RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Ring finger domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBY6_LEIBR

TriTrypDb:

LbrM.21.1510 , LBRM2903_210020600

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0000151	ubiquitin ligase complex	3	1
GO:0005634	nucleus	5	1
GO:0031461	cullin-RING ubiquitin ligase complex	4	1
GO:0032991	protein-containing complex	1	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1990234	transferase complex	3	1

Expansion

Sequence features

A4HBY6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBY6

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	1
GO:0006511	ubiquitin-dependent protein catabolic process	7	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0009987	cellular process	1	1
GO:0016567	protein ubiquitination	7	1
GO:0019538	protein metabolic process	3	1
GO:0019941	modification-dependent protein catabolic process	6	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0043632	modification-dependent macromolecule catabolic process	5	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0044248	cellular catabolic process	3	1
GO:0044260	obsolete cellular macromolecule metabolic process	3	1
GO:0044265	obsolete cellular macromolecule catabolic process	4	1
GO:0051603	proteolysis involved in protein catabolic process	5	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004842	ubiquitin-protein transferase activity	4	1
GO:0005488	binding	1	2
GO:0005515	protein binding	2	1
GO:0016740	transferase activity	2	1
GO:0019787	ubiquitin-like protein transferase activity	3	1
GO:0061630	ubiquitin protein ligase activity	5	1
GO:0061659	ubiquitin-like protein ligase activity	4	1
GO:0097602	cullin family protein binding	3	1
GO:0140096	catalytic activity, acting on a protein	2	1
GO:0008270	zinc ion binding	6	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1
GO:0046914	transition metal ion binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	165	167	PF00675	0.524
CLV_PCSK_KEX2_1	165	167	PF00082	0.524
CLV_PCSK_PC7_1	161	167	PF00082	0.493
CLV_PCSK_SKI1_1	259	263	PF00082	0.492
DOC_ANK_TNKS_1	164	171	PF00023	0.524
DOC_CDC14_PxL_1	69	77	PF14671	0.771
DOC_PP2B_LxvP_1	144	147	PF13499	0.527
DOC_PP4_FxxP_1	252	255	PF00568	0.299
DOC_PP4_FxxP_1	6	9	PF00568	0.552
DOC_USP7_MATH_1	124	128	PF00917	0.787
DOC_USP7_MATH_1	180	184	PF00917	0.574
DOC_USP7_MATH_1	205	209	PF00917	0.782
DOC_USP7_MATH_1	218	222	PF00917	0.558
DOC_USP7_MATH_1	57	61	PF00917	0.756
DOC_USP7_MATH_2	102	108	PF00917	0.764
DOC_WW_Pin1_4	115	120	PF00397	0.569
DOC_WW_Pin1_4	138	143	PF00397	0.757
DOC_WW_Pin1_4	270	275	PF00397	0.502
DOC_WW_Pin1_4	5	10	PF00397	0.554
DOC_WW_Pin1_4	80	85	PF00397	0.789
DOC_WW_Pin1_4	95	100	PF00397	0.733
LIG_14-3-3_CanoR_1	161	165	PF00244	0.598
LIG_14-3-3_CanoR_1	259	264	PF00244	0.513
LIG_FHA_1	106	112	PF00498	0.665
LIG_FHA_1	27	33	PF00498	0.758
LIG_FHA_2	240	246	PF00498	0.513
LIG_GSK3_LRP6_1	115	121	PF00069	0.542
LIG_LIR_Apic_2	4	9	PF02991	0.551
LIG_LIR_Gen_1	107	117	PF02991	0.673
LIG_LIR_Nem_3	107	112	PF02991	0.617
LIG_PCNA_yPIPBox_3	39	52	PF02747	0.517
LIG_SH2_STAT5	247	250	PF00017	0.411
LIG_SH2_STAT5	266	269	PF00017	0.290
LIG_SH3_1	190	196	PF00018	0.568
LIG_SH3_3	109	115	PF00018	0.518
LIG_SH3_3	190	196	PF00018	0.822
LIG_SH3_3	198	204	PF00018	0.693
LIG_SH3_3	210	216	PF00018	0.574
LIG_SH3_3	96	102	PF00018	0.676
LIG_SUMO_SIM_par_1	74	83	PF11976	0.784
LIG_TRAF2_1	101	104	PF00917	0.765
LIG_WRC_WIRS_1	106	111	PF05994	0.664
MOD_CK1_1	118	124	PF00069	0.760
MOD_CK1_1	183	189	PF00069	0.684
MOD_CK1_1	222	228	PF00069	0.786
MOD_CK1_1	4	10	PF00069	0.770
MOD_CK1_1	80	86	PF00069	0.749
MOD_CK2_1	142	148	PF00069	0.568
MOD_CK2_1	239	245	PF00069	0.583
MOD_DYRK1A_RPxSP_1	95	99	PF00069	0.522
MOD_GlcNHglycan	12	15	PF01048	0.684
MOD_GlcNHglycan	126	129	PF01048	0.552
MOD_GlcNHglycan	138	141	PF01048	0.521
MOD_GlcNHglycan	144	147	PF01048	0.457
MOD_GlcNHglycan	177	180	PF01048	0.791
MOD_GlcNHglycan	185	188	PF01048	0.690
MOD_GlcNHglycan	52	55	PF01048	0.672
MOD_GlcNHglycan	59	62	PF01048	0.612
MOD_GSK3_1	1	8	PF00069	0.793
MOD_GSK3_1	10	17	PF00069	0.653
MOD_GSK3_1	120	127	PF00069	0.656
MOD_GSK3_1	134	141	PF00069	0.624
MOD_GSK3_1	205	212	PF00069	0.690
MOD_GSK3_1	218	225	PF00069	0.503
MOD_GSK3_1	57	64	PF00069	0.698
MOD_N-GLC_1	183	188	PF02516	0.632
MOD_NEK2_1	120	125	PF00069	0.560
MOD_NEK2_1	160	165	PF00069	0.671
MOD_PIKK_1	194	200	PF00454	0.776
MOD_PIKK_1	222	228	PF00454	0.560
MOD_PKA_2	160	166	PF00069	0.630
MOD_Plk_2-3	239	245	PF00069	0.663
MOD_Plk_4	26	32	PF00069	0.761
MOD_ProDKin_1	115	121	PF00069	0.571
MOD_ProDKin_1	138	144	PF00069	0.757
MOD_ProDKin_1	270	276	PF00069	0.504
MOD_ProDKin_1	5	11	PF00069	0.556
MOD_ProDKin_1	80	86	PF00069	0.790
MOD_ProDKin_1	95	101	PF00069	0.728
MOD_SUMO_rev_2	235	243	PF00179	0.708
TRG_ER_diArg_1	164	166	PF00400	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3K6	Leptomonas seymouri	35%	96%
A0A3S7WWM2	Leishmania donovani	72%	100%
A4HZC7	Leishmania infantum	72%	100%
E9AVB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	100%
Q4QC66	Leishmania major	67%	98%