2-oxoisovalerate dehydrogenase subunit alpha

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

2-oxoisovalerate dehydrogenase alpha subunit, putative

Species:

Leishmania braziliensis

UniProt:

A4HC14_LEIBR

TriTrypDb:

LbrM.21.1810 , LBRM2903_210022000

Length:

479

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005947	mitochondrial alpha-ketoglutarate dehydrogenase complex	4	1
GO:0030062	mitochondrial tricarboxylic acid cycle enzyme complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0045239	tricarboxylic acid cycle enzyme complex	3	1
GO:0045240	dihydrolipoyl dehydrogenase complex	4	1
GO:0098798	mitochondrial protein-containing complex	2	1
GO:0110165	cellular anatomical entity	1	1
GO:1902494	catalytic complex	2	1
GO:1990204	oxidoreductase complex	3	1

Expansion

Sequence features

A4HC14

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC14

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	11
GO:0006520	amino acid metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009063	amino acid catabolic process	4	11
GO:0009081	branched-chain amino acid metabolic process	4	11
GO:0009083	branched-chain amino acid catabolic process	5	11
GO:0009987	cellular process	1	11
GO:0016054	organic acid catabolic process	4	11
GO:0019752	carboxylic acid metabolic process	5	11
GO:0043436	oxoacid metabolic process	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044281	small molecule metabolic process	2	11
GO:0044282	small molecule catabolic process	3	11
GO:0046395	carboxylic acid catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901565	organonitrogen compound catabolic process	4	11
GO:1901575	organic substance catabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0003863	3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity	5	11
GO:0016491	oxidoreductase activity	2	11
GO:0016624	oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor	4	11
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	3	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.521
CLV_C14_Caspase3-7	335	339	PF00656	0.516
CLV_C14_Caspase3-7	37	41	PF00656	0.484
CLV_NRD_NRD_1	346	348	PF00675	0.285
CLV_NRD_NRD_1	422	424	PF00675	0.305
CLV_NRD_NRD_1	431	433	PF00675	0.273
CLV_PCSK_KEX2_1	431	433	PF00082	0.282
CLV_PCSK_SKI1_1	123	127	PF00082	0.454
CLV_PCSK_SKI1_1	136	140	PF00082	0.354
CLV_PCSK_SKI1_1	358	362	PF00082	0.312
CLV_PCSK_SKI1_1	424	428	PF00082	0.328
CLV_PCSK_SKI1_1	69	73	PF00082	0.535
DEG_APCC_DBOX_1	122	130	PF00400	0.257
DEG_APCC_DBOX_1	68	76	PF00400	0.341
DEG_Nend_Nbox_1	1	3	PF02207	0.624
DEG_SCF_FBW7_1	307	313	PF00400	0.474
DEG_SCF_FBW7_2	452	457	PF00400	0.566
DEG_SPOP_SBC_1	42	46	PF00917	0.568
DOC_CKS1_1	307	312	PF01111	0.460
DOC_CKS1_1	409	414	PF01111	0.512
DOC_CKS1_1	451	456	PF01111	0.439
DOC_MAPK_FxFP_2	449	452	PF00069	0.334
DOC_MAPK_gen_1	347	354	PF00069	0.512
DOC_MAPK_gen_1	382	390	PF00069	0.470
DOC_PP1_RVXF_1	144	150	PF00149	0.460
DOC_PP4_FxxP_1	449	452	PF00568	0.456
DOC_USP7_MATH_1	310	314	PF00917	0.490
DOC_USP7_MATH_1	380	384	PF00917	0.540
DOC_USP7_MATH_1	412	416	PF00917	0.512
DOC_USP7_MATH_1	469	473	PF00917	0.590
DOC_USP7_MATH_1	81	85	PF00917	0.702
DOC_WW_Pin1_4	223	228	PF00397	0.491
DOC_WW_Pin1_4	306	311	PF00397	0.452
DOC_WW_Pin1_4	408	413	PF00397	0.443
DOC_WW_Pin1_4	450	455	PF00397	0.437
LIG_14-3-3_CanoR_1	146	150	PF00244	0.460
LIG_14-3-3_CanoR_1	20	30	PF00244	0.534
LIG_14-3-3_CanoR_1	266	272	PF00244	0.535
LIG_14-3-3_CanoR_1	471	475	PF00244	0.581
LIG_APCC_ABBA_1	151	156	PF00400	0.540
LIG_BRCT_BRCA1_1	23	27	PF00533	0.385
LIG_CSL_BTD_1	409	412	PF09270	0.491
LIG_DCNL_PONY_1	1	4	PF03556	0.437
LIG_FHA_1	115	121	PF00498	0.515
LIG_FHA_1	364	370	PF00498	0.522
LIG_FHA_1	43	49	PF00498	0.457
LIG_FHA_1	451	457	PF00498	0.498
LIG_FHA_2	187	193	PF00498	0.485
LIG_FHA_2	259	265	PF00498	0.564
LIG_FHA_2	420	426	PF00498	0.502
LIG_FHA_2	441	447	PF00498	0.496
LIG_FHA_2	47	53	PF00498	0.517
LIG_GBD_Chelix_1	361	369	PF00786	0.364
LIG_LIR_Apic_2	446	452	PF02991	0.447
LIG_LIR_Gen_1	148	158	PF02991	0.515
LIG_LIR_Gen_1	83	91	PF02991	0.463
LIG_LIR_Nem_3	171	177	PF02991	0.460
LIG_LIR_Nem_3	184	188	PF02991	0.460
LIG_LIR_Nem_3	24	30	PF02991	0.417
LIG_LIR_Nem_3	392	397	PF02991	0.469
LIG_LIR_Nem_3	83	88	PF02991	0.460
LIG_PDZ_Class_3	474	479	PF00595	0.630
LIG_Pex14_1	34	38	PF04695	0.431
LIG_Pex14_2	390	394	PF04695	0.474
LIG_PTB_Apo_2	32	39	PF02174	0.456
LIG_REV1ctd_RIR_1	296	305	PF16727	0.540
LIG_SH2_CRK	327	331	PF00017	0.474
LIG_SH2_CRK	343	347	PF00017	0.474
LIG_SH2_NCK_1	188	192	PF00017	0.534
LIG_SH2_SRC	305	308	PF00017	0.491
LIG_SH2_STAP1	240	244	PF00017	0.474
LIG_SH2_STAT5	188	191	PF00017	0.474
LIG_SH3_3	434	440	PF00018	0.539
LIG_SH3_3	53	59	PF00018	0.505
LIG_SUMO_SIM_par_1	358	363	PF11976	0.460
MOD_CK1_1	114	120	PF00069	0.540
MOD_CK1_1	252	258	PF00069	0.477
MOD_CK1_1	308	314	PF00069	0.451
MOD_CK1_1	370	376	PF00069	0.463
MOD_CK1_1	46	52	PF00069	0.512
MOD_CK2_1	166	172	PF00069	0.540
MOD_CK2_1	186	192	PF00069	0.328
MOD_CK2_1	258	264	PF00069	0.564
MOD_CK2_1	380	386	PF00069	0.491
MOD_CK2_1	419	425	PF00069	0.502
MOD_CK2_1	46	52	PF00069	0.426
MOD_GlcNHglycan	254	257	PF01048	0.288
MOD_GSK3_1	145	152	PF00069	0.451
MOD_GSK3_1	223	230	PF00069	0.460
MOD_GSK3_1	248	255	PF00069	0.537
MOD_GSK3_1	287	294	PF00069	0.474
MOD_GSK3_1	306	313	PF00069	0.356
MOD_GSK3_1	363	370	PF00069	0.473
MOD_GSK3_1	371	378	PF00069	0.443
MOD_GSK3_1	408	415	PF00069	0.460
MOD_GSK3_1	42	49	PF00069	0.444
MOD_NEK2_1	149	154	PF00069	0.458
MOD_NEK2_1	2	7	PF00069	0.596
MOD_NEK2_1	249	254	PF00069	0.533
MOD_NEK2_1	258	263	PF00069	0.561
MOD_NEK2_1	288	293	PF00069	0.488
MOD_NEK2_1	390	395	PF00069	0.540
MOD_NEK2_2	145	150	PF00069	0.460
MOD_NEK2_2	293	298	PF00069	0.474
MOD_PIKK_1	227	233	PF00454	0.470
MOD_PIKK_1	310	316	PF00454	0.490
MOD_PIKK_1	402	408	PF00454	0.449
MOD_PKA_2	145	151	PF00069	0.460
MOD_PKA_2	19	25	PF00069	0.551
MOD_PKA_2	2	8	PF00069	0.442
MOD_PKA_2	367	373	PF00069	0.480
MOD_PKA_2	470	476	PF00069	0.526
MOD_Plk_1	111	117	PF00069	0.489
MOD_Plk_4	111	117	PF00069	0.481
MOD_Plk_4	149	155	PF00069	0.534
MOD_Plk_4	254	260	PF00069	0.543
MOD_Plk_4	267	273	PF00069	0.494
MOD_Plk_4	293	299	PF00069	0.460
MOD_ProDKin_1	223	229	PF00069	0.491
MOD_ProDKin_1	306	312	PF00069	0.452
MOD_ProDKin_1	408	414	PF00069	0.443
MOD_ProDKin_1	450	456	PF00069	0.429
MOD_SUMO_for_1	109	112	PF00179	0.495
TRG_ENDOCYTIC_2	150	153	PF00928	0.540
TRG_ENDOCYTIC_2	343	346	PF00928	0.512
TRG_ER_diArg_1	381	384	PF00400	0.491
TRG_ER_diArg_1	430	432	PF00400	0.481

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKY9	Leptomonas seymouri	25%	100%
A0A0N1P9U6	Leptomonas seymouri	77%	100%
A0A0S4JJY6	Bodo saltans	27%	100%
A0A1X0NHX6	Trypanosomatidae	52%	100%
A0A3Q8IB83	Leishmania donovani	24%	100%
A0A3S7WWV0	Leishmania donovani	85%	100%
A0A422NSQ8	Trypanosoma rangeli	52%	100%
A4H9P1	Leishmania braziliensis	27%	100%
A4HY08	Leishmania infantum	24%	100%
A4HZE0	Leishmania infantum	85%	100%
A5A6H9	Pan troglodytes	45%	100%
A5A6L0	Pan troglodytes	26%	100%
A7MB35	Bos taurus	26%	100%
D0A145	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9ARS2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	24%	100%
E9AVC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
O24457	Arabidopsis thaliana	22%	100%
O31404	Bacillus subtilis (strain 168)	28%	100%
O45924	Caenorhabditis elegans	45%	100%
P08559	Homo sapiens	26%	100%
P09060	Pseudomonas putida	32%	100%
P11178	Bos taurus	45%	100%
P11960	Rattus norvegicus	45%	100%
P12694	Homo sapiens	45%	100%
P21873	Geobacillus stearothermophilus	28%	100%
P21881	Bacillus subtilis (strain 168)	29%	100%
P26267	Ascaris suum	26%	100%
P26268	Ascaris suum	26%	100%
P26284	Rattus norvegicus	25%	100%
P29804	Sus scrofa	26%	100%
P35485	Acholeplasma laidlawii	30%	100%
P35486	Mus musculus	25%	100%
P35487	Mus musculus	24%	100%
P37940	Bacillus subtilis (strain 168)	33%	100%
P47516	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	30%	100%
P50136	Mus musculus	46%	100%
P52900	Sminthopsis macroura	25%	100%
P60089	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	100%
P60090	Staphylococcus aureus (strain MW2)	28%	100%
P75390	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	29%	100%
P9WIS2	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	36%	100%
P9WIS3	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	36%	100%
Q06437	Rattus norvegicus	24%	100%
Q4MTG0	Bacillus cereus	27%	100%
Q4QC52	Leishmania major	85%	100%
Q4QDQ1	Leishmania major	26%	100%
Q54M22	Dictyostelium discoideum	44%	100%
Q5HGZ1	Staphylococcus aureus (strain COL)	28%	100%
Q5HQ76	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	29%	100%
Q5R490	Pongo abelii	26%	100%
Q5SLR4	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	34%	100%
Q6GAC1	Staphylococcus aureus (strain MSSA476)	28%	100%
Q6GHZ2	Staphylococcus aureus (strain MRSA252)	28%	100%
Q72GU1	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	34%	100%
Q7XTJ3	Oryza sativa subsp. japonica	25%	100%
Q820A6	Staphylococcus aureus (strain N315)	28%	100%
Q84JL2	Arabidopsis thaliana	42%	100%
Q8CPN3	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	29%	100%
Q8HXW9	Macaca fascicularis	26%	100%
Q8HXY4	Macaca fascicularis	45%	100%
Q9I1M2	Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)	34%	100%
Q9LPL5	Arabidopsis thaliana	46%	100%
V5DIA0	Trypanosoma cruzi	52%	100%