RF_PROK_I domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RF-1 domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBY7_LEIBR

TriTrypDb:

LbrM.21.1520 , LBRM2903_210020800

Length:

681

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBY7

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	2
GO:0032259	methylation	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003747	translation release factor activity	5	11
GO:0005488	binding	1	11
GO:0008079	translation termination factor activity	4	11
GO:0008135	translation factor activity, RNA binding	3	11
GO:0045182	translation regulator activity	1	11
GO:0090079	translation regulator activity, nucleic acid binding	2	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	2
GO:0008168	methyltransferase activity	4	2
GO:0016740	transferase activity	2	2
GO:0016741	transferase activity, transferring one-carbon groups	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	287	291	PF00656	0.521
CLV_C14_Caspase3-7	588	592	PF00656	0.448
CLV_C14_Caspase3-7	661	665	PF00656	0.501
CLV_NRD_NRD_1	123	125	PF00675	0.593
CLV_NRD_NRD_1	213	215	PF00675	0.737
CLV_NRD_NRD_1	234	236	PF00675	0.573
CLV_NRD_NRD_1	3	5	PF00675	0.514
CLV_NRD_NRD_1	345	347	PF00675	0.475
CLV_NRD_NRD_1	353	355	PF00675	0.459
CLV_NRD_NRD_1	37	39	PF00675	0.633
CLV_NRD_NRD_1	436	438	PF00675	0.375
CLV_NRD_NRD_1	610	612	PF00675	0.248
CLV_PCSK_FUR_1	350	354	PF00082	0.486
CLV_PCSK_KEX2_1	3	5	PF00082	0.514
CLV_PCSK_KEX2_1	352	354	PF00082	0.469
CLV_PCSK_KEX2_1	37	39	PF00082	0.633
CLV_PCSK_KEX2_1	436	438	PF00082	0.375
CLV_PCSK_KEX2_1	547	549	PF00082	0.487
CLV_PCSK_KEX2_1	610	612	PF00082	0.248
CLV_PCSK_KEX2_1	658	660	PF00082	0.301
CLV_PCSK_PC1ET2_1	547	549	PF00082	0.487
CLV_PCSK_PC1ET2_1	658	660	PF00082	0.301
CLV_PCSK_SKI1_1	14	18	PF00082	0.658
CLV_PCSK_SKI1_1	293	297	PF00082	0.543
CLV_PCSK_SKI1_1	303	307	PF00082	0.547
CLV_PCSK_SKI1_1	37	41	PF00082	0.524
CLV_PCSK_SKI1_1	593	597	PF00082	0.237
CLV_PCSK_SKI1_1	658	662	PF00082	0.356
DEG_Nend_Nbox_1	1	3	PF02207	0.542
DEG_SPOP_SBC_1	153	157	PF00917	0.620
DEG_SPOP_SBC_1	170	174	PF00917	0.519
DEG_SPOP_SBC_1	316	320	PF00917	0.564
DEG_SPOP_SBC_1	322	326	PF00917	0.568
DEG_SPOP_SBC_1	492	496	PF00917	0.463
DEG_SPOP_SBC_1	54	58	PF00917	0.650
DOC_ANK_TNKS_1	556	563	PF00023	0.437
DOC_CKS1_1	148	153	PF01111	0.661
DOC_MAPK_DCC_7	3	13	PF00069	0.519
DOC_MAPK_gen_1	270	280	PF00069	0.437
DOC_MAPK_gen_1	3	10	PF00069	0.474
DOC_MAPK_gen_1	350	360	PF00069	0.445
DOC_MAPK_MEF2A_6	352	360	PF00069	0.439
DOC_MAPK_MEF2A_6	4	13	PF00069	0.518
DOC_MAPK_RevD_3	220	236	PF00069	0.523
DOC_PP2B_LxvP_1	144	147	PF13499	0.489
DOC_PP2B_LxvP_1	524	527	PF13499	0.416
DOC_USP7_MATH_1	154	158	PF00917	0.706
DOC_USP7_MATH_1	168	172	PF00917	0.720
DOC_USP7_MATH_1	193	197	PF00917	0.560
DOC_USP7_MATH_1	21	25	PF00917	0.520
DOC_USP7_MATH_1	27	31	PF00917	0.498
DOC_USP7_MATH_1	315	319	PF00917	0.634
DOC_USP7_MATH_1	340	344	PF00917	0.561
DOC_USP7_MATH_1	388	392	PF00917	0.523
DOC_USP7_MATH_1	536	540	PF00917	0.362
DOC_USP7_MATH_1	54	58	PF00917	0.617
DOC_USP7_MATH_1	556	560	PF00917	0.345
DOC_USP7_MATH_1	589	593	PF00917	0.448
DOC_USP7_UBL2_3	121	125	PF12436	0.536
DOC_USP7_UBL2_3	131	135	PF12436	0.509
DOC_WW_Pin1_4	147	152	PF00397	0.681
DOC_WW_Pin1_4	17	22	PF00397	0.490
DOC_WW_Pin1_4	179	184	PF00397	0.714
DOC_WW_Pin1_4	370	375	PF00397	0.538
DOC_WW_Pin1_4	493	498	PF00397	0.376
DOC_WW_Pin1_4	69	74	PF00397	0.723
LIG_14-3-3_CanoR_1	14	23	PF00244	0.651
LIG_14-3-3_CanoR_1	3	9	PF00244	0.633
LIG_14-3-3_CanoR_1	519	525	PF00244	0.516
LIG_14-3-3_CanoR_1	548	554	PF00244	0.360
LIG_14-3-3_CanoR_1	659	667	PF00244	0.512
LIG_Actin_WH2_2	274	291	PF00022	0.510
LIG_BIR_III_2	489	493	PF00653	0.551
LIG_BIR_III_4	379	383	PF00653	0.467
LIG_EVH1_2	525	529	PF00568	0.371
LIG_FHA_1	135	141	PF00498	0.687
LIG_FHA_2	270	276	PF00498	0.517
LIG_FHA_2	324	330	PF00498	0.416
LIG_FHA_2	659	665	PF00498	0.347
LIG_GBD_Chelix_1	504	512	PF00786	0.329
LIG_LIR_Gen_1	223	232	PF02991	0.425
LIG_LIR_Gen_1	241	250	PF02991	0.423
LIG_LIR_Gen_1	324	334	PF02991	0.563
LIG_LIR_Gen_1	399	409	PF02991	0.424
LIG_LIR_Gen_1	446	454	PF02991	0.396
LIG_LIR_Gen_1	571	582	PF02991	0.539
LIG_LIR_Nem_3	223	229	PF02991	0.428
LIG_LIR_Nem_3	241	246	PF02991	0.427
LIG_LIR_Nem_3	324	330	PF02991	0.640
LIG_LIR_Nem_3	399	405	PF02991	0.430
LIG_LIR_Nem_3	446	451	PF02991	0.395
LIG_LIR_Nem_3	571	577	PF02991	0.539
LIG_NRBOX	139	145	PF00104	0.495
LIG_NRBOX	329	335	PF00104	0.525
LIG_PDZ_Class_1	676	681	PF00595	0.419
LIG_Pex14_2	40	44	PF04695	0.645
LIG_RPA_C_Fungi	594	606	PF08784	0.205
LIG_SH2_CRK	243	247	PF00017	0.340
LIG_SH2_CRK	448	452	PF00017	0.347
LIG_SH2_CRK	574	578	PF00017	0.417
LIG_SH2_PTP2	431	434	PF00017	0.491
LIG_SH2_STAP1	448	452	PF00017	0.369
LIG_SH2_STAP1	502	506	PF00017	0.416
LIG_SH2_STAP1	574	578	PF00017	0.448
LIG_SH2_STAT5	431	434	PF00017	0.432
LIG_SH2_STAT5	438	441	PF00017	0.390
LIG_SH3_1	145	151	PF00018	0.512
LIG_SH3_3	145	151	PF00018	0.782
LIG_SH3_3	80	86	PF00018	0.529
LIG_SUMO_SIM_anti_2	277	284	PF11976	0.442
LIG_SUMO_SIM_anti_2	30	36	PF11976	0.509
LIG_SUMO_SIM_anti_2	622	628	PF11976	0.364
LIG_TRAF2_1	274	277	PF00917	0.339
LIG_TRAF2_1	393	396	PF00917	0.591
LIG_TRAF2_1	619	622	PF00917	0.368
LIG_TRAF2_1	642	645	PF00917	0.421
LIG_TYR_ITIM	429	434	PF00017	0.508
LIG_UBA3_1	122	131	PF00899	0.698
LIG_WRC_WIRS_1	41	46	PF05994	0.490
MOD_CDK_SPK_2	179	184	PF00069	0.570
MOD_CDK_SPK_2	370	375	PF00069	0.418
MOD_CDK_SPxK_1	69	75	PF00069	0.799
MOD_CK1_1	155	161	PF00069	0.781
MOD_CK1_1	162	168	PF00069	0.727
MOD_CK1_1	169	175	PF00069	0.673
MOD_CK1_1	178	184	PF00069	0.606
MOD_CK1_1	202	208	PF00069	0.607
MOD_CK1_1	266	272	PF00069	0.460
MOD_CK1_1	291	297	PF00069	0.515
MOD_CK1_1	365	371	PF00069	0.538
MOD_CK1_1	391	397	PF00069	0.501
MOD_CK1_1	507	513	PF00069	0.426
MOD_CK1_1	53	59	PF00069	0.696
MOD_CK1_1	594	600	PF00069	0.341
MOD_CK1_1	71	77	PF00069	0.714
MOD_CK2_1	206	212	PF00069	0.558
MOD_CK2_1	245	251	PF00069	0.525
MOD_CK2_1	258	264	PF00069	0.527
MOD_CK2_1	269	275	PF00069	0.494
MOD_CK2_1	594	600	PF00069	0.340
MOD_GlcNHglycan	161	164	PF01048	0.616
MOD_GlcNHglycan	168	171	PF01048	0.621
MOD_GlcNHglycan	201	204	PF01048	0.614
MOD_GlcNHglycan	247	250	PF01048	0.598
MOD_GlcNHglycan	465	468	PF01048	0.279
MOD_GlcNHglycan	47	50	PF01048	0.629
MOD_GlcNHglycan	509	512	PF01048	0.412
MOD_GlcNHglycan	516	519	PF01048	0.594
MOD_GlcNHglycan	52	55	PF01048	0.618
MOD_GlcNHglycan	532	535	PF01048	0.486
MOD_GlcNHglycan	538	541	PF01048	0.431
MOD_GlcNHglycan	558	561	PF01048	0.145
MOD_GlcNHglycan	57	60	PF01048	0.584
MOD_GlcNHglycan	593	596	PF01048	0.274
MOD_GlcNHglycan	678	681	PF01048	0.351
MOD_GSK3_1	152	159	PF00069	0.727
MOD_GSK3_1	162	169	PF00069	0.672
MOD_GSK3_1	17	24	PF00069	0.520
MOD_GSK3_1	171	178	PF00069	0.637
MOD_GSK3_1	202	209	PF00069	0.614
MOD_GSK3_1	259	266	PF00069	0.587
MOD_GSK3_1	311	318	PF00069	0.663
MOD_GSK3_1	358	365	PF00069	0.425
MOD_GSK3_1	439	446	PF00069	0.357
MOD_GSK3_1	50	57	PF00069	0.652
MOD_GSK3_1	552	559	PF00069	0.341
MOD_GSK3_1	67	74	PF00069	0.779
MOD_N-GLC_1	199	204	PF02516	0.750
MOD_N-GLC_1	365	370	PF02516	0.508
MOD_N-GLC_1	4	9	PF02516	0.508
MOD_N-GLC_1	614	619	PF02516	0.350
MOD_N-GLC_1	67	72	PF02516	0.811
MOD_NEK2_1	100	105	PF00069	0.550
MOD_NEK2_1	15	20	PF00069	0.690
MOD_NEK2_1	199	204	PF00069	0.726
MOD_NEK2_1	288	293	PF00069	0.596
MOD_NEK2_1	298	303	PF00069	0.502
MOD_NEK2_1	33	38	PF00069	0.520
MOD_NEK2_1	358	363	PF00069	0.439
MOD_NEK2_1	40	45	PF00069	0.531
MOD_NEK2_1	504	509	PF00069	0.403
MOD_NEK2_1	529	534	PF00069	0.373
MOD_NEK2_1	676	681	PF00069	0.424
MOD_PIKK_1	100	106	PF00454	0.564
MOD_PIKK_1	193	199	PF00454	0.718
MOD_PIKK_1	296	302	PF00454	0.667
MOD_PIKK_1	391	397	PF00454	0.529
MOD_PIKK_1	568	574	PF00454	0.274
MOD_PK_1	4	10	PF00069	0.508
MOD_PKA_1	3	9	PF00069	0.633
MOD_PKA_1	658	664	PF00069	0.283
MOD_PKA_2	288	294	PF00069	0.520
MOD_PKA_2	3	9	PF00069	0.637
MOD_PKA_2	549	555	PF00069	0.344
MOD_PKA_2	556	562	PF00069	0.280
MOD_PKA_2	658	664	PF00069	0.283
MOD_Plk_1	263	269	PF00069	0.463
MOD_Plk_1	365	371	PF00069	0.581
MOD_Plk_1	4	10	PF00069	0.508
MOD_Plk_1	614	620	PF00069	0.350
MOD_ProDKin_1	147	153	PF00069	0.682
MOD_ProDKin_1	17	23	PF00069	0.486
MOD_ProDKin_1	179	185	PF00069	0.714
MOD_ProDKin_1	370	376	PF00069	0.542
MOD_ProDKin_1	493	499	PF00069	0.369
MOD_ProDKin_1	69	75	PF00069	0.724
MOD_SUMO_for_1	305	308	PF00179	0.665
MOD_SUMO_for_1	619	622	PF00179	0.358
MOD_SUMO_rev_2	251	260	PF00179	0.526
TRG_AP2beta_CARGO_1	223	233	PF09066	0.425
TRG_DiLeu_BaEn_1	118	123	PF01217	0.409
TRG_DiLeu_BaEn_1	622	627	PF01217	0.454
TRG_DiLeu_BaLyEn_6	11	16	PF01217	0.505
TRG_DiLeu_BaLyEn_6	353	358	PF01217	0.441
TRG_ENDOCYTIC_2	243	246	PF00928	0.584
TRG_ENDOCYTIC_2	327	330	PF00928	0.634
TRG_ENDOCYTIC_2	431	434	PF00928	0.402
TRG_ENDOCYTIC_2	448	451	PF00928	0.233
TRG_ENDOCYTIC_2	574	577	PF00928	0.417
TRG_ER_diArg_1	2	4	PF00400	0.508
TRG_ER_diArg_1	232	235	PF00400	0.528
TRG_ER_diArg_1	350	353	PF00400	0.470
TRG_ER_diArg_1	435	437	PF00400	0.364
TRG_ER_diArg_1	548	551	PF00400	0.276
TRG_ER_diArg_1	610	612	PF00400	0.337
TRG_Pf-PMV_PEXEL_1	138	142	PF00026	0.426
TRG_Pf-PMV_PEXEL_1	303	308	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P368	Leptomonas seymouri	55%	100%
A0A0S4JFA6	Bodo saltans	36%	100%
A0A1X0NXZ0	Trypanosomatidae	44%	96%
A0A3Q8IB76	Leishmania donovani	81%	100%
A0A422NSQ1	Trypanosoma rangeli	42%	100%
A4HZC8	Leishmania infantum	81%	100%
D0A156	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AVB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
Q4QC65	Leishmania major	81%	100%
V5BLU1	Trypanosoma cruzi	40%	100%