Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC17_LEIBR

TriTrypDb:

LbrM.21.1840 , LBRM2903_210022400

Length:

709

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC17

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	41	45	PF00656	0.558
CLV_NRD_NRD_1	147	149	PF00675	0.638
CLV_NRD_NRD_1	366	368	PF00675	0.562
CLV_NRD_NRD_1	385	387	PF00675	0.547
CLV_NRD_NRD_1	434	436	PF00675	0.613
CLV_NRD_NRD_1	451	453	PF00675	0.671
CLV_NRD_NRD_1	478	480	PF00675	0.785
CLV_NRD_NRD_1	700	702	PF00675	0.431
CLV_PCSK_KEX2_1	139	141	PF00082	0.652
CLV_PCSK_KEX2_1	147	149	PF00082	0.679
CLV_PCSK_KEX2_1	366	368	PF00082	0.562
CLV_PCSK_KEX2_1	385	387	PF00082	0.547
CLV_PCSK_KEX2_1	434	436	PF00082	0.613
CLV_PCSK_KEX2_1	451	453	PF00082	0.671
CLV_PCSK_KEX2_1	478	480	PF00082	0.785
CLV_PCSK_KEX2_1	658	660	PF00082	0.496
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.616
CLV_PCSK_PC1ET2_1	658	660	PF00082	0.629
CLV_PCSK_SKI1_1	159	163	PF00082	0.640
CLV_PCSK_SKI1_1	336	340	PF00082	0.543
CLV_PCSK_SKI1_1	435	439	PF00082	0.630
CLV_PCSK_SKI1_1	702	706	PF00082	0.610
DEG_APCC_DBOX_1	342	350	PF00400	0.535
DEG_APCC_DBOX_1	640	648	PF00400	0.584
DEG_SCF_FBW7_1	671	678	PF00400	0.570
DEG_SPOP_SBC_1	57	61	PF00917	0.610
DOC_CKS1_1	185	190	PF01111	0.597
DOC_CKS1_1	237	242	PF01111	0.548
DOC_CKS1_1	376	381	PF01111	0.706
DOC_CYCLIN_RxL_1	688	700	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.659
DOC_MAPK_FxFP_2	214	217	PF00069	0.691
DOC_MAPK_gen_1	478	485	PF00069	0.602
DOC_MAPK_gen_1	532	540	PF00069	0.419
DOC_MAPK_gen_1	688	697	PF00069	0.463
DOC_PP2B_LxvP_1	243	246	PF13499	0.680
DOC_PP2B_LxvP_1	591	594	PF13499	0.607
DOC_PP4_FxxP_1	214	217	PF00568	0.691
DOC_PP4_FxxP_1	249	252	PF00568	0.688
DOC_PP4_MxPP_1	285	288	PF00568	0.521
DOC_USP7_MATH_1	15	19	PF00917	0.561
DOC_USP7_MATH_1	190	194	PF00917	0.583
DOC_USP7_MATH_1	222	226	PF00917	0.608
DOC_USP7_MATH_1	238	242	PF00917	0.758
DOC_USP7_MATH_1	244	248	PF00917	0.708
DOC_USP7_MATH_1	257	261	PF00917	0.503
DOC_USP7_MATH_1	28	32	PF00917	0.498
DOC_USP7_MATH_1	311	315	PF00917	0.701
DOC_USP7_MATH_1	362	366	PF00917	0.708
DOC_USP7_MATH_1	372	376	PF00917	0.606
DOC_USP7_MATH_1	398	402	PF00917	0.575
DOC_USP7_MATH_1	440	444	PF00917	0.587
DOC_USP7_MATH_1	455	459	PF00917	0.519
DOC_USP7_MATH_1	487	491	PF00917	0.565
DOC_USP7_MATH_1	513	517	PF00917	0.420
DOC_USP7_MATH_1	630	634	PF00917	0.586
DOC_USP7_MATH_1	675	679	PF00917	0.663
DOC_USP7_UBL2_3	114	118	PF12436	0.547
DOC_WW_Pin1_4	184	189	PF00397	0.599
DOC_WW_Pin1_4	209	214	PF00397	0.628
DOC_WW_Pin1_4	236	241	PF00397	0.655
DOC_WW_Pin1_4	301	306	PF00397	0.610
DOC_WW_Pin1_4	307	312	PF00397	0.593
DOC_WW_Pin1_4	337	342	PF00397	0.568
DOC_WW_Pin1_4	375	380	PF00397	0.705
DOC_WW_Pin1_4	538	543	PF00397	0.612
DOC_WW_Pin1_4	589	594	PF00397	0.622
DOC_WW_Pin1_4	608	613	PF00397	0.645
DOC_WW_Pin1_4	622	627	PF00397	0.566
DOC_WW_Pin1_4	671	676	PF00397	0.691
LIG_14-3-3_CanoR_1	11	19	PF00244	0.591
LIG_14-3-3_CanoR_1	147	153	PF00244	0.603
LIG_14-3-3_CanoR_1	159	164	PF00244	0.606
LIG_14-3-3_CanoR_1	336	341	PF00244	0.671
LIG_14-3-3_CanoR_1	352	356	PF00244	0.541
LIG_14-3-3_CanoR_1	366	372	PF00244	0.521
LIG_14-3-3_CanoR_1	439	446	PF00244	0.590
LIG_14-3-3_CanoR_1	478	485	PF00244	0.683
LIG_14-3-3_CanoR_1	55	63	PF00244	0.641
LIG_BIR_III_4	387	391	PF00653	0.725
LIG_CSL_BTD_1	177	180	PF09270	0.569
LIG_EVH1_1	249	253	PF00568	0.687
LIG_EVH1_1	283	287	PF00568	0.621
LIG_EVH1_1	291	295	PF00568	0.610
LIG_EVH1_2	297	301	PF00568	0.620
LIG_FHA_1	160	166	PF00498	0.567
LIG_FHA_1	51	57	PF00498	0.643
LIG_FHA_1	664	670	PF00498	0.697
LIG_FHA_1	90	96	PF00498	0.535
LIG_FHA_2	136	142	PF00498	0.578
LIG_FHA_2	158	164	PF00498	0.576
LIG_FHA_2	237	243	PF00498	0.544
LIG_FHA_2	551	557	PF00498	0.720
LIG_HCF-1_HBM_1	525	528	PF13415	0.545
LIG_LIR_Apic_2	212	217	PF02991	0.527
LIG_LIR_Apic_2	234	240	PF02991	0.683
LIG_LIR_Apic_2	247	252	PF02991	0.565
LIG_LIR_Apic_2	290	294	PF02991	0.483
LIG_LIR_Gen_1	648	657	PF02991	0.706
LIG_LIR_Nem_3	525	531	PF02991	0.606
LIG_LIR_Nem_3	648	654	PF02991	0.706
LIG_MYND_1	626	630	PF01753	0.557
LIG_PDZ_Class_1	704	709	PF00595	0.574
LIG_PROFILIN_1	292	298	PF00235	0.610
LIG_PTAP_UEV_1	86	91	PF05743	0.526
LIG_SH2_CRK	185	189	PF00017	0.711
LIG_SH2_CRK	302	306	PF00017	0.615
LIG_SH2_CRK	528	532	PF00017	0.549
LIG_SH2_SRC	535	538	PF00017	0.571
LIG_SH2_STAP1	199	203	PF00017	0.682
LIG_SH2_STAP1	358	362	PF00017	0.576
LIG_SH2_STAP1	493	497	PF00017	0.547
LIG_SH2_STAP1	535	539	PF00017	0.574
LIG_SH2_STAT5	520	523	PF00017	0.559
LIG_SH3_1	291	297	PF00018	0.615
LIG_SH3_3	150	156	PF00018	0.638
LIG_SH3_3	174	180	PF00018	0.574
LIG_SH3_3	247	253	PF00018	0.686
LIG_SH3_3	281	287	PF00018	0.621
LIG_SH3_3	289	295	PF00018	0.497
LIG_SH3_3	366	372	PF00018	0.712
LIG_SH3_3	373	379	PF00018	0.636
LIG_SH3_3	46	52	PF00018	0.604
LIG_SH3_3	536	542	PF00018	0.571
LIG_SH3_3	596	602	PF00018	0.695
LIG_SH3_3	606	612	PF00018	0.613
LIG_SH3_3	614	620	PF00018	0.525
LIG_SH3_3	84	90	PF00018	0.588
LIG_SH3_4	114	121	PF00018	0.555
LIG_SUMO_SIM_par_1	620	625	PF11976	0.544
LIG_TRAF2_1	357	360	PF00917	0.548
LIG_WW_1	182	185	PF00397	0.584
MOD_CDC14_SPxK_1	340	343	PF00782	0.533
MOD_CDC14_SPxK_1	541	544	PF00782	0.631
MOD_CDK_SPxK_1	337	343	PF00069	0.537
MOD_CDK_SPxK_1	538	544	PF00069	0.616
MOD_CK1_1	126	132	PF00069	0.608
MOD_CK1_1	135	141	PF00069	0.595
MOD_CK1_1	18	24	PF00069	0.630
MOD_CK1_1	260	266	PF00069	0.585
MOD_CK1_1	31	37	PF00069	0.609
MOD_CK1_1	310	316	PF00069	0.685
MOD_CK1_1	317	323	PF00069	0.639
MOD_CK1_1	324	330	PF00069	0.543
MOD_CK1_1	331	337	PF00069	0.582
MOD_CK1_1	375	381	PF00069	0.706
MOD_CK1_1	401	407	PF00069	0.755
MOD_CK1_1	426	432	PF00069	0.695
MOD_CK1_1	457	463	PF00069	0.791
MOD_CK1_1	59	65	PF00069	0.718
MOD_CK1_1	592	598	PF00069	0.720
MOD_CK1_1	632	638	PF00069	0.637
MOD_CK1_1	663	669	PF00069	0.610
MOD_CK1_1	68	74	PF00069	0.688
MOD_CK1_1	9	15	PF00069	0.641
MOD_CK1_1	96	102	PF00069	0.697
MOD_CK2_1	157	163	PF00069	0.673
MOD_CK2_1	264	270	PF00069	0.631
MOD_CK2_1	45	51	PF00069	0.600
MOD_CK2_1	458	464	PF00069	0.643
MOD_CK2_1	512	518	PF00069	0.581
MOD_CK2_1	550	556	PF00069	0.559
MOD_Cter_Amidation	145	148	PF01082	0.640
MOD_GlcNHglycan	111	114	PF01048	0.573
MOD_GlcNHglycan	13	16	PF01048	0.594
MOD_GlcNHglycan	141	145	PF01048	0.653
MOD_GlcNHglycan	150	153	PF01048	0.589
MOD_GlcNHglycan	2	5	PF01048	0.565
MOD_GlcNHglycan	22	25	PF01048	0.559
MOD_GlcNHglycan	224	227	PF01048	0.668
MOD_GlcNHglycan	233	236	PF01048	0.699
MOD_GlcNHglycan	264	267	PF01048	0.697
MOD_GlcNHglycan	313	316	PF01048	0.708
MOD_GlcNHglycan	333	336	PF01048	0.722
MOD_GlcNHglycan	346	349	PF01048	0.623
MOD_GlcNHglycan	401	404	PF01048	0.740
MOD_GlcNHglycan	425	428	PF01048	0.721
MOD_GlcNHglycan	442	445	PF01048	0.660
MOD_GlcNHglycan	479	482	PF01048	0.582
MOD_GlcNHglycan	498	501	PF01048	0.535
MOD_GlcNHglycan	504	507	PF01048	0.483
MOD_GlcNHglycan	515	518	PF01048	0.644
MOD_GlcNHglycan	548	551	PF01048	0.533
MOD_GlcNHglycan	614	617	PF01048	0.826
MOD_GlcNHglycan	632	635	PF01048	0.520
MOD_GlcNHglycan	662	665	PF01048	0.583
MOD_GlcNHglycan	671	674	PF01048	0.558
MOD_GlcNHglycan	677	680	PF01048	0.527
MOD_GlcNHglycan	706	709	PF01048	0.770
MOD_GlcNHglycan	73	76	PF01048	0.641
MOD_GlcNHglycan	79	82	PF01048	0.587
MOD_GlcNHglycan	87	90	PF01048	0.578
MOD_GSK3_1	119	126	PF00069	0.606
MOD_GSK3_1	129	136	PF00069	0.554
MOD_GSK3_1	14	21	PF00069	0.567
MOD_GSK3_1	155	162	PF00069	0.625
MOD_GSK3_1	260	267	PF00069	0.622
MOD_GSK3_1	307	314	PF00069	0.679
MOD_GSK3_1	317	324	PF00069	0.605
MOD_GSK3_1	327	334	PF00069	0.626
MOD_GSK3_1	358	365	PF00069	0.549
MOD_GSK3_1	425	432	PF00069	0.770
MOD_GSK3_1	453	460	PF00069	0.732
MOD_GSK3_1	5	12	PF00069	0.583
MOD_GSK3_1	546	553	PF00069	0.531
MOD_GSK3_1	55	62	PF00069	0.735
MOD_GSK3_1	563	570	PF00069	0.652
MOD_GSK3_1	608	615	PF00069	0.704
MOD_GSK3_1	624	631	PF00069	0.550
MOD_GSK3_1	660	667	PF00069	0.640
MOD_GSK3_1	669	676	PF00069	0.631
MOD_GSK3_1	73	80	PF00069	0.595
MOD_GSK3_1	85	92	PF00069	0.509
MOD_N-GLC_2	501	503	PF02516	0.525
MOD_NEK2_1	107	112	PF00069	0.567
MOD_NEK2_1	351	356	PF00069	0.526
MOD_NEK2_1	425	430	PF00069	0.706
MOD_NEK2_1	587	592	PF00069	0.562
MOD_NEK2_1	63	68	PF00069	0.562
MOD_NEK2_1	646	651	PF00069	0.505
MOD_NEK2_1	7	12	PF00069	0.578
MOD_NEK2_1	704	709	PF00069	0.634
MOD_PIKK_1	107	113	PF00454	0.560
MOD_PIKK_1	646	652	PF00454	0.626
MOD_PIKK_1	65	71	PF00454	0.694
MOD_PIKK_1	9	15	PF00454	0.564
MOD_PK_1	367	373	PF00069	0.554
MOD_PKA_2	129	135	PF00069	0.627
MOD_PKA_2	324	330	PF00069	0.626
MOD_PKA_2	351	357	PF00069	0.579
MOD_PKA_2	438	444	PF00069	0.603
MOD_PKA_2	458	464	PF00069	0.518
MOD_PKA_2	477	483	PF00069	0.786
MOD_PKA_2	5	11	PF00069	0.575
MOD_PKA_2	546	552	PF00069	0.566
MOD_PKA_2	572	578	PF00069	0.622
MOD_PKA_2	687	693	PF00069	0.487
MOD_PKB_1	140	148	PF00069	0.617
MOD_Plk_4	372	378	PF00069	0.549
MOD_Plk_4	45	51	PF00069	0.624
MOD_Plk_4	624	630	PF00069	0.555
MOD_ProDKin_1	184	190	PF00069	0.595
MOD_ProDKin_1	209	215	PF00069	0.630
MOD_ProDKin_1	236	242	PF00069	0.650
MOD_ProDKin_1	301	307	PF00069	0.612
MOD_ProDKin_1	337	343	PF00069	0.570
MOD_ProDKin_1	375	381	PF00069	0.706
MOD_ProDKin_1	538	544	PF00069	0.616
MOD_ProDKin_1	589	595	PF00069	0.624
MOD_ProDKin_1	608	614	PF00069	0.646
MOD_ProDKin_1	622	628	PF00069	0.568
MOD_ProDKin_1	671	677	PF00069	0.689
MOD_SUMO_for_1	522	525	PF00179	0.396
TRG_ENDOCYTIC_2	528	531	PF00928	0.607
TRG_ENDOCYTIC_2	535	538	PF00928	0.517
TRG_ER_diArg_1	208	211	PF00400	0.542
TRG_ER_diArg_1	384	386	PF00400	0.583
TRG_ER_diArg_1	451	453	PF00400	0.715
TRG_ER_diArg_1	531	534	PF00400	0.540
TRG_ER_diArg_1	691	694	PF00400	0.626

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWP6	Leishmania donovani	63%	100%
A4HZE3	Leishmania infantum	63%	100%
E9AVD0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4QC49	Leishmania major	60%	99%