PhoLip_ATPase_C domain-containing protein

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HC03_LEIBR

TriTrypDb:

LbrM.21.1690 , LBRM2903_210023300

Length:

516

Annotations

LeishMANIAdb annotations

A small protein family largely unrelated to amastins.. Only expanded mildly during evolution compared to amastins

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

A4HC03

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC03

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	278	282	PF00656	0.623
CLV_C14_Caspase3-7	455	459	PF00656	0.606
CLV_NRD_NRD_1	142	144	PF00675	0.411
CLV_NRD_NRD_1	231	233	PF00675	0.358
CLV_NRD_NRD_1	313	315	PF00675	0.555
CLV_NRD_NRD_1	79	81	PF00675	0.622
CLV_PCSK_FUR_1	311	315	PF00082	0.415
CLV_PCSK_KEX2_1	231	233	PF00082	0.446
CLV_PCSK_KEX2_1	311	313	PF00082	0.500
CLV_PCSK_KEX2_1	79	81	PF00082	0.576
CLV_PCSK_SKI1_1	102	106	PF00082	0.452
CLV_PCSK_SKI1_1	125	129	PF00082	0.358
CLV_PCSK_SKI1_1	144	148	PF00082	0.204
CLV_PCSK_SKI1_1	170	174	PF00082	0.566
CLV_PCSK_SKI1_1	232	236	PF00082	0.433
CLV_PCSK_SKI1_1	353	357	PF00082	0.497
CLV_PCSK_SKI1_1	80	84	PF00082	0.603
DEG_SPOP_SBC_1	254	258	PF00917	0.576
DEG_SPOP_SBC_1	305	309	PF00917	0.719
DEG_SPOP_SBC_1	333	337	PF00917	0.627
DOC_CKS1_1	14	19	PF01111	0.600
DOC_CKS1_1	354	359	PF01111	0.671
DOC_CYCLIN_RxL_1	122	132	PF00134	0.285
DOC_CYCLIN_yClb1_LxF_4	123	128	PF00134	0.562
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.358
DOC_PP1_RVXF_1	123	129	PF00149	0.552
DOC_PP2B_LxvP_1	496	499	PF13499	0.740
DOC_PP2B_LxvP_1	64	67	PF13499	0.366
DOC_USP7_MATH_1	305	309	PF00917	0.719
DOC_USP7_MATH_1	332	336	PF00917	0.814
DOC_USP7_MATH_1	349	353	PF00917	0.676
DOC_USP7_MATH_1	48	52	PF00917	0.365
DOC_USP7_MATH_1	488	492	PF00917	0.773
DOC_WW_Pin1_4	13	18	PF00397	0.610
DOC_WW_Pin1_4	259	264	PF00397	0.742
DOC_WW_Pin1_4	334	339	PF00397	0.730
DOC_WW_Pin1_4	353	358	PF00397	0.686
DOC_WW_Pin1_4	384	389	PF00397	0.689
DOC_WW_Pin1_4	497	502	PF00397	0.741
DOC_WW_Pin1_4	62	67	PF00397	0.329
LIG_14-3-3_CanoR_1	24	29	PF00244	0.504
LIG_14-3-3_CanoR_1	311	321	PF00244	0.769
LIG_14-3-3_CanoR_1	43	52	PF00244	0.219
LIG_APCC_ABBA_1	193	198	PF00400	0.378
LIG_BRCT_BRCA1_1	185	189	PF00533	0.493
LIG_deltaCOP1_diTrp_1	19	28	PF00928	0.578
LIG_EH1_1	55	63	PF00400	0.271
LIG_FHA_1	121	127	PF00498	0.484
LIG_FHA_1	130	136	PF00498	0.590
LIG_FHA_1	147	153	PF00498	0.466
LIG_FHA_1	171	177	PF00498	0.314
LIG_FHA_1	195	201	PF00498	0.323
LIG_FHA_1	206	212	PF00498	0.338
LIG_FHA_1	25	31	PF00498	0.519
LIG_FHA_1	256	262	PF00498	0.592
LIG_FHA_1	354	360	PF00498	0.738
LIG_FHA_1	459	465	PF00498	0.739
LIG_FHA_1	510	516	PF00498	0.664
LIG_FHA_2	14	20	PF00498	0.546
LIG_FHA_2	146	152	PF00498	0.374
LIG_FHA_2	506	512	PF00498	0.752
LIG_GBD_Chelix_1	30	38	PF00786	0.382
LIG_LIR_Gen_1	134	142	PF02991	0.554
LIG_LIR_Gen_1	148	158	PF02991	0.323
LIG_LIR_Gen_1	19	30	PF02991	0.554
LIG_LIR_Gen_1	361	371	PF02991	0.729
LIG_LIR_Gen_1	411	419	PF02991	0.664
LIG_LIR_Nem_3	134	140	PF02991	0.554
LIG_LIR_Nem_3	148	153	PF02991	0.323
LIG_LIR_Nem_3	173	178	PF02991	0.297
LIG_LIR_Nem_3	27	31	PF02991	0.417
LIG_LIR_Nem_3	361	366	PF02991	0.723
LIG_LIR_Nem_3	411	416	PF02991	0.665
LIG_MYND_1	328	332	PF01753	0.622
LIG_PCNA_yPIPBox_3	169	183	PF02747	0.346
LIG_PCNA_yPIPBox_3	406	420	PF02747	0.613
LIG_PROFILIN_1	472	478	PF00235	0.601
LIG_PTB_Apo_2	103	110	PF02174	0.162
LIG_PTB_Apo_2	184	191	PF02174	0.321
LIG_PTB_Apo_2	210	217	PF02174	0.382
LIG_PTB_Apo_2	357	364	PF02174	0.711
LIG_PTB_Apo_2	51	58	PF02174	0.313
LIG_PTB_Apo_2	83	90	PF02174	0.393
LIG_PTB_Phospho_1	103	109	PF10480	0.233
LIG_PTB_Phospho_1	184	190	PF10480	0.322
LIG_PTB_Phospho_1	357	363	PF10480	0.711
LIG_SH2_CRK	137	141	PF00017	0.555
LIG_SH2_CRK	190	194	PF00017	0.402
LIG_SH2_NCK_1	363	367	PF00017	0.727
LIG_SH2_NCK_1	413	417	PF00017	0.667
LIG_SH2_SRC	109	112	PF00017	0.349
LIG_SH2_SRC	413	416	PF00017	0.611
LIG_SH2_STAP1	196	200	PF00017	0.352
LIG_SH2_STAT3	407	410	PF00017	0.618
LIG_SH2_STAT5	109	112	PF00017	0.323
LIG_SH2_STAT5	175	178	PF00017	0.311
LIG_SH2_STAT5	196	199	PF00017	0.294
LIG_SH2_STAT5	203	206	PF00017	0.277
LIG_SH2_STAT5	68	71	PF00017	0.355
LIG_SH2_STAT5	98	101	PF00017	0.311
LIG_SH3_3	248	254	PF00018	0.689
LIG_SH3_3	322	328	PF00018	0.753
LIG_SH3_3	348	354	PF00018	0.684
LIG_SH3_3	363	369	PF00018	0.677
LIG_SH3_3	382	388	PF00018	0.586
LIG_SH3_3	469	475	PF00018	0.667
LIG_SH3_3	495	501	PF00018	0.742
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.410
LIG_SUMO_SIM_anti_2	208	213	PF11976	0.209
LIG_SUMO_SIM_anti_2	27	33	PF11976	0.360
LIG_SUMO_SIM_anti_2	322	327	PF11976	0.627
LIG_SUMO_SIM_par_1	202	208	PF11976	0.308
LIG_SUMO_SIM_par_1	60	65	PF11976	0.278
LIG_TYR_ITIM	135	140	PF00017	0.598
LIG_WRC_WIRS_1	175	180	PF05994	0.377
LIG_WRC_WIRS_1	25	30	PF05994	0.456
LIG_WW_1	477	480	PF00397	0.682
MOD_CDK_SPxxK_3	13	20	PF00069	0.602
MOD_CK1_1	317	323	PF00069	0.757
MOD_CK1_1	401	407	PF00069	0.731
MOD_CK1_1	457	463	PF00069	0.733
MOD_CK1_1	46	52	PF00069	0.384
MOD_CK1_1	491	497	PF00069	0.621
MOD_CK1_1	60	66	PF00069	0.382
MOD_CK2_1	13	19	PF00069	0.553
MOD_CK2_1	145	151	PF00069	0.514
MOD_CK2_1	259	265	PF00069	0.627
MOD_CK2_1	312	318	PF00069	0.769
MOD_DYRK1A_RPxSP_1	353	357	PF00069	0.697
MOD_GlcNHglycan	120	123	PF01048	0.485
MOD_GlcNHglycan	273	276	PF01048	0.467
MOD_GlcNHglycan	277	280	PF01048	0.443
MOD_GlcNHglycan	38	41	PF01048	0.420
MOD_GlcNHglycan	403	406	PF01048	0.506
MOD_GlcNHglycan	45	48	PF01048	0.546
MOD_GlcNHglycan	454	457	PF01048	0.550
MOD_GlcNHglycan	480	483	PF01048	0.513
MOD_GSK3_1	170	177	PF00069	0.356
MOD_GSK3_1	199	206	PF00069	0.305
MOD_GSK3_1	20	27	PF00069	0.560
MOD_GSK3_1	249	256	PF00069	0.736
MOD_GSK3_1	271	278	PF00069	0.679
MOD_GSK3_1	301	308	PF00069	0.676
MOD_GSK3_1	349	356	PF00069	0.680
MOD_GSK3_1	454	461	PF00069	0.691
MOD_GSK3_1	46	53	PF00069	0.320
MOD_GSK3_1	505	512	PF00069	0.752
MOD_N-GLC_1	219	224	PF02516	0.430
MOD_N-GLC_1	275	280	PF02516	0.426
MOD_N-GLC_1	291	296	PF02516	0.392
MOD_N-GLC_1	75	80	PF02516	0.535
MOD_NEK2_1	127	132	PF00069	0.598
MOD_NEK2_1	189	194	PF00069	0.407
MOD_NEK2_1	199	204	PF00069	0.276
MOD_NEK2_1	399	404	PF00069	0.613
MOD_NEK2_1	463	468	PF00069	0.626
MOD_NEK2_1	57	62	PF00069	0.356
MOD_NEK2_1	75	80	PF00069	0.229
MOD_PIKK_1	488	494	PF00454	0.667
MOD_PKA_1	312	318	PF00069	0.719
MOD_PKA_2	312	318	PF00069	0.685
MOD_PKA_2	466	472	PF00069	0.659
MOD_PKB_1	312	320	PF00069	0.720
MOD_PKB_1	450	458	PF00069	0.702
MOD_Plk_1	317	323	PF00069	0.625
MOD_Plk_1	436	442	PF00069	0.712
MOD_Plk_1	509	515	PF00069	0.708
MOD_Plk_4	199	205	PF00069	0.316
MOD_Plk_4	207	213	PF00069	0.343
MOD_Plk_4	24	30	PF00069	0.504
MOD_Plk_4	393	399	PF00069	0.669
MOD_Plk_4	491	497	PF00069	0.810
MOD_Plk_4	57	63	PF00069	0.333
MOD_ProDKin_1	13	19	PF00069	0.604
MOD_ProDKin_1	259	265	PF00069	0.744
MOD_ProDKin_1	334	340	PF00069	0.732
MOD_ProDKin_1	353	359	PF00069	0.685
MOD_ProDKin_1	384	390	PF00069	0.686
MOD_ProDKin_1	497	503	PF00069	0.743
MOD_ProDKin_1	62	68	PF00069	0.327
MOD_SUMO_rev_2	239	244	PF00179	0.513
TRG_DiLeu_BaEn_3	239	245	PF01217	0.495
TRG_DiLeu_BaLyEn_6	122	127	PF01217	0.424
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.652
TRG_ENDOCYTIC_2	137	140	PF00928	0.573
TRG_ENDOCYTIC_2	175	178	PF00928	0.407
TRG_ENDOCYTIC_2	190	193	PF00928	0.355
TRG_ENDOCYTIC_2	196	199	PF00928	0.271
TRG_ENDOCYTIC_2	248	251	PF00928	0.645
TRG_ENDOCYTIC_2	363	366	PF00928	0.726
TRG_ENDOCYTIC_2	413	416	PF00928	0.669
TRG_ER_diArg_1	230	232	PF00400	0.606
TRG_ER_diArg_1	310	313	PF00400	0.730
TRG_ER_diArg_1	449	452	PF00400	0.703
TRG_Pf-PMV_PEXEL_1	125	129	PF00026	0.248

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA63	Leptomonas seymouri	47%	89%
A0A3R7L6A1	Trypanosoma rangeli	30%	100%
A0A3S5H7A1	Leishmania donovani	66%	95%
A4HZG0	Leishmania infantum	67%	95%
E9AVE0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	66%	95%
Q4QC39	Leishmania major	65%	97%
V5BHC7	Trypanosoma cruzi	31%	100%