Putative vesicule-associated membrane protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vesicle-associated membrane protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBY4_LEIBR

TriTrypDb:

LbrM.21.1490 , LBRM2903_210020400

Length:

257

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HBY4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBY4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	12
GO:0016192	vesicle-mediated transport	4	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	98	100	PF00675	0.307
CLV_PCSK_KEX2_1	98	100	PF00082	0.307
CLV_PCSK_SKI1_1	113	117	PF00082	0.307
CLV_PCSK_SKI1_1	219	223	PF00082	0.335
CLV_PCSK_SKI1_1	23	27	PF00082	0.253
DOC_MAPK_gen_1	154	162	PF00069	0.464
DOC_MAPK_MEF2A_6	154	162	PF00069	0.488
DOC_PP4_FxxP_1	116	119	PF00568	0.533
DOC_PP4_FxxP_1	131	134	PF00568	0.483
DOC_PP4_FxxP_1	37	40	PF00568	0.508
DOC_USP7_UBL2_3	122	126	PF12436	0.454
DOC_WW_Pin1_4	26	31	PF00397	0.567
LIG_14-3-3_CanoR_1	50	54	PF00244	0.506
LIG_14-3-3_CanoR_1	57	64	PF00244	0.478
LIG_BIR_II_1	1	5	PF00653	0.703
LIG_BIR_III_4	84	88	PF00653	0.476
LIG_CaM_IQ_9	197	212	PF13499	0.406
LIG_FHA_1	188	194	PF00498	0.409
LIG_FHA_1	27	33	PF00498	0.522
LIG_FHA_1	69	75	PF00498	0.555
LIG_LIR_Apic_2	129	134	PF02991	0.493
LIG_LIR_Apic_2	34	40	PF02991	0.519
LIG_LIR_Gen_1	227	235	PF02991	0.426
LIG_LIR_Gen_1	42	48	PF02991	0.469
LIG_LIR_Gen_1	58	66	PF02991	0.501
LIG_LIR_Gen_1	75	86	PF02991	0.466
LIG_LIR_Nem_3	42	47	PF02991	0.471
LIG_LIR_Nem_3	58	64	PF02991	0.496
LIG_PCNA_yPIPBox_3	122	131	PF02747	0.545
LIG_Pex14_2	112	116	PF04695	0.508
LIG_Pex14_2	233	237	PF04695	0.164
LIG_SH2_CRK	13	17	PF00017	0.462
LIG_SH2_CRK	88	92	PF00017	0.540
LIG_SH2_STAT5	234	237	PF00017	0.335
LIG_SH3_3	114	120	PF00018	0.589
LIG_SH3_3	27	33	PF00018	0.501
LIG_TRAF2_1	5	8	PF00917	0.520
LIG_TRAF2_1	70	73	PF00917	0.637
LIG_TYR_ITIM	86	91	PF00017	0.272
LIG_WRC_WIRS_1	234	239	PF05994	0.386
MOD_CK1_1	244	250	PF00069	0.625
MOD_CK1_1	49	55	PF00069	0.366
MOD_Cter_Amidation	96	99	PF01082	0.278
MOD_GlcNHglycan	143	146	PF01048	0.449
MOD_GlcNHglycan	253	256	PF01048	0.727
MOD_GlcNHglycan	51	54	PF01048	0.414
MOD_GlcNHglycan	58	61	PF01048	0.387
MOD_GSK3_1	240	247	PF00069	0.631
MOD_GSK3_1	31	38	PF00069	0.386
MOD_GSK3_1	56	63	PF00069	0.296
MOD_GSK3_1	68	75	PF00069	0.366
MOD_N-GLC_1	240	245	PF02516	0.533
MOD_NEK2_1	211	216	PF00069	0.277
MOD_NEK2_1	233	238	PF00069	0.301
MOD_NEK2_1	56	61	PF00069	0.375
MOD_NEK2_2	212	217	PF00069	0.275
MOD_PIKK_1	246	252	PF00454	0.686
MOD_PIKK_1	68	74	PF00454	0.412
MOD_PKA_1	245	251	PF00069	0.461
MOD_PKA_2	140	146	PF00069	0.319
MOD_PKA_2	201	207	PF00069	0.251
MOD_PKA_2	49	55	PF00069	0.368
MOD_PKA_2	56	62	PF00069	0.317
MOD_Plk_1	72	78	PF00069	0.471
MOD_Plk_4	224	230	PF00069	0.207
MOD_ProDKin_1	26	32	PF00069	0.467
MOD_SUMO_rev_2	163	168	PF00179	0.263
TRG_ENDOCYTIC_2	13	16	PF00928	0.322
TRG_ENDOCYTIC_2	234	237	PF00928	0.372
TRG_ENDOCYTIC_2	78	81	PF00928	0.322
TRG_ENDOCYTIC_2	88	91	PF00928	0.313
TRG_NES_CRM1_1	106	118	PF08389	0.480
TRG_Pf-PMV_PEXEL_1	205	210	PF00026	0.241

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P366	Leptomonas seymouri	79%	97%
A0A0S4JL59	Bodo saltans	45%	100%
A0A0S4JYF9	Bodo saltans	22%	100%
A0A1X0NYJ8	Trypanosomatidae	57%	100%
A0A3Q8IE03	Leishmania donovani	89%	100%
A0A422NSS3	Trypanosoma rangeli	58%	100%
A4HZC6	Leishmania infantum	89%	100%
D0A159	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9AVB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4QC67	Leishmania major	87%	100%
Q86AQ7	Dictyostelium discoideum	25%	99%
V5BHA3	Trypanosoma cruzi	58%	100%