIG_14-3-3_CanoR_1	12	17	PF00244	0.688
LIG_14-3-3_CanoR_1	202	212	PF00244	0.651
LIG_14-3-3_CanoR_1	21	25	PF00244	0.614
LIG_14-3-3_CanoR_1	75	80	PF00244	0.581
LIG_BIR_III_4	160	164	PF00653	0.429
LIG_FHA_1	126	132	PF00498	0.474
LIG_FHA_1	133	139	PF00498	0.441
LIG_FHA_1	57	63	PF00498	0.369
LIG_FHA_2	15	21	PF00498	0.646
LIG_FHA_2	32	38	PF00498	0.604
LIG_FHA_2	90	96	PF00498	0.553
LIG_LIR_Gen_1	151	161	PF02991	0.495
LIG_LIR_Gen_1	189	198	PF02991	0.527
LIG_LIR_Gen_1	91	100	PF02991	0.317
LIG_LIR_Nem_3	151	157	PF02991	0.445
LIG_LIR_Nem_3	183	187	PF02991	0.573
LIG_LIR_Nem_3	189	194	PF02991	0.631
LIG_LIR_Nem_3	91	96	PF02991	0.425
LIG_PCNA_yPIPBox_3	141	154	PF02747	0.522
LIG_SH2_CRK	66	70	PF00017	0.499
LIG_SH2_STAP1	56	60	PF00017	0.510
LIG_SH2_STAP1	66	70	PF00017	0.499
LIG_SH2_STAT5	110	113	PF00017	0.323
LIG_SH2_STAT5	232	235	PF00017	0.464
LIG_SH3_3	207	213	PF00018	0.691
LIG_SH3_3	57	63	PF00018	0.549
LIG_SUMO_SIM_par_1	101	109	PF11976	0.541
LIG_SUMO_SIM_par_1	134	139	PF11976	0.511
LIG_TRAF2_1	82	85	PF00917	0.659
LIG_UBA3_1	9	18	PF00899	0.498
MOD_CK1_1	125	131	PF00069	0.459
MOD_CK1_1	214	220	PF00069	0.386
MOD_CK1_1	23	29	PF00069	0.652
MOD_CK1_1	58	64	PF00069	0.489
MOD_CK1_1	89	95	PF00069	0.317
MOD_CK2_1	14	20	PF00069	0.640
MOD_CK2_1	145	151	PF00069	0.542
MOD_CK2_1	77	83	PF00069	0.484
MOD_CK2_1	89	95	PF00069	0.280
MOD_GlcNHglycan	218	221	PF01048	0.526
MOD_GlcNHglycan	43	46	PF01048	0.706
MOD_GlcNHglycan	66	69	PF01048	0.491
MOD_GlcNHglycan	79	82	PF01048	0.537
MOD_GSK3_1	113	120	PF00069	0.480
MOD_GSK3_1	36	43	PF00069	0.683
MOD_LATS_1	143	149	PF00433	0.578
MOD_LATS_1	29	35	PF00433	0.552
MOD_NEK2_1	114	119	PF00069	0.498
MOD_NEK2_1	77	82	PF00069	0.371
MOD_NEK2_2	46	51	PF00069	0.428
MOD_PIKK_1	177	183	PF00454	0.411
MOD_PKA_1	203	209	PF00069	0.461
MOD_PKA_1	30	36	PF00069	0.551
MOD_PKA_2	20	26	PF00069	0.782
MOD_PKA_2	203	209	PF00069	0.666
MOD_PKA_2	29	35	PF00069	0.580
MOD_PKA_2	86	92	PF00069	0.501
MOD_Plk_2-3	104	110	PF00069	0.328
MOD_Plk_4	20	26	PF00069	0.782
MOD_SUMO_rev_2	155	164	PF00179	0.575
TRG_DiLeu_BaEn_1	20	25	PF01217	0.520
TRG_DiLeu_BaEn_2	94	100	PF01217	0.416
TRG_ENDOCYTIC_2	66	69	PF00928	0.495
TRG_ER_diArg_1	202	204	PF00400	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3R6	Leptomonas seymouri	45%	69%
A0A3S5H7A2	Leishmania donovani	70%	100%
A0A422N8A3	Trypanosoma rangeli	31%	83%
A4HZG9	Leishmania infantum	70%	100%
D0A106	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	81%
E9AVF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QC20	Leishmania major	70%	97%
V5B1W6	Trypanosoma cruzi	32%	82%