LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania braziliensis
UniProt:
A4HBV9_LEIBR
TriTrypDb:
LbrM.21.1220 , LBRM2903_210016800
Length:
142

Annotations

LeishMANIAdb annotations

A single-pass helical protein with a potential mitochondrial transit signal. Localization: Mitochondrial (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Cellular components
Term Name Level Count
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7
GO:0005739 mitochondrion 5 1
GO:0043226 organelle 2 1
GO:0043227 membrane-bounded organelle 3 1
GO:0043229 intracellular organelle 3 1
GO:0043231 intracellular membrane-bounded organelle 4 1

Expansion

Sequence features

A4HBV9
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBV9

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 59 61 PF00675 0.450
CLV_NRD_NRD_1 73 75 PF00675 0.382
CLV_PCSK_KEX2_1 58 60 PF00082 0.470
CLV_PCSK_KEX2_1 73 75 PF00082 0.380
CLV_PCSK_SKI1_1 131 135 PF00082 0.417
CLV_PCSK_SKI1_1 60 64 PF00082 0.415
CLV_PCSK_SKI1_1 74 78 PF00082 0.411
DEG_APCC_DBOX_1 73 81 PF00400 0.684
DOC_MAPK_gen_1 122 130 PF00069 0.661
DOC_MAPK_gen_1 70 80 PF00069 0.676
DOC_WW_Pin1_4 16 21 PF00397 0.373
DOC_WW_Pin1_4 8 13 PF00397 0.378
LIG_14-3-3_CanoR_1 48 55 PF00244 0.560
LIG_14-3-3_CanoR_1 91 98 PF00244 0.613
LIG_BRCT_BRCA1_1 42 46 PF00533 0.631
LIG_Clathr_ClatBox_1 77 81 PF01394 0.691
LIG_MLH1_MIPbox_1 42 46 PF16413 0.603
LIG_PALB2_WD40_1 5 13 PF16756 0.428
LIG_PDZ_Class_3 137 142 PF00595 0.644
LIG_SH2_STAT5 4 7 PF00017 0.419
LIG_SH2_STAT5 45 48 PF00017 0.636
LIG_SH3_3 2 8 PF00018 0.421
LIG_SUMO_SIM_par_1 93 100 PF11976 0.653
LIG_UBA3_1 126 134 PF00899 0.646
MOD_CK1_1 18 24 PF00069 0.320
MOD_CK1_1 50 56 PF00069 0.555
MOD_CK1_1 97 103 PF00069 0.645
MOD_CK2_1 50 56 PF00069 0.671
MOD_GlcNHglycan 92 95 PF01048 0.452
MOD_GSK3_1 90 97 PF00069 0.696
MOD_NEK2_1 15 20 PF00069 0.439
MOD_PKA_2 47 53 PF00069 0.558
MOD_PKA_2 90 96 PF00069 0.616
MOD_ProDKin_1 16 22 PF00069 0.372
MOD_ProDKin_1 8 14 PF00069 0.373
MOD_SUMO_rev_2 129 135 PF00179 0.691
TRG_ENDOCYTIC_2 23 26 PF00928 0.392
TRG_ENDOCYTIC_2 65 68 PF00928 0.598
TRG_ER_diArg_1 57 60 PF00400 0.655

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P3R0 Leptomonas seymouri 76% 100%
A0A1X0NYD4 Trypanosomatidae 61% 100%
A0A3Q8IBW9 Leishmania donovani 91% 100%
D0A199 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 60% 96%
E9AGW7 Leishmania infantum 91% 100%
E9AV83 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
Q4QC97 Leishmania major 92% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS