LeishMANIAdb
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PhoLip_ATPase_C domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PhoLip_ATPase_C domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HC03_LEIBR
TriTrypDb:
LbrM.21.1690 , LBRM2903_210023300 *
Length:
516

Annotations

LeishMANIAdb annotations

A small protein family largely unrelated to amastins.. Only expanded mildly during evolution compared to amastins

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
TermNameLevelCount
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8
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Expansion

Sequence features

A4HC03
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HC03

Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_C14_Caspase3-7 278 282 PF00656 0.623
CLV_C14_Caspase3-7 455 459 PF00656 0.606
CLV_NRD_NRD_1 142 144 PF00675 0.411
CLV_NRD_NRD_1 231 233 PF00675 0.358
CLV_NRD_NRD_1 313 315 PF00675 0.555
CLV_NRD_NRD_1 79 81 PF00675 0.622
CLV_PCSK_FUR_1 311 315 PF00082 0.415
CLV_PCSK_KEX2_1 231 233 PF00082 0.446
CLV_PCSK_KEX2_1 311 313 PF00082 0.500
CLV_PCSK_KEX2_1 79 81 PF00082 0.576
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1PA63 Leptomonas seymouri 47% 89%
A0A3R7L6A1 Trypanosoma rangeli 30% 100%
A0A3S5H7A1 Leishmania donovani 66% 95%
A4HZG0 Leishmania infantum 67% 95%
E9AVE0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 66% 95%
Q4QC39 Leishmania major 65% 97%
V5BHC7 Trypanosoma cruzi 31% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS