Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HBZ7_LEIBR

TriTrypDb:

LbrM.21.1630 , LBRM2903_210022700

Length:

672

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBZ7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBZ7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	264	268	PF00656	0.587
CLV_C14_Caspase3-7	350	354	PF00656	0.817
CLV_C14_Caspase3-7	570	574	PF00656	0.840
CLV_NRD_NRD_1	143	145	PF00675	0.721
CLV_NRD_NRD_1	185	187	PF00675	0.680
CLV_PCSK_FUR_1	140	144	PF00082	0.726
CLV_PCSK_KEX2_1	142	144	PF00082	0.732
CLV_PCSK_KEX2_1	185	187	PF00082	0.684
CLV_PCSK_SKI1_1	160	164	PF00082	0.631
CLV_PCSK_SKI1_1	188	192	PF00082	0.835
CLV_PCSK_SKI1_1	245	249	PF00082	0.581
CLV_PCSK_SKI1_1	273	277	PF00082	0.841
CLV_PCSK_SKI1_1	646	650	PF00082	0.695
CLV_PCSK_SKI1_1	68	72	PF00082	0.577
DEG_APCC_DBOX_1	159	167	PF00400	0.789
DEG_Nend_UBRbox_3	1	3	PF02207	0.836
DEG_SPOP_SBC_1	329	333	PF00917	0.736
DEG_SPOP_SBC_1	482	486	PF00917	0.699
DEG_SPOP_SBC_1	492	496	PF00917	0.604
DEG_SPOP_SBC_1	560	564	PF00917	0.615
DOC_ANK_TNKS_1	389	396	PF00023	0.819
DOC_CDC14_PxL_1	603	611	PF14671	0.603
DOC_CKS1_1	177	182	PF01111	0.569
DOC_CYCLIN_yCln2_LP_2	287	293	PF00134	0.584
DOC_MAPK_DCC_7	160	168	PF00069	0.789
DOC_MAPK_gen_1	185	195	PF00069	0.573
DOC_MAPK_MEF2A_6	160	168	PF00069	0.789
DOC_MAPK_RevD_3	129	143	PF00069	0.571
DOC_PP2B_LxvP_1	287	290	PF13499	0.591
DOC_PP2B_LxvP_1	609	612	PF13499	0.842
DOC_PP4_FxxP_1	505	508	PF00568	0.573
DOC_USP7_MATH_1	11	15	PF00917	0.784
DOC_USP7_MATH_1	132	136	PF00917	0.825
DOC_USP7_MATH_1	207	211	PF00917	0.562
DOC_USP7_MATH_1	299	303	PF00917	0.594
DOC_USP7_MATH_1	337	341	PF00917	0.645
DOC_USP7_MATH_1	500	504	PF00917	0.620
DOC_USP7_MATH_1	558	562	PF00917	0.725
DOC_USP7_MATH_1	572	576	PF00917	0.604
DOC_USP7_MATH_1	631	635	PF00917	0.750
DOC_WW_Pin1_4	176	181	PF00397	0.625
DOC_WW_Pin1_4	265	270	PF00397	0.580
DOC_WW_Pin1_4	276	281	PF00397	0.532
DOC_WW_Pin1_4	29	34	PF00397	0.841
DOC_WW_Pin1_4	333	338	PF00397	0.715
DOC_WW_Pin1_4	504	509	PF00397	0.744
DOC_WW_Pin1_4	535	540	PF00397	0.866
DOC_WW_Pin1_4	548	553	PF00397	0.626
DOC_WW_Pin1_4	585	590	PF00397	0.699
DOC_WW_Pin1_4	656	661	PF00397	0.581
LIG_14-3-3_CanoR_1	192	202	PF00244	0.840
LIG_14-3-3_CanoR_1	278	284	PF00244	0.616
LIG_14-3-3_CanoR_1	616	625	PF00244	0.836
LIG_14-3-3_CanoR_1	68	77	PF00244	0.565
LIG_APCC_ABBAyCdc20_2	19	25	PF00400	0.610
LIG_deltaCOP1_diTrp_1	401	408	PF00928	0.719
LIG_EVH1_1	609	613	PF00568	0.573
LIG_FHA_1	151	157	PF00498	0.545
LIG_FHA_1	173	179	PF00498	0.765
LIG_FHA_1	224	230	PF00498	0.573
LIG_FHA_1	242	248	PF00498	0.583
LIG_FHA_1	269	275	PF00498	0.670
LIG_FHA_1	29	35	PF00498	0.604
LIG_FHA_1	303	309	PF00498	0.679
LIG_FHA_1	53	59	PF00498	0.709
LIG_FHA_1	561	567	PF00498	0.578
LIG_FHA_1	69	75	PF00498	0.585
LIG_FHA_2	319	325	PF00498	0.573
LIG_FHA_2	47	53	PF00498	0.594
LIG_FHA_2	568	574	PF00498	0.586
LIG_LIR_Apic_2	175	180	PF02991	0.562
LIG_LIR_Apic_2	450	456	PF02991	0.821
LIG_LIR_Apic_2	503	508	PF02991	0.575
LIG_LIR_Gen_1	649	660	PF02991	0.576
LIG_LIR_Nem_3	649	655	PF02991	0.574
LIG_LIR_Nem_3	88	94	PF02991	0.595
LIG_MYND_1	104	108	PF01753	0.845
LIG_PTAP_UEV_1	122	127	PF05743	0.571
LIG_SH2_GRB2like	367	370	PF00017	0.538
LIG_SH2_NCK_1	146	150	PF00017	0.553
LIG_SH2_PTP2	453	456	PF00017	0.711
LIG_SH2_PTP2	512	515	PF00017	0.818
LIG_SH2_SRC	453	456	PF00017	0.789
LIG_SH2_STAP1	652	656	PF00017	0.562
LIG_SH2_STAT5	453	456	PF00017	0.575
LIG_SH2_STAT5	512	515	PF00017	0.818
LIG_SH2_STAT5	519	522	PF00017	0.714
LIG_SH3_1	30	36	PF00018	0.607
LIG_SH3_1	541	547	PF00018	0.597
LIG_SH3_2	290	295	PF14604	0.581
LIG_SH3_3	120	126	PF00018	0.664
LIG_SH3_3	14	20	PF00018	0.652
LIG_SH3_3	161	167	PF00018	0.787
LIG_SH3_3	278	284	PF00018	0.743
LIG_SH3_3	287	293	PF00018	0.759
LIG_SH3_3	30	36	PF00018	0.739
LIG_SH3_3	306	312	PF00018	0.717
LIG_SH3_3	359	365	PF00018	0.658
LIG_SH3_3	541	547	PF00018	0.701
LIG_SH3_3	583	589	PF00018	0.696
LIG_SH3_3	604	610	PF00018	0.667
LIG_SH3_3	91	97	PF00018	0.663
LIG_SUMO_SIM_anti_2	210	217	PF11976	0.599
LIG_SUMO_SIM_par_1	210	217	PF11976	0.762
LIG_SUMO_SIM_par_1	513	518	PF11976	0.823
LIG_SUMO_SIM_par_1	551	557	PF11976	0.591
LIG_TRAF2_1	321	324	PF00917	0.728
LIG_TRAF2_1	399	402	PF00917	0.510
LIG_UBA3_1	418	426	PF00899	0.553
LIG_WW_1	20	23	PF00397	0.608
LIG_WW_3	102	106	PF00397	0.844
MOD_CDC14_SPxK_1	538	541	PF00782	0.861
MOD_CDK_SPxK_1	535	541	PF00069	0.866
MOD_CK1_1	135	141	PF00069	0.554
MOD_CK1_1	158	164	PF00069	0.770
MOD_CK1_1	268	274	PF00069	0.606
MOD_CK1_1	279	285	PF00069	0.582
MOD_CK1_1	298	304	PF00069	0.735
MOD_CK1_1	330	336	PF00069	0.810
MOD_CK1_1	40	46	PF00069	0.766
MOD_CK1_1	483	489	PF00069	0.751
MOD_CK1_1	526	532	PF00069	0.825
MOD_CK1_1	551	557	PF00069	0.844
MOD_CK1_1	561	567	PF00069	0.615
MOD_CK1_1	614	620	PF00069	0.847
MOD_CK1_1	64	70	PF00069	0.616
MOD_CK1_1	658	664	PF00069	0.813
MOD_CK2_1	298	304	PF00069	0.653
MOD_CK2_1	318	324	PF00069	0.728
MOD_CK2_1	396	402	PF00069	0.692
MOD_CK2_1	46	52	PF00069	0.627
MOD_CK2_1	484	490	PF00069	0.597
MOD_GlcNHglycan	157	160	PF01048	0.788
MOD_GlcNHglycan	168	171	PF01048	0.604
MOD_GlcNHglycan	207	210	PF01048	0.728
MOD_GlcNHglycan	216	219	PF01048	0.682
MOD_GlcNHglycan	248	251	PF01048	0.710
MOD_GlcNHglycan	297	300	PF01048	0.848
MOD_GlcNHglycan	353	356	PF01048	0.586
MOD_GlcNHglycan	40	43	PF01048	0.785
MOD_GlcNHglycan	473	476	PF01048	0.659
MOD_GlcNHglycan	486	489	PF01048	0.768
MOD_GlcNHglycan	500	503	PF01048	0.616
MOD_GlcNHglycan	529	532	PF01048	0.794
MOD_GlcNHglycan	556	559	PF01048	0.749
MOD_GlcNHglycan	573	577	PF01048	0.692
MOD_GlcNHglycan	603	606	PF01048	0.865
MOD_GlcNHglycan	613	616	PF01048	0.692
MOD_GlcNHglycan	661	664	PF01048	0.849
MOD_GlcNHglycan	71	74	PF01048	0.663
MOD_GSK3_1	172	179	PF00069	0.732
MOD_GSK3_1	184	191	PF00069	0.772
MOD_GSK3_1	214	221	PF00069	0.558
MOD_GSK3_1	256	263	PF00069	0.661
MOD_GSK3_1	276	283	PF00069	0.536
MOD_GSK3_1	291	298	PF00069	0.674
MOD_GSK3_1	327	334	PF00069	0.831
MOD_GSK3_1	337	344	PF00069	0.671
MOD_GSK3_1	34	41	PF00069	0.691
MOD_GSK3_1	347	354	PF00069	0.515
MOD_GSK3_1	480	487	PF00069	0.773
MOD_GSK3_1	500	507	PF00069	0.516
MOD_GSK3_1	519	526	PF00069	0.593
MOD_GSK3_1	530	537	PF00069	0.656
MOD_GSK3_1	554	561	PF00069	0.706
MOD_GSK3_1	57	64	PF00069	0.749
MOD_GSK3_1	655	662	PF00069	0.834
MOD_NEK2_1	235	240	PF00069	0.622
MOD_NEK2_1	341	346	PF00069	0.586
MOD_NEK2_1	38	43	PF00069	0.800
MOD_NEK2_1	44	49	PF00069	0.664
MOD_NEK2_1	647	652	PF00069	0.646
MOD_NEK2_1	655	660	PF00069	0.832
MOD_NEK2_1	82	87	PF00069	0.567
MOD_NEK2_2	337	342	PF00069	0.582
MOD_NEK2_2	500	505	PF00069	0.620
MOD_PIKK_1	11	17	PF00454	0.794
MOD_PIKK_1	172	178	PF00454	0.649
MOD_PIKK_1	375	381	PF00454	0.761
MOD_PIKK_1	411	417	PF00454	0.734
MOD_PIKK_1	530	536	PF00454	0.866
MOD_PIKK_1	542	548	PF00454	0.614
MOD_PKA_2	184	190	PF00069	0.835
MOD_PKA_2	256	262	PF00069	0.590
MOD_PKA_2	526	532	PF00069	0.854
MOD_PKB_1	66	74	PF00069	0.579
MOD_Plk_1	396	402	PF00069	0.523
MOD_Plk_2-3	396	402	PF00069	0.528
MOD_Plk_4	34	40	PF00069	0.604
MOD_Plk_4	403	409	PF00069	0.711
MOD_Plk_4	500	506	PF00069	0.621
MOD_ProDKin_1	176	182	PF00069	0.626
MOD_ProDKin_1	265	271	PF00069	0.582
MOD_ProDKin_1	276	282	PF00069	0.533
MOD_ProDKin_1	29	35	PF00069	0.840
MOD_ProDKin_1	333	339	PF00069	0.714
MOD_ProDKin_1	504	510	PF00069	0.744
MOD_ProDKin_1	535	541	PF00069	0.866
MOD_ProDKin_1	548	554	PF00069	0.625
MOD_ProDKin_1	585	591	PF00069	0.700
MOD_ProDKin_1	656	662	PF00069	0.583
TRG_DiLeu_BaEn_1	304	309	PF01217	0.620
TRG_DiLeu_BaLyEn_6	161	166	PF01217	0.789
TRG_DiLeu_BaLyEn_6	414	419	PF01217	0.533
TRG_ENDOCYTIC_2	512	515	PF00928	0.818
TRG_ENDOCYTIC_2	652	655	PF00928	0.560
TRG_ER_diArg_1	139	142	PF00400	0.717
TRG_ER_diArg_1	143	145	PF00400	0.601
TRG_ER_diArg_1	184	186	PF00400	0.840
TRG_ER_diArg_1	92	95	PF00400	0.641
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.808

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWS0	Leishmania donovani	56%	100%
A4HZE6	Leishmania infantum	56%	100%
E9AVD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	56%	99%
Q4QC46	Leishmania major	57%	99%