Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBY9_LEIBR

TriTrypDb:

LbrM.21.1550

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HBY9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBY9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.605
CLV_NRD_NRD_1	232	234	PF00675	0.473
CLV_NRD_NRD_1	257	259	PF00675	0.662
CLV_NRD_NRD_1	82	84	PF00675	0.507
CLV_PCSK_KEX2_1	232	234	PF00082	0.464
CLV_PCSK_KEX2_1	257	259	PF00082	0.610
CLV_PCSK_KEX2_1	82	84	PF00082	0.507
CLV_PCSK_SKI1_1	10	14	PF00082	0.498
CLV_PCSK_SKI1_1	143	147	PF00082	0.651
CLV_PCSK_SKI1_1	18	22	PF00082	0.578
CLV_PCSK_SKI1_1	206	210	PF00082	0.466
CLV_PCSK_SKI1_1	35	39	PF00082	0.410
CLV_PCSK_SKI1_1	82	86	PF00082	0.534
DEG_Nend_Nbox_1	1	3	PF02207	0.381
DEG_SPOP_SBC_1	163	167	PF00917	0.513
DOC_CKS1_1	87	92	PF01111	0.640
DOC_CYCLIN_RxL_1	15	24	PF00134	0.536
DOC_CYCLIN_RxL_1	5	14	PF00134	0.540
DOC_MAPK_MEF2A_6	202	209	PF00069	0.419
DOC_MAPK_NFAT4_5	202	210	PF00069	0.360
DOC_PP1_RVXF_1	204	210	PF00149	0.439
DOC_PP1_RVXF_1	65	71	PF00149	0.580
DOC_PP1_RVXF_1	80	87	PF00149	0.533
DOC_PP2B_LxvP_1	108	111	PF13499	0.631
DOC_PP4_MxPP_1	101	104	PF00568	0.446
DOC_SPAK_OSR1_1	202	206	PF12202	0.451
DOC_USP7_MATH_1	161	165	PF00917	0.515
DOC_USP7_MATH_1	90	94	PF00917	0.650
DOC_USP7_MATH_1	95	99	PF00917	0.651
DOC_WW_Pin1_4	86	91	PF00397	0.480
LIG_14-3-3_CanoR_1	262	269	PF00244	0.681
LIG_14-3-3_CanoR_1	40	45	PF00244	0.517
LIG_APCC_ABBA_1	115	120	PF00400	0.525
LIG_APCC_ABBA_1	196	201	PF00400	0.582
LIG_APCC_ABBAyCdc20_2	195	201	PF00400	0.577
LIG_CaM_IQ_9	27	42	PF13499	0.523
LIG_Clathr_ClatBox_1	116	120	PF01394	0.505
LIG_Clathr_ClatBox_1	20	24	PF01394	0.460
LIG_CtBP_PxDLS_1	111	115	PF00389	0.521
LIG_deltaCOP1_diTrp_1	256	261	PF00928	0.628
LIG_DLG_GKlike_1	40	47	PF00625	0.447
LIG_LIR_Gen_1	187	198	PF02991	0.507
LIG_LIR_Gen_1	39	50	PF02991	0.482
LIG_LIR_Nem_3	222	228	PF02991	0.400
LIG_LIR_Nem_3	39	45	PF02991	0.485
LIG_NRBOX	203	209	PF00104	0.354
LIG_NRP_CendR_1	270	271	PF00754	0.568
LIG_PCNA_APIM_2	200	206	PF02747	0.448
LIG_Pex14_1	224	228	PF04695	0.573
LIG_REV1ctd_RIR_1	83	89	PF16727	0.605
LIG_SH2_CRK	213	217	PF00017	0.469
LIG_SH2_CRK	9	13	PF00017	0.491
LIG_SH2_STAT5	190	193	PF00017	0.539
LIG_SH2_STAT5	213	216	PF00017	0.508
LIG_SH2_STAT5	228	231	PF00017	0.382
LIG_SH2_STAT5	36	39	PF00017	0.467
LIG_SH2_STAT5	50	53	PF00017	0.434
LIG_SH2_STAT5	69	72	PF00017	0.705
LIG_SH3_3	100	106	PF00018	0.552
LIG_SUMO_SIM_anti_2	112	118	PF11976	0.523
LIG_WW_3	267	271	PF00397	0.454
MOD_CK1_1	162	168	PF00069	0.612
MOD_CK1_1	170	176	PF00069	0.584
MOD_CK1_1	43	49	PF00069	0.494
MOD_CK1_1	72	78	PF00069	0.482
MOD_GlcNHglycan	161	164	PF01048	0.659
MOD_GlcNHglycan	172	175	PF01048	0.566
MOD_GlcNHglycan	247	250	PF01048	0.688
MOD_GlcNHglycan	92	95	PF01048	0.681
MOD_GSK3_1	147	154	PF00069	0.539
MOD_GSK3_1	159	166	PF00069	0.626
MOD_GSK3_1	184	191	PF00069	0.536
MOD_GSK3_1	86	93	PF00069	0.658
MOD_N-GLC_1	147	152	PF02516	0.549
MOD_N-GLC_1	188	193	PF02516	0.628
MOD_N-GLC_1	40	45	PF02516	0.493
MOD_NEK2_1	146	151	PF00069	0.542
MOD_NEK2_1	184	189	PF00069	0.524
MOD_PIKK_1	11	17	PF00454	0.640
MOD_PIKK_1	121	127	PF00454	0.572
MOD_Plk_1	141	147	PF00069	0.578
MOD_Plk_1	188	194	PF00069	0.535
MOD_Plk_1	40	46	PF00069	0.485
MOD_Plk_4	46	52	PF00069	0.369
MOD_ProDKin_1	86	92	PF00069	0.485
TRG_DiLeu_BaEn_1	112	117	PF01217	0.593
TRG_DiLeu_BaEn_2	180	186	PF01217	0.489
TRG_DiLeu_BaLyEn_6	203	208	PF01217	0.360
TRG_ENDOCYTIC_2	190	193	PF00928	0.509
TRG_ENDOCYTIC_2	213	216	PF00928	0.457
TRG_ENDOCYTIC_2	9	12	PF00928	0.480
TRG_ER_diArg_1	257	259	PF00400	0.620
TRG_ER_diArg_1	269	271	PF00400	0.652
TRG_ER_diArg_1	33	36	PF00400	0.622
TRG_ER_diArg_1	65	68	PF00400	0.668
TRG_ER_diArg_1	81	83	PF00400	0.384
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	82	87	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3V9	Leptomonas seymouri	60%	99%
A0A0S4IH77	Bodo saltans	31%	100%
A0A1X0NHE8	Trypanosomatidae	44%	100%
A0A3S7WWT7	Leishmania donovani	80%	100%
A4HZD9	Leishmania infantum	80%	100%
D0A146	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AVC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QC53	Leishmania major	79%	99%
V5B1U8	Trypanosoma cruzi	40%	100%