Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBY2_LEIBR

TriTrypDb:

LbrM.21.1470 , LBRM2903_210020200

Length:

840

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	198	202	PF00656	0.489
CLV_C14_Caspase3-7	561	565	PF00656	0.375
CLV_NRD_NRD_1	382	384	PF00675	0.527
CLV_NRD_NRD_1	398	400	PF00675	0.457
CLV_NRD_NRD_1	443	445	PF00675	0.405
CLV_NRD_NRD_1	48	50	PF00675	0.431
CLV_NRD_NRD_1	531	533	PF00675	0.713
CLV_NRD_NRD_1	632	634	PF00675	0.434
CLV_PCSK_KEX2_1	381	383	PF00082	0.545
CLV_PCSK_KEX2_1	443	445	PF00082	0.413
CLV_PCSK_KEX2_1	531	533	PF00082	0.713
CLV_PCSK_KEX2_1	632	634	PF00082	0.434
CLV_PCSK_KEX2_1	699	701	PF00082	0.483
CLV_PCSK_KEX2_1	837	839	PF00082	0.621
CLV_PCSK_PC1ET2_1	699	701	PF00082	0.483
CLV_PCSK_PC1ET2_1	837	839	PF00082	0.621
CLV_PCSK_SKI1_1	182	186	PF00082	0.370
CLV_PCSK_SKI1_1	254	258	PF00082	0.400
CLV_PCSK_SKI1_1	334	338	PF00082	0.465
CLV_PCSK_SKI1_1	632	636	PF00082	0.429
CLV_PCSK_SKI1_1	691	695	PF00082	0.521
DEG_APCC_DBOX_1	249	257	PF00400	0.456
DOC_ANK_TNKS_1	413	420	PF00023	0.454
DOC_CKS1_1	105	110	PF01111	0.513
DOC_CYCLIN_RxL_1	438	451	PF00134	0.396
DOC_CYCLIN_yClb3_PxF_3	536	542	PF00134	0.470
DOC_CYCLIN_yCln2_LP_2	446	452	PF00134	0.447
DOC_MAPK_gen_1	234	242	PF00069	0.380
DOC_MAPK_gen_1	443	450	PF00069	0.410
DOC_MAPK_gen_1	49	57	PF00069	0.495
DOC_MAPK_MEF2A_6	234	242	PF00069	0.380
DOC_MAPK_MEF2A_6	443	450	PF00069	0.499
DOC_MAPK_MEF2A_6	666	674	PF00069	0.374
DOC_MAPK_NFAT4_5	443	451	PF00069	0.508
DOC_PP1_RVXF_1	324	330	PF00149	0.444
DOC_PP1_RVXF_1	390	396	PF00149	0.334
DOC_PP2B_LxvP_1	446	449	PF13499	0.510
DOC_USP7_MATH_1	122	126	PF00917	0.444
DOC_USP7_MATH_1	308	312	PF00917	0.426
DOC_USP7_MATH_1	358	362	PF00917	0.802
DOC_USP7_MATH_1	401	405	PF00917	0.448
DOC_USP7_MATH_1	517	521	PF00917	0.819
DOC_USP7_MATH_1	543	547	PF00917	0.427
DOC_USP7_MATH_1	797	801	PF00917	0.417
DOC_USP7_MATH_2	733	739	PF00917	0.556
DOC_USP7_UBL2_3	691	695	PF12436	0.440
DOC_WW_Pin1_4	104	109	PF00397	0.511
DOC_WW_Pin1_4	24	29	PF00397	0.418
DOC_WW_Pin1_4	344	349	PF00397	0.669
DOC_WW_Pin1_4	354	359	PF00397	0.629
DOC_WW_Pin1_4	438	443	PF00397	0.442
DOC_WW_Pin1_4	601	606	PF00397	0.468
LIG_14-3-3_CanoR_1	104	108	PF00244	0.427
LIG_14-3-3_CanoR_1	16	22	PF00244	0.539
LIG_14-3-3_CanoR_1	176	184	PF00244	0.371
LIG_14-3-3_CanoR_1	438	442	PF00244	0.521
LIG_14-3-3_CanoR_1	736	742	PF00244	0.434
LIG_BIR_II_1	1	5	PF00653	0.713
LIG_BIR_III_1	1	5	PF00653	0.546
LIG_BIR_III_3	1	5	PF00653	0.546
LIG_BRCT_BRCA1_1	44	48	PF00533	0.490
LIG_BRCT_BRCA1_2	44	50	PF00533	0.502
LIG_CaM_NSCaTE_8	145	152	PF13499	0.264
LIG_CtBP_PxDLS_1	239	243	PF00389	0.455
LIG_CtBP_PxDLS_1	669	673	PF00389	0.373
LIG_deltaCOP1_diTrp_1	653	659	PF00928	0.453
LIG_EH1_1	426	434	PF00400	0.398
LIG_eIF4E_1	427	433	PF01652	0.391
LIG_eIF4E_1	789	795	PF01652	0.631
LIG_FHA_1	100	106	PF00498	0.512
LIG_FHA_1	205	211	PF00498	0.467
LIG_FHA_1	21	27	PF00498	0.644
LIG_FHA_1	222	228	PF00498	0.270
LIG_FHA_1	310	316	PF00498	0.424
LIG_FHA_1	328	334	PF00498	0.485
LIG_FHA_1	39	45	PF00498	0.418
LIG_FHA_1	52	58	PF00498	0.464
LIG_FHA_1	548	554	PF00498	0.471
LIG_FHA_1	66	72	PF00498	0.496
LIG_FHA_1	665	671	PF00498	0.382
LIG_FHA_2	196	202	PF00498	0.527
LIG_FHA_2	491	497	PF00498	0.591
LIG_FHA_2	503	509	PF00498	0.546
LIG_FHA_2	602	608	PF00498	0.296
LIG_LIR_Gen_1	169	174	PF02991	0.385
LIG_LIR_Gen_1	249	260	PF02991	0.392
LIG_LIR_Gen_1	263	273	PF02991	0.387
LIG_LIR_Gen_1	296	306	PF02991	0.383
LIG_LIR_Gen_1	323	332	PF02991	0.455
LIG_LIR_Gen_1	52	60	PF02991	0.404
LIG_LIR_Gen_1	653	663	PF02991	0.362
LIG_LIR_Gen_1	719	728	PF02991	0.462
LIG_LIR_Gen_1	803	814	PF02991	0.385
LIG_LIR_Nem_3	130	135	PF02991	0.390
LIG_LIR_Nem_3	142	148	PF02991	0.352
LIG_LIR_Nem_3	169	173	PF02991	0.394
LIG_LIR_Nem_3	249	255	PF02991	0.370
LIG_LIR_Nem_3	263	268	PF02991	0.386
LIG_LIR_Nem_3	323	327	PF02991	0.437
LIG_LIR_Nem_3	52	56	PF02991	0.406
LIG_LIR_Nem_3	558	562	PF02991	0.412
LIG_LIR_Nem_3	636	641	PF02991	0.339
LIG_LIR_Nem_3	652	658	PF02991	0.375
LIG_LIR_Nem_3	719	723	PF02991	0.460
LIG_LIR_Nem_3	803	809	PF02991	0.376
LIG_NRP_CendR_1	837	840	PF00754	0.639
LIG_PCNA_PIPBox_1	429	438	PF02747	0.400
LIG_Pex14_1	655	659	PF04695	0.443
LIG_Pex14_2	170	174	PF04695	0.378
LIG_Pex14_2	281	285	PF04695	0.363
LIG_Pex14_2	486	490	PF04695	0.542
LIG_PTB_Apo_2	126	133	PF02174	0.341
LIG_PTB_Phospho_1	126	132	PF10480	0.318
LIG_SH2_CRK	119	123	PF00017	0.432
LIG_SH2_CRK	324	328	PF00017	0.430
LIG_SH2_CRK	53	57	PF00017	0.478
LIG_SH2_CRK	720	724	PF00017	0.449
LIG_SH2_CRK	804	808	PF00017	0.373
LIG_SH2_GRB2like	789	792	PF00017	0.542
LIG_SH2_NCK_1	304	308	PF00017	0.411
LIG_SH2_NCK_1	779	783	PF00017	0.592
LIG_SH2_PTP2	806	809	PF00017	0.367
LIG_SH2_STAP1	298	302	PF00017	0.375
LIG_SH2_STAP1	53	57	PF00017	0.478
LIG_SH2_STAP1	639	643	PF00017	0.355
LIG_SH2_STAT3	232	235	PF00017	0.381
LIG_SH2_STAT3	388	391	PF00017	0.498
LIG_SH2_STAT3	575	578	PF00017	0.576
LIG_SH2_STAT3	7	10	PF00017	0.570
LIG_SH2_STAT5	135	138	PF00017	0.448
LIG_SH2_STAT5	180	183	PF00017	0.367
LIG_SH2_STAT5	232	235	PF00017	0.461
LIG_SH2_STAT5	252	255	PF00017	0.374
LIG_SH2_STAT5	388	391	PF00017	0.420
LIG_SH2_STAT5	427	430	PF00017	0.403
LIG_SH2_STAT5	436	439	PF00017	0.425
LIG_SH2_STAT5	53	56	PF00017	0.480
LIG_SH2_STAT5	541	544	PF00017	0.474
LIG_SH2_STAT5	551	554	PF00017	0.390
LIG_SH2_STAT5	618	621	PF00017	0.376
LIG_SH2_STAT5	641	644	PF00017	0.314
LIG_SH2_STAT5	658	661	PF00017	0.385
LIG_SH2_STAT5	779	782	PF00017	0.594
LIG_SH2_STAT5	806	809	PF00017	0.367
LIG_SH3_1	534	540	PF00018	0.601
LIG_SH3_3	213	219	PF00018	0.408
LIG_SH3_3	346	352	PF00018	0.659
LIG_SH3_3	534	540	PF00018	0.691
LIG_SH3_3	92	98	PF00018	0.410
LIG_SUMO_SIM_anti_2	196	201	PF11976	0.439
LIG_SUMO_SIM_anti_2	66	73	PF11976	0.355
LIG_SUMO_SIM_par_1	193	198	PF11976	0.391
LIG_SUMO_SIM_par_1	701	712	PF11976	0.365
LIG_TRAF2_1	493	496	PF00917	0.683
LIG_TRAF2_1	545	548	PF00917	0.408
LIG_TRAF2_1	768	771	PF00917	0.613
LIG_TRAF2_1	829	832	PF00917	0.514
LIG_TYR_ITIM	614	619	PF00017	0.358
LIG_TYR_ITIM	802	807	PF00017	0.457
LIG_UBA3_1	405	410	PF00899	0.430
LIG_UBA3_1	552	557	PF00899	0.392
LIG_WW_1	4	7	PF00397	0.533
LIG_WW_3	535	539	PF00397	0.500
MOD_CDK_SPK_2	438	443	PF00069	0.442
MOD_CDK_SPxK_1	438	444	PF00069	0.363
MOD_CDK_SPxxK_3	104	111	PF00069	0.506
MOD_CK1_1	125	131	PF00069	0.416
MOD_CK1_1	221	227	PF00069	0.317
MOD_CK1_1	558	564	PF00069	0.399
MOD_CK1_1	684	690	PF00069	0.516
MOD_CK1_1	777	783	PF00069	0.583
MOD_CK1_1	787	793	PF00069	0.577
MOD_CK1_1	800	806	PF00069	0.352
MOD_CK2_1	317	323	PF00069	0.469
MOD_CK2_1	401	407	PF00069	0.439
MOD_CK2_1	466	472	PF00069	0.679
MOD_CK2_1	490	496	PF00069	0.546
MOD_CK2_1	502	508	PF00069	0.525
MOD_CK2_1	542	548	PF00069	0.428
MOD_CK2_1	584	590	PF00069	0.278
MOD_CK2_1	64	70	PF00069	0.486
MOD_CK2_1	708	714	PF00069	0.329
MOD_Cter_Amidation	529	532	PF01082	0.708
MOD_DYRK1A_RPxSP_1	438	442	PF00069	0.521
MOD_GlcNHglycan	189	192	PF01048	0.497
MOD_GlcNHglycan	258	261	PF01048	0.534
MOD_GlcNHglycan	360	363	PF01048	0.675
MOD_GlcNHglycan	429	432	PF01048	0.395
MOD_GlcNHglycan	450	453	PF01048	0.543
MOD_GlcNHglycan	513	516	PF01048	0.675
MOD_GlcNHglycan	571	574	PF01048	0.450
MOD_GlcNHglycan	737	740	PF01048	0.679
MOD_GlcNHglycan	743	746	PF01048	0.638
MOD_GlcNHglycan	764	767	PF01048	0.642
MOD_GlcNHglycan	780	783	PF01048	0.623
MOD_GlcNHglycan	795	798	PF01048	0.402
MOD_GSK3_1	20	27	PF00069	0.491
MOD_GSK3_1	200	207	PF00069	0.536
MOD_GSK3_1	234	241	PF00069	0.424
MOD_GSK3_1	328	335	PF00069	0.565
MOD_GSK3_1	336	343	PF00069	0.615
MOD_GSK3_1	344	351	PF00069	0.620
MOD_GSK3_1	354	361	PF00069	0.722
MOD_GSK3_1	368	375	PF00069	0.628
MOD_GSK3_1	38	45	PF00069	0.454
MOD_GSK3_1	423	430	PF00069	0.438
MOD_GSK3_1	511	518	PF00069	0.704
MOD_GSK3_1	543	550	PF00069	0.493
MOD_GSK3_1	677	684	PF00069	0.436
MOD_GSK3_1	774	781	PF00069	0.627
MOD_GSK3_1	785	792	PF00069	0.543
MOD_GSK3_1	793	800	PF00069	0.371
MOD_GSK3_1	85	92	PF00069	0.501
MOD_GSK3_1	99	106	PF00069	0.483
MOD_N-GLC_1	221	226	PF02516	0.305
MOD_N-GLC_1	286	291	PF02516	0.420
MOD_N-GLC_1	337	342	PF02516	0.656
MOD_N-GLC_1	762	767	PF02516	0.713
MOD_NEK2_1	185	190	PF00069	0.458
MOD_NEK2_1	195	200	PF00069	0.368
MOD_NEK2_1	256	261	PF00069	0.329
MOD_NEK2_1	302	307	PF00069	0.452
MOD_NEK2_1	327	332	PF00069	0.467
MOD_NEK2_1	336	341	PF00069	0.585
MOD_NEK2_1	450	455	PF00069	0.549
MOD_NEK2_1	63	68	PF00069	0.562
MOD_NEK2_1	677	682	PF00069	0.425
MOD_NEK2_1	89	94	PF00069	0.459
MOD_NEK2_2	641	646	PF00069	0.461
MOD_NEK2_2	774	779	PF00069	0.594
MOD_PIKK_1	204	210	PF00454	0.507
MOD_PK_1	234	240	PF00069	0.387
MOD_PKA_1	699	705	PF00069	0.482
MOD_PKA_2	103	109	PF00069	0.428
MOD_PKA_2	15	21	PF00069	0.537
MOD_PKA_2	175	181	PF00069	0.381
MOD_PKA_2	38	44	PF00069	0.436
MOD_PKA_2	437	443	PF00069	0.437
MOD_PKA_2	465	471	PF00069	0.585
MOD_PKA_2	511	517	PF00069	0.620
MOD_PKA_2	530	536	PF00069	0.492
MOD_PKA_2	699	705	PF00069	0.482
MOD_PKA_2	735	741	PF00069	0.581
MOD_PKA_2	759	765	PF00069	0.565
MOD_PKA_2	797	803	PF00069	0.406
MOD_Plk_1	195	201	PF00069	0.462
MOD_Plk_1	221	227	PF00069	0.300
MOD_Plk_1	302	308	PF00069	0.413
MOD_Plk_1	384	390	PF00069	0.426
MOD_Plk_1	51	57	PF00069	0.405
MOD_Plk_1	684	690	PF00069	0.516
MOD_Plk_2-3	708	714	PF00069	0.329
MOD_Plk_4	195	201	PF00069	0.400
MOD_Plk_4	328	334	PF00069	0.566
MOD_Plk_4	401	407	PF00069	0.439
MOD_Plk_4	423	429	PF00069	0.448
MOD_Plk_4	502	508	PF00069	0.545
MOD_Plk_4	51	57	PF00069	0.409
MOD_Plk_4	547	553	PF00069	0.520
MOD_Plk_4	584	590	PF00069	0.278
MOD_Plk_4	774	780	PF00069	0.595
MOD_Plk_4	797	803	PF00069	0.419
MOD_ProDKin_1	104	110	PF00069	0.505
MOD_ProDKin_1	24	30	PF00069	0.403
MOD_ProDKin_1	344	350	PF00069	0.669
MOD_ProDKin_1	354	360	PF00069	0.627
MOD_ProDKin_1	438	444	PF00069	0.451
MOD_ProDKin_1	601	607	PF00069	0.465
MOD_SUMO_rev_2	394	401	PF00179	0.516
MOD_SUMO_rev_2	811	819	PF00179	0.482
TRG_DiLeu_BaEn_3	547	553	PF01217	0.389
TRG_DiLeu_BaEn_4	81	87	PF01217	0.425
TRG_ENDOCYTIC_2	252	255	PF00928	0.374
TRG_ENDOCYTIC_2	298	301	PF00928	0.376
TRG_ENDOCYTIC_2	324	327	PF00928	0.427
TRG_ENDOCYTIC_2	53	56	PF00928	0.480
TRG_ENDOCYTIC_2	616	619	PF00928	0.365
TRG_ENDOCYTIC_2	658	661	PF00928	0.496
TRG_ENDOCYTIC_2	720	723	PF00928	0.456
TRG_ENDOCYTIC_2	804	807	PF00928	0.376
TRG_ER_diArg_1	381	383	PF00400	0.545
TRG_ER_diArg_1	442	444	PF00400	0.380
TRG_ER_diArg_1	531	534	PF00400	0.715
TRG_ER_diArg_1	631	633	PF00400	0.436
TRG_NES_CRM1_1	187	201	PF08389	0.488
TRG_NES_CRM1_1	85	99	PF08389	0.443
TRG_Pf-PMV_PEXEL_1	154	158	PF00026	0.366
TRG_Pf-PMV_PEXEL_1	314	319	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	722	727	PF00026	0.458
TRG_Pf-PMV_PEXEL_1	810	815	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P586	Leptomonas seymouri	64%	100%
A0A3S7WWR8	Leishmania donovani	84%	100%
A4HZC4	Leishmania infantum	84%	100%
E9AVB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4QC69	Leishmania major	84%	100%