Atrophin-1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Atrophin-1

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBW3_LEIBR

TriTrypDb:

LbrM.21.1260 , LBRM2903_210017200

Length:

837

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBW3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	621	625	PF00656	0.575
CLV_C14_Caspase3-7	668	672	PF00656	0.680
CLV_NRD_NRD_1	242	244	PF00675	0.697
CLV_NRD_NRD_1	330	332	PF00675	0.496
CLV_NRD_NRD_1	359	361	PF00675	0.582
CLV_NRD_NRD_1	38	40	PF00675	0.649
CLV_NRD_NRD_1	396	398	PF00675	0.539
CLV_NRD_NRD_1	404	406	PF00675	0.628
CLV_NRD_NRD_1	47	49	PF00675	0.602
CLV_NRD_NRD_1	519	521	PF00675	0.500
CLV_NRD_NRD_1	536	538	PF00675	0.626
CLV_NRD_NRD_1	7	9	PF00675	0.523
CLV_NRD_NRD_1	714	716	PF00675	0.497
CLV_PCSK_FUR_1	305	309	PF00082	0.408
CLV_PCSK_FUR_1	367	371	PF00082	0.648
CLV_PCSK_KEX2_1	242	244	PF00082	0.697
CLV_PCSK_KEX2_1	307	309	PF00082	0.406
CLV_PCSK_KEX2_1	359	361	PF00082	0.582
CLV_PCSK_KEX2_1	369	371	PF00082	0.656
CLV_PCSK_KEX2_1	38	40	PF00082	0.649
CLV_PCSK_KEX2_1	396	398	PF00082	0.541
CLV_PCSK_KEX2_1	404	406	PF00082	0.582
CLV_PCSK_KEX2_1	47	49	PF00082	0.602
CLV_PCSK_KEX2_1	519	521	PF00082	0.500
CLV_PCSK_KEX2_1	536	538	PF00082	0.626
CLV_PCSK_KEX2_1	6	8	PF00082	0.528
CLV_PCSK_KEX2_1	793	795	PF00082	0.626
CLV_PCSK_PC1ET2_1	307	309	PF00082	0.406
CLV_PCSK_PC1ET2_1	369	371	PF00082	0.565
CLV_PCSK_PC1ET2_1	793	795	PF00082	0.525
CLV_PCSK_PC7_1	3	9	PF00082	0.532
CLV_PCSK_PC7_1	303	309	PF00082	0.414
CLV_PCSK_PC7_1	515	521	PF00082	0.576
CLV_PCSK_SKI1_1	323	327	PF00082	0.481
CLV_PCSK_SKI1_1	372	376	PF00082	0.515
CLV_PCSK_SKI1_1	519	523	PF00082	0.499
CLV_PCSK_SKI1_1	599	603	PF00082	0.527
CLV_Separin_Metazoa	833	837	PF03568	0.521
DEG_APCC_DBOX_1	514	522	PF00400	0.577
DEG_Nend_Nbox_1	1	3	PF02207	0.575
DEG_SCF_FBW7_1	736	743	PF00400	0.499
DEG_SPOP_SBC_1	619	623	PF00917	0.616
DEG_SPOP_SBC_1	710	714	PF00917	0.513
DEG_SPOP_SBC_1	819	823	PF00917	0.489
DOC_CYCLIN_yClb5_NLxxxL_5	472	481	PF00134	0.518
DOC_CYCLIN_yCln2_LP_2	172	178	PF00134	0.564
DOC_CYCLIN_yCln2_LP_2	460	466	PF00134	0.659
DOC_MAPK_gen_1	181	188	PF00069	0.606
DOC_MAPK_gen_1	307	317	PF00069	0.403
DOC_MAPK_MEF2A_6	181	188	PF00069	0.576
DOC_PP2B_LxvP_1	172	175	PF13499	0.625
DOC_PP2B_LxvP_1	454	457	PF13499	0.689
DOC_PP2B_LxvP_1	460	463	PF13499	0.605
DOC_PP2B_LxvP_1	607	610	PF13499	0.586
DOC_PP4_FxxP_1	683	686	PF00568	0.584
DOC_PP4_FxxP_1	687	690	PF00568	0.594
DOC_USP7_MATH_1	101	105	PF00917	0.548
DOC_USP7_MATH_1	192	196	PF00917	0.597
DOC_USP7_MATH_1	272	276	PF00917	0.770
DOC_USP7_MATH_1	513	517	PF00917	0.452
DOC_USP7_MATH_1	538	542	PF00917	0.645
DOC_USP7_MATH_1	552	556	PF00917	0.551
DOC_USP7_MATH_1	558	562	PF00917	0.486
DOC_USP7_MATH_1	575	579	PF00917	0.705
DOC_USP7_MATH_1	586	590	PF00917	0.583
DOC_USP7_MATH_1	618	622	PF00917	0.718
DOC_USP7_MATH_1	643	647	PF00917	0.563
DOC_USP7_MATH_1	65	69	PF00917	0.520
DOC_USP7_MATH_1	650	654	PF00917	0.570
DOC_USP7_MATH_1	740	744	PF00917	0.560
DOC_USP7_MATH_1	754	758	PF00917	0.503
DOC_USP7_MATH_1	772	776	PF00917	0.494
DOC_USP7_MATH_1	819	823	PF00917	0.517
DOC_USP7_UBL2_3	421	425	PF12436	0.692
DOC_WW_Pin1_4	118	123	PF00397	0.663
DOC_WW_Pin1_4	131	136	PF00397	0.530
DOC_WW_Pin1_4	201	206	PF00397	0.757
DOC_WW_Pin1_4	221	226	PF00397	0.558
DOC_WW_Pin1_4	232	237	PF00397	0.647
DOC_WW_Pin1_4	244	249	PF00397	0.679
DOC_WW_Pin1_4	268	273	PF00397	0.693
DOC_WW_Pin1_4	420	425	PF00397	0.585
DOC_WW_Pin1_4	426	431	PF00397	0.669
DOC_WW_Pin1_4	458	463	PF00397	0.605
DOC_WW_Pin1_4	485	490	PF00397	0.609
DOC_WW_Pin1_4	573	578	PF00397	0.588
DOC_WW_Pin1_4	693	698	PF00397	0.620
DOC_WW_Pin1_4	736	741	PF00397	0.699
DOC_WW_Pin1_4	768	773	PF00397	0.599
DOC_WW_Pin1_4	808	813	PF00397	0.748
LIG_14-3-3_CanoR_1	242	248	PF00244	0.633
LIG_14-3-3_CanoR_1	273	281	PF00244	0.692
LIG_14-3-3_CanoR_1	344	350	PF00244	0.404
LIG_14-3-3_CanoR_1	592	600	PF00244	0.664
LIG_14-3-3_CanoR_1	749	756	PF00244	0.497
LIG_AP2alpha_2	28	30	PF02296	0.480
LIG_BIR_III_2	100	104	PF00653	0.528
LIG_BIR_III_4	580	584	PF00653	0.564
LIG_BRCT_BRCA1_1	540	544	PF00533	0.510
LIG_EVH1_1	607	611	PF00568	0.599
LIG_EVH1_2	184	188	PF00568	0.584
LIG_EVH1_2	199	203	PF00568	0.601
LIG_FHA_1	509	515	PF00498	0.619
LIG_FHA_1	520	526	PF00498	0.444
LIG_FHA_1	704	710	PF00498	0.603
LIG_FHA_1	736	742	PF00498	0.528
LIG_FHA_1	819	825	PF00498	0.490
LIG_FHA_2	417	423	PF00498	0.587
LIG_FHA_2	668	674	PF00498	0.676
LIG_FHA_2	797	803	PF00498	0.649
LIG_LIR_Apic_2	681	686	PF02991	0.588
LIG_LIR_Nem_3	157	162	PF02991	0.552
LIG_LIR_Nem_3	202	206	PF02991	0.535
LIG_MYND_1	252	256	PF01753	0.571
LIG_MYND_1	443	447	PF01753	0.540
LIG_Pex14_1	635	639	PF04695	0.506
LIG_Pex14_2	683	687	PF04695	0.653
LIG_SH2_CRK	111	115	PF00017	0.522
LIG_SH2_CRK	132	136	PF00017	0.605
LIG_SH2_CRK	492	496	PF00017	0.564
LIG_SH2_NCK_1	127	131	PF00017	0.585
LIG_SH2_NCK_1	132	136	PF00017	0.605
LIG_SH2_SRC	117	120	PF00017	0.513
LIG_SH2_STAP1	820	824	PF00017	0.541
LIG_SH2_STAT5	117	120	PF00017	0.513
LIG_SH2_STAT5	21	24	PF00017	0.516
LIG_SH2_STAT5	233	236	PF00017	0.663
LIG_SH2_STAT5	471	474	PF00017	0.594
LIG_SH2_STAT5	494	497	PF00017	0.566
LIG_SH2_STAT5	569	572	PF00017	0.616
LIG_SH2_STAT5	820	823	PF00017	0.490
LIG_SH3_3	158	164	PF00018	0.558
LIG_SH3_3	176	182	PF00018	0.621
LIG_SH3_3	204	210	PF00018	0.742
LIG_SH3_3	247	253	PF00018	0.641
LIG_SH3_3	411	417	PF00018	0.643
LIG_SH3_3	440	446	PF00018	0.783
LIG_SH3_3	456	462	PF00018	0.641
LIG_SH3_3	554	560	PF00018	0.532
LIG_SH3_3	594	600	PF00018	0.693
LIG_SH3_3	605	611	PF00018	0.592
LIG_SH3_3	614	620	PF00018	0.611
LIG_SH3_3	691	697	PF00018	0.620
LIG_SUMO_SIM_anti_2	704	709	PF11976	0.531
LIG_SUMO_SIM_par_1	704	714	PF11976	0.523
LIG_TRAF2_1	31	34	PF00917	0.596
LIG_TRAF2_2	212	217	PF00917	0.555
LIG_WRPW_2	598	601	PF00400	0.535
MOD_CDC14_SPxK_1	771	774	PF00782	0.589
MOD_CDK_SPK_2	221	226	PF00069	0.744
MOD_CDK_SPK_2	268	273	PF00069	0.693
MOD_CDK_SPK_2	420	425	PF00069	0.549
MOD_CDK_SPxK_1	768	774	PF00069	0.595
MOD_CDK_SPxxK_3	118	125	PF00069	0.570
MOD_CDK_SPxxK_3	808	815	PF00069	0.527
MOD_CK1_1	134	140	PF00069	0.528
MOD_CK1_1	190	196	PF00069	0.525
MOD_CK1_1	277	283	PF00069	0.696
MOD_CK1_1	455	461	PF00069	0.581
MOD_CK1_1	465	471	PF00069	0.471
MOD_CK1_1	641	647	PF00069	0.494
MOD_CK1_1	658	664	PF00069	0.567
MOD_CK1_1	667	673	PF00069	0.650
MOD_CK1_1	732	738	PF00069	0.507
MOD_CK1_1	780	786	PF00069	0.579
MOD_CK1_1	788	794	PF00069	0.500
MOD_CK1_1	823	829	PF00069	0.500
MOD_CK2_1	191	197	PF00069	0.665
MOD_CK2_1	28	34	PF00069	0.582
MOD_CK2_1	295	301	PF00069	0.531
MOD_CK2_1	416	422	PF00069	0.558
MOD_CK2_1	756	762	PF00069	0.571
MOD_CK2_1	827	833	PF00069	0.709
MOD_GlcNHglycan	136	139	PF01048	0.543
MOD_GlcNHglycan	156	159	PF01048	0.538
MOD_GlcNHglycan	189	192	PF01048	0.675
MOD_GlcNHglycan	194	197	PF01048	0.619
MOD_GlcNHglycan	25	28	PF01048	0.468
MOD_GlcNHglycan	433	436	PF01048	0.632
MOD_GlcNHglycan	454	457	PF01048	0.551
MOD_GlcNHglycan	464	467	PF01048	0.672
MOD_GlcNHglycan	495	498	PF01048	0.521
MOD_GlcNHglycan	554	557	PF01048	0.620
MOD_GlcNHglycan	588	591	PF01048	0.641
MOD_GlcNHglycan	593	596	PF01048	0.656
MOD_GlcNHglycan	645	648	PF01048	0.590
MOD_GlcNHglycan	660	663	PF01048	0.508
MOD_GlcNHglycan	731	734	PF01048	0.499
MOD_GlcNHglycan	756	759	PF01048	0.646
MOD_GlcNHglycan	808	811	PF01048	0.518
MOD_GlcNHglycan	95	98	PF01048	0.647
MOD_GSK3_1	187	194	PF00069	0.671
MOD_GSK3_1	268	275	PF00069	0.691
MOD_GSK3_1	416	423	PF00069	0.553
MOD_GSK3_1	426	433	PF00069	0.597
MOD_GSK3_1	437	444	PF00069	0.661
MOD_GSK3_1	458	465	PF00069	0.523
MOD_GSK3_1	565	572	PF00069	0.601
MOD_GSK3_1	637	644	PF00069	0.507
MOD_GSK3_1	674	681	PF00069	0.580
MOD_GSK3_1	732	739	PF00069	0.499
MOD_GSK3_1	740	747	PF00069	0.605
MOD_GSK3_1	748	755	PF00069	0.546
MOD_GSK3_1	768	775	PF00069	0.627
MOD_GSK3_1	819	826	PF00069	0.490
MOD_N-GLC_2	498	500	PF02516	0.661
MOD_NEK2_1	539	544	PF00069	0.509
MOD_NEK2_1	638	643	PF00069	0.508
MOD_NEK2_1	665	670	PF00069	0.726
MOD_NEK2_1	748	753	PF00069	0.506
MOD_NEK2_1	827	832	PF00069	0.510
MOD_PIKK_1	390	396	PF00454	0.674
MOD_PIKK_1	508	514	PF00454	0.620
MOD_PIKK_1	65	71	PF00454	0.514
MOD_PIKK_1	827	833	PF00454	0.514
MOD_PKA_1	519	525	PF00069	0.501
MOD_PKA_2	23	29	PF00069	0.464
MOD_PKA_2	272	278	PF00069	0.694
MOD_PKA_2	343	349	PF00069	0.406
MOD_PKA_2	390	396	PF00069	0.674
MOD_PKA_2	519	525	PF00069	0.501
MOD_PKA_2	591	597	PF00069	0.657
MOD_PKA_2	748	754	PF00069	0.529
MOD_PKB_1	794	802	PF00069	0.524
MOD_Plk_1	539	545	PF00069	0.511
MOD_Plk_1	703	709	PF00069	0.528
MOD_Plk_2-3	295	301	PF00069	0.453
MOD_Plk_2-3	762	768	PF00069	0.512
MOD_Plk_4	144	150	PF00069	0.488
MOD_Plk_4	246	252	PF00069	0.693
MOD_Plk_4	437	443	PF00069	0.556
MOD_Plk_4	455	461	PF00069	0.641
MOD_Plk_4	565	571	PF00069	0.619
MOD_Plk_4	650	656	PF00069	0.634
MOD_Plk_4	703	709	PF00069	0.615
MOD_Plk_4	718	724	PF00069	0.446
MOD_ProDKin_1	118	124	PF00069	0.664
MOD_ProDKin_1	131	137	PF00069	0.529
MOD_ProDKin_1	201	207	PF00069	0.754
MOD_ProDKin_1	221	227	PF00069	0.557
MOD_ProDKin_1	232	238	PF00069	0.648
MOD_ProDKin_1	244	250	PF00069	0.680
MOD_ProDKin_1	268	274	PF00069	0.690
MOD_ProDKin_1	420	426	PF00069	0.580
MOD_ProDKin_1	458	464	PF00069	0.603
MOD_ProDKin_1	485	491	PF00069	0.611
MOD_ProDKin_1	573	579	PF00069	0.591
MOD_ProDKin_1	693	699	PF00069	0.620
MOD_ProDKin_1	736	742	PF00069	0.698
MOD_ProDKin_1	768	774	PF00069	0.600
MOD_ProDKin_1	808	814	PF00069	0.746
MOD_SUMO_rev_2	368	377	PF00179	0.509
TRG_DiLeu_BaEn_2	678	684	PF01217	0.600
TRG_ENDOCYTIC_2	146	149	PF00928	0.526
TRG_ENDOCYTIC_2	492	495	PF00928	0.528
TRG_ENDOCYTIC_2	598	601	PF00928	0.613
TRG_ER_diArg_1	242	244	PF00400	0.555
TRG_ER_diArg_1	38	40	PF00400	0.637
TRG_ER_diArg_1	404	407	PF00400	0.628
TRG_ER_diArg_1	46	48	PF00400	0.614
TRG_ER_diArg_1	518	520	PF00400	0.504
TRG_ER_diArg_1	6	8	PF00400	0.532
TRG_ER_diArg_1	794	797	PF00400	0.612
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.501
TRG_Pf-PMV_PEXEL_1	482	486	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I1W4	Leptomonas seymouri	46%	94%
A0A3S7WWJ6	Leishmania donovani	69%	100%
E9AGX1	Leishmania infantum	69%	100%
E9AV87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4QC93	Leishmania major	69%	99%