V-type proton ATPase subunit H

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ATP synthase, putative

Species:

Leishmania braziliensis

UniProt:

A4HBZ2_LEIBR

TriTrypDb:

LbrM.21.1580 , LBRM2903_210021400

Length:

484

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000221	vacuolar proton-transporting V-type ATPase, V1 domain	5	12
GO:0032991	protein-containing complex	1	12
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	12
GO:0033180	proton-transporting V-type ATPase, V1 domain	4	12
GO:0098796	membrane protein complex	2	12

Expansion

Sequence features

A4HBZ2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBZ2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0005215	transporter activity	1	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015078	proton transmembrane transporter activity	5	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0015399	primary active transmembrane transporter activity	4	12
GO:0016787	hydrolase activity	2	6
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022853	active monoatomic ion transmembrane transporter activity	4	12
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	12
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	12
GO:0042626	ATPase-coupled transmembrane transporter activity	2	12
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	12
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	12
GO:0140657	ATP-dependent activity	1	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	178	180	PF00675	0.311
CLV_NRD_NRD_1	270	272	PF00675	0.301
CLV_NRD_NRD_1	333	335	PF00675	0.256
CLV_PCSK_KEX2_1	178	180	PF00082	0.284
CLV_PCSK_KEX2_1	333	335	PF00082	0.287
CLV_PCSK_SKI1_1	183	187	PF00082	0.321
CLV_PCSK_SKI1_1	257	261	PF00082	0.222
CLV_PCSK_SKI1_1	389	393	PF00082	0.247
CLV_PCSK_SKI1_1	435	439	PF00082	0.254
CLV_PCSK_SKI1_1	463	467	PF00082	0.301
DEG_APCC_DBOX_1	256	264	PF00400	0.241
DEG_APCC_KENBOX_2	187	191	PF00400	0.161
DEG_SCF_FBW7_1	374	381	PF00400	0.298
DEG_SPOP_SBC_1	379	383	PF00917	0.384
DOC_CYCLIN_RxL_1	13	24	PF00134	0.304
DOC_CYCLIN_RxL_1	429	439	PF00134	0.384
DOC_CYCLIN_yCln2_LP_2	438	444	PF00134	0.161
DOC_MAPK_gen_1	178	187	PF00069	0.384
DOC_MAPK_gen_1	249	258	PF00069	0.241
DOC_MAPK_gen_1	384	393	PF00069	0.384
DOC_MAPK_gen_1	409	419	PF00069	0.304
DOC_MAPK_MEF2A_6	252	260	PF00069	0.254
DOC_MAPK_MEF2A_6	412	419	PF00069	0.384
DOC_MAPK_MEF2A_6	49	57	PF00069	0.252
DOC_MAPK_RevD_3	320	335	PF00069	0.234
DOC_PP1_RVXF_1	181	188	PF00149	0.323
DOC_PP2B_LxvP_1	438	441	PF13499	0.173
DOC_USP7_MATH_1	351	355	PF00917	0.370
DOC_USP7_UBL2_3	272	276	PF12436	0.304
DOC_WW_Pin1_4	154	159	PF00397	0.268
DOC_WW_Pin1_4	298	303	PF00397	0.304
DOC_WW_Pin1_4	374	379	PF00397	0.254
LIG_14-3-3_CanoR_1	153	157	PF00244	0.384
LIG_14-3-3_CanoR_1	435	441	PF00244	0.397
LIG_BH_BH3_1	66	82	PF00452	0.384
LIG_BRCT_BRCA1_1	305	309	PF00533	0.163
LIG_BRCT_BRCA1_1	381	385	PF00533	0.273
LIG_BRCT_BRCA1_2	305	311	PF00533	0.161
LIG_BRCT_BRCA1_2	381	387	PF00533	0.333
LIG_Clathr_ClatBox_1	223	227	PF01394	0.333
LIG_DLG_GKlike_1	49	57	PF00625	0.384
LIG_eIF4E_1	228	234	PF01652	0.384
LIG_FHA_1	158	164	PF00498	0.317
LIG_FHA_1	198	204	PF00498	0.316
LIG_FHA_1	215	221	PF00498	0.240
LIG_FHA_1	23	29	PF00498	0.203
LIG_FHA_1	41	47	PF00498	0.333
LIG_FHA_1	414	420	PF00498	0.277
LIG_FHA_1	467	473	PF00498	0.366
LIG_FHA_1	64	70	PF00498	0.276
LIG_FHA_1	9	15	PF00498	0.338
LIG_FHA_2	142	148	PF00498	0.161
LIG_FHA_2	162	168	PF00498	0.118
LIG_FHA_2	62	68	PF00498	0.375
LIG_LIR_Gen_1	142	152	PF02991	0.322
LIG_LIR_Gen_1	395	404	PF02991	0.301
LIG_LIR_Nem_3	142	148	PF02991	0.341
LIG_LIR_Nem_3	181	185	PF02991	0.348
LIG_LIR_Nem_3	225	231	PF02991	0.257
LIG_LIR_Nem_3	360	365	PF02991	0.254
LIG_LIR_Nem_3	375	379	PF02991	0.254
LIG_LIR_Nem_3	395	401	PF02991	0.118
LIG_NRBOX	219	225	PF00104	0.384
LIG_NRBOX	259	265	PF00104	0.384
LIG_Pex14_1	222	226	PF04695	0.239
LIG_Pex14_2	145	149	PF04695	0.384
LIG_Pex14_2	182	186	PF04695	0.249
LIG_REV1ctd_RIR_1	184	191	PF16727	0.188
LIG_SH2_GRB2like	273	276	PF00017	0.298
LIG_SH2_SRC	82	85	PF00017	0.161
LIG_SH2_STAP1	215	219	PF00017	0.239
LIG_SH2_STAP1	398	402	PF00017	0.352
LIG_SH2_STAP1	72	76	PF00017	0.384
LIG_SH2_STAT5	291	294	PF00017	0.161
LIG_Sin3_3	105	112	PF02671	0.353
LIG_SUMO_SIM_anti_2	10	16	PF11976	0.490
LIG_SUMO_SIM_anti_2	229	235	PF11976	0.366
LIG_SUMO_SIM_par_1	216	221	PF11976	0.298
LIG_SUMO_SIM_par_1	231	237	PF11976	0.298
LIG_SUMO_SIM_par_1	413	420	PF11976	0.161
LIG_TRAF2_1	281	284	PF00917	0.304
LIG_UBA3_1	401	406	PF00899	0.268
LIG_WRC_WIRS_1	191	196	PF05994	0.161
LIG_WRC_WIRS_1	223	228	PF05994	0.333
LIG_WRC_WIRS_1	359	364	PF05994	0.254
MOD_CK1_1	113	119	PF00069	0.435
MOD_CK1_1	157	163	PF00069	0.173
MOD_CK1_1	204	210	PF00069	0.287
MOD_CK1_1	329	335	PF00069	0.304
MOD_CK2_1	111	117	PF00069	0.384
MOD_CK2_1	141	147	PF00069	0.168
MOD_CK2_1	161	167	PF00069	0.118
MOD_CK2_1	278	284	PF00069	0.333
MOD_CK2_1	408	414	PF00069	0.341
MOD_CK2_1	454	460	PF00069	0.379
MOD_CK2_1	61	67	PF00069	0.375
MOD_GlcNHglycan	206	209	PF01048	0.297
MOD_GlcNHglycan	348	351	PF01048	0.175
MOD_GlcNHglycan	370	373	PF01048	0.254
MOD_GlcNHglycan	4	7	PF01048	0.482
MOD_GSK3_1	111	118	PF00069	0.384
MOD_GSK3_1	157	164	PF00069	0.321
MOD_GSK3_1	197	204	PF00069	0.337
MOD_GSK3_1	214	221	PF00069	0.188
MOD_GSK3_1	374	381	PF00069	0.257
MOD_GSK3_1	413	420	PF00069	0.243
MOD_NEK2_1	128	133	PF00069	0.247
MOD_NEK2_1	161	166	PF00069	0.268
MOD_NEK2_1	21	26	PF00069	0.275
MOD_NEK2_1	218	223	PF00069	0.297
MOD_NEK2_1	305	310	PF00069	0.174
MOD_NEK2_1	324	329	PF00069	0.239
MOD_NEK2_1	352	357	PF00069	0.507
MOD_NEK2_1	41	46	PF00069	0.254
MOD_NEK2_1	417	422	PF00069	0.237
MOD_NEK2_1	452	457	PF00069	0.390
MOD_NEK2_1	466	471	PF00069	0.347
MOD_PIKK_1	326	332	PF00454	0.333
MOD_PIKK_1	360	366	PF00454	0.384
MOD_PIKK_1	466	472	PF00454	0.384
MOD_PKA_2	152	158	PF00069	0.384
MOD_PKA_2	408	414	PF00069	0.304
MOD_Plk_1	141	147	PF00069	0.329
MOD_Plk_1	166	172	PF00069	0.245
MOD_Plk_1	21	27	PF00069	0.251
MOD_Plk_1	352	358	PF00069	0.408
MOD_Plk_1	413	419	PF00069	0.273
MOD_Plk_1	49	55	PF00069	0.372
MOD_Plk_4	103	109	PF00069	0.350
MOD_Plk_4	141	147	PF00069	0.328
MOD_Plk_4	190	196	PF00069	0.376
MOD_Plk_4	206	212	PF00069	0.169
MOD_Plk_4	214	220	PF00069	0.256
MOD_Plk_4	259	265	PF00069	0.328
MOD_Plk_4	311	317	PF00069	0.333
MOD_Plk_4	41	47	PF00069	0.250
MOD_ProDKin_1	154	160	PF00069	0.268
MOD_ProDKin_1	298	304	PF00069	0.304
MOD_ProDKin_1	374	380	PF00069	0.254
MOD_SUMO_for_1	391	394	PF00179	0.161
MOD_SUMO_rev_2	268	274	PF00179	0.384
TRG_DiLeu_BaEn_1	227	232	PF01217	0.390
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.333
TRG_ENDOCYTIC_2	215	218	PF00928	0.239
TRG_ENDOCYTIC_2	228	231	PF00928	0.239
TRG_ENDOCYTIC_2	398	401	PF00928	0.303
TRG_NES_CRM1_1	10	23	PF08389	0.399
TRG_Pf-PMV_PEXEL_1	238	242	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	27	31	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	406	410	PF00026	0.384
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.384

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIH3	Leptomonas seymouri	83%	100%
A0A0S4JQ71	Bodo saltans	43%	100%
A0A1X0NJ38	Trypanosomatidae	56%	100%
A0A3S5H7A0	Leishmania donovani	87%	100%
A0A422NSW7	Trypanosoma rangeli	53%	100%
A4HZD2	Leishmania infantum	87%	100%
D0A152	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AVB9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O14265	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q4QC61	Leishmania major	87%	100%
Q9U5N0	Manduca sexta	27%	100%
Q9V3J1	Drosophila melanogaster	31%	100%
V5B1U1	Trypanosoma cruzi	50%	100%