Choline dehydrogenase, like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

choline dehydrogenase, like protein

Species:

Leishmania braziliensis

UniProt:

A4HC08_LEIBR

TriTrypDb:

LbrM.21.1740 , LBRM2903_210023800

Length:

535

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	3

Expansion

Sequence features

A4HC08

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC08

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0050660	flavin adenine dinucleotide binding	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0008812	choline dehydrogenase activity	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	190	192	PF00675	0.391
CLV_NRD_NRD_1	2	4	PF00675	0.683
CLV_NRD_NRD_1	259	261	PF00675	0.404
CLV_NRD_NRD_1	54	56	PF00675	0.352
CLV_PCSK_FUR_1	154	158	PF00082	0.340
CLV_PCSK_KEX2_1	156	158	PF00082	0.340
CLV_PCSK_KEX2_1	2	4	PF00082	0.683
CLV_PCSK_KEX2_1	259	261	PF00082	0.426
CLV_PCSK_PC1ET2_1	156	158	PF00082	0.391
CLV_PCSK_SKI1_1	220	224	PF00082	0.426
CLV_PCSK_SKI1_1	284	288	PF00082	0.453
CLV_PCSK_SKI1_1	3	7	PF00082	0.720
CLV_PCSK_SKI1_1	476	480	PF00082	0.275
DEG_APCC_DBOX_1	219	227	PF00400	0.406
DEG_Nend_UBRbox_1	1	4	PF02207	0.690
DOC_CKS1_1	101	106	PF01111	0.321
DOC_CKS1_1	84	89	PF01111	0.363
DOC_CYCLIN_RxL_1	217	225	PF00134	0.426
DOC_CYCLIN_yCln2_LP_2	228	234	PF00134	0.292
DOC_MAPK_DCC_7	301	311	PF00069	0.216
DOC_MAPK_gen_1	140	149	PF00069	0.363
DOC_MAPK_gen_1	474	483	PF00069	0.363
DOC_MAPK_MEF2A_6	142	151	PF00069	0.426
DOC_PP1_RVXF_1	329	335	PF00149	0.433
DOC_USP7_MATH_1	184	188	PF00917	0.363
DOC_USP7_MATH_1	29	33	PF00917	0.462
DOC_USP7_MATH_1	383	387	PF00917	0.503
DOC_USP7_MATH_1	407	411	PF00917	0.453
DOC_USP7_UBL2_3	511	515	PF12436	0.402
DOC_WW_Pin1_4	100	105	PF00397	0.328
DOC_WW_Pin1_4	126	131	PF00397	0.340
DOC_WW_Pin1_4	166	171	PF00397	0.308
DOC_WW_Pin1_4	361	366	PF00397	0.406
DOC_WW_Pin1_4	437	442	PF00397	0.454
DOC_WW_Pin1_4	488	493	PF00397	0.345
DOC_WW_Pin1_4	83	88	PF00397	0.340
LIG_14-3-3_CanoR_1	140	145	PF00244	0.420
LIG_14-3-3_CanoR_1	284	293	PF00244	0.426
LIG_14-3-3_CanoR_1	3	9	PF00244	0.591
LIG_14-3-3_CanoR_1	341	347	PF00244	0.536
LIG_14-3-3_CanoR_1	402	411	PF00244	0.392
LIG_BRCT_BRCA1_1	16	20	PF00533	0.506
LIG_BRCT_BRCA1_1	168	172	PF00533	0.321
LIG_Clathr_ClatBox_1	265	269	PF01394	0.453
LIG_CSL_BTD_1	99	102	PF09270	0.426
LIG_deltaCOP1_diTrp_1	122	133	PF00928	0.317
LIG_eIF4E_1	431	437	PF01652	0.426
LIG_FHA_1	101	107	PF00498	0.321
LIG_FHA_1	115	121	PF00498	0.303
LIG_FHA_1	17	23	PF00498	0.287
LIG_FHA_1	223	229	PF00498	0.359
LIG_FHA_1	362	368	PF00498	0.380
LIG_FHA_1	43	49	PF00498	0.351
LIG_FHA_1	499	505	PF00498	0.422
LIG_FHA_1	529	535	PF00498	0.681
LIG_FHA_2	188	194	PF00498	0.416
LIG_FHA_2	203	209	PF00498	0.321
LIG_LIR_Gen_1	143	152	PF02991	0.426
LIG_LIR_Gen_1	17	25	PF02991	0.421
LIG_LIR_Gen_1	348	356	PF02991	0.353
LIG_LIR_Gen_1	59	69	PF02991	0.453
LIG_LIR_LC3C_4	269	274	PF02991	0.453
LIG_LIR_Nem_3	166	171	PF02991	0.309
LIG_LIR_Nem_3	17	23	PF02991	0.421
LIG_LIR_Nem_3	348	353	PF02991	0.426
LIG_LIR_Nem_3	368	374	PF02991	0.488
LIG_LIR_Nem_3	440	445	PF02991	0.372
LIG_LIR_Nem_3	59	64	PF02991	0.426
LIG_MLH1_MIPbox_1	168	172	PF16413	0.340
LIG_PCNA_yPIPBox_3	215	227	PF02747	0.399
LIG_Pex14_2	168	172	PF04695	0.372
LIG_SH2_CRK	61	65	PF00017	0.392
LIG_SH2_SRC	324	327	PF00017	0.506
LIG_SH2_STAP1	500	504	PF00017	0.426
LIG_SH2_STAT5	171	174	PF00017	0.392
LIG_SH2_STAT5	221	224	PF00017	0.306
LIG_SH2_STAT5	324	327	PF00017	0.506
LIG_SH2_STAT5	415	418	PF00017	0.314
LIG_SH2_STAT5	431	434	PF00017	0.426
LIG_SH2_STAT5	482	485	PF00017	0.321
LIG_SH2_STAT5	500	503	PF00017	0.122
LIG_SH3_1	438	444	PF00018	0.453
LIG_SH3_3	146	152	PF00018	0.363
LIG_SH3_3	390	396	PF00018	0.451
LIG_SH3_3	438	444	PF00018	0.453
LIG_SH3_3	96	102	PF00018	0.312
LIG_SUMO_SIM_anti_2	21	26	PF11976	0.426
LIG_SUMO_SIM_anti_2	269	276	PF11976	0.453
LIG_SUMO_SIM_anti_2	421	426	PF11976	0.180
LIG_SUMO_SIM_par_1	264	271	PF11976	0.426
LIG_SUMO_SIM_par_1	44	50	PF11976	0.340
LIG_SUMO_SIM_par_1	500	506	PF11976	0.340
LIG_TRAF2_2	87	92	PF00917	0.426
LIG_UBA3_1	222	227	PF00899	0.340
LIG_WRC_WIRS_1	141	146	PF05994	0.426
MOD_CDK_SPK_2	100	105	PF00069	0.340
MOD_CDK_SPxxK_3	166	173	PF00069	0.320
MOD_CK1_1	129	135	PF00069	0.453
MOD_CK1_1	166	172	PF00069	0.200
MOD_CK1_1	187	193	PF00069	0.349
MOD_CK1_1	276	282	PF00069	0.373
MOD_CK1_1	289	295	PF00069	0.303
MOD_CK1_1	345	351	PF00069	0.441
MOD_CK1_1	359	365	PF00069	0.404
MOD_CK1_1	414	420	PF00069	0.363
MOD_CK1_1	491	497	PF00069	0.441
MOD_CK2_1	187	193	PF00069	0.469
MOD_Cter_Amidation	154	157	PF01082	0.340
MOD_GlcNHglycan	245	248	PF01048	0.350
MOD_GlcNHglycan	275	278	PF01048	0.439
MOD_GlcNHglycan	281	284	PF01048	0.391
MOD_GlcNHglycan	29	32	PF01048	0.454
MOD_GlcNHglycan	405	408	PF01048	0.354
MOD_GlcNHglycan	455	459	PF01048	0.309
MOD_GlcNHglycan	464	467	PF01048	0.312
MOD_GSK3_1	342	349	PF00069	0.444
MOD_GSK3_1	355	362	PF00069	0.310
MOD_GSK3_1	403	410	PF00069	0.416
MOD_GSK3_1	484	491	PF00069	0.353
MOD_GSK3_1	494	501	PF00069	0.313
MOD_GSK3_1	60	67	PF00069	0.382
MOD_LATS_1	451	457	PF00433	0.355
MOD_N-GLC_1	166	171	PF02516	0.409
MOD_N-GLC_1	214	219	PF02516	0.391
MOD_N-GLC_1	295	300	PF02516	0.247
MOD_N-GLC_1	407	412	PF02516	0.453
MOD_NEK2_1	222	227	PF00069	0.363
MOD_NEK2_1	286	291	PF00069	0.322
MOD_NEK2_1	355	360	PF00069	0.447
MOD_NEK2_1	454	459	PF00069	0.391
MOD_NEK2_1	493	498	PF00069	0.331
MOD_NEK2_2	254	259	PF00069	0.453
MOD_NEK2_2	342	347	PF00069	0.478
MOD_PIKK_1	177	183	PF00454	0.426
MOD_PIKK_1	378	384	PF00454	0.502
MOD_PKA_2	163	169	PF00069	0.287
MOD_PKA_2	243	249	PF00069	0.411
MOD_PKA_2	289	295	PF00069	0.468
MOD_PKA_2	317	323	PF00069	0.499
MOD_PKA_2	346	352	PF00069	0.484
MOD_PKA_2	528	534	PF00069	0.469
MOD_Plk_1	207	213	PF00069	0.411
MOD_Plk_1	214	220	PF00069	0.361
MOD_Plk_1	268	274	PF00069	0.426
MOD_Plk_1	295	301	PF00069	0.457
MOD_Plk_1	484	490	PF00069	0.321
MOD_Plk_4	202	208	PF00069	0.319
MOD_Plk_4	268	274	PF00069	0.367
MOD_Plk_4	29	35	PF00069	0.389
MOD_Plk_4	411	417	PF00069	0.200
MOD_Plk_4	42	48	PF00069	0.265
MOD_Plk_4	484	490	PF00069	0.317
MOD_ProDKin_1	100	106	PF00069	0.328
MOD_ProDKin_1	126	132	PF00069	0.340
MOD_ProDKin_1	166	172	PF00069	0.308
MOD_ProDKin_1	361	367	PF00069	0.400
MOD_ProDKin_1	437	443	PF00069	0.454
MOD_ProDKin_1	488	494	PF00069	0.345
MOD_ProDKin_1	83	89	PF00069	0.340
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.322
TRG_ENDOCYTIC_2	61	64	PF00928	0.426
TRG_ER_diArg_1	1	3	PF00400	0.688
TRG_ER_diArg_1	139	142	PF00400	0.408
TRG_ER_diArg_1	258	260	PF00400	0.426
TRG_ER_diArg_1	397	400	PF00400	0.507
TRG_NLS_MonoExtN_4	154	160	PF00514	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HUY3	Leptomonas seymouri	75%	100%
A0A0S4JLI4	Bodo saltans	41%	93%
A0A1X0NHH3	Trypanosomatidae	48%	100%
A0A3Q8IC21	Leishmania donovani	90%	100%
A0A3R7KBI5	Trypanosoma rangeli	48%	100%
A4HZM3	Leishmania infantum	90%	100%
A5IW37	Staphylococcus aureus (strain JH9)	23%	94%
A6QK99	Staphylococcus aureus (strain Newman)	23%	94%
A6U4Z2	Staphylococcus aureus (strain JH1)	23%	94%
A6U6Y8	Sinorhizobium medicae (strain WSM419)	23%	97%
A6X2G7	Brucella anthropi (strain ATCC 49188 / DSM 6882 / CCUG 24695 / JCM 21032 / LMG 3331 / NBRC 15819 / NCTC 12168 / Alc 37)	25%	97%
A7N2P9	Vibrio campbellii (strain ATCC BAA-1116)	25%	94%
A7X6Z3	Staphylococcus aureus (strain Mu3 / ATCC 700698)	23%	94%
A8Z5A4	Staphylococcus aureus (strain USA300 / TCH1516)	23%	94%
C3MIE4	Sinorhizobium fredii (strain NBRC 101917 / NGR234)	23%	97%
D0A120	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AVE5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
P60336	Staphylococcus aureus (strain Mu50 / ATCC 700699)	23%	94%
P60337	Staphylococcus aureus (strain N315)	23%	94%
Q2FDP9	Staphylococcus aureus (strain USA300)	23%	94%
Q2FV11	Staphylococcus aureus (strain NCTC 8325 / PS 47)	23%	94%
Q2YWJ5	Staphylococcus aureus (strain bovine RF122 / ET3-1)	23%	94%
Q47944	Gluconobacter oxydans	23%	100%
Q4A0Q1	Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41)	24%	96%
Q4L9D7	Staphylococcus haemolyticus (strain JCSC1435)	24%	94%
Q4QC34	Leishmania major	89%	100%
Q5HCU1	Staphylococcus aureus (strain COL)	23%	94%
Q6G664	Staphylococcus aureus (strain MSSA476)	23%	94%
Q6GDJ1	Staphylococcus aureus (strain MRSA252)	23%	94%
Q7MF12	Vibrio vulnificus (strain YJ016)	23%	96%
Q8D3K2	Vibrio vulnificus (strain CMCP6)	24%	96%
Q8NUM0	Staphylococcus aureus (strain MW2)	23%	94%
Q985M5	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	23%	97%
Q9X2M2	Staphylococcus xylosus	24%	96%
V5DIB3	Trypanosoma cruzi	48%	100%