CSTF2_hinge domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC07_LEIBR

TriTrypDb:

LbrM.21.1730 , LBRM2903_210023700

Length:

338

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HC07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC07

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	123	125	PF00675	0.734
CLV_NRD_NRD_1	86	88	PF00675	0.691
CLV_PCSK_KEX2_1	123	125	PF00082	0.734
CLV_PCSK_KEX2_1	178	180	PF00082	0.711
CLV_PCSK_KEX2_1	86	88	PF00082	0.789
CLV_PCSK_PC1ET2_1	178	180	PF00082	0.711
CLV_PCSK_SKI1_1	145	149	PF00082	0.537
CLV_PCSK_SKI1_1	178	182	PF00082	0.567
DEG_Nend_UBRbox_2	1	3	PF02207	0.440
DEG_SPOP_SBC_1	115	119	PF00917	0.749
DOC_CKS1_1	99	104	PF01111	0.685
DOC_CYCLIN_RxL_1	145	156	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	57	63	PF00134	0.538
DOC_MAPK_gen_1	145	154	PF00069	0.533
DOC_MAPK_gen_1	178	186	PF00069	0.560
DOC_MAPK_MEF2A_6	145	154	PF00069	0.533
DOC_PP4_FxxP_1	207	210	PF00568	0.815
DOC_SPAK_OSR1_1	222	226	PF12202	0.630
DOC_USP7_MATH_1	201	205	PF00917	0.745
DOC_USP7_MATH_1	251	255	PF00917	0.648
DOC_USP7_MATH_1	93	97	PF00917	0.763
DOC_WW_Pin1_4	109	114	PF00397	0.729
DOC_WW_Pin1_4	116	121	PF00397	0.740
DOC_WW_Pin1_4	173	178	PF00397	0.691
DOC_WW_Pin1_4	184	189	PF00397	0.709
DOC_WW_Pin1_4	197	202	PF00397	0.567
DOC_WW_Pin1_4	206	211	PF00397	0.527
DOC_WW_Pin1_4	239	244	PF00397	0.637
DOC_WW_Pin1_4	281	286	PF00397	0.581
DOC_WW_Pin1_4	309	314	PF00397	0.723
DOC_WW_Pin1_4	71	76	PF00397	0.644
DOC_WW_Pin1_4	98	103	PF00397	0.671
LIG_14-3-3_CanoR_1	179	185	PF00244	0.812
LIG_14-3-3_CanoR_1	222	231	PF00244	0.598
LIG_14-3-3_CanoR_1	256	262	PF00244	0.581
LIG_14-3-3_CanoR_1	306	314	PF00244	0.770
LIG_14-3-3_CanoR_1	86	93	PF00244	0.678
LIG_BRCT_BRCA1_1	203	207	PF00533	0.789
LIG_CSL_BTD_1	99	102	PF09270	0.674
LIG_FHA_1	179	185	PF00498	0.634
LIG_FHA_1	197	203	PF00498	0.807
LIG_FHA_1	309	315	PF00498	0.711
LIG_FHA_1	53	59	PF00498	0.539
LIG_FHA_2	239	245	PF00498	0.721
LIG_LIR_Apic_2	204	210	PF02991	0.779
LIG_LIR_Gen_1	156	165	PF02991	0.545
LIG_LIR_Nem_3	156	162	PF02991	0.491
LIG_NRBOX	324	330	PF00104	0.579
LIG_NRBOX	45	51	PF00104	0.517
LIG_SH2_CRK	236	240	PF00017	0.520
LIG_SH2_CRK	7	11	PF00017	0.537
LIG_SH2_NCK_1	236	240	PF00017	0.520
LIG_SH2_STAT3	32	35	PF00017	0.524
LIG_SH2_STAT3	327	330	PF00017	0.634
LIG_SH2_STAT5	327	330	PF00017	0.603
LIG_SH2_STAT5	7	10	PF00017	0.537
LIG_SH3_2	75	80	PF14604	0.525
LIG_SH3_3	166	172	PF00018	0.646
LIG_SH3_3	185	191	PF00018	0.704
LIG_SH3_3	195	201	PF00018	0.653
LIG_SH3_3	205	211	PF00018	0.725
LIG_SH3_3	240	246	PF00018	0.561
LIG_SH3_3	282	288	PF00018	0.577
LIG_SH3_3	310	316	PF00018	0.667
LIG_SH3_3	72	78	PF00018	0.651
LIG_SH3_3	96	102	PF00018	0.675
LIG_SUMO_SIM_par_1	181	187	PF11976	0.656
MOD_CDC14_SPxK_1	176	179	PF00782	0.707
MOD_CDK_SPK_2	173	178	PF00069	0.691
MOD_CDK_SPxK_1	173	179	PF00069	0.695
MOD_CDK_SPxxK_3	116	123	PF00069	0.842
MOD_CK1_1	209	215	PF00069	0.612
MOD_CK1_1	218	224	PF00069	0.678
MOD_CK1_1	269	275	PF00069	0.821
MOD_CK1_1	281	287	PF00069	0.619
MOD_CK1_1	308	314	PF00069	0.672
MOD_CK1_1	48	54	PF00069	0.371
MOD_CK2_1	197	203	PF00069	0.570
MOD_CK2_1	221	227	PF00069	0.626
MOD_Cter_Amidation	84	87	PF01082	0.791
MOD_GlcNHglycan	107	110	PF01048	0.731
MOD_GlcNHglycan	217	220	PF01048	0.664
MOD_GlcNHglycan	275	278	PF01048	0.763
MOD_GlcNHglycan	280	283	PF01048	0.711
MOD_GlcNHglycan	289	292	PF01048	0.668
MOD_GlcNHglycan	302	305	PF01048	0.770
MOD_GlcNHglycan	83	86	PF01048	0.727
MOD_GlcNHglycan	95	98	PF01048	0.654
MOD_GSK3_1	101	108	PF00069	0.695
MOD_GSK3_1	111	118	PF00069	0.677
MOD_GSK3_1	180	187	PF00069	0.701
MOD_GSK3_1	192	199	PF00069	0.758
MOD_GSK3_1	234	241	PF00069	0.600
MOD_GSK3_1	252	259	PF00069	0.614
MOD_GSK3_1	268	275	PF00069	0.768
MOD_GSK3_1	300	307	PF00069	0.728
MOD_GSK3_1	41	48	PF00069	0.514
MOD_N-GLC_1	115	120	PF02516	0.690
MOD_N-GLC_1	152	157	PF02516	0.573
MOD_N-GLC_1	239	244	PF02516	0.604
MOD_N-GLC_1	27	32	PF02516	0.521
MOD_N-GLC_1	93	98	PF02516	0.769
MOD_NEK2_1	105	110	PF00069	0.719
MOD_NEK2_1	152	157	PF00069	0.643
MOD_NEK2_1	234	239	PF00069	0.528
MOD_NEK2_1	261	266	PF00069	0.688
MOD_NEK2_1	268	273	PF00069	0.732
MOD_NEK2_1	278	283	PF00069	0.692
MOD_NEK2_1	328	333	PF00069	0.601
MOD_NEK2_2	27	32	PF00069	0.521
MOD_PIKK_1	201	207	PF00454	0.785
MOD_PKA_1	178	184	PF00069	0.815
MOD_PKA_1	86	92	PF00069	0.788
MOD_PKA_2	105	111	PF00069	0.491
MOD_PKA_2	178	184	PF00069	0.786
MOD_PKA_2	221	227	PF00069	0.626
MOD_PKA_2	305	311	PF00069	0.757
MOD_PKA_2	86	92	PF00069	0.718
MOD_Plk_1	27	33	PF00069	0.522
MOD_Plk_2-3	321	327	PF00069	0.612
MOD_Plk_4	209	215	PF00069	0.773
MOD_Plk_4	41	47	PF00069	0.513
MOD_Plk_4	5	11	PF00069	0.543
MOD_Plk_4	53	59	PF00069	0.539
MOD_ProDKin_1	109	115	PF00069	0.731
MOD_ProDKin_1	116	122	PF00069	0.740
MOD_ProDKin_1	173	179	PF00069	0.695
MOD_ProDKin_1	184	190	PF00069	0.710
MOD_ProDKin_1	197	203	PF00069	0.570
MOD_ProDKin_1	206	212	PF00069	0.525
MOD_ProDKin_1	239	245	PF00069	0.641
MOD_ProDKin_1	281	287	PF00069	0.581
MOD_ProDKin_1	309	315	PF00069	0.720
MOD_ProDKin_1	71	77	PF00069	0.649
MOD_ProDKin_1	98	104	PF00069	0.678
TRG_DiLeu_BaEn_2	202	208	PF01217	0.574
TRG_ENDOCYTIC_2	159	162	PF00928	0.503
TRG_ENDOCYTIC_2	7	10	PF00928	0.537
TRG_ER_diArg_1	123	126	PF00400	0.735
TRG_ER_diArg_1	61	64	PF00400	0.547
TRG_ER_diArg_1	86	88	PF00400	0.672
TRG_Pf-PMV_PEXEL_1	333	337	PF00026	0.650

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1K6	Leptomonas seymouri	62%	80%
A0A3S7WWV7	Leishmania donovani	83%	77%
A4HZG3	Leishmania infantum	83%	77%
E9AVE4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	79%
Q4QC35	Leishmania major	83%	100%