Putative dynein arm light chain

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dynein arm light chain, putative

Species:

Leishmania braziliensis

UniProt:

A4HBW2_LEIBR

TriTrypDb:

LbrM.21.1250 , LBRM2903_210017100

Length:

313

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HBW2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBW2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0045504	dynein heavy chain binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	147	151	PF00656	0.405
CLV_NRD_NRD_1	126	128	PF00675	0.366
CLV_NRD_NRD_1	168	170	PF00675	0.373
CLV_NRD_NRD_1	217	219	PF00675	0.252
CLV_NRD_NRD_1	263	265	PF00675	0.332
CLV_NRD_NRD_1	57	59	PF00675	0.530
CLV_NRD_NRD_1	99	101	PF00675	0.465
CLV_PCSK_KEX2_1	126	128	PF00082	0.358
CLV_PCSK_KEX2_1	168	170	PF00082	0.386
CLV_PCSK_KEX2_1	217	219	PF00082	0.252
CLV_PCSK_KEX2_1	263	265	PF00082	0.340
CLV_PCSK_KEX2_1	292	294	PF00082	0.302
CLV_PCSK_KEX2_1	298	300	PF00082	0.258
CLV_PCSK_KEX2_1	57	59	PF00082	0.565
CLV_PCSK_KEX2_1	93	95	PF00082	0.379
CLV_PCSK_KEX2_1	99	101	PF00082	0.427
CLV_PCSK_PC1ET2_1	292	294	PF00082	0.279
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.222
CLV_PCSK_PC1ET2_1	93	95	PF00082	0.379
CLV_PCSK_SKI1_1	176	180	PF00082	0.251
CLV_PCSK_SKI1_1	189	193	PF00082	0.368
CLV_PCSK_SKI1_1	198	202	PF00082	0.275
CLV_PCSK_SKI1_1	217	221	PF00082	0.232
CLV_PCSK_SKI1_1	229	233	PF00082	0.268
CLV_PCSK_SKI1_1	94	98	PF00082	0.373
CLV_Separin_Metazoa	186	190	PF03568	0.366
DEG_SPOP_SBC_1	11	15	PF00917	0.481
DOC_CKS1_1	122	127	PF01111	0.308
DOC_CYCLIN_RxL_1	173	182	PF00134	0.249
DOC_CYCLIN_RxL_1	91	101	PF00134	0.398
DOC_CYCLIN_yCln2_LP_2	306	312	PF00134	0.585
DOC_MAPK_MEF2A_6	109	117	PF00069	0.443
DOC_MAPK_MEF2A_6	198	205	PF00069	0.283
DOC_MAPK_NFAT4_5	198	206	PF00069	0.303
DOC_MAPK_RevD_3	113	127	PF00069	0.366
DOC_MAPK_RevD_3	42	58	PF00069	0.421
DOC_PP2B_LxvP_1	306	309	PF13499	0.489
DOC_PP4_FxxP_1	122	125	PF00568	0.232
DOC_USP7_MATH_1	11	15	PF00917	0.674
DOC_USP7_MATH_1	143	147	PF00917	0.366
DOC_USP7_MATH_1	174	178	PF00917	0.232
DOC_USP7_MATH_1	212	216	PF00917	0.238
DOC_USP7_MATH_1	38	42	PF00917	0.551
DOC_USP7_MATH_1	56	60	PF00917	0.462
DOC_USP7_MATH_1	74	78	PF00917	0.439
DOC_USP7_MATH_1	92	96	PF00917	0.362
DOC_USP7_UBL2_3	236	240	PF12436	0.366
DOC_USP7_UBL2_3	93	97	PF12436	0.393
DOC_WW_Pin1_4	121	126	PF00397	0.296
DOC_WW_Pin1_4	139	144	PF00397	0.258
DOC_WW_Pin1_4	170	175	PF00397	0.308
LIG_14-3-3_CanoR_1	12	20	PF00244	0.522
LIG_14-3-3_CanoR_1	189	196	PF00244	0.232
LIG_14-3-3_CanoR_1	57	66	PF00244	0.399
LIG_14-3-3_CanoR_1	99	103	PF00244	0.414
LIG_APCC_ABBA_1	203	208	PF00400	0.249
LIG_FHA_1	131	137	PF00498	0.365
LIG_FHA_1	170	176	PF00498	0.376
LIG_LIR_Apic_2	120	125	PF02991	0.232
LIG_PCNA_TLS_4	116	123	PF02747	0.232
LIG_PCNA_yPIPBox_3	48	58	PF02747	0.477
LIG_SH2_CRK	83	87	PF00017	0.353
LIG_SH2_NCK_1	83	87	PF00017	0.336
LIG_SH2_PTP2	67	70	PF00017	0.382
LIG_SH2_SRC	67	70	PF00017	0.499
LIG_SH2_SRC	83	86	PF00017	0.373
LIG_SH2_SRC	87	90	PF00017	0.391
LIG_SH2_STAT5	67	70	PF00017	0.382
LIG_SH3_1	83	89	PF00018	0.352
LIG_SH3_2	73	78	PF14604	0.469
LIG_SH3_2	89	94	PF14604	0.394
LIG_SH3_3	107	113	PF00018	0.439
LIG_SH3_3	5	11	PF00018	0.486
LIG_SH3_3	67	73	PF00018	0.389
LIG_SH3_3	83	89	PF00018	0.388
LIG_TRAF2_1	59	62	PF00917	0.626
LIG_WRC_WIRS_1	119	124	PF05994	0.232
MOD_CDC14_SPxK_1	173	176	PF00782	0.308
MOD_CDK_SPK_2	121	126	PF00069	0.304
MOD_CDK_SPxK_1	121	127	PF00069	0.366
MOD_CDK_SPxK_1	170	176	PF00069	0.308
MOD_CK1_1	121	127	PF00069	0.307
MOD_CK1_1	3	9	PF00069	0.513
MOD_CK1_1	37	43	PF00069	0.661
MOD_CK2_1	264	270	PF00069	0.322
MOD_CK2_1	56	62	PF00069	0.511
MOD_GlcNHglycan	2	5	PF01048	0.683
MOD_GlcNHglycan	23	26	PF01048	0.566
MOD_GlcNHglycan	35	39	PF01048	0.730
MOD_GlcNHglycan	40	43	PF01048	0.717
MOD_GSK3_1	139	146	PF00069	0.280
MOD_GSK3_1	170	177	PF00069	0.317
MOD_GSK3_1	21	28	PF00069	0.623
MOD_GSK3_1	30	37	PF00069	0.681
MOD_N-GLC_1	29	34	PF02516	0.521
MOD_NEK2_1	21	26	PF00069	0.487
MOD_NEK2_1	219	224	PF00069	0.268
MOD_NEK2_1	98	103	PF00069	0.490
MOD_NEK2_2	92	97	PF00069	0.395
MOD_PIKK_1	151	157	PF00454	0.366
MOD_PKA_1	57	63	PF00069	0.468
MOD_PKA_2	11	17	PF00069	0.513
MOD_PKA_2	167	173	PF00069	0.317
MOD_PKA_2	30	36	PF00069	0.479
MOD_PKA_2	56	62	PF00069	0.501
MOD_PKA_2	98	104	PF00069	0.411
MOD_Plk_1	243	249	PF00069	0.199
MOD_Plk_4	118	124	PF00069	0.226
MOD_ProDKin_1	121	127	PF00069	0.296
MOD_ProDKin_1	139	145	PF00069	0.258
MOD_ProDKin_1	170	176	PF00069	0.308
MOD_SUMO_for_1	232	235	PF00179	0.232
MOD_SUMO_for_1	239	242	PF00179	0.232
MOD_SUMO_for_1	291	294	PF00179	0.249
TRG_DiLeu_BaEn_1	197	202	PF01217	0.283
TRG_DiLeu_BaEn_1	274	279	PF01217	0.232
TRG_ENDOCYTIC_2	67	70	PF00928	0.368
TRG_ER_diArg_1	125	127	PF00400	0.366
TRG_ER_diArg_1	217	219	PF00400	0.462
TRG_ER_diArg_1	262	264	PF00400	0.391
TRG_ER_diArg_1	56	58	PF00400	0.627
TRG_ER_diArg_1	98	100	PF00400	0.310
TRG_NES_CRM1_1	243	258	PF08389	0.313
TRG_Pf-PMV_PEXEL_1	116	120	PF00026	0.156
TRG_Pf-PMV_PEXEL_1	217	221	PF00026	0.268

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3Q9	Leptomonas seymouri	74%	100%
A0A0S4J9S1	Bodo saltans	34%	100%
A0A0S4KGN7	Bodo saltans	57%	100%
A0A1X0NVG2	Trypanosomatidae	33%	100%
A0A1X0NXR5	Trypanosomatidae	61%	100%
A0A3Q8IC16	Leishmania donovani	32%	100%
A0A3Q8IM75	Leishmania donovani	34%	100%
A0A3R7KMX9	Trypanosoma rangeli	33%	100%
A0A3S7WWL7	Leishmania donovani	89%	100%
A0A422NWB3	Trypanosoma rangeli	59%	100%
A4I0S3	Leishmania infantum	32%	100%
A4I8Y3	Leishmania infantum	34%	100%
D0A1A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	59%	100%
E9AGX0	Leishmania infantum	88%	100%
E9AIH0	Leishmania braziliensis	36%	100%
E9AV86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
E9AWS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B3V2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
Q39604	Chlamydomonas reinhardtii	34%	100%
Q4QAP9	Leishmania major	35%	100%
Q4QC94	Leishmania major	88%	100%
Q4R3K5	Macaca fascicularis	32%	100%
Q9VGG6	Drosophila melanogaster	30%	100%
V5BR59	Trypanosoma cruzi	32%	100%