Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBX1_LEIBR

TriTrypDb:

LbrM.21.1350 , LBRM2903_210018700

Length:

627

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005794	Golgi apparatus	5	6
GO:0016020	membrane	2	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	7
GO:0000139	Golgi membrane	5	1
GO:0031090	organelle membrane	3	1
GO:0031984	organelle subcompartment	2	1
GO:0031985	Golgi cisterna	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0098791	Golgi apparatus subcompartment	3	1

Expansion

Sequence features

A4HBX1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBX1

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	7
GO:0007030	Golgi organization	5	7
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	7
GO:0071840	cellular component organization or biogenesis	2	7
GO:0000301	retrograde transport, vesicle recycling within Golgi	7	1
GO:0006810	transport	3	1
GO:0006891	intra-Golgi vesicle-mediated transport	6	1
GO:0016192	vesicle-mediated transport	4	1
GO:0048193	Golgi vesicle transport	5	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.666
CLV_C14_Caspase3-7	195	199	PF00656	0.583
CLV_NRD_NRD_1	276	278	PF00675	0.349
CLV_NRD_NRD_1	379	381	PF00675	0.440
CLV_PCSK_KEX2_1	276	278	PF00082	0.349
CLV_PCSK_KEX2_1	379	381	PF00082	0.440
CLV_PCSK_PC7_1	375	381	PF00082	0.435
CLV_PCSK_SKI1_1	233	237	PF00082	0.387
CLV_PCSK_SKI1_1	375	379	PF00082	0.393
CLV_PCSK_SKI1_1	577	581	PF00082	0.400
CLV_Separin_Metazoa	619	623	PF03568	0.396
DEG_APCC_DBOX_1	374	382	PF00400	0.634
DEG_APCC_DBOX_1	417	425	PF00400	0.597
DEG_Nend_Nbox_1	1	3	PF02207	0.640
DEG_SPOP_SBC_1	102	106	PF00917	0.647
DEG_SPOP_SBC_1	179	183	PF00917	0.658
DOC_MAPK_gen_1	342	350	PF00069	0.640
DOC_MAPK_gen_1	425	433	PF00069	0.596
DOC_MAPK_gen_1	541	550	PF00069	0.665
DOC_MAPK_MEF2A_6	115	124	PF00069	0.630
DOC_MAPK_MEF2A_6	461	470	PF00069	0.540
DOC_MIT_MIM_1	303	312	PF04212	0.637
DOC_PP2B_LxvP_1	122	125	PF13499	0.677
DOC_PP2B_LxvP_1	155	158	PF13499	0.700
DOC_PP2B_LxvP_1	618	621	PF13499	0.392
DOC_PP4_FxxP_1	490	493	PF00568	0.772
DOC_USP7_MATH_1	102	106	PF00917	0.706
DOC_USP7_MATH_1	165	169	PF00917	0.744
DOC_USP7_MATH_1	227	231	PF00917	0.566
DOC_USP7_MATH_1	283	287	PF00917	0.703
DOC_USP7_MATH_1	346	350	PF00917	0.597
DOC_USP7_MATH_1	360	364	PF00917	0.558
DOC_USP7_MATH_1	395	399	PF00917	0.669
DOC_USP7_MATH_1	494	498	PF00917	0.721
DOC_USP7_MATH_1	509	513	PF00917	0.673
DOC_USP7_MATH_1	564	568	PF00917	0.660
DOC_USP7_MATH_1	79	83	PF00917	0.639
DOC_WW_Pin1_4	391	396	PF00397	0.658
LIG_14-3-3_CanoR_1	226	236	PF00244	0.723
LIG_14-3-3_CanoR_1	38	48	PF00244	0.698
LIG_14-3-3_CanoR_1	475	480	PF00244	0.613
LIG_14-3-3_CanoR_1	523	530	PF00244	0.637
LIG_14-3-3_CanoR_1	559	568	PF00244	0.578
LIG_14-3-3_CanoR_1	577	586	PF00244	0.706
LIG_14-3-3_CanoR_1	587	591	PF00244	0.469
LIG_APCC_ABBA_1	257	262	PF00400	0.624
LIG_BRCT_BRCA1_1	392	396	PF00533	0.592
LIG_BRCT_BRCA1_1	486	490	PF00533	0.727
LIG_EVH1_1	490	494	PF00568	0.724
LIG_FHA_1	14	20	PF00498	0.671
LIG_FHA_1	331	337	PF00498	0.719
LIG_FHA_1	350	356	PF00498	0.502
LIG_FHA_1	606	612	PF00498	0.369
LIG_FHA_2	136	142	PF00498	0.652
LIG_FHA_2	530	536	PF00498	0.702
LIG_LIR_Apic_2	487	493	PF02991	0.723
LIG_LIR_Nem_3	130	134	PF02991	0.640
LIG_PTB_Apo_2	610	617	PF02174	0.422
LIG_PTB_Phospho_1	610	616	PF10480	0.417
LIG_SH2_NCK_1	486	490	PF00017	0.624
LIG_SH2_PTP2	593	596	PF00017	0.304
LIG_SH2_STAP1	486	490	PF00017	0.625
LIG_SH2_STAT5	593	596	PF00017	0.304
LIG_SH2_STAT5	616	619	PF00017	0.385
LIG_SH3_3	488	494	PF00018	0.752
LIG_SH3_3	614	620	PF00018	0.514
LIG_SUMO_SIM_par_1	120	126	PF11976	0.725
LIG_SUMO_SIM_par_1	607	612	PF11976	0.369
LIG_TRAF2_1	271	274	PF00917	0.535
LIG_TRAF2_2	291	296	PF00917	0.700
LIG_TRFH_1	616	620	PF08558	0.386
LIG_TYR_ITIM	454	459	PF00017	0.532
LIG_UBA3_1	8	15	PF00899	0.561
LIG_WRC_WIRS_1	128	133	PF05994	0.688
LIG_WRPW_2	131	134	PF00400	0.642
LIG_WW_3	619	623	PF00397	0.396
MOD_CK1_1	123	129	PF00069	0.727
MOD_CK1_1	168	174	PF00069	0.695
MOD_CK1_1	286	292	PF00069	0.678
MOD_CK1_1	349	355	PF00069	0.528
MOD_CK1_1	391	397	PF00069	0.668
MOD_CK1_1	526	532	PF00069	0.630
MOD_CK1_1	567	573	PF00069	0.615
MOD_CK2_1	284	290	PF00069	0.691
MOD_CK2_1	407	413	PF00069	0.567
MOD_CK2_1	529	535	PF00069	0.691
MOD_GlcNHglycan	229	232	PF01048	0.359
MOD_GlcNHglycan	286	289	PF01048	0.498
MOD_GlcNHglycan	375	378	PF01048	0.458
MOD_GlcNHglycan	390	393	PF01048	0.403
MOD_GlcNHglycan	397	400	PF01048	0.475
MOD_GlcNHglycan	409	412	PF01048	0.373
MOD_GlcNHglycan	42	45	PF01048	0.500
MOD_GlcNHglycan	486	489	PF01048	0.531
MOD_GlcNHglycan	511	514	PF01048	0.475
MOD_GlcNHglycan	515	518	PF01048	0.505
MOD_GlcNHglycan	525	528	PF01048	0.447
MOD_GlcNHglycan	569	572	PF01048	0.348
MOD_GlcNHglycan	66	70	PF01048	0.493
MOD_GlcNHglycan	88	91	PF01048	0.594
MOD_GSK3_1	104	111	PF00069	0.705
MOD_GSK3_1	123	130	PF00069	0.724
MOD_GSK3_1	156	163	PF00069	0.658
MOD_GSK3_1	164	171	PF00069	0.723
MOD_GSK3_1	193	200	PF00069	0.670
MOD_GSK3_1	310	317	PF00069	0.531
MOD_GSK3_1	391	398	PF00069	0.656
MOD_GSK3_1	40	47	PF00069	0.684
MOD_GSK3_1	429	436	PF00069	0.609
MOD_GSK3_1	509	516	PF00069	0.618
MOD_GSK3_1	526	533	PF00069	0.727
MOD_GSK3_1	560	567	PF00069	0.613
MOD_GSK3_1	601	608	PF00069	0.227
MOD_NEK2_1	101	106	PF00069	0.739
MOD_NEK2_1	164	169	PF00069	0.686
MOD_NEK2_1	39	44	PF00069	0.643
MOD_NEK2_1	474	479	PF00069	0.689
MOD_NEK2_1	70	75	PF00069	0.679
MOD_PIKK_1	169	175	PF00454	0.764
MOD_PIKK_1	261	267	PF00454	0.627
MOD_PIKK_1	52	58	PF00454	0.633
MOD_PIKK_1	577	583	PF00454	0.597
MOD_PKA_2	243	249	PF00069	0.642
MOD_PKA_2	360	366	PF00069	0.638
MOD_PKA_2	474	480	PF00069	0.690
MOD_PKA_2	586	592	PF00069	0.414
MOD_PKA_2	79	85	PF00069	0.674
MOD_Plk_1	197	203	PF00069	0.598
MOD_Plk_2-3	13	19	PF00069	0.623
MOD_Plk_4	165	171	PF00069	0.689
MOD_Plk_4	255	261	PF00069	0.586
MOD_Plk_4	475	481	PF00069	0.632
MOD_Plk_4	586	592	PF00069	0.414
MOD_Plk_4	601	607	PF00069	0.236
MOD_ProDKin_1	391	397	PF00069	0.657
MOD_SUMO_rev_2	10	16	PF00179	0.618
MOD_SUMO_rev_2	448	454	PF00179	0.594
TRG_DiLeu_BaLyEn_6	263	268	PF01217	0.578
TRG_DiLeu_BaLyEn_6	35	40	PF01217	0.609
TRG_ENDOCYTIC_2	456	459	PF00928	0.582
TRG_ENDOCYTIC_2	593	596	PF00928	0.304
TRG_ER_diArg_1	275	277	PF00400	0.538
TRG_ER_diArg_1	378	380	PF00400	0.641
TRG_NES_CRM1_1	458	469	PF08389	0.535
TRG_Pf-PMV_PEXEL_1	26	30	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	266	270	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	379	384	PF00026	0.398
TRG_Pf-PMV_PEXEL_1	577	581	PF00026	0.400

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCL5	Leptomonas seymouri	39%	94%
A0A3Q8IB66	Leishmania donovani	73%	100%
A4HZ89	Leishmania infantum	73%	100%
E9AV97	Leishmania mexicana (strain MHOM/GT/2001/U1103)	73%	100%
Q4QC83	Leishmania major	72%	100%