Putative U4/U6 small nuclear ribonuclear protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

U4/U6 small nuclear ribonuclear protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBX0_LEIBR

TriTrypDb:

LbrM.21.1340 , LBRM2903_210018600

Length:

608

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0030532	small nuclear ribonucleoprotein complex	3	1
GO:0032991	protein-containing complex	1	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	1
GO:0097525	spliceosomal snRNP complex	4	1
GO:0097526	spliceosomal tri-snRNP complex	5	1
GO:0110165	cellular anatomical entity	1	6
GO:0120114	Sm-like protein family complex	2	1
GO:0140513	nuclear protein-containing complex	2	1
GO:1990904	ribonucleoprotein complex	2	5
GO:0005840	ribosome	5	4
GO:0043228	non-membrane-bounded organelle	3	4
GO:0043232	intracellular non-membrane-bounded organelle	4	4

Expansion

Sequence features

A4HBX0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBX0

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	1
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	1
GO:0000398	mRNA splicing, via spliceosome	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006396	RNA processing	6	1
GO:0006397	mRNA processing	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0008380	RNA splicing	7	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	5
GO:0016740	transferase activity	2	5
GO:0003676	nucleic acid binding	3	1
GO:0003723	RNA binding	4	1
GO:0005488	binding	1	1
GO:0017069	snRNA binding	5	1
GO:0017070	U6 snRNA binding	6	1
GO:0030621	U4 snRNA binding	6	1
GO:0030627	pre-mRNA 5'-splice site binding	6	1
GO:0036002	pre-mRNA binding	5	1
GO:0097159	organic cyclic compound binding	2	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	235	239	PF00656	0.631
CLV_C14_Caspase3-7	324	328	PF00656	0.482
CLV_C14_Caspase3-7	424	428	PF00656	0.501
CLV_C14_Caspase3-7	556	560	PF00656	0.737
CLV_NRD_NRD_1	383	385	PF00675	0.551
CLV_NRD_NRD_1	569	571	PF00675	0.607
CLV_NRD_NRD_1	604	606	PF00675	0.700
CLV_PCSK_KEX2_1	52	54	PF00082	0.473
CLV_PCSK_PC1ET2_1	52	54	PF00082	0.455
CLV_PCSK_SKI1_1	132	136	PF00082	0.457
CLV_PCSK_SKI1_1	275	279	PF00082	0.553
CLV_PCSK_SKI1_1	78	82	PF00082	0.427
CLV_PCSK_SKI1_1	84	88	PF00082	0.466
DEG_APCC_DBOX_1	472	480	PF00400	0.535
DEG_SCF_FBW7_1	231	236	PF00400	0.432
DEG_SPOP_SBC_1	286	290	PF00917	0.659
DOC_CYCLIN_yClb3_PxF_3	477	483	PF00134	0.427
DOC_MAPK_DCC_7	429	439	PF00069	0.379
DOC_MAPK_gen_1	78	88	PF00069	0.442
DOC_PP1_RVXF_1	329	336	PF00149	0.378
DOC_PP2B_LxvP_1	102	105	PF13499	0.460
DOC_PP4_FxxP_1	483	486	PF00568	0.325
DOC_USP7_MATH_1	105	109	PF00917	0.434
DOC_USP7_MATH_1	152	156	PF00917	0.408
DOC_USP7_MATH_1	23	27	PF00917	0.645
DOC_USP7_MATH_1	233	237	PF00917	0.627
DOC_USP7_MATH_1	285	289	PF00917	0.540
DOC_USP7_MATH_1	318	322	PF00917	0.380
DOC_USP7_MATH_1	412	416	PF00917	0.539
DOC_USP7_MATH_1	425	429	PF00917	0.480
DOC_USP7_MATH_1	532	536	PF00917	0.459
DOC_USP7_MATH_1	546	550	PF00917	0.664
DOC_WW_Pin1_4	11	16	PF00397	0.657
DOC_WW_Pin1_4	148	153	PF00397	0.540
DOC_WW_Pin1_4	19	24	PF00397	0.533
DOC_WW_Pin1_4	229	234	PF00397	0.443
DOC_WW_Pin1_4	290	295	PF00397	0.598
DOC_WW_Pin1_4	360	365	PF00397	0.344
DOC_WW_Pin1_4	477	482	PF00397	0.495
LIG_14-3-3_CanoR_1	182	187	PF00244	0.684
LIG_14-3-3_CanoR_1	540	544	PF00244	0.622
LIG_APCC_ABBA_1	391	396	PF00400	0.616
LIG_BIR_II_1	1	5	PF00653	0.548
LIG_BIR_III_4	327	331	PF00653	0.477
LIG_BIR_III_4	396	400	PF00653	0.500
LIG_BRCT_BRCA1_1	13	17	PF00533	0.670
LIG_BRCT_BRCA1_1	187	191	PF00533	0.463
LIG_BRCT_BRCA1_1	414	418	PF00533	0.437
LIG_BRCT_BRCA1_1	479	483	PF00533	0.565
LIG_CSL_BTD_1	361	364	PF09270	0.390
LIG_FHA_1	226	232	PF00498	0.507
LIG_FHA_1	254	260	PF00498	0.372
LIG_FHA_1	264	270	PF00498	0.353
LIG_FHA_1	291	297	PF00498	0.563
LIG_FHA_1	309	315	PF00498	0.265
LIG_FHA_1	439	445	PF00498	0.464
LIG_FHA_2	141	147	PF00498	0.432
LIG_FHA_2	230	236	PF00498	0.654
LIG_FHA_2	322	328	PF00498	0.466
LIG_FHA_2	440	446	PF00498	0.448
LIG_FHA_2	503	509	PF00498	0.547
LIG_FHA_2	556	562	PF00498	0.755
LIG_LIR_Apic_2	417	422	PF02991	0.510
LIG_LIR_Apic_2	480	486	PF02991	0.339
LIG_LIR_Gen_1	194	202	PF02991	0.496
LIG_LIR_Gen_1	401	412	PF02991	0.299
LIG_LIR_Gen_1	6	15	PF02991	0.649
LIG_LIR_Nem_3	162	168	PF02991	0.461
LIG_LIR_Nem_3	194	199	PF02991	0.496
LIG_LIR_Nem_3	401	407	PF02991	0.532
LIG_LIR_Nem_3	6	11	PF02991	0.660
LIG_MYND_1	474	478	PF01753	0.554
LIG_PCNA_yPIPBox_3	30	43	PF02747	0.530
LIG_Rb_pABgroove_1	375	383	PF01858	0.483
LIG_SH2_CRK	55	59	PF00017	0.485
LIG_SH2_GRB2like	419	422	PF00017	0.504
LIG_SH2_NCK_1	305	309	PF00017	0.538
LIG_SH2_PTP2	419	422	PF00017	0.379
LIG_SH2_PTP2	8	11	PF00017	0.708
LIG_SH2_SRC	419	422	PF00017	0.504
LIG_SH2_STAT5	419	422	PF00017	0.379
LIG_SH2_STAT5	8	11	PF00017	0.689
LIG_SH3_1	570	576	PF00018	0.713
LIG_SH3_3	110	116	PF00018	0.473
LIG_SH3_3	169	175	PF00018	0.416
LIG_SH3_3	219	225	PF00018	0.388
LIG_SH3_3	471	477	PF00018	0.498
LIG_SH3_3	570	576	PF00018	0.713
LIG_SUMO_SIM_anti_2	487	493	PF11976	0.379
LIG_SUMO_SIM_par_1	139	146	PF11976	0.406
LIG_TRAF2_1	510	513	PF00917	0.471
LIG_TRAF2_1	554	557	PF00917	0.619
LIG_UBA3_1	566	572	PF00899	0.598
LIG_WRC_WIRS_1	186	191	PF05994	0.278
MOD_CDK_SPK_2	11	16	PF00069	0.679
MOD_CDK_SPxxK_3	11	18	PF00069	0.661
MOD_CK1_1	123	129	PF00069	0.671
MOD_CK1_1	154	160	PF00069	0.428
MOD_CK1_1	185	191	PF00069	0.422
MOD_CK1_1	236	242	PF00069	0.719
MOD_CK1_1	3	9	PF00069	0.626
MOD_CK1_1	321	327	PF00069	0.383
MOD_CK1_1	485	491	PF00069	0.353
MOD_CK1_1	549	555	PF00069	0.684
MOD_CK1_1	582	588	PF00069	0.532
MOD_CK2_1	229	235	PF00069	0.650
MOD_CK2_1	502	508	PF00069	0.585
MOD_CK2_1	583	589	PF00069	0.528
MOD_CK2_1	594	600	PF00069	0.705
MOD_GlcNHglycan	121	125	PF01048	0.678
MOD_GlcNHglycan	129	132	PF01048	0.284
MOD_GlcNHglycan	136	139	PF01048	0.522
MOD_GlcNHglycan	241	244	PF01048	0.654
MOD_GlcNHglycan	283	286	PF01048	0.712
MOD_GlcNHglycan	338	341	PF01048	0.427
MOD_GlcNHglycan	370	373	PF01048	0.396
MOD_GlcNHglycan	423	426	PF01048	0.337
MOD_GlcNHglycan	530	533	PF01048	0.509
MOD_GlcNHglycan	534	537	PF01048	0.515
MOD_GlcNHglycan	95	98	PF01048	0.542
MOD_GSK3_1	120	127	PF00069	0.656
MOD_GSK3_1	148	155	PF00069	0.465
MOD_GSK3_1	185	192	PF00069	0.481
MOD_GSK3_1	19	26	PF00069	0.592
MOD_GSK3_1	225	232	PF00069	0.547
MOD_GSK3_1	233	240	PF00069	0.599
MOD_GSK3_1	281	288	PF00069	0.659
MOD_GSK3_1	290	297	PF00069	0.578
MOD_GSK3_1	318	325	PF00069	0.409
MOD_GSK3_1	421	428	PF00069	0.421
MOD_GSK3_1	440	447	PF00069	0.495
MOD_GSK3_1	528	535	PF00069	0.684
MOD_GSK3_1	579	586	PF00069	0.652
MOD_N-GLC_1	148	153	PF02516	0.364
MOD_N-GLC_1	552	557	PF02516	0.517
MOD_NEK2_1	17	22	PF00069	0.623
MOD_NEK2_1	189	194	PF00069	0.344
MOD_NEK2_1	260	265	PF00069	0.435
MOD_NEK2_1	278	283	PF00069	0.587
MOD_NEK2_1	439	444	PF00069	0.450
MOD_NEK2_1	539	544	PF00069	0.648
MOD_NEK2_1	580	585	PF00069	0.658
MOD_NEK2_1	70	75	PF00069	0.507
MOD_NEK2_2	265	270	PF00069	0.285
MOD_OFUCOSY	103	109	PF10250	0.378
MOD_PIKK_1	152	158	PF00454	0.486
MOD_PIKK_1	17	23	PF00454	0.596
MOD_PIKK_1	211	217	PF00454	0.607
MOD_PIKK_1	38	44	PF00454	0.591
MOD_PK_1	167	173	PF00069	0.455
MOD_PK_1	182	188	PF00069	0.566
MOD_PKA_1	384	390	PF00069	0.593
MOD_PKA_2	539	545	PF00069	0.646
MOD_PKA_2	549	555	PF00069	0.500
MOD_Plk_1	233	239	PF00069	0.465
MOD_Plk_1	444	450	PF00069	0.539
MOD_Plk_2-3	557	563	PF00069	0.637
MOD_Plk_2-3	594	600	PF00069	0.720
MOD_Plk_4	140	146	PF00069	0.358
MOD_Plk_4	167	173	PF00069	0.473
MOD_Plk_4	191	197	PF00069	0.384
MOD_Plk_4	318	324	PF00069	0.375
MOD_Plk_4	4	10	PF00069	0.705
MOD_Plk_4	414	420	PF00069	0.513
MOD_Plk_4	485	491	PF00069	0.371
MOD_Plk_4	539	545	PF00069	0.567
MOD_Plk_4	583	589	PF00069	0.652
MOD_ProDKin_1	11	17	PF00069	0.644
MOD_ProDKin_1	148	154	PF00069	0.538
MOD_ProDKin_1	19	25	PF00069	0.531
MOD_ProDKin_1	229	235	PF00069	0.458
MOD_ProDKin_1	290	296	PF00069	0.581
MOD_ProDKin_1	360	366	PF00069	0.346
MOD_ProDKin_1	477	483	PF00069	0.488
TRG_ENDOCYTIC_2	8	11	PF00928	0.708
TRG_ER_diArg_1	76	79	PF00400	0.429
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.179

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3A5	Leptomonas seymouri	60%	94%
A0A0S4JGF5	Bodo saltans	32%	100%
A0A1X0NYH8	Trypanosomatidae	35%	93%
A0A3S7WWM8	Leishmania donovani	83%	100%
A0A422NAK4	Trypanosoma rangeli	40%	100%
D0A183	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AGY0	Leishmania infantum	83%	100%
E9AV96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	99%
Q4QC84	Leishmania major	81%	100%
V5B548	Trypanosoma cruzi	39%	100%