Cytochrome b5 heme-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytochrome b5-like Heme/Steroid binding domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HC15_LEIBR

TriTrypDb:

LbrM.21.1820 , LBRM2903_210022100

Length:

221

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC15

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC15

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	191	195	PF00656	0.635
CLV_NRD_NRD_1	125	127	PF00675	0.547
CLV_PCSK_FUR_1	123	127	PF00082	0.647
CLV_PCSK_KEX2_1	125	127	PF00082	0.612
CLV_Separin_Metazoa	150	154	PF03568	0.661
DOC_PP2B_LxvP_1	90	93	PF13499	0.439
DOC_USP7_MATH_1	119	123	PF00917	0.651
DOC_USP7_MATH_1	19	23	PF00917	0.519
DOC_USP7_UBL2_3	38	42	PF12436	0.675
DOC_WW_Pin1_4	28	33	PF00397	0.541
DOC_WW_Pin1_4	37	42	PF00397	0.562
LIG_14-3-3_CanoR_1	128	134	PF00244	0.560
LIG_14-3-3_CanoR_1	164	169	PF00244	0.644
LIG_14-3-3_CanoR_1	3	10	PF00244	0.616
LIG_BIR_II_1	1	5	PF00653	0.615
LIG_BRCT_BRCA1_1	39	43	PF00533	0.668
LIG_FHA_1	122	128	PF00498	0.530
LIG_FHA_1	137	143	PF00498	0.530
LIG_FHA_1	29	35	PF00498	0.508
LIG_FHA_1	45	51	PF00498	0.563
LIG_FHA_2	132	138	PF00498	0.613
LIG_FHA_2	145	151	PF00498	0.423
LIG_FHA_2	167	173	PF00498	0.590
LIG_FHA_2	181	187	PF00498	0.528
LIG_FHA_2	4	10	PF00498	0.503
LIG_FHA_2	69	75	PF00498	0.415
LIG_LIR_Apic_2	102	108	PF02991	0.524
LIG_LIR_Apic_2	204	208	PF02991	0.543
LIG_LIR_Apic_2	81	85	PF02991	0.536
LIG_LIR_Gen_1	154	163	PF02991	0.608
LIG_LIR_Gen_1	165	175	PF02991	0.580
LIG_LIR_Gen_1	17	28	PF02991	0.562
LIG_LIR_Gen_1	194	203	PF02991	0.517
LIG_LIR_Gen_1	40	51	PF02991	0.431
LIG_LIR_Nem_3	154	159	PF02991	0.553
LIG_LIR_Nem_3	165	171	PF02991	0.552
LIG_LIR_Nem_3	17	23	PF02991	0.559
LIG_LIR_Nem_3	194	199	PF02991	0.520
LIG_LIR_Nem_3	40	46	PF02991	0.432
LIG_NRBOX	147	153	PF00104	0.634
LIG_PDZ_Class_1	216	221	PF00595	0.550
LIG_SH2_CRK	82	86	PF00017	0.543
LIG_SH2_GRB2like	213	216	PF00017	0.590
LIG_SH2_PTP2	20	23	PF00017	0.590
LIG_SH2_SRC	105	108	PF00017	0.578
LIG_SH2_SRC	115	118	PF00017	0.521
LIG_SH2_SRC	206	209	PF00017	0.516
LIG_SH2_STAT5	115	118	PF00017	0.534
LIG_SH2_STAT5	156	159	PF00017	0.536
LIG_SH2_STAT5	166	169	PF00017	0.564
LIG_SH2_STAT5	20	23	PF00017	0.560
LIG_SH2_STAT5	206	209	PF00017	0.520
LIG_SH2_STAT5	5	8	PF00017	0.532
LIG_SH3_4	48	55	PF00018	0.634
LIG_SUMO_SIM_par_1	26	31	PF11976	0.530
LIG_TRAF2_1	147	150	PF00917	0.673
LIG_TRAF2_1	183	186	PF00917	0.556
MOD_CDK_SPK_2	37	42	PF00069	0.422
MOD_CK2_1	131	137	PF00069	0.561
MOD_CK2_1	144	150	PF00069	0.438
MOD_CK2_1	180	186	PF00069	0.452
MOD_CK2_1	3	9	PF00069	0.512
MOD_GlcNHglycan	76	79	PF01048	0.627
MOD_GSK3_1	131	138	PF00069	0.609
MOD_GSK3_1	162	169	PF00069	0.542
MOD_GSK3_1	74	81	PF00069	0.518
MOD_LATS_1	162	168	PF00433	0.663
MOD_NEK2_1	178	183	PF00069	0.636
MOD_PK_1	155	161	PF00069	0.679
MOD_PKB_1	153	161	PF00069	0.674
MOD_Plk_1	135	141	PF00069	0.533
MOD_Plk_1	144	150	PF00069	0.499
MOD_Plk_1	56	62	PF00069	0.532
MOD_Plk_2-3	136	142	PF00069	0.600
MOD_Plk_2-3	192	198	PF00069	0.631
MOD_Plk_4	91	97	PF00069	0.560
MOD_ProDKin_1	28	34	PF00069	0.542
MOD_ProDKin_1	37	43	PF00069	0.562
TRG_DiLeu_BaLyEn_6	29	34	PF01217	0.540
TRG_ENDOCYTIC_2	156	159	PF00928	0.578
TRG_ENDOCYTIC_2	20	23	PF00928	0.590
TRG_ER_diArg_1	123	126	PF00400	0.609
TRG_Pf-PMV_PEXEL_1	182	186	PF00026	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3G7	Leptomonas seymouri	85%	100%
A0A0S4IWY2	Bodo saltans	58%	100%
A0A1X0NJA6	Trypanosomatidae	66%	99%
A0A3R7MUY6	Trypanosoma rangeli	64%	100%
A0A3S7WWT8	Leishmania donovani	94%	100%
A4HZE1	Leishmania infantum	94%	100%
D0A144	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	63%	100%
E9AVC8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
Q0IHR1	Xenopus tropicalis	47%	100%
Q4QC51	Leishmania major	94%	100%
Q567I9	Danio rerio	47%	100%
Q5NCY3	Mus musculus	45%	97%
Q5PPR6	Xenopus laevis	48%	100%
Q5R4Q5	Pongo abelii	45%	97%
Q6P9G0	Homo sapiens	45%	97%