LeishMANIAdb
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Ubiquitin-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Ubiquitin-like domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HC23_LEIBR
TriTrypDb:
LbrM.21.1900 , LBRM2903_210024900 *
Length:
161

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 3
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 10
NetGPI no yes: 0, no: 10
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 1
GO:0110165 cellular anatomical entity 1 1

Expansion

Sequence features

A4HC23
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC23

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 100 104 PF00656 0.646
CLV_C14_Caspase3-7 76 80 PF00656 0.488
CLV_PCSK_SKI1_1 67 71 PF00082 0.412
CLV_PCSK_SKI1_1 7 11 PF00082 0.332
DEG_Nend_UBRbox_2 1 3 PF02207 0.533
DOC_MAPK_MEF2A_6 110 119 PF00069 0.395
DOC_USP7_MATH_1 32 36 PF00917 0.455
DOC_USP7_UBL2_3 132 136 PF12436 0.676
DOC_WW_Pin1_4 83 88 PF00397 0.343
LIG_14-3-3_CanoR_1 21 27 PF00244 0.283
LIG_14-3-3_CanoR_1 73 82 PF00244 0.442
LIG_Actin_WH2_2 54 72 PF00022 0.386
LIG_BIR_III_4 103 107 PF00653 0.377
LIG_FHA_2 35 41 PF00498 0.517
LIG_FHA_2 84 90 PF00498 0.464
LIG_FHA_2 98 104 PF00498 0.485
LIG_LIR_Gen_1 25 32 PF02991 0.441
LIG_LIR_Nem_3 25 29 PF02991 0.425
LIG_SH2_PTP2 26 29 PF00017 0.279
LIG_SH2_STAT5 26 29 PF00017 0.493
LIG_SH2_STAT5 8 11 PF00017 0.457
LIG_SH3_3 120 126 PF00018 0.508
MOD_CAAXbox 158 161 PF01239 0.545
MOD_CK2_1 83 89 PF00069 0.397
MOD_CK2_1 93 99 PF00069 0.423
MOD_GlcNHglycan 145 148 PF01048 0.622
MOD_GlcNHglycan 18 21 PF01048 0.392
MOD_GlcNHglycan 33 37 PF01048 0.461
MOD_GlcNHglycan 95 98 PF01048 0.468
MOD_GSK3_1 34 41 PF00069 0.433
MOD_GSK3_1 73 80 PF00069 0.427
MOD_GSK3_1 89 96 PF00069 0.439
MOD_N-GLC_2 45 47 PF02516 0.350
MOD_NEK2_1 57 62 PF00069 0.398
MOD_PKA_1 153 159 PF00069 0.562
MOD_Plk_4 109 115 PF00069 0.418
MOD_Plk_4 22 28 PF00069 0.563
MOD_Plk_4 77 83 PF00069 0.483
MOD_ProDKin_1 83 89 PF00069 0.338
TRG_ENDOCYTIC_2 26 29 PF00928 0.279
TRG_ER_diArg_1 3 6 PF00400 0.353
TRG_ER_diArg_1 64 67 PF00400 0.554
TRG_Pf-PMV_PEXEL_1 55 59 PF00026 0.596
TRG_Pf-PMV_PEXEL_1 73 77 PF00026 0.338

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2H2 Leptomonas seymouri 53% 100%
A0A0S4JTL1 Bodo saltans 34% 100%
A0A1X0NHK7 Trypanosomatidae 34% 100%
A0A3Q8IB92 Leishmania donovani 63% 100%
A0A3R7RFJ8 Trypanosoma rangeli 32% 100%
A4HZG6 Leishmania infantum 63% 100%
D0A109 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 32% 100%
E9AVF6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 61% 100%
Q4QC23 Leishmania major 61% 99%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS