Thymidine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Thymidine kinase

Gene product:

thymidine kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HBX7_LEIBR

TriTrypDb:

LbrM.21.1410 , LBRM2903_210019500

Length:

283

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBX7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBX7

PDB structure(s): 4uxh_A , 4uxh_B , 4uxi_A , 4uxi_B , 4uxj_A , 4uxj_B , 4uxj_C , 4uxj_D , 4uxj_E , 4uxj_F , 4uxj_G , 4uxj_H

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	9
GO:0006259	DNA metabolic process	4	9
GO:0006725	cellular aromatic compound metabolic process	3	9
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009058	biosynthetic process	2	9
GO:0009059	macromolecule biosynthetic process	4	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0018130	heterocycle biosynthetic process	4	9
GO:0019438	aromatic compound biosynthetic process	4	9
GO:0034641	cellular nitrogen compound metabolic process	3	9
GO:0034654	nucleobase-containing compound biosynthetic process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044249	cellular biosynthetic process	3	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0044271	cellular nitrogen compound biosynthetic process	4	9
GO:0046483	heterocycle metabolic process	3	9
GO:0071704	organic substance metabolic process	2	9
GO:0071897	DNA biosynthetic process	5	9
GO:0090304	nucleic acid metabolic process	4	9
GO:1901360	organic cyclic compound metabolic process	3	9
GO:1901362	organic cyclic compound biosynthetic process	4	9
GO:1901576	organic substance biosynthetic process	3	9
GO:0006213	pyrimidine nucleoside metabolic process	5	1
GO:0009116	nucleoside metabolic process	4	1
GO:0009120	deoxyribonucleoside metabolic process	5	1
GO:0044281	small molecule metabolic process	2	1
GO:0046104	thymidine metabolic process	7	1
GO:0046125	pyrimidine deoxyribonucleoside metabolic process	6	1
GO:0055086	nucleobase-containing small molecule metabolic process	3	1
GO:0072527	pyrimidine-containing compound metabolic process	4	1
GO:1901135	carbohydrate derivative metabolic process	3	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901657	glycosyl compound metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004797	thymidine kinase activity	8	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0017076	purine nucleotide binding	4	9
GO:0019136	deoxynucleoside kinase activity	7	9
GO:0019205	nucleobase-containing compound kinase activity	5	9
GO:0019206	nucleoside kinase activity	6	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.440
CLV_C14_Caspase3-7	98	102	PF00656	0.504
CLV_NRD_NRD_1	116	118	PF00675	0.278
CLV_NRD_NRD_1	152	154	PF00675	0.291
CLV_NRD_NRD_1	23	25	PF00675	0.277
CLV_PCSK_FUR_1	24	28	PF00082	0.277
CLV_PCSK_KEX2_1	116	118	PF00082	0.301
CLV_PCSK_KEX2_1	152	154	PF00082	0.284
CLV_PCSK_KEX2_1	200	202	PF00082	0.616
CLV_PCSK_KEX2_1	23	25	PF00082	0.277
CLV_PCSK_KEX2_1	26	28	PF00082	0.277
CLV_PCSK_PC1ET2_1	200	202	PF00082	0.616
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.283
CLV_PCSK_SKI1_1	153	157	PF00082	0.277
CLV_PCSK_SKI1_1	228	232	PF00082	0.498
CLV_PCSK_SKI1_1	23	27	PF00082	0.280
CLV_Separin_Metazoa	20	24	PF03568	0.477
DEG_Nend_Nbox_1	1	3	PF02207	0.528
DOC_CKS1_1	213	218	PF01111	0.662
DOC_MAPK_gen_1	3	10	PF00069	0.414
DOC_MAPK_MEF2A_6	3	10	PF00069	0.414
DOC_MAPK_NFAT4_5	3	11	PF00069	0.414
DOC_SPAK_OSR1_1	77	81	PF12202	0.573
DOC_USP7_MATH_1	240	244	PF00917	0.764
DOC_USP7_MATH_1	279	283	PF00917	0.759
DOC_USP7_MATH_1	31	35	PF00917	0.535
DOC_USP7_MATH_1	63	67	PF00917	0.504
DOC_USP7_UBL2_3	196	200	PF12436	0.541
DOC_WW_Pin1_4	209	214	PF00397	0.629
LIG_14-3-3_CanoR_1	152	156	PF00244	0.477
LIG_14-3-3_CanoR_1	32	40	PF00244	0.505
LIG_Actin_WH2_2	191	206	PF00022	0.372
LIG_APCC_ABBA_1	126	131	PF00400	0.535
LIG_deltaCOP1_diTrp_1	73	78	PF00928	0.535
LIG_FHA_1	152	158	PF00498	0.535
LIG_FHA_1	16	22	PF00498	0.459
LIG_FHA_1	232	238	PF00498	0.679
LIG_FHA_1	257	263	PF00498	0.515
LIG_FHA_2	170	176	PF00498	0.501
LIG_FHA_2	42	48	PF00498	0.535
LIG_FHA_2	96	102	PF00498	0.535
LIG_LIR_Gen_1	199	209	PF02991	0.390
LIG_LIR_Gen_1	266	274	PF02991	0.590
LIG_LIR_Gen_1	73	83	PF02991	0.452
LIG_LIR_Nem_3	266	271	PF02991	0.589
LIG_LIR_Nem_3	73	78	PF02991	0.476
LIG_LYPXL_SIV_4	128	136	PF13949	0.573
LIG_SH2_SRC	46	49	PF00017	0.573
LIG_SH2_STAT3	177	180	PF00017	0.522
LIG_SH2_STAT5	129	132	PF00017	0.573
LIG_SH2_STAT5	169	172	PF00017	0.477
LIG_SH2_STAT5	177	180	PF00017	0.410
LIG_SH2_STAT5	202	205	PF00017	0.578
LIG_SH3_2	213	218	PF14604	0.759
LIG_SH3_3	210	216	PF00018	0.645
LIG_SH3_3	259	265	PF00018	0.603
LIG_SH3_4	118	125	PF00018	0.535
LIG_SUMO_SIM_par_1	104	109	PF11976	0.477
LIG_SUMO_SIM_par_1	233	238	PF11976	0.495
LIG_SUMO_SIM_par_1	79	85	PF11976	0.470
LIG_TRAF2_1	184	187	PF00917	0.632
LIG_UBA3_1	9	17	PF00899	0.501
MOD_CDK_SPxK_1	212	218	PF00069	0.707
MOD_CK1_1	212	218	PF00069	0.729
MOD_CK1_1	243	249	PF00069	0.746
MOD_CK1_1	41	47	PF00069	0.546
MOD_CK2_1	169	175	PF00069	0.501
MOD_CK2_1	181	187	PF00069	0.563
MOD_GlcNHglycan	108	111	PF01048	0.277
MOD_GlcNHglycan	242	245	PF01048	0.778
MOD_GSK3_1	224	231	PF00069	0.621
MOD_GSK3_1	240	247	PF00069	0.682
MOD_GSK3_1	256	263	PF00069	0.565
MOD_NEK2_1	95	100	PF00069	0.535
MOD_NEK2_2	169	174	PF00069	0.501
MOD_NEK2_2	31	36	PF00069	0.499
MOD_PIKK_1	187	193	PF00454	0.563
MOD_PIKK_1	63	69	PF00454	0.546
MOD_PKA_2	151	157	PF00069	0.493
MOD_PKA_2	31	37	PF00069	0.525
MOD_ProDKin_1	209	215	PF00069	0.633
MOD_SUMO_for_1	155	158	PF00179	0.393
MOD_SUMO_for_1	25	28	PF00179	0.501
TRG_DiLeu_BaEn_1	158	163	PF01217	0.501
TRG_DiLeu_BaEn_2	256	262	PF01217	0.519
TRG_ENDOCYTIC_2	202	205	PF00928	0.578
TRG_ENDOCYTIC_2	268	271	PF00928	0.754
TRG_ER_diArg_1	115	117	PF00400	0.501
TRG_ER_diArg_1	2	5	PF00400	0.500
TRG_ER_diArg_1	22	24	PF00400	0.337
TRG_Pf-PMV_PEXEL_1	253	257	PF00026	0.787

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3M4	Leptomonas seymouri	79%	100%
A0A0S4JEG8	Bodo saltans	68%	100%
A0A3Q8IAE5	Leishmania donovani	87%	100%
A0A3R7KQH5	Trypanosoma rangeli	54%	100%
A0A3R7M8B4	Trypanosoma rangeli	38%	100%
A4HZ97	Leishmania infantum	87%	100%
A5D7R8	Bos taurus	45%	100%
A5UZV5	Roseiflexus sp. (strain RS-1)	31%	100%
A7GV80	Bacillus cytotoxicus (strain DSM 22905 / CIP 110041 / 391-98 / NVH 391-98)	39%	100%
A7NI79	Roseiflexus castenholzii (strain DSM 13941 / HLO8)	34%	100%
A9VSC8	Bacillus mycoides (strain KBAB4)	40%	100%
B1AJN5	Ureaplasma parvum serovar 3 (strain ATCC 27815 / 27 / NCTC 11736)	34%	100%
B2RJJ6	Porphyromonas gingivalis (strain ATCC 33277 / DSM 20709 / CIP 103683 / JCM 12257 / NCTC 11834 / 2561)	39%	100%
B5ZCA9	Ureaplasma urealyticum serovar 10 (strain ATCC 33699 / Western)	34%	100%
B7GMH4	Anoxybacillus flavithermus (strain DSM 21510 / WK1)	35%	100%
B7JHF2	Bacillus cereus (strain AH820)	40%	100%
C3LFK4	Bacillus anthracis (strain CDC 684 / NRRL 3495)	40%	100%
C3P292	Bacillus anthracis (strain A0248)	40%	100%
C5D9N8	Geobacillus sp. (strain WCH70)	37%	100%
E9AVA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
O96720	Encephalitozoon cuniculi (strain GB-M1)	25%	100%
P04047	Gallus gallus	46%	100%
Q18J88	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	34%	100%
Q2RZH4	Salinibacter ruber (strain DSM 13855 / M31)	38%	100%
Q2SSX9	Mycoplasma capricolum subsp. capricolum (strain California kid / ATCC 27343 / NCTC 10154)	35%	100%
Q4QC75	Leishmania major	87%	100%
Q6F0I2	Mesoplasma florum (strain ATCC 33453 / NBRC 100688 / NCTC 11704 / L1)	37%	100%
Q6MHW4	Bdellovibrio bacteriovorus (strain ATCC 15356 / DSM 50701 / NCIMB 9529 / HD100)	36%	100%
Q7MVV7	Porphyromonas gingivalis (strain ATCC BAA-308 / W83)	39%	100%
Q81JX0	Bacillus anthracis	40%	100%
Q8EU99	Malacoplasma penetrans (strain HF-2)	31%	100%
Q8RLE0	Mycoplasma gallisepticum (strain R(low / passage 15 / clone 2))	32%	100%
Q8VVL0	Mycoplasma mycoides subsp. mycoides SC (strain PG1)	34%	100%
Q97F65	Clostridium acetobutylicum (strain ATCC 824 / DSM 792 / JCM 1419 / LMG 5710 / VKM B-1787)	38%	100%
Q9K6F0	Halalkalibacterium halodurans (strain ATCC BAA-125 / DSM 18197 / FERM 7344 / JCM 9153 / C-125)	36%	100%
Q9PPP5	Ureaplasma parvum serovar 3 (strain ATCC 700970)	34%	100%
Q9RSY5	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	37%	100%