GBBH-like_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF971), putative

Species:

Leishmania braziliensis

UniProt:

A4HBZ0_LEIBR

TriTrypDb:

LbrM.21.1560

Length:

321

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBZ0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBZ0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	109	111	PF00675	0.409
CLV_NRD_NRD_1	23	25	PF00675	0.614
CLV_NRD_NRD_1	235	237	PF00675	0.241
CLV_NRD_NRD_1	292	294	PF00675	0.493
CLV_NRD_NRD_1	85	87	PF00675	0.552
CLV_PCSK_FUR_1	21	25	PF00082	0.514
CLV_PCSK_FUR_1	290	294	PF00082	0.587
CLV_PCSK_KEX2_1	109	111	PF00082	0.541
CLV_PCSK_KEX2_1	21	23	PF00082	0.609
CLV_PCSK_KEX2_1	235	237	PF00082	0.228
CLV_PCSK_KEX2_1	292	294	PF00082	0.496
CLV_PCSK_KEX2_1	300	302	PF00082	0.525
CLV_PCSK_KEX2_1	85	87	PF00082	0.532
CLV_PCSK_PC1ET2_1	300	302	PF00082	0.496
CLV_PCSK_PC7_1	296	302	PF00082	0.509
CLV_PCSK_SKI1_1	252	256	PF00082	0.271
CLV_PCSK_SKI1_1	47	51	PF00082	0.589
CLV_PCSK_SKI1_1	79	83	PF00082	0.584
CLV_PCSK_SKI1_1	9	13	PF00082	0.526
DEG_Nend_UBRbox_3	1	3	PF02207	0.464
DEG_SPOP_SBC_1	154	158	PF00917	0.736
DOC_CYCLIN_RxL_1	44	53	PF00134	0.531
DOC_MAPK_gen_1	118	128	PF00069	0.390
DOC_MAPK_gen_1	235	243	PF00069	0.378
DOC_MAPK_gen_1	7	16	PF00069	0.637
DOC_PP2B_LxvP_1	197	200	PF13499	0.402
DOC_PP4_FxxP_1	128	131	PF00568	0.459
DOC_USP7_MATH_1	137	141	PF00917	0.385
DOC_USP7_MATH_1	154	158	PF00917	0.554
DOC_USP7_MATH_1	164	168	PF00917	0.543
DOC_USP7_MATH_1	174	178	PF00917	0.574
DOC_USP7_MATH_1	40	44	PF00917	0.577
DOC_USP7_MATH_1	94	98	PF00917	0.635
DOC_WW_Pin1_4	144	149	PF00397	0.701
DOC_WW_Pin1_4	150	155	PF00397	0.505
DOC_WW_Pin1_4	160	165	PF00397	0.694
DOC_WW_Pin1_4	190	195	PF00397	0.670
DOC_WW_Pin1_4	215	220	PF00397	0.414
DOC_WW_Pin1_4	26	31	PF00397	0.630
DOC_WW_Pin1_4	299	304	PF00397	0.504
LIG_14-3-3_CanoR_1	139	144	PF00244	0.580
LIG_14-3-3_CanoR_1	21	30	PF00244	0.580
LIG_14-3-3_CanoR_1	47	55	PF00244	0.566
LIG_14-3-3_CanoR_1	9	17	PF00244	0.606
LIG_14-3-3_CanoR_1	92	102	PF00244	0.554
LIG_Actin_WH2_2	237	254	PF00022	0.441
LIG_BH_BH3_1	47	63	PF00452	0.497
LIG_FHA_1	145	151	PF00498	0.464
LIG_FHA_1	173	179	PF00498	0.486
LIG_FHA_1	205	211	PF00498	0.354
LIG_FHA_1	49	55	PF00498	0.549
LIG_FHA_1	6	12	PF00498	0.450
LIG_FHA_2	127	133	PF00498	0.329
LIG_LIR_Apic_2	127	131	PF02991	0.463
LIG_LIR_Gen_1	122	131	PF02991	0.359
LIG_LIR_Gen_1	265	272	PF02991	0.516
LIG_LIR_Gen_1	304	315	PF02991	0.374
LIG_LIR_Nem_3	122	128	PF02991	0.365
LIG_LIR_Nem_3	265	271	PF02991	0.525
LIG_LIR_Nem_3	304	310	PF02991	0.330
LIG_RPA_C_Fungi	231	243	PF08784	0.257
LIG_SH2_CRK	307	311	PF00017	0.312
LIG_SH2_GRB2like	307	310	PF00017	0.314
LIG_SH2_STAP1	249	253	PF00017	0.260
LIG_SH2_STAP1	264	268	PF00017	0.260
LIG_SH2_STAP1	307	311	PF00017	0.433
LIG_SH2_STAT5	125	128	PF00017	0.350
LIG_SH2_STAT5	213	216	PF00017	0.434
LIG_SH2_STAT5	217	220	PF00017	0.440
LIG_SH2_STAT5	268	271	PF00017	0.316
LIG_SH2_STAT5	285	288	PF00017	0.368
LIG_SH2_STAT5	48	51	PF00017	0.517
LIG_SH3_2	201	206	PF14604	0.325
LIG_SH3_3	11	17	PF00018	0.580
LIG_SH3_3	198	204	PF00018	0.562
LIG_SH3_3	78	84	PF00018	0.561
LIG_SH3_CIN85_PxpxPR_1	190	195	PF14604	0.455
LIG_TYR_ITIM	305	310	PF00017	0.328
MOD_CDK_SPK_2	150	155	PF00069	0.499
MOD_CDK_SPK_2	190	195	PF00069	0.455
MOD_CDK_SPxxK_3	299	306	PF00069	0.374
MOD_CK1_1	142	148	PF00069	0.690
MOD_CK1_1	153	159	PF00069	0.685
MOD_CK1_1	28	34	PF00069	0.515
MOD_CK1_1	53	59	PF00069	0.586
MOD_CK1_1	61	67	PF00069	0.468
MOD_CK2_1	126	132	PF00069	0.501
MOD_CK2_1	94	100	PF00069	0.458
MOD_Cter_Amidation	233	236	PF01082	0.260
MOD_DYRK1A_RPxSP_1	215	219	PF00069	0.277
MOD_GlcNHglycan	172	175	PF01048	0.744
MOD_GlcNHglycan	181	184	PF01048	0.708
MOD_GlcNHglycan	187	190	PF01048	0.577
MOD_GlcNHglycan	259	262	PF01048	0.239
MOD_GlcNHglycan	42	45	PF01048	0.661
MOD_GSK3_1	150	157	PF00069	0.655
MOD_GSK3_1	160	167	PF00069	0.694
MOD_GSK3_1	170	177	PF00069	0.677
MOD_GSK3_1	22	29	PF00069	0.641
MOD_GSK3_1	253	260	PF00069	0.231
MOD_GSK3_1	270	277	PF00069	0.455
MOD_GSK3_1	49	56	PF00069	0.508
MOD_GSK3_1	5	12	PF00069	0.705
MOD_N-GLC_1	94	99	PF02516	0.481
MOD_NEK2_1	49	54	PF00069	0.574
MOD_NEK2_1	58	63	PF00069	0.389
MOD_NEK2_1	69	74	PF00069	0.414
MOD_PIKK_1	165	171	PF00454	0.645
MOD_PIKK_1	32	38	PF00454	0.540
MOD_PIKK_1	64	70	PF00454	0.505
MOD_PK_1	301	307	PF00069	0.418
MOD_PKA_1	22	28	PF00069	0.579
MOD_PKA_1	292	298	PF00069	0.430
MOD_PKA_2	22	28	PF00069	0.621
MOD_PKA_2	292	298	PF00069	0.453
MOD_PKB_1	290	298	PF00069	0.464
MOD_PKB_1	7	15	PF00069	0.448
MOD_Plk_1	126	132	PF00069	0.467
MOD_Plk_1	94	100	PF00069	0.478
MOD_Plk_4	50	56	PF00069	0.483
MOD_Plk_4	69	75	PF00069	0.404
MOD_ProDKin_1	144	150	PF00069	0.703
MOD_ProDKin_1	160	166	PF00069	0.693
MOD_ProDKin_1	190	196	PF00069	0.667
MOD_ProDKin_1	215	221	PF00069	0.240
MOD_ProDKin_1	26	32	PF00069	0.633
MOD_ProDKin_1	299	305	PF00069	0.501
MOD_SUMO_rev_2	71	81	PF00179	0.561
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.568
TRG_ENDOCYTIC_2	125	128	PF00928	0.333
TRG_ENDOCYTIC_2	266	269	PF00928	0.260
TRG_ENDOCYTIC_2	279	282	PF00928	0.346
TRG_ENDOCYTIC_2	307	310	PF00928	0.368
TRG_ER_diArg_1	108	110	PF00400	0.523
TRG_ER_diArg_1	20	23	PF00400	0.608
TRG_ER_diArg_1	205	208	PF00400	0.371
TRG_ER_diArg_1	289	292	PF00400	0.495
TRG_ER_diArg_1	84	86	PF00400	0.529
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3G8	Leptomonas seymouri	62%	100%
A0A0S4ILQ9	Bodo saltans	37%	100%
A0A1X0NI95	Trypanosomatidae	39%	100%
A0A3Q8IAY8	Leishmania donovani	67%	75%
A4HZD8	Leishmania infantum	67%	68%
D0A147	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AVC5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	72%
Q4QC54	Leishmania major	71%	100%
V5BHB7	Trypanosoma cruzi	44%	100%