F-box domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

F-box-like, putative

Species:

Leishmania braziliensis

UniProt:

A4HC20_LEIBR

TriTrypDb:

LbrM.21.1870 , LBRM2903_210024600

Length:

435

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1

Expansion

Sequence features

A4HC20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	115	117	PF00675	0.453
CLV_NRD_NRD_1	123	125	PF00675	0.428
CLV_NRD_NRD_1	139	141	PF00675	0.186
CLV_NRD_NRD_1	214	216	PF00675	0.381
CLV_NRD_NRD_1	246	248	PF00675	0.613
CLV_NRD_NRD_1	3	5	PF00675	0.477
CLV_PCSK_FUR_1	137	141	PF00082	0.459
CLV_PCSK_FUR_1	212	216	PF00082	0.448
CLV_PCSK_KEX2_1	123	125	PF00082	0.432
CLV_PCSK_KEX2_1	137	139	PF00082	0.291
CLV_PCSK_KEX2_1	214	216	PF00082	0.435
CLV_PCSK_KEX2_1	3	5	PF00082	0.485
CLV_PCSK_SKI1_1	112	116	PF00082	0.494
CLV_PCSK_SKI1_1	13	17	PF00082	0.361
CLV_PCSK_SKI1_1	140	144	PF00082	0.408
CLV_Separin_Metazoa	412	416	PF03568	0.635
DEG_APCC_DBOX_1	12	20	PF00400	0.561
DEG_MDM2_SWIB_1	180	188	PF02201	0.485
DEG_MDM2_SWIB_1	251	258	PF02201	0.348
DOC_CDC14_PxL_1	204	212	PF14671	0.683
DOC_CYCLIN_yClb1_LxF_4	85	90	PF00134	0.549
DOC_MAPK_DCC_7	383	392	PF00069	0.287
DOC_MAPK_DCC_7	59	69	PF00069	0.673
DOC_MAPK_gen_1	10	19	PF00069	0.528
DOC_MAPK_gen_1	137	145	PF00069	0.563
DOC_MAPK_gen_1	212	220	PF00069	0.589
DOC_MAPK_MEF2A_6	10	19	PF00069	0.561
DOC_MAPK_MEF2A_6	137	145	PF00069	0.533
DOC_MAPK_MEF2A_6	383	392	PF00069	0.257
DOC_PP1_RVXF_1	85	91	PF00149	0.551
DOC_PP2B_LxvP_1	107	110	PF13499	0.655
DOC_PP2B_LxvP_1	301	304	PF13499	0.369
DOC_USP7_MATH_1	108	112	PF00917	0.706
DOC_USP7_MATH_1	312	316	PF00917	0.444
DOC_USP7_UBL2_3	117	121	PF12436	0.653
DOC_WW_Pin1_4	370	375	PF00397	0.233
LIG_14-3-3_CanoR_1	116	120	PF00244	0.702
LIG_14-3-3_CanoR_1	250	254	PF00244	0.408
LIG_14-3-3_CanoR_1	3	12	PF00244	0.647
LIG_14-3-3_CanoR_1	357	363	PF00244	0.411
LIG_14-3-3_CanoR_1	383	388	PF00244	0.223
LIG_APCC_ABBA_1	17	22	PF00400	0.561
LIG_BRCT_BRCA1_1	164	168	PF00533	0.386
LIG_eIF4E_1	326	332	PF01652	0.363
LIG_FHA_1	173	179	PF00498	0.385
LIG_FHA_1	224	230	PF00498	0.370
LIG_FHA_1	236	242	PF00498	0.302
LIG_FHA_1	257	263	PF00498	0.370
LIG_FHA_2	407	413	PF00498	0.476
LIG_GBD_Chelix_1	154	162	PF00786	0.485
LIG_LIR_Gen_1	249	258	PF02991	0.332
LIG_LIR_Gen_1	294	304	PF02991	0.547
LIG_LIR_Gen_1	315	324	PF02991	0.455
LIG_LIR_Gen_1	365	375	PF02991	0.348
LIG_LIR_Gen_1	43	52	PF02991	0.449
LIG_LIR_Nem_3	128	134	PF02991	0.581
LIG_LIR_Nem_3	177	183	PF02991	0.336
LIG_LIR_Nem_3	249	254	PF02991	0.361
LIG_LIR_Nem_3	29	34	PF02991	0.497
LIG_LIR_Nem_3	315	319	PF02991	0.390
LIG_LIR_Nem_3	351	355	PF02991	0.617
LIG_LIR_Nem_3	381	385	PF02991	0.379
LIG_LIR_Nem_3	43	47	PF02991	0.463
LIG_LYPXL_S_1	64	68	PF13949	0.447
LIG_LYPXL_yS_3	65	68	PF13949	0.610
LIG_NRBOX	345	351	PF00104	0.372
LIG_Pex14_2	180	184	PF04695	0.348
LIG_Pex14_2	251	255	PF04695	0.305
LIG_Pex14_2	307	311	PF04695	0.401
LIG_Pex14_2	348	352	PF04695	0.434
LIG_SH2_CRK	101	105	PF00017	0.571
LIG_SH2_CRK	132	136	PF00017	0.605
LIG_SH2_CRK	270	274	PF00017	0.339
LIG_SH2_PTP2	329	332	PF00017	0.424
LIG_SH2_STAT5	134	137	PF00017	0.565
LIG_SH2_STAT5	187	190	PF00017	0.362
LIG_SH2_STAT5	270	273	PF00017	0.320
LIG_SH2_STAT5	321	324	PF00017	0.366
LIG_SH2_STAT5	329	332	PF00017	0.344
LIG_SH2_STAT5	404	407	PF00017	0.465
LIG_SH2_STAT5	56	59	PF00017	0.611
LIG_SH3_3	100	106	PF00018	0.724
LIG_SH3_3	231	237	PF00018	0.339
LIG_SH3_3	60	66	PF00018	0.597
LIG_SUMO_SIM_anti_2	223	229	PF11976	0.406
LIG_SUMO_SIM_anti_2	373	379	PF11976	0.396
LIG_SUMO_SIM_par_1	258	263	PF11976	0.405
LIG_SUMO_SIM_par_1	33	39	PF11976	0.411
LIG_SUMO_SIM_par_1	335	340	PF11976	0.370
LIG_TYR_ITIM	63	68	PF00017	0.609
LIG_TYR_ITIM	99	104	PF00017	0.752
LIG_UBA3_1	209	217	PF00899	0.586
LIG_UBA3_1	239	248	PF00899	0.522
LIG_WRC_WIRS_1	261	266	PF05994	0.444
MOD_CK1_1	223	229	PF00069	0.406
MOD_CK1_1	315	321	PF00069	0.233
MOD_CK1_1	373	379	PF00069	0.353
MOD_CK2_1	243	249	PF00069	0.288
MOD_CK2_1	3	9	PF00069	0.684
MOD_CK2_1	406	412	PF00069	0.550
MOD_Cter_Amidation	1	4	PF01082	0.381
MOD_GlcNHglycan	222	225	PF01048	0.369
MOD_GSK3_1	256	263	PF00069	0.369
MOD_GSK3_1	36	43	PF00069	0.534
MOD_GSK3_1	428	435	PF00069	0.573
MOD_N-GLC_1	243	248	PF02516	0.475
MOD_NEK2_1	145	150	PF00069	0.334
MOD_NEK2_1	156	161	PF00069	0.303
MOD_NEK2_1	173	178	PF00069	0.396
MOD_NEK2_1	413	418	PF00069	0.613
MOD_PIKK_1	125	131	PF00454	0.688
MOD_PIKK_1	78	84	PF00454	0.684
MOD_PKA_1	3	9	PF00069	0.601
MOD_PKA_2	115	121	PF00069	0.705
MOD_PKA_2	125	131	PF00069	0.632
MOD_PKA_2	249	255	PF00069	0.416
MOD_PKA_2	3	9	PF00069	0.570
MOD_PKA_2	356	362	PF00069	0.470
MOD_PKA_2	426	432	PF00069	0.608
MOD_Plk_4	174	180	PF00069	0.317
MOD_Plk_4	223	229	PF00069	0.394
MOD_Plk_4	235	241	PF00069	0.280
MOD_Plk_4	268	274	PF00069	0.434
MOD_Plk_4	342	348	PF00069	0.230
MOD_Plk_4	383	389	PF00069	0.244
MOD_ProDKin_1	370	376	PF00069	0.233
TRG_DiLeu_BaEn_2	293	299	PF01217	0.633
TRG_DiLeu_LyEn_5	205	210	PF01217	0.657
TRG_ENDOCYTIC_2	101	104	PF00928	0.751
TRG_ENDOCYTIC_2	132	135	PF00928	0.564
TRG_ENDOCYTIC_2	187	190	PF00928	0.341
TRG_ENDOCYTIC_2	270	273	PF00928	0.344
TRG_ENDOCYTIC_2	329	332	PF00928	0.359
TRG_ENDOCYTIC_2	65	68	PF00928	0.610
TRG_ER_diArg_1	122	124	PF00400	0.667
TRG_ER_diArg_1	137	140	PF00400	0.493
TRG_ER_diArg_1	211	214	PF00400	0.588
TRG_ER_diArg_1	3	5	PF00400	0.618
TRG_ER_diArg_1	87	90	PF00400	0.640
TRG_NES_CRM1_1	281	294	PF08389	0.639
TRG_NES_CRM1_1	9	22	PF08389	0.591
TRG_Pf-PMV_PEXEL_1	89	94	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVU0	Leptomonas seymouri	75%	93%
A0A1X0NI23	Trypanosomatidae	51%	96%
A0A3Q8IAZ7	Leishmania donovani	87%	93%
A0A422N8A5	Trypanosoma rangeli	47%	95%
A4HZJ5	Leishmania infantum	87%	93%
D0A112	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	91%
E9AVF3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	94%
Q4QC26	Leishmania major	85%	100%