LETM1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC05_LEIBR

TriTrypDb:

LbrM.21.1710 , LBRM2903_210023500

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HC05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	334	338	PF00656	0.534
CLV_NRD_NRD_1	188	190	PF00675	0.599
CLV_NRD_NRD_1	211	213	PF00675	0.547
CLV_NRD_NRD_1	273	275	PF00675	0.503
CLV_NRD_NRD_1	354	356	PF00675	0.618
CLV_PCSK_KEX2_1	188	190	PF00082	0.599
CLV_PCSK_KEX2_1	211	213	PF00082	0.547
CLV_PCSK_KEX2_1	273	275	PF00082	0.503
CLV_PCSK_KEX2_1	354	356	PF00082	0.623
CLV_PCSK_KEX2_1	61	63	PF00082	0.364
CLV_PCSK_KEX2_1	9	11	PF00082	0.266
CLV_PCSK_PC1ET2_1	61	63	PF00082	0.364
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.266
CLV_PCSK_SKI1_1	27	31	PF00082	0.407
CLV_PCSK_SKI1_1	273	277	PF00082	0.513
CLV_PCSK_SKI1_1	349	353	PF00082	0.627
DEG_APCC_DBOX_1	211	219	PF00400	0.326
DEG_Nend_UBRbox_3	1	3	PF02207	0.622
DOC_CKS1_1	54	59	PF01111	0.650
DOC_CYCLIN_RxL_1	349	359	PF00134	0.419
DOC_MAPK_gen_1	9	15	PF00069	0.630
DOC_MAPK_MEF2A_6	97	106	PF00069	0.536
DOC_PP1_RVXF_1	352	359	PF00149	0.420
DOC_PP4_FxxP_1	275	278	PF00568	0.313
DOC_USP7_MATH_1	23	27	PF00917	0.609
DOC_USP7_UBL2_3	384	388	PF12436	0.376
DOC_WW_Pin1_4	123	128	PF00397	0.300
DOC_WW_Pin1_4	53	58	PF00397	0.584
LIG_14-3-3_CanoR_1	148	153	PF00244	0.386
LIG_14-3-3_CanoR_1	211	216	PF00244	0.333
LIG_14-3-3_CanoR_1	232	242	PF00244	0.446
LIG_14-3-3_CanoR_1	62	71	PF00244	0.553
LIG_BRCT_BRCA1_1	121	125	PF00533	0.422
LIG_BRCT_BRCA1_1	220	224	PF00533	0.340
LIG_deltaCOP1_diTrp_1	158	165	PF00928	0.350
LIG_deltaCOP1_diTrp_1	175	182	PF00928	0.354
LIG_deltaCOP1_diTrp_1	241	247	PF00928	0.305
LIG_deltaCOP1_diTrp_1	269	275	PF00928	0.314
LIG_DLG_GKlike_1	211	218	PF00625	0.339
LIG_FHA_1	2	8	PF00498	0.642
LIG_FHA_1	224	230	PF00498	0.427
LIG_FHA_1	253	259	PF00498	0.341
LIG_FHA_1	314	320	PF00498	0.342
LIG_FHA_1	369	375	PF00498	0.397
LIG_FHA_2	131	137	PF00498	0.367
LIG_FHA_2	170	176	PF00498	0.460
LIG_LIR_Gen_1	175	182	PF02991	0.354
LIG_LIR_Gen_1	202	210	PF02991	0.339
LIG_LIR_Gen_1	249	258	PF02991	0.328
LIG_LIR_Gen_1	294	303	PF02991	0.327
LIG_LIR_Gen_1	31	41	PF02991	0.549
LIG_LIR_Gen_1	340	347	PF02991	0.425
LIG_LIR_Nem_3	164	168	PF02991	0.378
LIG_LIR_Nem_3	175	181	PF02991	0.342
LIG_LIR_Nem_3	199	204	PF02991	0.357
LIG_LIR_Nem_3	221	227	PF02991	0.335
LIG_LIR_Nem_3	241	245	PF02991	0.305
LIG_LIR_Nem_3	249	254	PF02991	0.313
LIG_LIR_Nem_3	269	275	PF02991	0.369
LIG_LIR_Nem_3	294	298	PF02991	0.319
LIG_LIR_Nem_3	31	36	PF02991	0.558
LIG_LIR_Nem_3	4	8	PF02991	0.556
LIG_PCNA_yPIPBox_3	75	89	PF02747	0.530
LIG_PDZ_Class_2	389	394	PF00595	0.568
LIG_Pex14_1	161	165	PF04695	0.365
LIG_Pex14_1	178	182	PF04695	0.350
LIG_Pex14_1	247	251	PF04695	0.297
LIG_Pex14_1	33	37	PF04695	0.529
LIG_PTB_Apo_2	35	42	PF02174	0.633
LIG_PTB_Phospho_1	35	41	PF10480	0.630
LIG_SH2_CRK	111	115	PF00017	0.321
LIG_SH2_CRK	251	255	PF00017	0.323
LIG_SH2_GRB2like	242	245	PF00017	0.300
LIG_SH2_GRB2like	322	325	PF00017	0.312
LIG_SH2_NCK_1	111	115	PF00017	0.381
LIG_SH2_NCK_1	323	327	PF00017	0.343
LIG_SH2_NCK_1	49	53	PF00017	0.610
LIG_SH2_STAP1	279	283	PF00017	0.368
LIG_SH2_STAT3	43	46	PF00017	0.553
LIG_SH2_STAT5	155	158	PF00017	0.325
LIG_SH2_STAT5	318	321	PF00017	0.304
LIG_SH2_STAT5	328	331	PF00017	0.405
LIG_SH2_STAT5	55	58	PF00017	0.708
LIG_SH3_3	190	196	PF00018	0.366
LIG_SH3_3	222	228	PF00018	0.349
LIG_SH3_3	51	57	PF00018	0.624
LIG_SUMO_SIM_par_1	311	316	PF11976	0.304
LIG_TRAF2_1	133	136	PF00917	0.386
LIG_TRAF2_1	172	175	PF00917	0.432
LIG_TRAF2_1	284	287	PF00917	0.341
LIG_TRFH_1	111	115	PF08558	0.465
MOD_CK1_1	121	127	PF00069	0.418
MOD_CK1_1	151	157	PF00069	0.328
MOD_CK1_1	260	266	PF00069	0.294
MOD_CK2_1	130	136	PF00069	0.350
MOD_CK2_1	169	175	PF00069	0.389
MOD_CK2_1	281	287	PF00069	0.396
MOD_CK2_1	78	84	PF00069	0.535
MOD_GlcNHglycan	150	153	PF01048	0.632
MOD_GlcNHglycan	331	336	PF01048	0.662
MOD_GSK3_1	119	126	PF00069	0.366
MOD_GSK3_1	230	237	PF00069	0.397
MOD_GSK3_1	74	81	PF00069	0.553
MOD_N-GLC_1	170	175	PF02516	0.579
MOD_N-GLC_1	281	286	PF02516	0.577
MOD_NEK2_1	1	6	PF00069	0.600
MOD_NEK2_1	21	26	PF00069	0.440
MOD_NEK2_1	218	223	PF00069	0.315
MOD_NEK2_1	230	235	PF00069	0.354
MOD_NEK2_1	252	257	PF00069	0.339
MOD_PIKK_1	170	176	PF00454	0.381
MOD_PIKK_1	21	27	PF00454	0.558
MOD_PIKK_1	252	258	PF00454	0.337
MOD_PIKK_1	368	374	PF00454	0.425
MOD_PIKK_1	62	68	PF00454	0.559
MOD_PIKK_1	78	84	PF00454	0.546
MOD_PKA_1	211	217	PF00069	0.331
MOD_PKA_2	211	217	PF00069	0.331
MOD_Plk_1	331	337	PF00069	0.519
MOD_Plk_4	151	157	PF00069	0.317
MOD_Plk_4	29	35	PF00069	0.609
MOD_ProDKin_1	123	129	PF00069	0.299
MOD_ProDKin_1	53	59	PF00069	0.593
MOD_SUMO_rev_2	134	139	PF00179	0.430
MOD_SUMO_rev_2	305	310	PF00179	0.438
MOD_SUMO_rev_2	67	77	PF00179	0.613
TRG_AP2beta_CARGO_1	202	211	PF09066	0.351
TRG_DiLeu_BaEn_1	84	89	PF01217	0.512
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.518
TRG_ENDOCYTIC_2	111	114	PF00928	0.465
TRG_ENDOCYTIC_2	201	204	PF00928	0.365
TRG_ENDOCYTIC_2	242	245	PF00928	0.311
TRG_ENDOCYTIC_2	251	254	PF00928	0.303
TRG_ENDOCYTIC_2	295	298	PF00928	0.319
TRG_ER_diArg_1	187	189	PF00400	0.399
TRG_ER_diArg_1	210	212	PF00400	0.352
TRG_ER_diArg_1	272	274	PF00400	0.303
TRG_ER_diArg_1	353	355	PF00400	0.418
TRG_Pf-PMV_PEXEL_1	354	359	PF00026	0.620

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIK3	Leptomonas seymouri	82%	100%
A0A0S4J380	Bodo saltans	64%	100%
A0A1X0NI33	Trypanosomatidae	73%	100%
A0A3R7KN89	Trypanosoma rangeli	73%	100%
A0A3S7WWT0	Leishmania donovani	92%	100%
A4HZF7	Leishmania infantum	92%	100%
D0A125	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	72%	99%
E9AVE2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
Q4QC37	Leishmania major	92%	100%
V5DIA8	Trypanosoma cruzi	72%	100%