TPR_MalT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC18_LEIBR

TriTrypDb:

LbrM.21.1850 , LBRM2903_210022500

Length:

273

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC18

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	9	13	PF00656	0.483
CLV_NRD_NRD_1	145	147	PF00675	0.340
CLV_NRD_NRD_1	223	225	PF00675	0.445
CLV_NRD_NRD_1	231	233	PF00675	0.406
CLV_NRD_NRD_1	271	273	PF00675	0.447
CLV_PCSK_KEX2_1	145	147	PF00082	0.340
CLV_PCSK_KEX2_1	231	233	PF00082	0.429
CLV_PCSK_SKI1_1	146	150	PF00082	0.434
DEG_APCC_DBOX_1	145	153	PF00400	0.413
DOC_MAPK_MEF2A_6	22	31	PF00069	0.507
DOC_PP1_RVXF_1	119	126	PF00149	0.480
DOC_PP1_RVXF_1	223	230	PF00149	0.341
DOC_USP7_MATH_1	74	78	PF00917	0.383
DOC_USP7_UBL2_3	263	267	PF12436	0.583
LIG_14-3-3_CanoR_1	145	149	PF00244	0.363
LIG_14-3-3_CanoR_1	224	230	PF00244	0.445
LIG_Actin_WH2_2	132	147	PF00022	0.516
LIG_Actin_WH2_2	20	37	PF00022	0.427
LIG_BIR_II_1	1	5	PF00653	0.522
LIG_BIR_III_4	235	239	PF00653	0.514
LIG_Clathr_ClatBox_1	49	53	PF01394	0.352
LIG_FHA_2	14	20	PF00498	0.301
LIG_FHA_2	180	186	PF00498	0.505
LIG_FHA_2	206	212	PF00498	0.426
LIG_LIR_Gen_1	193	203	PF02991	0.417
LIG_LIR_Nem_3	193	199	PF02991	0.423
LIG_LIR_Nem_3	208	213	PF02991	0.433
LIG_Rb_LxCxE_1	47	66	PF01857	0.485
LIG_SH2_SRC	64	67	PF00017	0.492
LIG_SH2_STAP1	64	68	PF00017	0.440
LIG_SH2_STAT5	226	229	PF00017	0.350
LIG_SH3_4	83	90	PF00018	0.432
LIG_WRC_WIRS_1	207	212	PF05994	0.428
MOD_CK1_1	147	153	PF00069	0.376
MOD_CK2_1	179	185	PF00069	0.486
MOD_CK2_1	205	211	PF00069	0.376
MOD_GlcNHglycan	131	134	PF01048	0.500
MOD_GlcNHglycan	234	239	PF01048	0.443
MOD_GSK3_1	154	161	PF00069	0.465
MOD_GSK3_1	214	221	PF00069	0.342
MOD_NEK2_1	144	149	PF00069	0.346
MOD_NEK2_1	152	157	PF00069	0.325
MOD_NEK2_1	52	57	PF00069	0.372
MOD_NEK2_2	219	224	PF00069	0.472
MOD_PIKK_1	214	220	PF00454	0.418
MOD_PIKK_1	52	58	PF00454	0.358
MOD_PKA_2	144	150	PF00069	0.341
MOD_PKA_2	74	80	PF00069	0.498
MOD_Plk_4	158	164	PF00069	0.259
MOD_Plk_4	179	185	PF00069	0.448
MOD_Plk_4	45	51	PF00069	0.376
MOD_Plk_4	74	80	PF00069	0.427
MOD_SUMO_rev_2	127	133	PF00179	0.398
MOD_SUMO_rev_2	168	175	PF00179	0.424
MOD_SUMO_rev_2	76	84	PF00179	0.544
TRG_DiLeu_BaEn_1	114	119	PF01217	0.481
TRG_ER_diArg_1	144	146	PF00400	0.354
TRG_NES_CRM1_1	116	129	PF08389	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVJ3	Leptomonas seymouri	75%	74%
A0A0S4JQG6	Bodo saltans	37%	76%
A0A1X0PAZ2	Trypanosomatidae	47%	88%
A0A3Q8IE15	Leishmania donovani	90%	100%
A0A3R7KWQ9	Trypanosoma rangeli	51%	87%
A4HZE4	Leishmania infantum	90%	100%
C9ZMM7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	85%
E9AVD1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QC48	Leishmania major	86%	100%
V5BFW6	Trypanosoma cruzi	49%	88%