DUF5745 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBZ6_LEIBR

TriTrypDb:

LbrM.21.1620 , LBRM2903_210022600

Length:

815

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000922	spindle pole	2	7
GO:0005813	centrosome	3	7
GO:0005815	microtubule organizing center	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HBZ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBZ6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	305	309	PF00656	0.470
CLV_C14_Caspase3-7	538	542	PF00656	0.514
CLV_C14_Caspase3-7	94	98	PF00656	0.606
CLV_NRD_NRD_1	239	241	PF00675	0.458
CLV_NRD_NRD_1	472	474	PF00675	0.699
CLV_NRD_NRD_1	501	503	PF00675	0.593
CLV_NRD_NRD_1	510	512	PF00675	0.787
CLV_NRD_NRD_1	531	533	PF00675	0.493
CLV_NRD_NRD_1	545	547	PF00675	0.597
CLV_NRD_NRD_1	701	703	PF00675	0.472
CLV_NRD_NRD_1	722	724	PF00675	0.461
CLV_NRD_NRD_1	731	733	PF00675	0.424
CLV_NRD_NRD_1	793	795	PF00675	0.436
CLV_NRD_NRD_1	87	89	PF00675	0.728
CLV_PCSK_FUR_1	699	703	PF00082	0.458
CLV_PCSK_KEX2_1	238	240	PF00082	0.455
CLV_PCSK_KEX2_1	472	474	PF00082	0.711
CLV_PCSK_KEX2_1	501	503	PF00082	0.602
CLV_PCSK_KEX2_1	510	512	PF00082	0.734
CLV_PCSK_KEX2_1	531	533	PF00082	0.493
CLV_PCSK_KEX2_1	545	547	PF00082	0.597
CLV_PCSK_KEX2_1	603	605	PF00082	0.710
CLV_PCSK_KEX2_1	67	69	PF00082	0.600
CLV_PCSK_KEX2_1	701	703	PF00082	0.476
CLV_PCSK_KEX2_1	731	733	PF00082	0.433
CLV_PCSK_KEX2_1	793	795	PF00082	0.443
CLV_PCSK_KEX2_1	87	89	PF00082	0.745
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.455
CLV_PCSK_PC1ET2_1	603	605	PF00082	0.697
CLV_PCSK_PC1ET2_1	67	69	PF00082	0.600
CLV_PCSK_PC7_1	697	703	PF00082	0.454
CLV_PCSK_SKI1_1	29	33	PF00082	0.576
CLV_PCSK_SKI1_1	660	664	PF00082	0.612
CLV_Separin_Metazoa	798	802	PF03568	0.514
DEG_SPOP_SBC_1	328	332	PF00917	0.662
DEG_SPOP_SBC_1	48	52	PF00917	0.653
DOC_CKS1_1	43	48	PF01111	0.626
DOC_MAPK_gen_1	238	247	PF00069	0.430
DOC_MAPK_gen_1	479	488	PF00069	0.539
DOC_MAPK_gen_1	516	524	PF00069	0.536
DOC_MAPK_gen_1	603	611	PF00069	0.555
DOC_MAPK_gen_1	720	729	PF00069	0.443
DOC_MAPK_MEF2A_6	238	247	PF00069	0.430
DOC_MAPK_MEF2A_6	275	283	PF00069	0.385
DOC_PP2B_LxvP_1	159	162	PF13499	0.566
DOC_PP4_FxxP_1	366	369	PF00568	0.768
DOC_PP4_FxxP_1	551	554	PF00568	0.549
DOC_USP7_MATH_1	121	125	PF00917	0.576
DOC_USP7_MATH_1	145	149	PF00917	0.637
DOC_USP7_MATH_1	151	155	PF00917	0.643
DOC_USP7_MATH_1	37	41	PF00917	0.761
DOC_USP7_MATH_1	484	488	PF00917	0.692
DOC_USP7_MATH_1	554	558	PF00917	0.542
DOC_USP7_MATH_1	585	589	PF00917	0.616
DOC_USP7_MATH_1	628	632	PF00917	0.596
DOC_USP7_MATH_1	63	67	PF00917	0.795
DOC_USP7_MATH_1	71	75	PF00917	0.618
DOC_USP7_MATH_1	76	80	PF00917	0.553
DOC_WW_Pin1_4	147	152	PF00397	0.728
DOC_WW_Pin1_4	154	159	PF00397	0.671
DOC_WW_Pin1_4	229	234	PF00397	0.488
DOC_WW_Pin1_4	35	40	PF00397	0.646
DOC_WW_Pin1_4	375	380	PF00397	0.556
DOC_WW_Pin1_4	411	416	PF00397	0.642
DOC_WW_Pin1_4	42	47	PF00397	0.622
DOC_WW_Pin1_4	490	495	PF00397	0.646
DOC_WW_Pin1_4	503	508	PF00397	0.726
DOC_WW_Pin1_4	509	514	PF00397	0.639
DOC_WW_Pin1_4	621	626	PF00397	0.570
LIG_14-3-3_CanoR_1	207	217	PF00244	0.389
LIG_14-3-3_CanoR_1	682	689	PF00244	0.522
LIG_14-3-3_CanoR_1	764	772	PF00244	0.424
LIG_14-3-3_CanoR_1	87	93	PF00244	0.667
LIG_APCC_ABBA_1	522	527	PF00400	0.479
LIG_APCC_ABBAyCdc20_2	521	527	PF00400	0.488
LIG_BIR_III_4	308	312	PF00653	0.564
LIG_BRCT_BRCA1_1	210	214	PF00533	0.377
LIG_CaM_IQ_9	689	704	PF13499	0.446
LIG_FHA_1	139	145	PF00498	0.551
LIG_FHA_1	357	363	PF00498	0.543
LIG_FHA_1	427	433	PF00498	0.568
LIG_FHA_1	764	770	PF00498	0.423
LIG_FHA_2	170	176	PF00498	0.624
LIG_FHA_2	339	345	PF00498	0.506
LIG_FHA_2	654	660	PF00498	0.520
LIG_FHA_2	793	799	PF00498	0.406
LIG_LIR_Apic_2	371	377	PF02991	0.552
LIG_LIR_Gen_1	194	203	PF02991	0.480
LIG_LIR_Gen_1	211	222	PF02991	0.377
LIG_LIR_Nem_3	194	198	PF02991	0.458
LIG_LIR_Nem_3	210	216	PF02991	0.384
LIG_LIR_Nem_3	332	338	PF02991	0.598
LIG_LIR_Nem_3	434	440	PF02991	0.528
LIG_MLH1_MIPbox_1	210	214	PF16413	0.377
LIG_Pex14_1	809	813	PF04695	0.346
LIG_SH2_CRK	218	222	PF00017	0.384
LIG_SH2_CRK	335	339	PF00017	0.657
LIG_SH2_CRK	437	441	PF00017	0.531
LIG_SH2_CRK	744	748	PF00017	0.422
LIG_SH2_NCK_1	335	339	PF00017	0.605
LIG_SH2_NCK_1	340	344	PF00017	0.569
LIG_SH2_PTP2	374	377	PF00017	0.571
LIG_SH2_SRC	335	338	PF00017	0.655
LIG_SH2_SRC	421	424	PF00017	0.603
LIG_SH2_STAP1	704	708	PF00017	0.453
LIG_SH2_STAP1	744	748	PF00017	0.422
LIG_SH2_STAP1	773	777	PF00017	0.404
LIG_SH2_STAP1	802	806	PF00017	0.417
LIG_SH2_STAT3	4	7	PF00017	0.692
LIG_SH2_STAT3	589	592	PF00017	0.560
LIG_SH2_STAT3	704	707	PF00017	0.461
LIG_SH2_STAT5	340	343	PF00017	0.514
LIG_SH2_STAT5	374	377	PF00017	0.571
LIG_SH2_STAT5	421	424	PF00017	0.603
LIG_SH2_STAT5	661	664	PF00017	0.614
LIG_SH2_STAT5	688	691	PF00017	0.436
LIG_SH3_1	374	380	PF00018	0.569
LIG_SH3_1	575	581	PF00018	0.571
LIG_SH3_1	622	628	PF00018	0.579
LIG_SH3_3	150	156	PF00018	0.697
LIG_SH3_3	342	348	PF00018	0.683
LIG_SH3_3	374	380	PF00018	0.636
LIG_SH3_3	40	46	PF00018	0.633
LIG_SH3_3	438	444	PF00018	0.623
LIG_SH3_3	511	517	PF00018	0.568
LIG_SH3_3	575	581	PF00018	0.681
LIG_SH3_3	617	623	PF00018	0.569
LIG_SH3_3	647	653	PF00018	0.712
LIG_SH3_3	70	76	PF00018	0.659
LIG_SUMO_SIM_anti_2	725	731	PF11976	0.361
LIG_SUMO_SIM_par_1	243	248	PF11976	0.420
LIG_TRAF2_1	172	175	PF00917	0.615
LIG_TRAF2_1	351	354	PF00917	0.531
LIG_TRAF2_1	448	451	PF00917	0.685
LIG_TRAF2_1	656	659	PF00917	0.521
LIG_TRAF2_2	590	595	PF00917	0.556
LIG_TYR_ITIM	216	221	PF00017	0.381
LIG_UBA3_1	22	29	PF00899	0.503
LIG_WRC_WIRS_1	192	197	PF05994	0.410
LIG_WW_3	619	623	PF00397	0.566
MOD_CDK_SPxxK_3	503	510	PF00069	0.741
MOD_CK1_1	124	130	PF00069	0.535
MOD_CK1_1	154	160	PF00069	0.620
MOD_CK1_1	232	238	PF00069	0.500
MOD_CK1_1	356	362	PF00069	0.621
MOD_CK1_1	38	44	PF00069	0.631
MOD_CK1_1	414	420	PF00069	0.623
MOD_CK1_1	47	53	PF00069	0.656
MOD_CK1_1	487	493	PF00069	0.655
MOD_CK1_1	512	518	PF00069	0.624
MOD_CK1_1	557	563	PF00069	0.577
MOD_CK1_1	706	712	PF00069	0.458
MOD_CK1_1	718	724	PF00069	0.401
MOD_CK1_1	763	769	PF00069	0.425
MOD_CK2_1	169	175	PF00069	0.641
MOD_CK2_1	338	344	PF00069	0.503
MOD_CK2_1	445	451	PF00069	0.622
MOD_CK2_1	49	55	PF00069	0.687
MOD_CK2_1	503	509	PF00069	0.738
MOD_CK2_1	596	602	PF00069	0.615
MOD_CK2_1	653	659	PF00069	0.520
MOD_CK2_1	711	717	PF00069	0.455
MOD_CK2_1	792	798	PF00069	0.404
MOD_GlcNHglycan	106	109	PF01048	0.483
MOD_GlcNHglycan	123	126	PF01048	0.714
MOD_GlcNHglycan	135	138	PF01048	0.630
MOD_GlcNHglycan	147	150	PF01048	0.659
MOD_GlcNHglycan	331	334	PF01048	0.631
MOD_GlcNHglycan	354	358	PF01048	0.656
MOD_GlcNHglycan	386	389	PF01048	0.669
MOD_GlcNHglycan	403	406	PF01048	0.621
MOD_GlcNHglycan	447	450	PF01048	0.609
MOD_GlcNHglycan	455	458	PF01048	0.687
MOD_GlcNHglycan	490	493	PF01048	0.628
MOD_GlcNHglycan	503	506	PF01048	0.682
MOD_GlcNHglycan	51	54	PF01048	0.690
MOD_GlcNHglycan	598	601	PF01048	0.648
MOD_GlcNHglycan	684	687	PF01048	0.522
MOD_GlcNHglycan	708	711	PF01048	0.448
MOD_GlcNHglycan	73	76	PF01048	0.766
MOD_GlcNHglycan	78	81	PF01048	0.700
MOD_GlcNHglycan	804	809	PF01048	0.407
MOD_GlcNHglycan	88	91	PF01048	0.805
MOD_GlcNHglycan	93	96	PF01048	0.588
MOD_GSK3_1	139	146	PF00069	0.642
MOD_GSK3_1	147	154	PF00069	0.694
MOD_GSK3_1	194	201	PF00069	0.573
MOD_GSK3_1	35	42	PF00069	0.669
MOD_GSK3_1	422	429	PF00069	0.594
MOD_GSK3_1	44	51	PF00069	0.682
MOD_GSK3_1	445	452	PF00069	0.728
MOD_GSK3_1	484	491	PF00069	0.626
MOD_GSK3_1	501	508	PF00069	0.556
MOD_GSK3_1	554	561	PF00069	0.593
MOD_GSK3_1	628	635	PF00069	0.569
MOD_GSK3_1	711	718	PF00069	0.427
MOD_GSK3_1	82	89	PF00069	0.801
MOD_NEK2_1	222	227	PF00069	0.452
MOD_NEK2_1	422	427	PF00069	0.583
MOD_NEK2_1	488	493	PF00069	0.629
MOD_NEK2_1	49	54	PF00069	0.670
MOD_NEK2_1	495	500	PF00069	0.648
MOD_NEK2_1	5	10	PF00069	0.627
MOD_NEK2_1	711	716	PF00069	0.457
MOD_NEK2_1	777	782	PF00069	0.408
MOD_NEK2_2	209	214	PF00069	0.375
MOD_NEK2_2	461	466	PF00069	0.693
MOD_PIKK_1	151	157	PF00454	0.651
MOD_PIKK_1	467	473	PF00454	0.697
MOD_PIKK_1	5	11	PF00454	0.636
MOD_PIKK_1	632	638	PF00454	0.626
MOD_PIKK_1	703	709	PF00454	0.455
MOD_PK_1	202	208	PF00069	0.422
MOD_PKA_1	501	507	PF00069	0.557
MOD_PKA_2	201	207	PF00069	0.516
MOD_PKA_2	501	507	PF00069	0.562
MOD_PKA_2	639	645	PF00069	0.549
MOD_PKA_2	711	717	PF00069	0.455
MOD_PKA_2	763	769	PF00069	0.425
MOD_PKA_2	792	798	PF00069	0.402
MOD_PKA_2	86	92	PF00069	0.743
MOD_Plk_1	222	228	PF00069	0.458
MOD_Plk_1	422	428	PF00069	0.577
MOD_Plk_1	804	810	PF00069	0.409
MOD_Plk_4	139	145	PF00069	0.616
MOD_Plk_4	209	215	PF00069	0.377
MOD_Plk_4	422	428	PF00069	0.607
MOD_ProDKin_1	147	153	PF00069	0.723
MOD_ProDKin_1	154	160	PF00069	0.668
MOD_ProDKin_1	229	235	PF00069	0.484
MOD_ProDKin_1	35	41	PF00069	0.647
MOD_ProDKin_1	375	381	PF00069	0.556
MOD_ProDKin_1	411	417	PF00069	0.642
MOD_ProDKin_1	42	48	PF00069	0.623
MOD_ProDKin_1	490	496	PF00069	0.648
MOD_ProDKin_1	503	509	PF00069	0.727
MOD_ProDKin_1	621	627	PF00069	0.571
MOD_SUMO_for_1	787	790	PF00179	0.433
MOD_SUMO_rev_2	672	680	PF00179	0.482
TRG_DiLeu_BaEn_1	725	730	PF01217	0.355
TRG_DiLeu_BaEn_4	263	269	PF01217	0.422
TRG_DiLeu_BaLyEn_6	272	277	PF01217	0.370
TRG_ENDOCYTIC_2	218	221	PF00928	0.382
TRG_ENDOCYTIC_2	335	338	PF00928	0.579
TRG_ENDOCYTIC_2	437	440	PF00928	0.529
TRG_ENDOCYTIC_2	744	747	PF00928	0.424
TRG_ER_diArg_1	521	524	PF00400	0.568
TRG_ER_diArg_1	530	532	PF00400	0.476
TRG_ER_diArg_1	545	548	PF00400	0.608
TRG_ER_diArg_1	696	699	PF00400	0.447
TRG_ER_diArg_1	700	702	PF00400	0.464
TRG_ER_diArg_1	730	732	PF00400	0.440
TRG_NES_CRM1_1	271	286	PF08389	0.390
TRG_Pf-PMV_PEXEL_1	687	691	PF00026	0.439

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PC22	Leptomonas seymouri	51%	86%
A0A3Q8IB84	Leishmania donovani	74%	99%
A4HZE5	Leishmania infantum	75%	92%
E9AVD2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4QC47	Leishmania major	73%	99%