Mitochondrial RNA binding complex 1 subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial RNA binding complex 1 subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HC24_LEIBR

TriTrypDb:

LbrM.21.1910 , LBRM2903_210025000

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC24

PDB structure(s): 7aih_Am , 7am2_Am , 7ane_Am

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043631	RNA polyadenylation	6	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	21	23	PF00675	0.406
CLV_NRD_NRD_1	299	301	PF00675	0.456
CLV_NRD_NRD_1	3	5	PF00675	0.639
CLV_NRD_NRD_1	50	52	PF00675	0.419
CLV_PCSK_FUR_1	19	23	PF00082	0.504
CLV_PCSK_KEX2_1	138	140	PF00082	0.415
CLV_PCSK_KEX2_1	204	206	PF00082	0.544
CLV_PCSK_KEX2_1	21	23	PF00082	0.406
CLV_PCSK_KEX2_1	299	301	PF00082	0.456
CLV_PCSK_KEX2_1	3	5	PF00082	0.639
CLV_PCSK_KEX2_1	50	52	PF00082	0.419
CLV_PCSK_PC1ET2_1	138	140	PF00082	0.415
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.544
CLV_PCSK_PC7_1	134	140	PF00082	0.399
CLV_PCSK_SKI1_1	205	209	PF00082	0.553
DEG_APCC_KENBOX_2	122	126	PF00400	0.561
DEG_Nend_Nbox_1	1	3	PF02207	0.585
DOC_MAPK_gen_1	3	9	PF00069	0.652
DOC_PP1_RVXF_1	23	30	PF00149	0.488
DOC_PP1_RVXF_1	69	76	PF00149	0.401
DOC_USP7_MATH_1	211	215	PF00917	0.452
DOC_USP7_UBL2_3	204	208	PF12436	0.490
DOC_WW_Pin1_4	82	87	PF00397	0.403
LIG_14-3-3_CanoR_1	3	9	PF00244	0.599
LIG_14-3-3_CanoR_1	30	38	PF00244	0.450
LIG_14-3-3_CanoR_1	51	57	PF00244	0.327
LIG_14-3-3_CanoR_1	59	65	PF00244	0.294
LIG_deltaCOP1_diTrp_1	255	262	PF00928	0.417
LIG_FHA_1	291	297	PF00498	0.441
LIG_LIR_Apic_2	313	317	PF02991	0.431
LIG_LIR_Gen_1	181	189	PF02991	0.328
LIG_LIR_Gen_1	238	249	PF02991	0.496
LIG_LIR_Gen_1	58	66	PF02991	0.409
LIG_LIR_Nem_3	131	136	PF02991	0.474
LIG_LIR_Nem_3	230	235	PF02991	0.415
LIG_LIR_Nem_3	238	244	PF02991	0.485
LIG_LIR_Nem_3	58	64	PF02991	0.385
LIG_LIR_Nem_3	87	93	PF02991	0.397
LIG_LIR_Nem_3	99	105	PF02991	0.386
LIG_SH2_CRK	147	151	PF00017	0.328
LIG_SH2_CRK	314	318	PF00017	0.486
LIG_SH2_CRK	319	323	PF00017	0.511
LIG_SH2_GRB2like	182	185	PF00017	0.328
LIG_SH2_NCK_1	160	164	PF00017	0.359
LIG_SH2_SRC	93	96	PF00017	0.504
LIG_SH2_STAP1	331	335	PF00017	0.684
LIG_SH2_STAT5	136	139	PF00017	0.427
LIG_SH2_STAT5	145	148	PF00017	0.300
LIG_SH2_STAT5	182	185	PF00017	0.328
LIG_SH2_STAT5	202	205	PF00017	0.425
LIG_SH2_STAT5	241	244	PF00017	0.455
LIG_SH2_STAT5	295	298	PF00017	0.559
LIG_SH2_STAT5	331	334	PF00017	0.676
LIG_SH2_STAT5	66	69	PF00017	0.412
LIG_SH2_STAT5	93	96	PF00017	0.419
LIG_SH3_3	323	329	PF00018	0.600
LIG_SUMO_SIM_anti_2	110	116	PF11976	0.498
LIG_TRAF2_1	55	58	PF00917	0.360
LIG_UBA3_1	111	120	PF00899	0.418
LIG_WRC_WIRS_1	232	237	PF05994	0.394
MOD_CK2_1	240	246	PF00069	0.486
MOD_CK2_1	52	58	PF00069	0.327
MOD_CMANNOS	257	260	PF00535	0.412
MOD_GlcNHglycan	238	241	PF01048	0.536
MOD_GlcNHglycan	77	80	PF01048	0.307
MOD_GSK3_1	231	238	PF00069	0.441
MOD_GSK3_1	264	271	PF00069	0.504
MOD_GSK3_1	60	67	PF00069	0.511
MOD_NEK2_1	235	240	PF00069	0.546
MOD_NEK2_1	290	295	PF00069	0.462
MOD_NEK2_1	64	69	PF00069	0.436
MOD_PKA_2	2	8	PF00069	0.580
MOD_Plk_1	107	113	PF00069	0.464
MOD_Plk_4	107	113	PF00069	0.455
MOD_Plk_4	178	184	PF00069	0.328
MOD_Plk_4	42	48	PF00069	0.361
MOD_ProDKin_1	82	88	PF00069	0.399
MOD_SUMO_rev_2	265	270	PF00179	0.434
TRG_ENDOCYTIC_2	147	150	PF00928	0.328
TRG_ENDOCYTIC_2	182	185	PF00928	0.328
TRG_ENDOCYTIC_2	241	244	PF00928	0.455
TRG_ER_diArg_1	19	22	PF00400	0.454
TRG_ER_diArg_1	2	4	PF00400	0.617
TRG_ER_diArg_1	280	283	PF00400	0.516
TRG_ER_diArg_1	49	51	PF00400	0.439
TRG_NES_CRM1_1	164	176	PF08389	0.385

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4F9	Leptomonas seymouri	81%	100%
A0A0S4J3G5	Bodo saltans	46%	86%
A0A1X0NHG3	Trypanosomatidae	71%	99%
A0A3Q8IL95	Leishmania donovani	92%	100%
A0A3R7N7R7	Trypanosoma rangeli	68%	99%
A4HZG7	Leishmania infantum	92%	100%
D0A108	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	99%
E9AVF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q4QC22	Leishmania major	92%	100%
V5BHD8	Trypanosoma cruzi	71%	100%