LeishMANIAdb
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Surface antigen-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Surface antigen-like protein
Gene product:
surface antigen-like protein
Species:
Leishmania braziliensis
UniProt:
A4HBX3_LEIBR
TriTrypDb:
LbrM.21.1370 , LBRM2903_210019100
Length:
454

Annotations

LeishMANIAdb interaction annotations

by homology
Contact email: handman@wehi.edu.au
Publication title: A Leucine-Rich Repeat Motif of Leishmania Parasite Surface Antigen 2 Binds to Macrophages through the Complement Receptor 3
Publication 1st author(s): Kedzierski
Publication Identifier(s): 15067069
Host organism: -1
Interaction detection method(s): fluorescence activated cell sorting
Interaction type: physical association
Identification method participant A: identification by antibody
Identification method participant B: identification by antibody
ID(s) interactor A: P11215
ID(s) interactor B: E9AGG4
Taxid interactor A: Homo sapiens
Taxid interactor B: Leishmania infantum
Biological role(s) interactor A: unspecified role
Biological role(s) interactor B: unspecified role
Experimental role(s) interactor A: unspecified role

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 135
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 7
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 72, no: 18
NetGPI no yes: 0, no: 90
Cellular components
Term Name Level Count
GO:0005929 cilium 4 91
GO:0042995 cell projection 2 91
GO:0043226 organelle 2 91
GO:0043227 membrane-bounded organelle 3 91
GO:0110165 cellular anatomical entity 1 91
GO:0120025 plasma membrane bounded cell projection 3 91
GO:0016020 membrane 2 30
GO:0005886 plasma membrane 3 5

Expansion

Sequence features

A4HBX3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBX3

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0004672 protein kinase activity 3 3
GO:0004674 protein serine/threonine kinase activity 4 3
GO:0016301 kinase activity 4 3
GO:0016740 transferase activity 2 3
GO:0016772 transferase activity, transferring phosphorus-containing groups 3 3
GO:0016773 phosphotransferase activity, alcohol group as acceptor 4 3
GO:0140096 catalytic activity, acting on a protein 2 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 318 322 PF00656 0.306
CLV_NRD_NRD_1 309 311 PF00675 0.606
CLV_NRD_NRD_1 52 54 PF00675 0.606
CLV_NRD_NRD_1 9 11 PF00675 0.500
CLV_PCSK_FUR_1 7 11 PF00082 0.315
CLV_PCSK_KEX2_1 309 311 PF00082 0.415
CLV_PCSK_KEX2_1 52 54 PF00082 0.572
CLV_PCSK_KEX2_1 9 11 PF00082 0.500
CLV_PCSK_SKI1_1 189 193 PF00082 0.487
CLV_PCSK_SKI1_1 201 205 PF00082 0.507
CLV_PCSK_SKI1_1 309 313 PF00082 0.530
CLV_PCSK_SKI1_1 52 56 PF00082 0.515
DEG_APCC_DBOX_1 344 352 PF00400 0.357
DOC_CYCLIN_RxL_1 214 224 PF00134 0.179
DOC_CYCLIN_yClb5_NLxxxL_5 343 352 PF00134 0.295
DOC_CYCLIN_yCln2_LP_2 396 402 PF00134 0.136
DOC_MAPK_gen_1 189 199 PF00069 0.136
DOC_MAPK_gen_1 214 223 PF00069 0.211
DOC_MAPK_gen_1 225 234 PF00069 0.181
DOC_MAPK_gen_1 342 351 PF00069 0.380
DOC_MAPK_gen_1 392 402 PF00069 0.319
DOC_PP1_RVXF_1 190 197 PF00149 0.357
DOC_PP4_MxPP_1 1 4 PF00568 0.544
DOC_USP7_MATH_1 105 109 PF00917 0.424
DOC_USP7_MATH_1 261 265 PF00917 0.347
DOC_USP7_MATH_1 283 287 PF00917 0.307
DOC_USP7_MATH_1 334 338 PF00917 0.275
DOC_WW_Pin1_4 427 432 PF00397 0.383
LIG_14-3-3_CanoR_1 152 156 PF00244 0.298
LIG_14-3-3_CanoR_1 216 222 PF00244 0.317
LIG_14-3-3_CanoR_1 262 266 PF00244 0.385
LIG_14-3-3_CanoR_1 309 314 PF00244 0.328
LIG_14-3-3_CanoR_1 38 43 PF00244 0.439
LIG_14-3-3_CanoR_1 7 17 PF00244 0.554
LIG_AP2alpha_1 54 58 PF02296 0.191
LIG_APCC_ABBA_1 40 45 PF00400 0.208
LIG_BRCT_BRCA1_1 192 196 PF00533 0.337
LIG_BRCT_BRCA1_1 285 289 PF00533 0.271
LIG_FHA_1 132 138 PF00498 0.282
LIG_FHA_1 154 160 PF00498 0.255
LIG_FHA_1 178 184 PF00498 0.303
LIG_FHA_1 203 209 PF00498 0.213
LIG_FHA_1 229 235 PF00498 0.340
LIG_FHA_1 242 248 PF00498 0.271
LIG_FHA_1 275 281 PF00498 0.277
LIG_FHA_1 299 305 PF00498 0.255
LIG_FHA_1 30 36 PF00498 0.550
LIG_FHA_1 373 379 PF00498 0.188
LIG_FHA_1 386 392 PF00498 0.163
LIG_FHA_1 90 96 PF00498 0.320
LIG_FHA_2 310 316 PF00498 0.345
LIG_FHA_2 434 440 PF00498 0.328
LIG_LIR_Gen_1 162 170 PF02991 0.216
LIG_LIR_Gen_1 193 204 PF02991 0.246
LIG_LIR_Gen_1 235 242 PF02991 0.243
LIG_LIR_Gen_1 259 266 PF02991 0.216
LIG_LIR_Gen_1 331 338 PF02991 0.273
LIG_LIR_Gen_1 390 401 PF02991 0.199
LIG_LIR_Gen_1 92 101 PF02991 0.457
LIG_LIR_Nem_3 138 142 PF02991 0.305
LIG_LIR_Nem_3 162 166 PF02991 0.238
LIG_LIR_Nem_3 193 199 PF02991 0.222
LIG_LIR_Nem_3 307 311 PF02991 0.285
LIG_LIR_Nem_3 390 396 PF02991 0.204
LIG_LIR_Nem_3 92 97 PF02991 0.435
LIG_NRBOX 23 29 PF00104 0.334
LIG_Pex14_2 54 58 PF04695 0.231
LIG_SH2_CRK 393 397 PF00017 0.300
LIG_SH2_NCK_1 43 47 PF00017 0.397
LIG_SH2_STAT5 173 176 PF00017 0.220
LIG_SH2_STAT5 43 46 PF00017 0.361
LIG_SUMO_SIM_par_1 20 25 PF11976 0.261
LIG_SUMO_SIM_par_1 363 368 PF11976 0.230
LIG_TRAF2_1 34 37 PF00917 0.278
LIG_TYR_ITIM 391 396 PF00017 0.261
LIG_UBA3_1 141 147 PF00899 0.320
LIG_UBA3_1 217 225 PF00899 0.170
MOD_CK1_1 175 181 PF00069 0.256
MOD_CK1_1 190 196 PF00069 0.264
MOD_CK1_1 243 249 PF00069 0.300
MOD_CK1_1 333 339 PF00069 0.288
MOD_CK1_1 368 374 PF00069 0.233
MOD_CK1_1 379 385 PF00069 0.228
MOD_CK1_1 41 47 PF00069 0.379
MOD_CK2_1 309 315 PF00069 0.349
MOD_CK2_1 334 340 PF00069 0.334
MOD_CK2_1 433 439 PF00069 0.350
MOD_GlcNHglycan 131 134 PF01048 0.524
MOD_GlcNHglycan 24 27 PF01048 0.371
MOD_GlcNHglycan 251 255 PF01048 0.451
MOD_GlcNHglycan 29 32 PF01048 0.604
MOD_GlcNHglycan 332 335 PF01048 0.467
MOD_GlcNHglycan 366 370 PF01048 0.452
MOD_GlcNHglycan 372 375 PF01048 0.460
MOD_GlcNHglycan 89 92 PF01048 0.528
MOD_GSK3_1 131 138 PF00069 0.317
MOD_GSK3_1 151 158 PF00069 0.220
MOD_GSK3_1 175 182 PF00069 0.244
MOD_GSK3_1 183 190 PF00069 0.238
MOD_GSK3_1 270 277 PF00069 0.262
MOD_GSK3_1 294 301 PF00069 0.268
MOD_GSK3_1 324 331 PF00069 0.252
MOD_GSK3_1 368 375 PF00069 0.211
MOD_GSK3_1 441 448 PF00069 0.280
MOD_GSK3_1 85 92 PF00069 0.341
MOD_N-GLC_1 129 134 PF02516 0.504
MOD_N-GLC_1 175 180 PF02516 0.413
MOD_N-GLC_1 228 233 PF02516 0.474
MOD_N-GLC_2 450 452 PF02516 0.423
MOD_NEK2_1 131 136 PF00069 0.291
MOD_NEK2_1 155 160 PF00069 0.242
MOD_NEK2_1 172 177 PF00069 0.222
MOD_NEK2_1 179 184 PF00069 0.204
MOD_NEK2_1 204 209 PF00069 0.228
MOD_NEK2_1 217 222 PF00069 0.269
MOD_NEK2_1 228 233 PF00069 0.276
MOD_NEK2_1 252 257 PF00069 0.255
MOD_NEK2_1 27 32 PF00069 0.314
MOD_NEK2_1 276 281 PF00069 0.232
MOD_NEK2_1 300 305 PF00069 0.198
MOD_NEK2_1 365 370 PF00069 0.216
MOD_NEK2_1 372 377 PF00069 0.198
MOD_NEK2_1 58 63 PF00069 0.263
MOD_NEK2_2 187 192 PF00069 0.309
MOD_OFUCOSY 75 82 PF10250 0.483
MOD_PIKK_1 112 118 PF00454 0.369
MOD_PKA_1 309 315 PF00069 0.201
MOD_PKA_1 9 15 PF00069 0.509
MOD_PKA_2 151 157 PF00069 0.238
MOD_PKA_2 261 267 PF00069 0.320
MOD_PKA_2 309 315 PF00069 0.355
MOD_PKA_2 8 14 PF00069 0.613
MOD_PKB_1 7 15 PF00069 0.506
MOD_Plk_1 105 111 PF00069 0.253
MOD_Plk_1 112 118 PF00069 0.332
MOD_Plk_1 175 181 PF00069 0.226
MOD_Plk_1 315 321 PF00069 0.276
MOD_Plk_1 36 42 PF00069 0.325
MOD_Plk_1 433 439 PF00069 0.283
MOD_Plk_2-3 106 112 PF00069 0.208
MOD_Plk_2-3 315 321 PF00069 0.168
MOD_Plk_4 192 198 PF00069 0.266
MOD_Plk_4 261 267 PF00069 0.284
MOD_Plk_4 285 291 PF00069 0.291
MOD_Plk_4 309 315 PF00069 0.324
MOD_Plk_4 38 44 PF00069 0.309
MOD_ProDKin_1 427 433 PF00069 0.377
TRG_DiLeu_BaLyEn_6 1 6 PF01217 0.531
TRG_DiLeu_BaLyEn_6 213 218 PF01217 0.183
TRG_ENDOCYTIC_2 393 396 PF00928 0.230
TRG_ER_diArg_1 214 217 PF00400 0.196
TRG_ER_diArg_1 308 310 PF00400 0.414
TRG_ER_diArg_1 52 54 PF00400 0.408
TRG_ER_diArg_1 8 10 PF00400 0.735
TRG_Pf-PMV_PEXEL_1 219 224 PF00026 0.370
TRG_Pf-PMV_PEXEL_1 53 57 PF00026 0.445

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P6A5 Leptomonas seymouri 35% 71%
A0A0N1I661 Leptomonas seymouri 37% 80%
A0A0N1I7S5 Leptomonas seymouri 36% 89%
A0A0S4IIK7 Bodo saltans 28% 100%
A0A0S4IJN2 Bodo saltans 32% 67%
A0A0S4ILC9 Bodo saltans 38% 82%
A0A0S4IN27 Bodo saltans 43% 84%
A0A0S4IQE4 Bodo saltans 31% 80%
A0A0S4IQP4 Bodo saltans 39% 100%
A0A0S4IR61 Bodo saltans 33% 100%
A0A0S4ISU4 Bodo saltans 37% 69%
A0A0S4IU23 Bodo saltans 29% 77%
A0A0S4IU73 Bodo saltans 44% 91%
A0A0S4IV96 Bodo saltans 40% 75%
A0A0S4IVN7 Bodo saltans 40% 100%
A0A0S4IVQ8 Bodo saltans 37% 75%
A0A0S4IW93 Bodo saltans 31% 75%
A0A0S4IY44 Bodo saltans 30% 68%
A0A0S4IZC7 Bodo saltans 30% 100%
A0A0S4J1A6 Bodo saltans 32% 100%
A0A0S4J206 Bodo saltans 34% 74%
A0A0S4J2H8 Bodo saltans 34% 78%
A0A0S4J3T7 Bodo saltans 36% 100%
A0A0S4J5A0 Bodo saltans 36% 79%
A0A0S4J7Q5 Bodo saltans 30% 100%
A0A0S4JAQ6 Bodo saltans 33% 88%
A0A0S4JAS1 Bodo saltans 40% 72%
A0A0S4JAW7 Bodo saltans 31% 89%
A0A0S4JB95 Bodo saltans 28% 75%
A0A0S4JBV9 Bodo saltans 35% 93%
A0A0S4JCG7 Bodo saltans 42% 100%
A0A0S4JD35 Bodo saltans 30% 76%
A0A0S4JDS1 Bodo saltans 28% 85%
A0A0S4JDT0 Bodo saltans 40% 69%
A0A0S4JEK1 Bodo saltans 26% 100%
A0A0S4JEP2 Bodo saltans 27% 78%
A0A0S4JFC9 Bodo saltans 39% 95%
A0A0S4JFY5 Bodo saltans 37% 100%
A0A0S4JJI3 Bodo saltans 26% 69%
A0A0S4JL29 Bodo saltans 36% 89%
A0A0S4JMF9 Bodo saltans 45% 100%
A0A0S4JP43 Bodo saltans 39% 100%
A0A0S4JQW3 Bodo saltans 25% 100%
A0A0S4JS12 Bodo saltans 30% 100%
A0A0S4JS89 Bodo saltans 37% 100%
A0A0S4JSB8 Bodo saltans 41% 82%
A0A0S4JTQ7 Bodo saltans 36% 86%
A0A0S4KGV4 Bodo saltans 30% 83%
A0A0S4KJA7 Bodo saltans 28% 68%
A0A0S4KK37 Bodo saltans 35% 78%
A0A0S4KL26 Bodo saltans 27% 100%
A0A0S4KMV2 Bodo saltans 30% 100%
A0A3Q8I9A6 Leishmania donovani 36% 100%
A0A3Q8IC27 Leishmania donovani 64% 95%
A0A3Q8IIJ9 Leishmania donovani 34% 94%
A0A3S5H6M3 Leishmania donovani 36% 66%
A0A3S5H6M4 Leishmania donovani 32% 69%
A0A3S7WS66 Leishmania donovani 32% 69%
A0A3S7X4J4 Leishmania donovani 35% 100%
A4HJC8 Leishmania braziliensis 35% 100%
A4HVB0 Leishmania infantum 36% 100%
A4HZ93 Leishmania infantum 64% 95%
A4I6S4 Leishmania infantum 35% 100%
A6NIV6 Homo sapiens 29% 81%
A8XWW4 Caenorhabditis briggsae 25% 81%
D1GJ51 Leishmania infantum 38% 98%
E8NHP8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
E9AGG2 Leishmania infantum 36% 68%
E9AGG5 Leishmania infantum 31% 100%
E9AGG7 Leishmania infantum 31% 72%
E9AGG9 Leishmania infantum 35% 84%
E9AGH0 Leishmania infantum 33% 100%
E9AP02 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9AP03 Leishmania mexicana (strain MHOM/GT/2001/U1103) 31% 100%
E9AP05 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 88%
E9AP07 Leishmania mexicana (strain MHOM/GT/2001/U1103) 37% 100%
E9AVA1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 56% 98%
E9B1U4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 100%
E9B1U6 Leishmania mexicana (strain MHOM/GT/2001/U1103) 36% 100%
O02833 Papio hamadryas 25% 75%
O08770 Rattus norvegicus 25% 80%
P35858 Homo sapiens 25% 75%
Q00874 Arabidopsis thaliana 26% 100%
Q1L8Y7 Danio rerio 28% 81%
Q22875 Caenorhabditis elegans 25% 81%
Q25331 Leishmania major 31% 100%
Q4Q6B6 Leishmania major 36% 100%
Q4Q6B7 Leishmania major 36% 100%
Q4QC79 Leishmania major 67% 100%
Q4QGI0 Leishmania major 34% 100%
Q4QGI2 Leishmania major 34% 100%
Q4QGI4 Leishmania major 33% 100%
Q4QGI6 Leishmania major 34% 100%
Q4QGJ0 Leishmania major 34% 100%
Q4QGJ2 Leishmania major 37% 100%
Q4QGJ4 Leishmania major 31% 100%
Q4QGJ6 Leishmania major 34% 79%
Q4QGJ7 Leishmania major 31% 100%
Q4QGJ9 Leishmania major 37% 100%
Q4QGK0 Leishmania major 32% 100%
Q4QGK2 Leishmania major 32% 100%
Q4QGK4 Leishmania major 37% 100%
Q4QGK6 Leishmania major 31% 100%
Q4QGK8 Leishmania major 32% 100%
Q4QGL2 Leishmania major 32% 100%
Q4QGL4 Leishmania major 34% 100%
Q4QGL8 Leishmania major 36% 100%
Q54AX5 Dictyostelium discoideum 24% 89%
Q5F4C4 Gallus gallus 27% 86%
Q6K7R2 Oryza sativa subsp. japonica 28% 77%
Q7TQ62 Mus musculus 27% 74%
Q7Z5L7 Homo sapiens 27% 74%
Q80VQ1 Mus musculus 30% 87%
Q8AVI4 Xenopus laevis 27% 79%
Q8W3M4 Arabidopsis thaliana 26% 100%
Q940E8 Zea mays 27% 74%
Q9BTT6 Homo sapiens 29% 87%
Q9SKK5 Arabidopsis thaliana 28% 68%
Q9SSD1 Arabidopsis thaliana 29% 92%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS