Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Exocyst complex component EXO99

Species:

Leishmania braziliensis

UniProt:

A4HC13_LEIBR

TriTrypDb:

LbrM.21.1790 , LBRM2903_210024300

Length:

932

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	11
GO:0032991	protein-containing complex	1	11
GO:0043226	organelle	2	11
GO:0043228	non-membrane-bounded organelle	3	11
GO:0043229	intracellular organelle	3	11
GO:0043232	intracellular non-membrane-bounded organelle	4	11
GO:0110165	cellular anatomical entity	1	11
GO:1990904	ribonucleoprotein complex	2	11
GO:0000145	exocyst	3	1
GO:0005634	nucleus	5	1
GO:0020016	ciliary pocket	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0099023	vesicle tethering complex	2	1

Expansion

Sequence features

A4HC13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC13

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006364	rRNA processing	8	6
GO:0006396	RNA processing	6	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016070	RNA metabolic process	5	6
GO:0016072	rRNA metabolic process	7	6
GO:0034470	ncRNA processing	7	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034660	ncRNA metabolic process	6	6
GO:0043170	macromolecule metabolic process	3	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046483	heterocycle metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0090304	nucleic acid metabolic process	4	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:0006810	transport	3	1
GO:0006897	endocytosis	5	1
GO:0016192	vesicle-mediated transport	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	285	289	PF00656	0.459
CLV_MEL_PAP_1	175	181	PF00089	0.311
CLV_NRD_NRD_1	17	19	PF00675	0.549
CLV_NRD_NRD_1	399	401	PF00675	0.628
CLV_NRD_NRD_1	433	435	PF00675	0.467
CLV_NRD_NRD_1	447	449	PF00675	0.250
CLV_NRD_NRD_1	462	464	PF00675	0.308
CLV_NRD_NRD_1	612	614	PF00675	0.506
CLV_NRD_NRD_1	666	668	PF00675	0.461
CLV_NRD_NRD_1	874	876	PF00675	0.371
CLV_NRD_NRD_1	921	923	PF00675	0.519
CLV_PCSK_KEX2_1	19	21	PF00082	0.564
CLV_PCSK_KEX2_1	447	449	PF00082	0.337
CLV_PCSK_KEX2_1	462	464	PF00082	0.308
CLV_PCSK_KEX2_1	666	668	PF00082	0.423
CLV_PCSK_KEX2_1	921	923	PF00082	0.497
CLV_PCSK_PC1ET2_1	19	21	PF00082	0.429
CLV_PCSK_SKI1_1	24	28	PF00082	0.557
CLV_PCSK_SKI1_1	463	467	PF00082	0.454
CLV_PCSK_SKI1_1	583	587	PF00082	0.522
CLV_PCSK_SKI1_1	609	613	PF00082	0.360
CLV_PCSK_SKI1_1	714	718	PF00082	0.413
CLV_PCSK_SKI1_1	726	730	PF00082	0.327
CLV_Separin_Metazoa	642	646	PF03568	0.278
DEG_APCC_DBOX_1	19	27	PF00400	0.550
DEG_APCC_DBOX_1	296	304	PF00400	0.466
DEG_APCC_DBOX_1	353	361	PF00400	0.268
DEG_APCC_DBOX_1	582	590	PF00400	0.517
DEG_SCF_FBW7_2	423	430	PF00400	0.401
DEG_SPOP_SBC_1	34	38	PF00917	0.284
DOC_ANK_TNKS_1	246	253	PF00023	0.337
DOC_CDC14_PxL_1	391	399	PF14671	0.512
DOC_CKS1_1	424	429	PF01111	0.454
DOC_CYCLIN_RxL_1	18	28	PF00134	0.520
DOC_CYCLIN_RxL_1	459	470	PF00134	0.491
DOC_MAPK_gen_1	631	639	PF00069	0.392
DOC_MAPK_HePTP_8	570	582	PF00069	0.304
DOC_MAPK_JIP1_4	726	732	PF00069	0.333
DOC_MAPK_MEF2A_6	573	582	PF00069	0.485
DOC_MAPK_MEF2A_6	583	590	PF00069	0.512
DOC_MAPK_NFAT4_5	583	591	PF00069	0.524
DOC_MAPK_RevD_3	599	614	PF00069	0.475
DOC_PP1_RVXF_1	313	319	PF00149	0.452
DOC_PP1_RVXF_1	619	626	PF00149	0.464
DOC_PP2B_LxvP_1	40	43	PF13499	0.310
DOC_PP4_FxxP_1	79	82	PF00568	0.318
DOC_PP4_FxxP_1	795	798	PF00568	0.439
DOC_SPAK_OSR1_1	794	798	PF12202	0.471
DOC_USP7_MATH_1	128	132	PF00917	0.481
DOC_USP7_MATH_1	13	17	PF00917	0.621
DOC_USP7_MATH_1	152	156	PF00917	0.582
DOC_USP7_MATH_1	164	168	PF00917	0.617
DOC_USP7_MATH_1	34	38	PF00917	0.284
DOC_USP7_MATH_1	412	416	PF00917	0.648
DOC_USP7_MATH_1	549	553	PF00917	0.449
DOC_USP7_MATH_1	646	650	PF00917	0.464
DOC_USP7_MATH_1	82	86	PF00917	0.476
DOC_USP7_MATH_1	924	928	PF00917	0.422
DOC_WW_Pin1_4	137	142	PF00397	0.525
DOC_WW_Pin1_4	157	162	PF00397	0.400
DOC_WW_Pin1_4	214	219	PF00397	0.528
DOC_WW_Pin1_4	35	40	PF00397	0.288
DOC_WW_Pin1_4	416	421	PF00397	0.735
DOC_WW_Pin1_4	423	428	PF00397	0.596
DOC_WW_Pin1_4	63	68	PF00397	0.396
LIG_14-3-3_CanoR_1	211	219	PF00244	0.350
LIG_14-3-3_CanoR_1	354	362	PF00244	0.419
LIG_14-3-3_CanoR_1	645	654	PF00244	0.481
LIG_14-3-3_CanoR_1	801	807	PF00244	0.414
LIG_14-3-3_CanoR_1	808	816	PF00244	0.425
LIG_14-3-3_CanoR_1	883	892	PF00244	0.405
LIG_APCC_ABBA_1	76	81	PF00400	0.277
LIG_BIR_II_1	1	5	PF00653	0.432
LIG_BIR_III_4	439	443	PF00653	0.389
LIG_Clathr_ClatBox_1	507	511	PF01394	0.391
LIG_Clathr_ClatBox_1	76	80	PF01394	0.367
LIG_deltaCOP1_diTrp_1	107	114	PF00928	0.445
LIG_FHA_1	215	221	PF00498	0.496
LIG_FHA_1	288	294	PF00498	0.333
LIG_FHA_1	517	523	PF00498	0.411
LIG_FHA_1	535	541	PF00498	0.480
LIG_FHA_1	69	75	PF00498	0.417
LIG_FHA_1	781	787	PF00498	0.429
LIG_FHA_1	813	819	PF00498	0.429
LIG_FHA_2	363	369	PF00498	0.454
LIG_FHA_2	424	430	PF00498	0.533
LIG_FHA_2	5	11	PF00498	0.419
LIG_FHA_2	582	588	PF00498	0.447
LIG_FHA_2	807	813	PF00498	0.476
LIG_FHA_2	882	888	PF00498	0.546
LIG_LIR_Apic_2	792	798	PF02991	0.452
LIG_LIR_Gen_1	451	460	PF02991	0.372
LIG_LIR_Gen_1	488	496	PF02991	0.276
LIG_LIR_Gen_1	620	630	PF02991	0.479
LIG_LIR_Gen_1	640	648	PF02991	0.230
LIG_LIR_Gen_1	670	679	PF02991	0.283
LIG_LIR_Gen_1	695	704	PF02991	0.284
LIG_LIR_Gen_1	738	749	PF02991	0.341
LIG_LIR_Gen_1	753	761	PF02991	0.368
LIG_LIR_Gen_1	810	820	PF02991	0.340
LIG_LIR_Gen_1	913	924	PF02991	0.422
LIG_LIR_Nem_3	273	277	PF02991	0.311
LIG_LIR_Nem_3	451	456	PF02991	0.368
LIG_LIR_Nem_3	488	492	PF02991	0.518
LIG_LIR_Nem_3	620	625	PF02991	0.468
LIG_LIR_Nem_3	640	644	PF02991	0.241
LIG_LIR_Nem_3	695	700	PF02991	0.375
LIG_LIR_Nem_3	738	744	PF02991	0.351
LIG_LIR_Nem_3	753	758	PF02991	0.375
LIG_LIR_Nem_3	810	816	PF02991	0.342
LIG_LIR_Nem_3	856	861	PF02991	0.380
LIG_LIR_Nem_3	913	919	PF02991	0.382
LIG_NRBOX	22	28	PF00104	0.516
LIG_NRBOX	561	567	PF00104	0.256
LIG_PCNA_yPIPBox_3	561	570	PF02747	0.372
LIG_PDZ_Class_3	927	932	PF00595	0.579
LIG_Pex14_2	668	672	PF04695	0.511
LIG_PTAP_UEV_1	160	165	PF05743	0.650
LIG_REV1ctd_RIR_1	255	265	PF16727	0.333
LIG_SH2_CRK	353	357	PF00017	0.348
LIG_SH2_CRK	453	457	PF00017	0.398
LIG_SH2_SRC	616	619	PF00017	0.362
LIG_SH2_STAP1	237	241	PF00017	0.411
LIG_SH2_STAP1	294	298	PF00017	0.476
LIG_SH2_STAP1	489	493	PF00017	0.351
LIG_SH2_STAT3	298	301	PF00017	0.488
LIG_SH2_STAT5	11	14	PF00017	0.488
LIG_SH2_STAT5	445	448	PF00017	0.403
LIG_SH2_STAT5	616	619	PF00017	0.422
LIG_SH2_STAT5	741	744	PF00017	0.475
LIG_SH2_STAT5	877	880	PF00017	0.490
LIG_SH3_3	158	164	PF00018	0.582
LIG_SH3_3	273	279	PF00018	0.368
LIG_SH3_3	414	420	PF00018	0.738
LIG_SH3_3	421	427	PF00018	0.626
LIG_SH3_5	485	489	PF00018	0.388
LIG_SUMO_SIM_anti_2	238	246	PF11976	0.399
LIG_SUMO_SIM_anti_2	477	483	PF11976	0.406
LIG_SUMO_SIM_anti_2	503	511	PF11976	0.354
LIG_SUMO_SIM_anti_2	584	590	PF11976	0.516
LIG_SUMO_SIM_anti_2	699	705	PF11976	0.468
LIG_SUMO_SIM_anti_2	812	818	PF11976	0.356
LIG_SUMO_SIM_par_1	280	285	PF11976	0.346
LIG_SUMO_SIM_par_1	287	295	PF11976	0.305
LIG_SUMO_SIM_par_1	4	10	PF11976	0.418
LIG_SUMO_SIM_par_1	503	511	PF11976	0.354
LIG_SUMO_SIM_par_1	890	896	PF11976	0.435
LIG_SUMO_SIM_par_1	907	914	PF11976	0.466
LIG_TRAF2_1	427	430	PF00917	0.595
LIG_TYR_ITIM	639	644	PF00017	0.475
LIG_UBA3_1	626	634	PF00899	0.323
LIG_Vh1_VBS_1	775	793	PF01044	0.367
LIG_WRC_WIRS_1	489	494	PF05994	0.375
LIG_WRC_WIRS_1	741	746	PF05994	0.342
LIG_WRC_WIRS_1	882	887	PF05994	0.410
MOD_CK1_1	155	161	PF00069	0.589
MOD_CK1_1	180	186	PF00069	0.404
MOD_CK1_1	287	293	PF00069	0.350
MOD_CK1_1	331	337	PF00069	0.432
MOD_CK1_1	4	10	PF00069	0.439
MOD_CK1_1	516	522	PF00069	0.521
MOD_CK1_1	533	539	PF00069	0.335
MOD_CK2_1	101	107	PF00069	0.359
MOD_CK2_1	128	134	PF00069	0.360
MOD_CK2_1	245	251	PF00069	0.438
MOD_CK2_1	423	429	PF00069	0.622
MOD_CK2_1	846	852	PF00069	0.448
MOD_CK2_1	881	887	PF00069	0.473
MOD_GlcNHglycan	134	138	PF01048	0.401
MOD_GlcNHglycan	149	152	PF01048	0.487
MOD_GlcNHglycan	161	164	PF01048	0.686
MOD_GlcNHglycan	227	230	PF01048	0.433
MOD_GlcNHglycan	233	236	PF01048	0.396
MOD_GlcNHglycan	247	250	PF01048	0.468
MOD_GlcNHglycan	414	417	PF01048	0.723
MOD_GlcNHglycan	48	51	PF01048	0.462
MOD_GlcNHglycan	648	651	PF01048	0.516
MOD_GlcNHglycan	71	74	PF01048	0.368
MOD_GlcNHglycan	894	898	PF01048	0.490
MOD_GlcNHglycan	926	929	PF01048	0.499
MOD_GSK3_1	128	135	PF00069	0.381
MOD_GSK3_1	155	162	PF00069	0.543
MOD_GSK3_1	165	172	PF00069	0.400
MOD_GSK3_1	210	217	PF00069	0.421
MOD_GSK3_1	227	234	PF00069	0.327
MOD_GSK3_1	324	331	PF00069	0.469
MOD_GSK3_1	360	367	PF00069	0.475
MOD_GSK3_1	412	419	PF00069	0.810
MOD_GSK3_1	530	537	PF00069	0.486
MOD_GSK3_1	549	556	PF00069	0.488
MOD_GSK3_1	736	743	PF00069	0.356
MOD_GSK3_1	789	796	PF00069	0.425
MOD_GSK3_1	803	810	PF00069	0.333
MOD_N-GLC_1	155	160	PF02516	0.438
MOD_N-GLC_1	188	193	PF02516	0.340
MOD_N-GLC_1	790	795	PF02516	0.322
MOD_N-GLC_1	847	852	PF02516	0.377
MOD_NEK2_1	1	6	PF00069	0.496
MOD_NEK2_1	114	119	PF00069	0.327
MOD_NEK2_1	145	150	PF00069	0.405
MOD_NEK2_1	169	174	PF00069	0.391
MOD_NEK2_1	243	248	PF00069	0.526
MOD_NEK2_1	325	330	PF00069	0.392
MOD_NEK2_1	33	38	PF00069	0.556
MOD_NEK2_1	362	367	PF00069	0.360
MOD_NEK2_1	380	385	PF00069	0.349
MOD_NEK2_1	46	51	PF00069	0.368
MOD_NEK2_1	524	529	PF00069	0.381
MOD_NEK2_1	61	66	PF00069	0.296
MOD_NEK2_1	625	630	PF00069	0.423
MOD_NEK2_1	68	73	PF00069	0.390
MOD_NEK2_1	745	750	PF00069	0.412
MOD_NEK2_1	789	794	PF00069	0.544
MOD_NEK2_2	128	133	PF00069	0.418
MOD_NEK2_2	878	883	PF00069	0.459
MOD_OFUCOSY	125	132	PF10250	0.474
MOD_PIKK_1	625	631	PF00454	0.530
MOD_PIKK_1	682	688	PF00454	0.450
MOD_PKA_2	177	183	PF00069	0.318
MOD_PKA_2	210	216	PF00069	0.384
MOD_PKA_2	662	668	PF00069	0.342
MOD_PKA_2	793	799	PF00069	0.544
MOD_PKA_2	800	806	PF00069	0.501
MOD_PKA_2	807	813	PF00069	0.476
MOD_PKB_1	542	550	PF00069	0.529
MOD_Plk_1	155	161	PF00069	0.441
MOD_Plk_1	187	193	PF00069	0.414
MOD_Plk_1	237	243	PF00069	0.406
MOD_Plk_1	378	384	PF00069	0.325
MOD_Plk_1	524	530	PF00069	0.465
MOD_Plk_1	790	796	PF00069	0.532
MOD_Plk_1	803	809	PF00069	0.406
MOD_Plk_2-3	553	559	PF00069	0.488
MOD_Plk_4	1	7	PF00069	0.522
MOD_Plk_4	165	171	PF00069	0.420
MOD_Plk_4	180	186	PF00069	0.356
MOD_Plk_4	188	194	PF00069	0.356
MOD_Plk_4	227	233	PF00069	0.361
MOD_Plk_4	237	243	PF00069	0.402
MOD_Plk_4	277	283	PF00069	0.373
MOD_Plk_4	488	494	PF00069	0.538
MOD_Plk_4	524	530	PF00069	0.436
MOD_Plk_4	740	746	PF00069	0.343
MOD_Plk_4	812	818	PF00069	0.427
MOD_ProDKin_1	137	143	PF00069	0.524
MOD_ProDKin_1	157	163	PF00069	0.396
MOD_ProDKin_1	214	220	PF00069	0.508
MOD_ProDKin_1	35	41	PF00069	0.287
MOD_ProDKin_1	416	422	PF00069	0.724
MOD_ProDKin_1	423	429	PF00069	0.592
MOD_ProDKin_1	63	69	PF00069	0.409
MOD_SUMO_for_1	897	900	PF00179	0.501
TRG_DiLeu_BaEn_1	134	139	PF01217	0.361
TRG_DiLeu_BaEn_1	503	508	PF01217	0.460
TRG_DiLeu_BaEn_2	109	115	PF01217	0.445
TRG_DiLeu_BaEn_2	617	623	PF01217	0.333
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.439
TRG_DiLeu_BaLyEn_6	606	611	PF01217	0.394
TRG_DiLeu_BaLyEn_6	724	729	PF01217	0.397
TRG_ENDOCYTIC_2	453	456	PF00928	0.350
TRG_ENDOCYTIC_2	489	492	PF00928	0.451
TRG_ENDOCYTIC_2	641	644	PF00928	0.466
TRG_ENDOCYTIC_2	673	676	PF00928	0.441
TRG_ENDOCYTIC_2	697	700	PF00928	0.364
TRG_ENDOCYTIC_2	741	744	PF00928	0.342
TRG_ER_diArg_1	119	122	PF00400	0.330
TRG_ER_diArg_1	17	20	PF00400	0.552
TRG_ER_diArg_1	314	317	PF00400	0.457
TRG_ER_diArg_1	446	448	PF00400	0.344
TRG_ER_diArg_1	462	464	PF00400	0.294
TRG_ER_diArg_1	666	668	PF00400	0.543
TRG_ER_diArg_1	91	94	PF00400	0.446
TRG_NES_CRM1_1	474	488	PF08389	0.480
TRG_NES_CRM1_1	812	825	PF08389	0.382
TRG_Pf-PMV_PEXEL_1	121	126	PF00026	0.459
TRG_Pf-PMV_PEXEL_1	447	451	PF00026	0.331

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBU1	Leptomonas seymouri	71%	100%
A0A1X0NJ82	Trypanosomatidae	44%	100%
A0A3S7WWR2	Leishmania donovani	85%	100%
A0A422N8B4	Trypanosoma rangeli	43%	100%
A4HZF4	Leishmania infantum	86%	100%
D0A113	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AVF0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
Q4QC29	Leishmania major	86%	100%
V5B1W3	Trypanosoma cruzi	43%	100%