Putative serine/threonine-protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NIMA-related kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HC09_LEIBR

TriTrypDb:

LbrM.21.1750 , LBRM2903_210023900

Length:

806

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC09

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	13
GO:0006793	phosphorus metabolic process	3	13
GO:0006796	phosphate-containing compound metabolic process	4	13
GO:0006807	nitrogen compound metabolic process	2	13
GO:0008152	metabolic process	1	13
GO:0009987	cellular process	1	13
GO:0016310	phosphorylation	5	13
GO:0019538	protein metabolic process	3	13
GO:0036211	protein modification process	4	13
GO:0043170	macromolecule metabolic process	3	13
GO:0043412	macromolecule modification	4	13
GO:0044237	cellular metabolic process	2	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:1901564	organonitrogen compound metabolic process	3	13

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0004672	protein kinase activity	3	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016301	kinase activity	4	13
GO:0016740	transferase activity	2	13
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	13
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	13
GO:0017076	purine nucleotide binding	4	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:0140096	catalytic activity, acting on a protein	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0004674	protein serine/threonine kinase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	515	519	PF00656	0.706
CLV_C14_Caspase3-7	701	705	PF00656	0.513
CLV_NRD_NRD_1	276	278	PF00675	0.642
CLV_NRD_NRD_1	294	296	PF00675	0.538
CLV_NRD_NRD_1	332	334	PF00675	0.566
CLV_NRD_NRD_1	340	342	PF00675	0.447
CLV_NRD_NRD_1	352	354	PF00675	0.384
CLV_NRD_NRD_1	364	366	PF00675	0.473
CLV_NRD_NRD_1	381	383	PF00675	0.441
CLV_NRD_NRD_1	439	441	PF00675	0.503
CLV_NRD_NRD_1	493	495	PF00675	0.621
CLV_NRD_NRD_1	513	515	PF00675	0.404
CLV_NRD_NRD_1	519	521	PF00675	0.557
CLV_NRD_NRD_1	588	590	PF00675	0.625
CLV_PCSK_KEX2_1	245	247	PF00082	0.370
CLV_PCSK_KEX2_1	276	278	PF00082	0.670
CLV_PCSK_KEX2_1	294	296	PF00082	0.503
CLV_PCSK_KEX2_1	331	333	PF00082	0.566
CLV_PCSK_KEX2_1	340	342	PF00082	0.510
CLV_PCSK_KEX2_1	354	356	PF00082	0.432
CLV_PCSK_KEX2_1	380	382	PF00082	0.472
CLV_PCSK_KEX2_1	439	441	PF00082	0.503
CLV_PCSK_KEX2_1	513	515	PF00082	0.534
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.396
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.511
CLV_PCSK_SKI1_1	103	107	PF00082	0.281
CLV_PCSK_SKI1_1	127	131	PF00082	0.293
CLV_PCSK_SKI1_1	214	218	PF00082	0.256
CLV_PCSK_SKI1_1	285	289	PF00082	0.376
CLV_PCSK_SKI1_1	318	322	PF00082	0.422
CLV_PCSK_SKI1_1	354	358	PF00082	0.523
CLV_PCSK_SKI1_1	494	498	PF00082	0.666
CLV_PCSK_SKI1_1	521	525	PF00082	0.574
CLV_PCSK_SKI1_1	636	640	PF00082	0.671
CLV_PCSK_SKI1_1	647	651	PF00082	0.510
CLV_PCSK_SKI1_1	688	692	PF00082	0.674
CLV_PCSK_SKI1_1	707	711	PF00082	0.456
CLV_PCSK_SKI1_1	734	738	PF00082	0.360
DEG_APCC_DBOX_1	258	266	PF00400	0.330
DEG_Nend_UBRbox_2	1	3	PF02207	0.398
DEG_SCF_FBW7_1	481	488	PF00400	0.725
DEG_SCF_FBW7_2	638	643	PF00400	0.599
DEG_SPOP_SBC_1	485	489	PF00917	0.621
DOC_CKS1_1	482	487	PF01111	0.727
DOC_CYCLIN_RxL_1	519	529	PF00134	0.473
DOC_CYCLIN_yCln2_LP_2	476	482	PF00134	0.504
DOC_CYCLIN_yCln2_LP_2	559	565	PF00134	0.474
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.472
DOC_MAPK_gen_1	127	136	PF00069	0.284
DOC_MAPK_gen_1	273	282	PF00069	0.629
DOC_MAPK_gen_1	340	350	PF00069	0.435
DOC_MAPK_gen_1	520	526	PF00069	0.461
DOC_MAPK_MEF2A_6	553	561	PF00069	0.494
DOC_MAPK_MEF2A_6	729	737	PF00069	0.381
DOC_MAPK_MEF2A_6	73	80	PF00069	0.264
DOC_PP2B_LxvP_1	472	475	PF13499	0.773
DOC_PP2B_LxvP_1	559	562	PF13499	0.533
DOC_PP2B_LxvP_1	573	576	PF13499	0.555
DOC_PP4_FxxP_1	715	718	PF00568	0.569
DOC_USP7_MATH_1	247	251	PF00917	0.288
DOC_USP7_MATH_1	486	490	PF00917	0.709
DOC_USP7_MATH_1	536	540	PF00917	0.658
DOC_USP7_MATH_1	565	569	PF00917	0.507
DOC_USP7_MATH_1	579	583	PF00917	0.518
DOC_USP7_MATH_1	702	706	PF00917	0.614
DOC_USP7_MATH_1	718	722	PF00917	0.450
DOC_USP7_MATH_2	42	48	PF00917	0.249
DOC_USP7_UBL2_3	373	377	PF12436	0.613
DOC_USP7_UBL2_3	581	585	PF12436	0.624
DOC_USP7_UBL2_3	8	12	PF12436	0.339
DOC_WW_Pin1_4	163	168	PF00397	0.284
DOC_WW_Pin1_4	411	416	PF00397	0.682
DOC_WW_Pin1_4	481	486	PF00397	0.603
DOC_WW_Pin1_4	544	549	PF00397	0.667
DOC_WW_Pin1_4	571	576	PF00397	0.545
DOC_WW_Pin1_4	591	596	PF00397	0.662
DOC_WW_Pin1_4	636	641	PF00397	0.616
DOC_WW_Pin1_4	655	660	PF00397	0.666
LIG_14-3-3_CanoR_1	154	158	PF00244	0.256
LIG_14-3-3_CanoR_1	233	241	PF00244	0.337
LIG_14-3-3_CanoR_1	246	255	PF00244	0.206
LIG_14-3-3_CanoR_1	276	280	PF00244	0.495
LIG_14-3-3_CanoR_1	45	52	PF00244	0.182
LIG_14-3-3_CanoR_1	494	501	PF00244	0.566
LIG_14-3-3_CanoR_1	553	557	PF00244	0.495
LIG_14-3-3_CanoR_1	686	691	PF00244	0.623
LIG_Actin_WH2_2	145	162	PF00022	0.249
LIG_Actin_WH2_2	204	219	PF00022	0.262
LIG_Actin_WH2_2	28	43	PF00022	0.339
LIG_AP2alpha_1	690	694	PF02296	0.523
LIG_APCC_ABBA_1	733	738	PF00400	0.358
LIG_BRCT_BRCA1_1	505	509	PF00533	0.659
LIG_BRCT_BRCA1_1	554	558	PF00533	0.506
LIG_FHA_1	129	135	PF00498	0.280
LIG_FHA_1	154	160	PF00498	0.272
LIG_FHA_1	62	68	PF00498	0.281
LIG_FHA_1	712	718	PF00498	0.458
LIG_FHA_1	721	727	PF00498	0.446
LIG_FHA_2	495	501	PF00498	0.617
LIG_FHA_2	658	664	PF00498	0.589
LIG_FHA_2	687	693	PF00498	0.499
LIG_FHA_2	696	702	PF00498	0.418
LIG_LIR_Apic_2	166	172	PF02991	0.311
LIG_LIR_Apic_2	714	718	PF02991	0.468
LIG_LIR_Gen_1	2	10	PF02991	0.270
LIG_LIR_Gen_1	555	565	PF02991	0.479
LIG_LIR_Gen_1	668	678	PF02991	0.394
LIG_LIR_Gen_1	75	83	PF02991	0.317
LIG_LIR_Nem_3	2	7	PF02991	0.281
LIG_LIR_Nem_3	555	561	PF02991	0.491
LIG_LIR_Nem_3	668	674	PF02991	0.405
LIG_LIR_Nem_3	87	92	PF02991	0.249
LIG_LYPXL_S_1	219	223	PF13949	0.262
LIG_LYPXL_yS_3	220	223	PF13949	0.249
LIG_MAD2	214	222	PF02301	0.249
LIG_PCNA_yPIPBox_3	209	220	PF02747	0.267
LIG_PDZ_Class_2	801	806	PF00595	0.577
LIG_Pex14_2	15	19	PF04695	0.249
LIG_Pex14_2	690	694	PF04695	0.523
LIG_PTAP_UEV_1	608	613	PF05743	0.476
LIG_RPA_C_Plants	285	296	PF08784	0.375
LIG_SH2_CRK	4	8	PF00017	0.304
LIG_SH2_CRK	89	93	PF00017	0.249
LIG_SH2_GRB2like	82	85	PF00017	0.280
LIG_SH2_SRC	66	69	PF00017	0.284
LIG_SH2_SRC	82	85	PF00017	0.260
LIG_SH2_STAP1	227	231	PF00017	0.300
LIG_SH2_STAT5	169	172	PF00017	0.249
LIG_SH2_STAT5	4	7	PF00017	0.253
LIG_SH2_STAT5	454	457	PF00017	0.706
LIG_SH2_STAT5	66	69	PF00017	0.318
LIG_SH3_3	216	222	PF00018	0.328
LIG_SH3_3	476	482	PF00018	0.610
LIG_SH3_3	558	564	PF00018	0.629
LIG_SH3_3	569	575	PF00018	0.584
LIG_SH3_3	602	608	PF00018	0.613
LIG_SH3_3	613	619	PF00018	0.727
LIG_SUMO_SIM_par_1	250	256	PF11976	0.253
LIG_SUMO_SIM_par_1	278	284	PF11976	0.509
LIG_TRAF2_1	281	284	PF00917	0.510
LIG_TRAF2_1	349	352	PF00917	0.521
LIG_TRAF2_1	497	500	PF00917	0.606
LIG_UBA3_1	238	245	PF00899	0.304
LIG_WW_3	480	484	PF00397	0.719
MOD_CK1_1	14	20	PF00069	0.292
MOD_CK1_1	229	235	PF00069	0.334
MOD_CK1_1	278	284	PF00069	0.598
MOD_CK1_1	489	495	PF00069	0.505
MOD_CK1_1	534	540	PF00069	0.602
MOD_CK1_1	544	550	PF00069	0.690
MOD_CK1_1	610	616	PF00069	0.785
MOD_CK1_1	799	805	PF00069	0.557
MOD_CK2_1	278	284	PF00069	0.595
MOD_CK2_1	427	433	PF00069	0.575
MOD_CK2_1	494	500	PF00069	0.626
MOD_CK2_1	590	596	PF00069	0.571
MOD_CK2_1	655	661	PF00069	0.583
MOD_CK2_1	695	701	PF00069	0.414
MOD_CK2_1	756	762	PF00069	0.604
MOD_GlcNHglycan	16	19	PF01048	0.249
MOD_GlcNHglycan	235	238	PF01048	0.308
MOD_GlcNHglycan	428	432	PF01048	0.545
MOD_GlcNHglycan	46	49	PF01048	0.249
MOD_GlcNHglycan	543	546	PF01048	0.695
MOD_GlcNHglycan	554	557	PF01048	0.657
MOD_GlcNHglycan	585	588	PF01048	0.544
MOD_GlcNHglycan	609	612	PF01048	0.676
MOD_GlcNHglycan	613	616	PF01048	0.630
MOD_GlcNHglycan	720	723	PF01048	0.600
MOD_GlcNHglycan	756	759	PF01048	0.568
MOD_GlcNHglycan	768	771	PF01048	0.557
MOD_GlcNHglycan	801	804	PF01048	0.696
MOD_GSK3_1	159	166	PF00069	0.266
MOD_GSK3_1	225	232	PF00069	0.313
MOD_GSK3_1	407	414	PF00069	0.745
MOD_GSK3_1	481	488	PF00069	0.725
MOD_GSK3_1	490	497	PF00069	0.708
MOD_GSK3_1	537	544	PF00069	0.735
MOD_GSK3_1	579	586	PF00069	0.716
MOD_GSK3_1	590	597	PF00069	0.680
MOD_GSK3_1	607	614	PF00069	0.750
MOD_N-GLC_1	181	186	PF02516	0.249
MOD_N-GLC_1	229	234	PF02516	0.319
MOD_N-GLC_1	247	252	PF02516	0.409
MOD_N-GLC_1	551	556	PF02516	0.650
MOD_N-GLC_1	583	588	PF02516	0.524
MOD_N-GLC_1	61	66	PF02516	0.279
MOD_N-GLC_1	686	691	PF02516	0.431
MOD_N-GLC_1	718	723	PF02516	0.552
MOD_N-GLC_1	754	759	PF02516	0.540
MOD_NEK2_1	114	119	PF00069	0.288
MOD_NEK2_1	147	152	PF00069	0.284
MOD_NEK2_1	159	164	PF00069	0.284
MOD_NEK2_1	226	231	PF00069	0.348
MOD_NEK2_1	253	258	PF00069	0.439
MOD_NEK2_1	526	531	PF00069	0.595
MOD_NEK2_1	54	59	PF00069	0.414
MOD_PIKK_1	107	113	PF00454	0.262
MOD_PIKK_1	128	134	PF00454	0.249
MOD_PIKK_1	2	8	PF00454	0.328
MOD_PIKK_1	247	253	PF00454	0.280
MOD_PIKK_1	459	465	PF00454	0.586
MOD_PIKK_1	531	537	PF00454	0.528
MOD_PKA_1	494	500	PF00069	0.469
MOD_PKA_2	153	159	PF00069	0.249
MOD_PKA_2	258	264	PF00069	0.294
MOD_PKA_2	275	281	PF00069	0.613
MOD_PKA_2	44	50	PF00069	0.256
MOD_PKA_2	552	558	PF00069	0.491
MOD_Plk_1	194	200	PF00069	0.249
MOD_Plk_1	229	235	PF00069	0.331
MOD_Plk_1	247	253	PF00069	0.183
MOD_Plk_1	61	67	PF00069	0.272
MOD_Plk_1	686	692	PF00069	0.629
MOD_Plk_1	695	701	PF00069	0.631
MOD_Plk_2-3	695	701	PF00069	0.521
MOD_Plk_4	114	120	PF00069	0.328
MOD_Plk_4	148	154	PF00069	0.262
MOD_Plk_4	253	259	PF00069	0.328
MOD_Plk_4	450	456	PF00069	0.578
MOD_Plk_4	566	572	PF00069	0.498
MOD_Plk_4	673	679	PF00069	0.414
MOD_Plk_4	72	78	PF00069	0.309
MOD_ProDKin_1	163	169	PF00069	0.284
MOD_ProDKin_1	411	417	PF00069	0.681
MOD_ProDKin_1	481	487	PF00069	0.605
MOD_ProDKin_1	544	550	PF00069	0.659
MOD_ProDKin_1	571	577	PF00069	0.547
MOD_ProDKin_1	591	597	PF00069	0.659
MOD_ProDKin_1	636	642	PF00069	0.611
MOD_ProDKin_1	655	661	PF00069	0.659
MOD_SUMO_rev_2	347	356	PF00179	0.549
MOD_SUMO_rev_2	68	75	PF00179	0.288
MOD_SUMO_rev_2	705	715	PF00179	0.671
TRG_DiLeu_BaEn_1	283	288	PF01217	0.378
TRG_DiLeu_BaEn_4	283	289	PF01217	0.541
TRG_DiLeu_BaLyEn_6	230	235	PF01217	0.396
TRG_ENDOCYTIC_2	220	223	PF00928	0.249
TRG_ENDOCYTIC_2	4	7	PF00928	0.249
TRG_ENDOCYTIC_2	435	438	PF00928	0.506
TRG_ENDOCYTIC_2	671	674	PF00928	0.375
TRG_ENDOCYTIC_2	750	753	PF00928	0.389
TRG_ENDOCYTIC_2	89	92	PF00928	0.276
TRG_ER_diArg_1	331	333	PF00400	0.570
TRG_ER_diArg_1	340	342	PF00400	0.558
TRG_ER_diArg_1	380	382	PF00400	0.574
TRG_ER_diArg_1	438	440	PF00400	0.509
TRG_ER_diArg_1	512	514	PF00400	0.520
TRG_NES_CRM1_1	724	738	PF08389	0.388
TRG_NES_CRM1_1	762	776	PF08389	0.421
TRG_Pf-PMV_PEXEL_1	123	128	PF00026	0.259
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.375
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	340	345	PF00026	0.450
TRG_Pf-PMV_PEXEL_1	355	359	PF00026	0.386
TRG_Pf-PMV_PEXEL_1	365	370	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P9W7	Leptomonas seymouri	64%	100%
A0A0S4JKY4	Bodo saltans	44%	100%
A0A1X0NHD4	Trypanosomatidae	48%	100%
A0A3Q8IBZ9	Leishmania donovani	84%	100%
A0A3R7M6Z7	Trypanosoma rangeli	47%	100%
A4HZM2	Leishmania infantum	84%	100%
D0A118	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	46%	100%
E9AJJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AVE6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4QC33	Leishmania major	84%	99%
V5BLW4	Trypanosoma cruzi	47%	100%