Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBY1_LEIBR

TriTrypDb:

LbrM.21.1460 , LBRM2903_210020100

Length:

487

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	6
GO:0042995	cell projection	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0110165	cellular anatomical entity	1	6
GO:0120025	plasma membrane bounded cell projection	3	6

Expansion

Sequence features

A4HBY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBY1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	233	237	PF00656	0.644
CLV_NRD_NRD_1	201	203	PF00675	0.663
CLV_NRD_NRD_1	206	208	PF00675	0.639
CLV_NRD_NRD_1	225	227	PF00675	0.513
CLV_NRD_NRD_1	376	378	PF00675	0.723
CLV_NRD_NRD_1	401	403	PF00675	0.603
CLV_NRD_NRD_1	97	99	PF00675	0.596
CLV_PCSK_FUR_1	374	378	PF00082	0.590
CLV_PCSK_KEX2_1	201	203	PF00082	0.663
CLV_PCSK_KEX2_1	205	207	PF00082	0.645
CLV_PCSK_KEX2_1	376	378	PF00082	0.723
CLV_PCSK_KEX2_1	401	403	PF00082	0.603
CLV_PCSK_KEX2_1	97	99	PF00082	0.596
CLV_PCSK_PC7_1	201	207	PF00082	0.688
DEG_APCC_DBOX_1	62	70	PF00400	0.530
DEG_SCF_FBW7_1	412	419	PF00400	0.565
DEG_SCF_TRCP1_1	139	145	PF00400	0.552
DEG_SPOP_SBC_1	231	235	PF00917	0.578
DOC_CKS1_1	253	258	PF01111	0.559
DOC_CKS1_1	316	321	PF01111	0.584
DOC_CKS1_1	413	418	PF01111	0.562
DOC_CYCLIN_RxL_1	377	391	PF00134	0.591
DOC_CYCLIN_RxL_1	79	89	PF00134	0.538
DOC_PP4_FxxP_1	387	390	PF00568	0.599
DOC_USP7_MATH_1	149	153	PF00917	0.716
DOC_USP7_MATH_1	232	236	PF00917	0.819
DOC_USP7_MATH_1	237	241	PF00917	0.742
DOC_USP7_MATH_1	390	394	PF00917	0.706
DOC_USP7_MATH_1	403	407	PF00917	0.533
DOC_USP7_MATH_1	416	420	PF00917	0.679
DOC_USP7_MATH_1	430	434	PF00917	0.660
DOC_USP7_MATH_1	466	470	PF00917	0.580
DOC_WW_Pin1_4	154	159	PF00397	0.693
DOC_WW_Pin1_4	252	257	PF00397	0.621
DOC_WW_Pin1_4	315	320	PF00397	0.581
DOC_WW_Pin1_4	356	361	PF00397	0.728
DOC_WW_Pin1_4	386	391	PF00397	0.583
DOC_WW_Pin1_4	412	417	PF00397	0.780
DOC_WW_Pin1_4	442	447	PF00397	0.581
LIG_14-3-3_CanoR_1	216	224	PF00244	0.680
LIG_14-3-3_CanoR_1	226	232	PF00244	0.551
LIG_14-3-3_CanoR_1	376	386	PF00244	0.588
LIG_14-3-3_CanoR_1	402	408	PF00244	0.694
LIG_14-3-3_CanoR_1	442	446	PF00244	0.589
LIG_14-3-3_CanoR_1	63	67	PF00244	0.530
LIG_Actin_WH2_2	436	451	PF00022	0.587
LIG_BIR_II_1	1	5	PF00653	0.509
LIG_BIR_III_2	478	482	PF00653	0.699
LIG_BIR_III_4	323	327	PF00653	0.560
LIG_BRCT_BRCA1_1	21	25	PF00533	0.334
LIG_BRCT_BRCA1_1	419	423	PF00533	0.652
LIG_BRCT_BRCA1_1	476	480	PF00533	0.528
LIG_FHA_1	253	259	PF00498	0.596
LIG_FHA_1	288	294	PF00498	0.599
LIG_FHA_1	330	336	PF00498	0.561
LIG_FHA_1	344	350	PF00498	0.690
LIG_FHA_2	471	477	PF00498	0.561
LIG_Integrin_RGD_1	207	209	PF01839	0.497
LIG_LIR_Gen_1	22	30	PF02991	0.354
LIG_LIR_Nem_3	172	178	PF02991	0.535
LIG_LIR_Nem_3	22	28	PF02991	0.345
LIG_LIR_Nem_3	338	343	PF02991	0.553
LIG_LIR_Nem_3	420	426	PF02991	0.766
LIG_PTB_Apo_2	87	94	PF02174	0.456
LIG_RPA_C_Fungi	189	201	PF08784	0.409
LIG_SH2_PTP2	175	178	PF00017	0.548
LIG_SH2_STAP1	475	479	PF00017	0.555
LIG_SH2_STAT5	175	178	PF00017	0.548
LIG_SH3_2	342	347	PF14604	0.546
LIG_SH3_3	250	256	PF00018	0.787
LIG_SH3_3	339	345	PF00018	0.559
LIG_SH3_3	410	416	PF00018	0.807
LIG_SH3_3	424	430	PF00018	0.595
LIG_SUMO_SIM_par_1	2	10	PF11976	0.610
LIG_SUMO_SIM_par_1	38	43	PF11976	0.608
LIG_TRFH_1	423	427	PF08558	0.575
LIG_TYR_ITIM	173	178	PF00017	0.553
MOD_CDK_SPK_2	154	159	PF00069	0.538
MOD_CDK_SPxxK_3	442	449	PF00069	0.581
MOD_CK1_1	140	146	PF00069	0.745
MOD_CK1_1	230	236	PF00069	0.580
MOD_CK1_1	268	274	PF00069	0.581
MOD_CK1_1	405	411	PF00069	0.709
MOD_CK2_1	388	394	PF00069	0.726
MOD_GlcNHglycan	139	142	PF01048	0.765
MOD_GlcNHglycan	21	24	PF01048	0.442
MOD_GlcNHglycan	227	230	PF01048	0.835
MOD_GlcNHglycan	267	270	PF01048	0.571
MOD_GlcNHglycan	322	327	PF01048	0.811
MOD_GlcNHglycan	351	354	PF01048	0.659
MOD_GlcNHglycan	379	382	PF01048	0.749
MOD_GlcNHglycan	42	45	PF01048	0.555
MOD_GlcNHglycan	429	433	PF01048	0.753
MOD_GlcNHglycan	468	471	PF01048	0.668
MOD_GSK3_1	140	147	PF00069	0.583
MOD_GSK3_1	208	215	PF00069	0.766
MOD_GSK3_1	218	225	PF00069	0.644
MOD_GSK3_1	227	234	PF00069	0.537
MOD_GSK3_1	247	254	PF00069	0.605
MOD_GSK3_1	386	393	PF00069	0.698
MOD_GSK3_1	408	415	PF00069	0.739
MOD_GSK3_1	466	473	PF00069	0.576
MOD_GSK3_1	65	72	PF00069	0.413
MOD_LATS_1	375	381	PF00433	0.847
MOD_N-GLC_1	14	19	PF02516	0.362
MOD_N-GLC_1	218	223	PF02516	0.573
MOD_N-GLC_1	285	290	PF02516	0.597
MOD_N-GLC_1	395	400	PF02516	0.668
MOD_NEK2_1	1	6	PF00069	0.652
MOD_NEK2_1	183	188	PF00069	0.387
MOD_NEK2_1	28	33	PF00069	0.472
MOD_NEK2_1	40	45	PF00069	0.514
MOD_NEK2_1	86	91	PF00069	0.462
MOD_NEK2_2	120	125	PF00069	0.659
MOD_NEK2_2	62	67	PF00069	0.608
MOD_PIKK_1	127	133	PF00454	0.542
MOD_PIKK_1	208	214	PF00454	0.768
MOD_PIKK_1	237	243	PF00454	0.629
MOD_PIKK_1	405	411	PF00454	0.581
MOD_PIKK_1	430	436	PF00454	0.578
MOD_PK_1	14	20	PF00069	0.362
MOD_PK_1	227	233	PF00069	0.580
MOD_PKA_2	149	155	PF00069	0.555
MOD_PKA_2	217	223	PF00069	0.765
MOD_PKA_2	225	231	PF00069	0.645
MOD_PKA_2	375	381	PF00069	0.731
MOD_PKA_2	441	447	PF00069	0.586
MOD_PKA_2	62	68	PF00069	0.530
MOD_PKB_1	205	213	PF00069	0.515
MOD_PKB_1	216	224	PF00069	0.530
MOD_Plk_1	14	20	PF00069	0.400
MOD_Plk_1	285	291	PF00069	0.597
MOD_Plk_4	1	7	PF00069	0.646
MOD_ProDKin_1	154	160	PF00069	0.693
MOD_ProDKin_1	252	258	PF00069	0.623
MOD_ProDKin_1	315	321	PF00069	0.583
MOD_ProDKin_1	356	362	PF00069	0.729
MOD_ProDKin_1	386	392	PF00069	0.578
MOD_ProDKin_1	412	418	PF00069	0.777
MOD_ProDKin_1	442	448	PF00069	0.581
TRG_ENDOCYTIC_2	175	178	PF00928	0.548
TRG_ER_diArg_1	205	207	PF00400	0.684
TRG_ER_diArg_1	213	216	PF00400	0.700
TRG_ER_diArg_1	374	377	PF00400	0.593
TRG_ER_diArg_1	96	98	PF00400	0.597
TRG_NLS_MonoExtC_3	201	206	PF00514	0.427
TRG_NLS_MonoExtN_4	201	206	PF00514	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WWT1	Leishmania donovani	55%	98%
A4HZC3	Leishmania infantum	56%	98%
E9AVB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	53%	99%
Q4QC70	Leishmania major	54%	99%