IMD domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HC21_LEIBR

TriTrypDb:

LbrM.21.1880 , LBRM2903_210024700

Length:

241

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC21

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC21

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	92	96	PF00656	0.642
CLV_NRD_NRD_1	129	131	PF00675	0.641
CLV_NRD_NRD_1	220	222	PF00675	0.645
CLV_PCSK_KEX2_1	129	131	PF00082	0.389
CLV_PCSK_KEX2_1	168	170	PF00082	0.463
CLV_PCSK_PC1ET2_1	129	131	PF00082	0.389
CLV_PCSK_PC1ET2_1	168	170	PF00082	0.624
CLV_PCSK_SKI1_1	122	126	PF00082	0.652
CLV_PCSK_SKI1_1	43	47	PF00082	0.639
CLV_PCSK_SKI1_1	58	62	PF00082	0.373
DEG_Nend_UBRbox_1	1	4	PF02207	0.792
DEG_SPOP_SBC_1	23	27	PF00917	0.492
DOC_CKS1_1	231	236	PF01111	0.755
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.623
DOC_MAPK_gen_1	129	140	PF00069	0.602
DOC_MAPK_gen_1	43	51	PF00069	0.381
DOC_USP7_MATH_1	15	19	PF00917	0.596
DOC_USP7_UBL2_3	125	129	PF12436	0.394
DOC_USP7_UBL2_3	36	40	PF12436	0.669
DOC_USP7_UBL2_3	43	47	PF12436	0.523
DOC_WW_Pin1_4	230	235	PF00397	0.741
DOC_WW_Pin1_4	24	29	PF00397	0.714
LIG_14-3-3_CanoR_1	211	220	PF00244	0.618
LIG_14-3-3_CanoR_1	58	67	PF00244	0.396
LIG_Actin_WH2_2	110	127	PF00022	0.636
LIG_Actin_WH2_2	134	151	PF00022	0.373
LIG_AP2alpha_1	183	187	PF02296	0.612
LIG_BIR_III_2	153	157	PF00653	0.425
LIG_BRCT_BRCA1_1	110	114	PF00533	0.618
LIG_BRCT_BRCA1_1	65	69	PF00533	0.487
LIG_BRCT_BRCA1_2	110	116	PF00533	0.379
LIG_FHA_1	135	141	PF00498	0.571
LIG_FHA_1	55	61	PF00498	0.588
LIG_FHA_2	141	147	PF00498	0.371
LIG_FHA_2	24	30	PF00498	0.475
LIG_LIR_Gen_1	111	118	PF02991	0.383
LIG_LIR_Gen_1	184	194	PF02991	0.625
LIG_LIR_Gen_1	196	206	PF02991	0.510
LIG_LIR_Gen_1	65	71	PF02991	0.439
LIG_LIR_Gen_1	7	15	PF02991	0.531
LIG_LIR_Nem_3	111	117	PF02991	0.633
LIG_LIR_Nem_3	184	190	PF02991	0.470
LIG_LIR_Nem_3	191	197	PF02991	0.462
LIG_LIR_Nem_3	65	70	PF02991	0.444
LIG_LIR_Nem_3	7	13	PF02991	0.533
LIG_PDZ_Class_2	236	241	PF00595	0.533
LIG_Pex14_2	183	187	PF04695	0.612
LIG_Pex14_2	190	194	PF04695	0.507
LIG_SH2_STAP1	108	112	PF00017	0.361
LIG_SH2_STAT5	162	165	PF00017	0.635
LIG_SH3_3	228	234	PF00018	0.585
LIG_SUMO_SIM_anti_2	137	143	PF11976	0.532
LIG_SUMO_SIM_anti_2	236	241	PF11976	0.640
LIG_SUMO_SIM_par_1	76	83	PF11976	0.502
MOD_CK1_1	214	220	PF00069	0.617
MOD_CK2_1	129	135	PF00069	0.622
MOD_CK2_1	23	29	PF00069	0.491
MOD_GlcNHglycan	110	113	PF01048	0.368
MOD_GlcNHglycan	213	216	PF01048	0.617
MOD_GlcNHglycan	82	85	PF01048	0.608
MOD_GSK3_1	189	196	PF00069	0.379
MOD_GSK3_1	24	31	PF00069	0.470
MOD_GSK3_1	4	11	PF00069	0.654
MOD_GSK3_1	50	57	PF00069	0.485
MOD_GSK3_1	58	65	PF00069	0.420
MOD_NEK2_1	124	129	PF00069	0.412
MOD_NEK2_1	13	18	PF00069	0.615
MOD_NEK2_1	140	145	PF00069	0.511
MOD_NEK2_1	163	168	PF00069	0.621
MOD_NEK2_1	174	179	PF00069	0.429
MOD_NEK2_1	4	9	PF00069	0.632
MOD_NEK2_2	28	33	PF00069	0.417
MOD_PIKK_1	140	146	PF00454	0.618
MOD_PIKK_1	163	169	PF00454	0.629
MOD_PKA_1	129	135	PF00069	0.370
MOD_PKA_2	129	135	PF00069	0.622
MOD_Plk_1	106	112	PF00069	0.607
MOD_Plk_1	134	140	PF00069	0.608
MOD_Plk_1	174	180	PF00069	0.530
MOD_Plk_1	28	34	PF00069	0.673
MOD_Plk_4	193	199	PF00069	0.396
MOD_Plk_4	223	229	PF00069	0.431
MOD_ProDKin_1	230	236	PF00069	0.745
MOD_ProDKin_1	24	30	PF00069	0.708
MOD_SUMO_rev_2	119	127	PF00179	0.640
MOD_SUMO_rev_2	153	158	PF00179	0.675
MOD_SUMO_rev_2	200	205	PF00179	0.622
TRG_ENDOCYTIC_2	199	202	PF00928	0.639
TRG_NLS_MonoExtC_3	128	133	PF00514	0.383
TRG_NLS_MonoExtN_4	129	134	PF00514	0.374
TRG_Pf-PMV_PEXEL_1	122	126	PF00026	0.652
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.525
TRG_Pf-PMV_PEXEL_1	44	48	PF00026	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWW7	Leishmania donovani	74%	100%
A4HZG4	Leishmania infantum	73%	100%
E9AVF4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	98%
Q4QC25	Leishmania major	72%	100%