GST_C_6 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Present in the outer mitochondrial membrane proteome 19

Species:

Leishmania braziliensis

UniProt:

A4HC06_LEIBR

TriTrypDb:

LbrM.21.1720 , LBRM2903_210023600

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HC06

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC06

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	146	150	PF00656	0.324
CLV_C14_Caspase3-7	92	96	PF00656	0.400
CLV_NRD_NRD_1	123	125	PF00675	0.520
CLV_NRD_NRD_1	176	178	PF00675	0.546
CLV_NRD_NRD_1	54	56	PF00675	0.556
CLV_PCSK_KEX2_1	176	178	PF00082	0.514
CLV_PCSK_KEX2_1	5	7	PF00082	0.465
CLV_PCSK_PC1ET2_1	5	7	PF00082	0.442
CLV_PCSK_PC7_1	172	178	PF00082	0.368
CLV_PCSK_SKI1_1	124	128	PF00082	0.525
CLV_PCSK_SKI1_1	2	6	PF00082	0.333
DEG_Nend_UBRbox_1	1	4	PF02207	0.542
DOC_PP2B_LxvP_1	293	296	PF13499	0.553
DOC_USP7_MATH_1	126	130	PF00917	0.316
DOC_USP7_MATH_1	15	19	PF00917	0.665
DOC_USP7_MATH_1	154	158	PF00917	0.229
DOC_WW_Pin1_4	85	90	PF00397	0.261
LIG_14-3-3_CanoR_1	124	129	PF00244	0.404
LIG_14-3-3_CanoR_1	233	238	PF00244	0.374
LIG_14-3-3_CanoR_1	55	59	PF00244	0.410
LIG_BIR_III_2	180	184	PF00653	0.317
LIG_BRCT_BRCA1_1	244	248	PF00533	0.325
LIG_EH_1	80	84	PF12763	0.324
LIG_FHA_2	131	137	PF00498	0.409
LIG_FHA_2	144	150	PF00498	0.380
LIG_FHA_2	41	47	PF00498	0.339
LIG_FHA_2	70	76	PF00498	0.267
LIG_LIR_Gen_1	114	123	PF02991	0.366
LIG_LIR_Gen_1	240	251	PF02991	0.318
LIG_LIR_Nem_3	10	16	PF02991	0.587
LIG_LIR_Nem_3	114	120	PF02991	0.365
LIG_LIR_Nem_3	236	242	PF02991	0.298
LIG_LIR_Nem_3	245	251	PF02991	0.285
LIG_LIR_Nem_3	64	69	PF02991	0.321
LIG_MLH1_MIPbox_1	244	248	PF16413	0.325
LIG_NRBOX	255	261	PF00104	0.525
LIG_PDZ_Class_2	296	301	PF00595	0.650
LIG_Pex14_1	239	243	PF04695	0.349
LIG_Pex14_2	41	45	PF04695	0.412
LIG_PTB_Apo_2	78	85	PF02174	0.328
LIG_SH2_NCK_1	153	157	PF00017	0.229
LIG_SH2_STAT5	188	191	PF00017	0.229
LIG_SH2_STAT5	204	207	PF00017	0.360
LIG_SH2_STAT5	247	250	PF00017	0.272
LIG_SUMO_SIM_par_1	254	261	PF11976	0.470
LIG_TRFH_1	204	208	PF08558	0.459
LIG_WRC_WIRS_1	62	67	PF05994	0.418
MOD_CK1_1	131	137	PF00069	0.332
MOD_CK1_1	143	149	PF00069	0.315
MOD_CK1_1	165	171	PF00069	0.168
MOD_CK1_1	284	290	PF00069	0.635
MOD_CK2_1	61	67	PF00069	0.434
MOD_CK2_1	69	75	PF00069	0.362
MOD_GlcNHglycan	128	131	PF01048	0.544
MOD_GlcNHglycan	166	170	PF01048	0.368
MOD_GlcNHglycan	200	203	PF01048	0.595
MOD_GlcNHglycan	230	233	PF01048	0.646
MOD_GlcNHglycan	85	88	PF01048	0.619
MOD_GSK3_1	124	131	PF00069	0.344
MOD_GSK3_1	139	146	PF00069	0.202
MOD_GSK3_1	16	23	PF00069	0.534
MOD_GSK3_1	233	240	PF00069	0.260
MOD_GSK3_1	281	288	PF00069	0.701
MOD_GSK3_1	50	57	PF00069	0.363
MOD_NEK2_1	139	144	PF00069	0.317
MOD_NEK2_1	237	242	PF00069	0.318
MOD_NEK2_1	40	45	PF00069	0.404
MOD_NEK2_1	83	88	PF00069	0.321
MOD_NEK2_1	98	103	PF00069	0.402
MOD_NEK2_2	50	55	PF00069	0.226
MOD_PKA_1	124	130	PF00069	0.237
MOD_PKA_2	143	149	PF00069	0.168
MOD_PKA_2	54	60	PF00069	0.382
MOD_PKA_2	69	75	PF00069	0.259
MOD_Plk_4	155	161	PF00069	0.202
MOD_Plk_4	20	26	PF00069	0.452
MOD_Plk_4	233	239	PF00069	0.298
MOD_Plk_4	242	248	PF00069	0.378
MOD_Plk_4	61	67	PF00069	0.353
MOD_ProDKin_1	85	91	PF00069	0.266
MOD_SUMO_rev_2	57	63	PF00179	0.405
MOD_SUMO_rev_2	92	99	PF00179	0.250
TRG_AP2beta_CARGO_1	114	124	PF09066	0.314
TRG_ENDOCYTIC_2	247	250	PF00928	0.293
TRG_ER_diArg_1	176	178	PF00400	0.347

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2X3	Leptomonas seymouri	53%	83%
A0A1X0NHP3	Trypanosomatidae	37%	84%
A0A3R7N7N1	Trypanosoma rangeli	34%	89%
A0A3S7WWQ5	Leishmania donovani	77%	67%
A4HZF6	Leishmania infantum	77%	67%
D0A124	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	91%
E9AVE3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	81%
V5BLW0	Trypanosoma cruzi	37%	96%