PEROXIDASE_4 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peroxidase, putative

Species:

Leishmania braziliensis

UniProt:

A4HC12_LEIBR

TriTrypDb:

LbrM.21.1780 , LBRM2903_210024200

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 16

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HC12

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC12

PDB structure(s): 5via_A

Function

Biological processes
Term	Name	Level	Count
GO:0006950	response to stress	2	17
GO:0006979	response to oxidative stress	3	17
GO:0009987	cellular process	1	17
GO:0033554	cellular response to stress	3	17
GO:0034599	cellular response to oxidative stress	4	17
GO:0042221	response to chemical	2	17
GO:0050896	response to stimulus	1	17
GO:0051716	cellular response to stimulus	2	17
GO:0062197	cellular response to chemical stress	4	17
GO:0070887	cellular response to chemical stimulus	3	17
GO:0000302	response to reactive oxygen species	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0010941	regulation of cell death	4	1
GO:0030322	stabilization of membrane potential	4	1
GO:0042391	regulation of membrane potential	3	1
GO:0042592	homeostatic process	3	1
GO:0042743	hydrogen peroxide metabolic process	4	2
GO:0042744	hydrogen peroxide catabolic process	4	2
GO:0042981	regulation of apoptotic process	6	1
GO:0043066	negative regulation of apoptotic process	7	1
GO:0043067	regulation of programmed cell death	5	1
GO:0043069	negative regulation of programmed cell death	6	1
GO:0044237	cellular metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0048878	chemical homeostasis	4	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0050801	monoatomic ion homeostasis	5	1
GO:0055065	obsolete metal ion homeostasis	7	1
GO:0055074	calcium ion homeostasis	8	1
GO:0055080	monoatomic cation homeostasis	6	1
GO:0060548	negative regulation of cell death	5	1
GO:0065007	biological regulation	1	1
GO:0065008	regulation of biological quality	2	1
GO:0072507	obsolete divalent inorganic cation homeostasis	7	1
GO:0072593	reactive oxygen species metabolic process	3	2
GO:0098771	inorganic ion homeostasis	6	1
GO:1901700	response to oxygen-containing compound	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	17
GO:0004601	peroxidase activity	2	17
GO:0005488	binding	1	17
GO:0016209	antioxidant activity	1	17
GO:0016491	oxidoreductase activity	2	17
GO:0016684	oxidoreductase activity, acting on peroxide as acceptor	3	17
GO:0020037	heme binding	4	17
GO:0046906	tetrapyrrole binding	3	17
GO:0097159	organic cyclic compound binding	2	17
GO:1901363	heterocyclic compound binding	2	17
GO:0004129	cytochrome-c oxidase activity	4	1
GO:0004447	iodide peroxidase activity	4	1
GO:0005215	transporter activity	1	1
GO:0008324	monoatomic cation transmembrane transporter activity	4	1
GO:0008447	L-ascorbate oxidase activity	5	1
GO:0009055	electron transfer activity	3	1
GO:0015075	monoatomic ion transmembrane transporter activity	3	1
GO:0015078	proton transmembrane transporter activity	5	1
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	1
GO:0015399	primary active transmembrane transporter activity	4	1
GO:0015453	oxidoreduction-driven active transmembrane transporter activity	5	1
GO:0016675	oxidoreductase activity, acting on a heme group of donors	3	1
GO:0016679	oxidoreductase activity, acting on diphenols and related substances as donors	3	1
GO:0016682	oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor	4	1
GO:0016688	L-ascorbate peroxidase activity	3	5
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	1
GO:0022804	active transmembrane transporter activity	3	1
GO:0022853	active monoatomic ion transmembrane transporter activity	4	1
GO:0022857	transmembrane transporter activity	2	1
GO:0022890	inorganic cation transmembrane transporter activity	4	1
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0140905	haloperoxidase activity	3	1
GO:0140906	halogenase activity	4	1
GO:0140825	lactoperoxidase activity	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	211	215	PF00656	0.375
CLV_C14_Caspase3-7	264	268	PF00656	0.190
CLV_NRD_NRD_1	142	144	PF00675	0.255
CLV_NRD_NRD_1	26	28	PF00675	0.314
CLV_NRD_NRD_1	361	363	PF00675	0.563
CLV_NRD_NRD_1	59	61	PF00675	0.719
CLV_PCSK_KEX2_1	142	144	PF00082	0.255
CLV_PCSK_KEX2_1	218	220	PF00082	0.514
CLV_PCSK_KEX2_1	26	28	PF00082	0.314
CLV_PCSK_KEX2_1	274	276	PF00082	0.506
CLV_PCSK_KEX2_1	329	331	PF00082	0.442
CLV_PCSK_KEX2_1	378	380	PF00082	0.529
CLV_PCSK_PC1ET2_1	218	220	PF00082	0.523
CLV_PCSK_PC1ET2_1	274	276	PF00082	0.490
CLV_PCSK_PC1ET2_1	329	331	PF00082	0.442
CLV_PCSK_PC1ET2_1	378	380	PF00082	0.529
CLV_PCSK_SKI1_1	108	112	PF00082	0.237
CLV_PCSK_SKI1_1	134	138	PF00082	0.255
CLV_PCSK_SKI1_1	275	279	PF00082	0.440
CLV_PCSK_SKI1_1	305	309	PF00082	0.425
DEG_APCC_KENBOX_2	319	323	PF00400	0.210
DEG_Nend_Nbox_1	1	3	PF02207	0.602
DEG_SPOP_SBC_1	38	42	PF00917	0.460
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.333
DOC_PP1_RVXF_1	132	138	PF00149	0.277
DOC_PP4_FxxP_1	50	53	PF00568	0.422
DOC_USP7_MATH_1	129	133	PF00917	0.329
DOC_USP7_MATH_1	17	21	PF00917	0.318
DOC_USP7_MATH_1	176	180	PF00917	0.252
DOC_USP7_MATH_1	252	256	PF00917	0.243
DOC_USP7_MATH_1	34	38	PF00917	0.437
DOC_USP7_MATH_1	68	72	PF00917	0.395
DOC_USP7_UBL2_3	104	108	PF12436	0.579
DOC_WW_Pin1_4	213	218	PF00397	0.183
LIG_14-3-3_CanoR_1	27	33	PF00244	0.526
LIG_14-3-3_CanoR_1	381	386	PF00244	0.343
LIG_14-3-3_CanoR_1	46	51	PF00244	0.416
LIG_APCC_ABBA_1	380	385	PF00400	0.402
LIG_APCC_ABBAyCdc20_2	379	385	PF00400	0.319
LIG_BIR_III_2	214	218	PF00653	0.247
LIG_deltaCOP1_diTrp_1	204	208	PF00928	0.231
LIG_deltaCOP1_diTrp_1	357	365	PF00928	0.281
LIG_EH1_1	229	237	PF00400	0.198
LIG_FHA_1	23	29	PF00498	0.280
LIG_FHA_1	368	374	PF00498	0.289
LIG_FHA_1	76	82	PF00498	0.252
LIG_FHA_2	148	154	PF00498	0.310
LIG_FHA_2	241	247	PF00498	0.255
LIG_FHA_2	344	350	PF00498	0.316
LIG_IBAR_NPY_1	67	69	PF08397	0.420
LIG_LIR_Apic_2	49	53	PF02991	0.421
LIG_LIR_Gen_1	196	203	PF02991	0.245
LIG_LIR_Gen_1	367	377	PF02991	0.268
LIG_LIR_Gen_1	71	80	PF02991	0.337
LIG_LIR_LC3C_4	349	352	PF02991	0.242
LIG_LIR_Nem_3	196	202	PF02991	0.245
LIG_LIR_Nem_3	279	285	PF02991	0.244
LIG_LIR_Nem_3	290	296	PF02991	0.284
LIG_LIR_Nem_3	313	317	PF02991	0.190
LIG_LIR_Nem_3	346	350	PF02991	0.277
LIG_LIR_Nem_3	374	380	PF02991	0.292
LIG_LIR_Nem_3	71	75	PF02991	0.364
LIG_LIR_Nem_3	78	82	PF02991	0.340
LIG_Pex14_1	361	365	PF04695	0.270
LIG_Pex14_2	365	369	PF04695	0.297
LIG_PTB_Apo_2	277	284	PF02174	0.277
LIG_PTB_Phospho_1	277	283	PF10480	0.248
LIG_SH2_CRK	283	287	PF00017	0.238
LIG_SH2_NCK_1	383	387	PF00017	0.409
LIG_SH2_STAP1	199	203	PF00017	0.252
LIG_SH2_STAT5	170	173	PF00017	0.336
LIG_SH2_STAT5	194	197	PF00017	0.360
LIG_SH2_STAT5	276	279	PF00017	0.302
LIG_SH2_STAT5	318	321	PF00017	0.292
LIG_SH3_1	219	225	PF00018	0.349
LIG_SH3_3	219	225	PF00018	0.348
LIG_SUMO_SIM_anti_2	246	252	PF11976	0.288
LIG_SUMO_SIM_anti_2	337	343	PF11976	0.353
LIG_SUMO_SIM_anti_2	78	84	PF11976	0.288
LIG_TRAF2_1	356	359	PF00917	0.395
MOD_CDK_SPK_2	213	218	PF00069	0.183
MOD_CDK_SPxK_1	213	219	PF00069	0.183
MOD_CK1_1	13	19	PF00069	0.239
MOD_CK1_1	213	219	PF00069	0.183
MOD_CK1_1	324	330	PF00069	0.369
MOD_CK1_1	367	373	PF00069	0.262
MOD_CK1_1	37	43	PF00069	0.446
MOD_CK2_1	147	153	PF00069	0.292
MOD_CK2_1	175	181	PF00069	0.401
MOD_CK2_1	240	246	PF00069	0.255
MOD_CK2_1	252	258	PF00069	0.302
MOD_CK2_1	334	340	PF00069	0.218
MOD_CK2_1	343	349	PF00069	0.373
MOD_Cter_Amidation	272	275	PF01082	0.533
MOD_Cter_Amidation	58	61	PF01082	0.712
MOD_GlcNHglycan	116	119	PF01048	0.383
MOD_GlcNHglycan	15	18	PF01048	0.282
MOD_GlcNHglycan	19	22	PF01048	0.247
MOD_GlcNHglycan	195	198	PF01048	0.512
MOD_GlcNHglycan	261	266	PF01048	0.469
MOD_GlcNHglycan	267	270	PF01048	0.465
MOD_GlcNHglycan	323	326	PF01048	0.459
MOD_GlcNHglycan	366	369	PF01048	0.477
MOD_GSK3_1	147	154	PF00069	0.246
MOD_GSK3_1	171	178	PF00069	0.333
MOD_GSK3_1	261	268	PF00069	0.235
MOD_GSK3_1	294	301	PF00069	0.397
MOD_GSK3_1	306	313	PF00069	0.269
MOD_GSK3_1	34	41	PF00069	0.455
MOD_GSK3_1	381	388	PF00069	0.364
MOD_GSK3_1	42	49	PF00069	0.516
MOD_GSK3_1	9	16	PF00069	0.325
MOD_N-GLC_1	321	326	PF02516	0.383
MOD_N-GLC_1	334	339	PF02516	0.435
MOD_N-GLC_1	343	348	PF02516	0.447
MOD_N-GLC_1	75	80	PF02516	0.452
MOD_NEK2_1	11	16	PF00069	0.252
MOD_NEK2_1	128	133	PF00069	0.338
MOD_NEK2_1	171	176	PF00069	0.355
MOD_NEK2_1	28	33	PF00069	0.548
MOD_NEK2_1	3	8	PF00069	0.577
MOD_NEK2_1	372	377	PF00069	0.281
MOD_NEK2_2	129	134	PF00069	0.309
MOD_PIKK_1	223	229	PF00454	0.255
MOD_PIKK_1	298	304	PF00454	0.338
MOD_PK_1	228	234	PF00069	0.317
MOD_PKA_1	60	66	PF00069	0.497
MOD_PKB_1	379	387	PF00069	0.409
MOD_PKB_1	44	52	PF00069	0.362
MOD_Plk_1	305	311	PF00069	0.183
MOD_Plk_1	343	349	PF00069	0.272
MOD_Plk_1	75	81	PF00069	0.252
MOD_Plk_4	75	81	PF00069	0.404
MOD_ProDKin_1	213	219	PF00069	0.183
MOD_SUMO_rev_2	99	105	PF00179	0.652
TRG_DiLeu_BaEn_1	246	251	PF01217	0.267
TRG_ENDOCYTIC_2	199	202	PF00928	0.350
TRG_ENDOCYTIC_2	282	285	PF00928	0.228
TRG_ER_diArg_1	26	28	PF00400	0.314
TRG_ER_diArg_1	379	382	PF00400	0.344
TRG_ER_diArg_1	43	46	PF00400	0.370
TRG_NLS_Bipartite_1	362	382	PF00514	0.228
TRG_NLS_MonoExtN_4	326	332	PF00514	0.254

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Y9	Leptomonas seymouri	76%	96%
A0A0S4JPM4	Bodo saltans	48%	78%
A0A1X0NHV6	Trypanosomatidae	54%	100%
A0A3S7WWR4	Leishmania donovani	89%	100%
A0A422N895	Trypanosoma rangeli	52%	100%
A4HAD2	Leishmania braziliensis	27%	100%
A4HZF3	Leishmania infantum	88%	100%
A4I9H5	Leishmania infantum	25%	100%
D0A114	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AVE9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9B4H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
H6V7N3	Leishmania donovani	25%	100%
Q4Q3K2	Leishmania major	25%	100%
Q4QC30	Leishmania major	86%	100%
V5BHD3	Trypanosoma cruzi	55%	100%