TRAF3-interacting protein 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Microtubule-binding protein MIP-T3, putative

Species:

Leishmania braziliensis

UniProt:

A4HC10_LEIBR

TriTrypDb:

LbrM.21.1760 , LBRM2903_210024000

Length:

491

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005813	centrosome	3	1
GO:0005815	microtubule organizing center	2	1
GO:0005930	axoneme	2	1
GO:0030992	intraciliary transport particle B	2	1
GO:0032991	protein-containing complex	1	1
GO:0036064	ciliary basal body	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC10

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC10

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006996	organelle organization	4	1
GO:0007017	microtubule-based process	2	1
GO:0007018	microtubule-based movement	3	1
GO:0009987	cellular process	1	1
GO:0010970	transport along microtubule	4	1
GO:0016043	cellular component organization	3	1
GO:0022607	cellular component assembly	4	1
GO:0030030	cell projection organization	4	1
GO:0030031	cell projection assembly	5	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0031503	protein-containing complex localization	2	1
GO:0032886	regulation of microtubule-based process	4	1
GO:0033043	regulation of organelle organization	5	1
GO:0042073	intraciliary transport	3	1
GO:0044782	cilium organization	5	1
GO:0046907	intracellular transport	3	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0051128	regulation of cellular component organization	4	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051493	regulation of cytoskeleton organization	6	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1
GO:0060271	cilium assembly	6	1
GO:0065007	biological regulation	1	1
GO:0070507	regulation of microtubule cytoskeleton organization	5	1
GO:0070925	organelle assembly	5	1
GO:0071840	cellular component organization or biogenesis	2	1
GO:0099111	microtubule-based transport	4	1
GO:0120031	plasma membrane bounded cell projection assembly	6	1
GO:0120036	plasma membrane bounded cell projection organization	5	1

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	6
GO:0005515	protein binding	2	6
GO:0008017	microtubule binding	5	6
GO:0008092	cytoskeletal protein binding	3	6
GO:0015631	tubulin binding	4	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	236	240	PF00656	0.634
CLV_C14_Caspase3-7	407	411	PF00656	0.546
CLV_C14_Caspase3-7	55	59	PF00656	0.546
CLV_NRD_NRD_1	177	179	PF00675	0.639
CLV_NRD_NRD_1	184	186	PF00675	0.546
CLV_NRD_NRD_1	190	192	PF00675	0.483
CLV_NRD_NRD_1	248	250	PF00675	0.621
CLV_NRD_NRD_1	342	344	PF00675	0.415
CLV_NRD_NRD_1	434	436	PF00675	0.346
CLV_PCSK_FUR_1	182	186	PF00082	0.559
CLV_PCSK_KEX2_1	176	178	PF00082	0.637
CLV_PCSK_KEX2_1	182	184	PF00082	0.562
CLV_PCSK_KEX2_1	189	191	PF00082	0.483
CLV_PCSK_KEX2_1	234	236	PF00082	0.718
CLV_PCSK_KEX2_1	282	284	PF00082	0.728
CLV_PCSK_KEX2_1	334	336	PF00082	0.398
CLV_PCSK_KEX2_1	342	344	PF00082	0.374
CLV_PCSK_KEX2_1	434	436	PF00082	0.346
CLV_PCSK_PC1ET2_1	176	178	PF00082	0.637
CLV_PCSK_PC1ET2_1	189	191	PF00082	0.483
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.728
CLV_PCSK_PC1ET2_1	282	284	PF00082	0.728
CLV_PCSK_PC1ET2_1	334	336	PF00082	0.346
CLV_PCSK_PC7_1	178	184	PF00082	0.626
CLV_PCSK_PC7_1	185	191	PF00082	0.544
CLV_PCSK_PC7_1	230	236	PF00082	0.732
CLV_PCSK_SKI1_1	112	116	PF00082	0.234
CLV_PCSK_SKI1_1	158	162	PF00082	0.560
CLV_PCSK_SKI1_1	164	168	PF00082	0.524
CLV_PCSK_SKI1_1	199	203	PF00082	0.499
CLV_PCSK_SKI1_1	323	327	PF00082	0.346
CLV_PCSK_SKI1_1	65	69	PF00082	0.346
DEG_APCC_DBOX_1	384	392	PF00400	0.546
DEG_Nend_UBRbox_2	1	3	PF02207	0.564
DOC_CYCLIN_yCln2_LP_2	143	149	PF00134	0.578
DOC_MAPK_gen_1	65	71	PF00069	0.546
DOC_MAPK_RevD_3	320	335	PF00069	0.546
DOC_PP1_RVXF_1	66	72	PF00149	0.546
DOC_PP2B_LxvP_1	143	146	PF13499	0.575
DOC_USP7_MATH_1	153	157	PF00917	0.747
DOC_USP7_MATH_1	244	248	PF00917	0.733
DOC_USP7_MATH_1	273	277	PF00917	0.579
DOC_USP7_MATH_1	344	348	PF00917	0.441
DOC_USP7_MATH_1	89	93	PF00917	0.537
DOC_USP7_UBL2_3	129	133	PF12436	0.496
DOC_USP7_UBL2_3	20	24	PF12436	0.494
DOC_USP7_UBL2_3	61	65	PF12436	0.546
DOC_WW_Pin1_4	114	119	PF00397	0.580
DOC_WW_Pin1_4	137	142	PF00397	0.567
DOC_WW_Pin1_4	82	87	PF00397	0.531
LIG_14-3-3_CanoR_1	152	160	PF00244	0.571
LIG_14-3-3_CanoR_1	434	441	PF00244	0.546
LIG_Actin_WH2_2	452	468	PF00022	0.561
LIG_BIR_III_2	270	274	PF00653	0.719
LIG_FHA_1	101	107	PF00498	0.529
LIG_FHA_1	20	26	PF00498	0.546
LIG_FHA_1	256	262	PF00498	0.693
LIG_FHA_1	311	317	PF00498	0.706
LIG_FHA_1	411	417	PF00498	0.546
LIG_FHA_1	460	466	PF00498	0.546
LIG_FHA_1	478	484	PF00498	0.414
LIG_FHA_2	198	204	PF00498	0.617
LIG_FHA_2	206	212	PF00498	0.673
LIG_FHA_2	402	408	PF00498	0.451
LIG_FHA_2	438	444	PF00498	0.434
LIG_FHA_2	6	12	PF00498	0.546
LIG_LIR_Gen_1	105	114	PF02991	0.595
LIG_LIR_Gen_1	297	305	PF02991	0.670
LIG_LIR_Nem_3	105	110	PF02991	0.595
LIG_LIR_Nem_3	297	301	PF02991	0.653
LIG_PCNA_yPIPBox_3	7	16	PF02747	0.546
LIG_SH2_STAT5	33	36	PF00017	0.546
LIG_SH3_1	249	255	PF00018	0.719
LIG_SH3_3	249	255	PF00018	0.719
LIG_TRAF2_1	208	211	PF00917	0.725
LIG_TRAF2_1	440	443	PF00917	0.546
LIG_TRAF2_1	96	99	PF00917	0.546
LIG_UBA3_1	106	112	PF00899	0.434
LIG_WW_3	251	255	PF00397	0.718
MOD_CDK_SPxxK_3	114	121	PF00069	0.551
MOD_CK1_1	205	211	PF00069	0.591
MOD_CK1_1	368	374	PF00069	0.544
MOD_CK1_1	60	66	PF00069	0.434
MOD_CK2_1	153	159	PF00069	0.729
MOD_CK2_1	167	173	PF00069	0.534
MOD_CK2_1	197	203	PF00069	0.587
MOD_CK2_1	205	211	PF00069	0.691
MOD_CK2_1	219	225	PF00069	0.589
MOD_CK2_1	437	443	PF00069	0.598
MOD_CK2_1	5	11	PF00069	0.546
MOD_Cter_Amidation	280	283	PF01082	0.721
MOD_GlcNHglycan	122	125	PF01048	0.576
MOD_GlcNHglycan	129	132	PF01048	0.669
MOD_GlcNHglycan	143	146	PF01048	0.672
MOD_GlcNHglycan	246	249	PF01048	0.820
MOD_GlcNHglycan	370	373	PF01048	0.234
MOD_GSK3_1	137	144	PF00069	0.597
MOD_GSK3_1	197	204	PF00069	0.589
MOD_GSK3_1	205	212	PF00069	0.692
MOD_GSK3_1	215	222	PF00069	0.610
MOD_GSK3_1	240	247	PF00069	0.731
MOD_GSK3_1	359	366	PF00069	0.601
MOD_GSK3_1	370	377	PF00069	0.473
MOD_GSK3_1	418	425	PF00069	0.434
MOD_GSK3_1	56	63	PF00069	0.451
MOD_NEK2_1	401	406	PF00069	0.455
MOD_NEK2_1	42	47	PF00069	0.545
MOD_NEK2_1	459	464	PF00069	0.573
MOD_NEK2_1	465	470	PF00069	0.622
MOD_NEK2_1	479	484	PF00069	0.459
MOD_NEK2_1	57	62	PF00069	0.435
MOD_PIKK_1	158	164	PF00454	0.555
MOD_PIKK_1	210	216	PF00454	0.578
MOD_PIKK_1	422	428	PF00454	0.434
MOD_PIKK_1	5	11	PF00454	0.546
MOD_PK_1	234	240	PF00069	0.574
MOD_PKA_1	234	240	PF00069	0.707
MOD_PKA_1	434	440	PF00069	0.546
MOD_PKA_2	120	126	PF00069	0.488
MOD_PKA_2	151	157	PF00069	0.575
MOD_PKA_2	234	240	PF00069	0.707
MOD_PKA_2	368	374	PF00069	0.434
MOD_PKA_2	42	48	PF00069	0.447
MOD_PKA_2	434	440	PF00069	0.546
MOD_PKA_2	465	471	PF00069	0.593
MOD_PKA_2	89	95	PF00069	0.486
MOD_Plk_1	197	203	PF00069	0.493
MOD_Plk_1	437	443	PF00069	0.546
MOD_Plk_2-3	287	293	PF00069	0.701
MOD_Plk_4	273	279	PF00069	0.606
MOD_Plk_4	37	43	PF00069	0.546
MOD_Plk_4	465	471	PF00069	0.632
MOD_Plk_4	479	485	PF00069	0.469
MOD_ProDKin_1	114	120	PF00069	0.582
MOD_ProDKin_1	137	143	PF00069	0.569
MOD_ProDKin_1	82	88	PF00069	0.531
MOD_SUMO_rev_2	287	296	PF00179	0.573
MOD_SUMO_rev_2	303	310	PF00179	0.648
MOD_SUMO_rev_2	318	325	PF00179	0.429
MOD_SUMO_rev_2	58	67	PF00179	0.546
TRG_DiLeu_BaEn_1	321	326	PF01217	0.434
TRG_DiLeu_BaEn_1	386	391	PF01217	0.529
TRG_ER_diArg_1	182	185	PF00400	0.623
TRG_NES_CRM1_1	407	422	PF08389	0.632
TRG_NLS_MonoExtC_3	281	287	PF00514	0.726
TRG_NLS_MonoExtN_4	279	286	PF00514	0.723
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWV8	Leishmania donovani	79%	100%
A4HZM1	Leishmania infantum	79%	100%
E9AVE7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4QC32	Leishmania major	80%	98%