SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBV7_LEIBR

TriTrypDb:

LbrM.21.1200 , LBRM2903_210016600

Length:

707

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBV7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBV7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	322	326	PF00656	0.534
CLV_C14_Caspase3-7	353	357	PF00656	0.587
CLV_C14_Caspase3-7	386	390	PF00656	0.656
CLV_C14_Caspase3-7	481	485	PF00656	0.541
CLV_C14_Caspase3-7	499	503	PF00656	0.608
CLV_C14_Caspase3-7	628	632	PF00656	0.533
CLV_NRD_NRD_1	172	174	PF00675	0.505
CLV_NRD_NRD_1	250	252	PF00675	0.683
CLV_NRD_NRD_1	42	44	PF00675	0.586
CLV_NRD_NRD_1	516	518	PF00675	0.580
CLV_NRD_NRD_1	52	54	PF00675	0.520
CLV_NRD_NRD_1	521	523	PF00675	0.624
CLV_NRD_NRD_1	531	533	PF00675	0.654
CLV_NRD_NRD_1	585	587	PF00675	0.466
CLV_NRD_NRD_1	600	602	PF00675	0.379
CLV_PCSK_FUR_1	519	523	PF00082	0.646
CLV_PCSK_KEX2_1	172	174	PF00082	0.505
CLV_PCSK_KEX2_1	249	251	PF00082	0.711
CLV_PCSK_KEX2_1	42	44	PF00082	0.586
CLV_PCSK_KEX2_1	518	520	PF00082	0.620
CLV_PCSK_KEX2_1	52	54	PF00082	0.520
CLV_PCSK_KEX2_1	521	523	PF00082	0.630
CLV_PCSK_KEX2_1	531	533	PF00082	0.668
CLV_PCSK_KEX2_1	587	589	PF00082	0.491
CLV_PCSK_KEX2_1	600	602	PF00082	0.354
CLV_PCSK_PC1ET2_1	518	520	PF00082	0.645
CLV_PCSK_PC1ET2_1	587	589	PF00082	0.596
CLV_PCSK_PC7_1	517	523	PF00082	0.706
CLV_PCSK_SKI1_1	100	104	PF00082	0.592
CLV_PCSK_SKI1_1	172	176	PF00082	0.463
CLV_PCSK_SKI1_1	178	182	PF00082	0.427
CLV_PCSK_SKI1_1	223	227	PF00082	0.700
CLV_PCSK_SKI1_1	380	384	PF00082	0.646
CLV_PCSK_SKI1_1	396	400	PF00082	0.585
CLV_PCSK_SKI1_1	473	477	PF00082	0.627
CLV_PCSK_SKI1_1	52	56	PF00082	0.493
CLV_PCSK_SKI1_1	577	581	PF00082	0.527
CLV_PCSK_SKI1_1	587	591	PF00082	0.436
CLV_PCSK_SKI1_1	611	615	PF00082	0.344
CLV_PCSK_SKI1_1	640	644	PF00082	0.526
CLV_PCSK_SKI1_1	648	652	PF00082	0.573
DEG_APCC_DBOX_1	610	618	PF00400	0.359
DEG_SPOP_SBC_1	124	128	PF00917	0.732
DEG_SPOP_SBC_1	234	238	PF00917	0.743
DEG_SPOP_SBC_1	556	560	PF00917	0.781
DEG_SPOP_SBC_1	69	73	PF00917	0.714
DOC_CYCLIN_RxL_1	467	477	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	225	231	PF00134	0.760
DOC_MAPK_gen_1	109	116	PF00069	0.602
DOC_MAPK_gen_1	375	383	PF00069	0.577
DOC_MAPK_gen_1	42	50	PF00069	0.594
DOC_MAPK_gen_1	431	440	PF00069	0.552
DOC_MAPK_gen_1	453	463	PF00069	0.429
DOC_MAPK_gen_1	600	608	PF00069	0.324
DOC_MAPK_HePTP_8	320	332	PF00069	0.534
DOC_MAPK_MEF2A_6	323	332	PF00069	0.533
DOC_MAPK_MEF2A_6	431	440	PF00069	0.538
DOC_MAPK_MEF2A_6	473	482	PF00069	0.580
DOC_PP1_RVXF_1	471	477	PF00149	0.613
DOC_PP2B_LxvP_1	197	200	PF13499	0.565
DOC_PP2B_LxvP_1	334	337	PF13499	0.783
DOC_PP2B_LxvP_1	67	70	PF13499	0.501
DOC_PP4_FxxP_1	332	335	PF00568	0.733
DOC_USP7_MATH_1	123	127	PF00917	0.644
DOC_USP7_MATH_1	137	141	PF00917	0.790
DOC_USP7_MATH_1	165	169	PF00917	0.433
DOC_USP7_MATH_1	232	236	PF00917	0.748
DOC_USP7_MATH_1	434	438	PF00917	0.414
DOC_USP7_MATH_1	551	555	PF00917	0.776
DOC_USP7_MATH_1	557	561	PF00917	0.756
DOC_USP7_MATH_1	568	572	PF00917	0.675
DOC_WW_Pin1_4	339	344	PF00397	0.717
DOC_WW_Pin1_4	70	75	PF00397	0.715
DOC_WW_Pin1_4	9	14	PF00397	0.688
LIG_14-3-3_CanoR_1	166	172	PF00244	0.487
LIG_14-3-3_CanoR_1	178	187	PF00244	0.403
LIG_14-3-3_CanoR_1	233	241	PF00244	0.597
LIG_14-3-3_CanoR_1	249	257	PF00244	0.672
LIG_14-3-3_CanoR_1	412	420	PF00244	0.440
LIG_14-3-3_CanoR_1	473	479	PF00244	0.477
LIG_14-3-3_CanoR_1	586	595	PF00244	0.491
LIG_14-3-3_CanoR_1	600	609	PF00244	0.375
LIG_14-3-3_CanoR_1	62	68	PF00244	0.611
LIG_Actin_WH2_2	327	342	PF00022	0.530
LIG_Actin_WH2_2	442	458	PF00022	0.459
LIG_Actin_WH2_2	632	650	PF00022	0.482
LIG_CSL_BTD_1	36	39	PF09270	0.458
LIG_CtBP_PxDLS_1	264	270	PF00389	0.457
LIG_deltaCOP1_diTrp_1	468	476	PF00928	0.627
LIG_EVH1_1	360	364	PF00568	0.585
LIG_FHA_1	103	109	PF00498	0.585
LIG_FHA_1	408	414	PF00498	0.454
LIG_FHA_1	442	448	PF00498	0.597
LIG_FHA_1	469	475	PF00498	0.583
LIG_FHA_1	82	88	PF00498	0.508
LIG_FHA_2	250	256	PF00498	0.652
LIG_IRF3_LxIS_1	506	512	PF10401	0.356
LIG_LIR_Gen_1	183	190	PF02991	0.671
LIG_LIR_Gen_1	424	434	PF02991	0.575
LIG_LIR_Gen_1	63	70	PF02991	0.506
LIG_LIR_Nem_3	183	189	PF02991	0.572
LIG_LIR_Nem_3	192	198	PF02991	0.536
LIG_LIR_Nem_3	424	430	PF02991	0.553
LIG_LIR_Nem_3	505	510	PF02991	0.524
LIG_LIR_Nem_3	63	67	PF02991	0.513
LIG_NRBOX	474	480	PF00104	0.571
LIG_PDZ_Class_2	702	707	PF00595	0.621
LIG_PTB_Apo_2	157	164	PF02174	0.613
LIG_PTB_Apo_2	367	374	PF02174	0.666
LIG_PTB_Phospho_1	367	373	PF10480	0.674
LIG_SH2_CRK	581	585	PF00017	0.527
LIG_SH2_NCK_1	420	424	PF00017	0.571
LIG_SH2_NCK_1	581	585	PF00017	0.495
LIG_SH2_SRC	186	189	PF00017	0.600
LIG_SH2_STAT5	186	189	PF00017	0.534
LIG_SH2_STAT5	196	199	PF00017	0.469
LIG_SH2_STAT5	224	227	PF00017	0.652
LIG_SH2_STAT5	555	558	PF00017	0.531
LIG_SH3_3	140	146	PF00018	0.582
LIG_SH3_3	242	248	PF00018	0.665
LIG_SH3_3	298	304	PF00018	0.787
LIG_SH3_3	355	361	PF00018	0.705
LIG_SH3_3	567	573	PF00018	0.521
LIG_SH3_CIN85_PxpxPR_1	228	233	PF14604	0.525
LIG_SUMO_SIM_par_1	477	484	PF11976	0.578
LIG_SUMO_SIM_par_1	507	512	PF11976	0.350
LIG_TRAF2_1	276	279	PF00917	0.622
LIG_TRAF2_1	315	318	PF00917	0.541
LIG_TRAF2_1	415	418	PF00917	0.541
LIG_TRAF2_1	422	425	PF00917	0.532
LIG_TRAF2_1	457	460	PF00917	0.670
LIG_TRFH_1	332	336	PF08558	0.789
LIG_TYR_ITIM	16	21	PF00017	0.405
LIG_TYR_ITIM	579	584	PF00017	0.517
LIG_UBA3_1	426	433	PF00899	0.568
MOD_CK1_1	126	132	PF00069	0.637
MOD_CK1_1	148	154	PF00069	0.682
MOD_CK1_1	235	241	PF00069	0.734
MOD_CK1_1	542	548	PF00069	0.623
MOD_CK1_1	559	565	PF00069	0.761
MOD_CK1_1	63	69	PF00069	0.747
MOD_CK1_1	656	662	PF00069	0.523
MOD_CK1_1	671	677	PF00069	0.509
MOD_CK1_1	72	78	PF00069	0.588
MOD_CK2_1	412	418	PF00069	0.528
MOD_CK2_1	509	515	PF00069	0.363
MOD_CK2_1	616	622	PF00069	0.577
MOD_CMANNOS	33	36	PF00535	0.465
MOD_GlcNHglycan	121	124	PF01048	0.741
MOD_GlcNHglycan	135	138	PF01048	0.601
MOD_GlcNHglycan	183	186	PF01048	0.536
MOD_GlcNHglycan	201	204	PF01048	0.653
MOD_GlcNHglycan	238	241	PF01048	0.635
MOD_GlcNHglycan	26	29	PF01048	0.593
MOD_GlcNHglycan	498	501	PF01048	0.584
MOD_GlcNHglycan	511	514	PF01048	0.417
MOD_GlcNHglycan	544	547	PF01048	0.797
MOD_GlcNHglycan	574	577	PF01048	0.561
MOD_GlcNHglycan	618	621	PF01048	0.460
MOD_GlcNHglycan	670	673	PF01048	0.735
MOD_GlcNHglycan	77	80	PF01048	0.643
MOD_GSK3_1	119	126	PF00069	0.686
MOD_GSK3_1	129	136	PF00069	0.718
MOD_GSK3_1	145	152	PF00069	0.748
MOD_GSK3_1	232	239	PF00069	0.672
MOD_GSK3_1	24	31	PF00069	0.453
MOD_GSK3_1	441	448	PF00069	0.618
MOD_GSK3_1	474	481	PF00069	0.503
MOD_GSK3_1	535	542	PF00069	0.639
MOD_GSK3_1	551	558	PF00069	0.700
MOD_GSK3_1	568	575	PF00069	0.670
MOD_GSK3_1	625	632	PF00069	0.622
MOD_GSK3_1	68	75	PF00069	0.728
MOD_GSK3_1	77	84	PF00069	0.573
MOD_LATS_1	247	253	PF00433	0.492
MOD_N-GLC_1	434	439	PF02516	0.672
MOD_N-GLC_1	674	679	PF02516	0.520
MOD_NEK2_1	180	185	PF00069	0.592
MOD_NEK2_1	338	343	PF00069	0.578
MOD_NEK2_1	383	388	PF00069	0.656
MOD_NEK2_1	407	412	PF00069	0.602
MOD_NEK2_1	426	431	PF00069	0.312
MOD_NEK2_1	474	479	PF00069	0.472
MOD_NEK2_1	496	501	PF00069	0.425
MOD_NEK2_1	509	514	PF00069	0.321
MOD_NEK2_1	580	585	PF00069	0.564
MOD_NEK2_1	60	65	PF00069	0.739
MOD_NEK2_1	643	648	PF00069	0.523
MOD_NEK2_1	77	82	PF00069	0.623
MOD_NEK2_2	54	59	PF00069	0.481
MOD_PIKK_1	149	155	PF00454	0.732
MOD_PIKK_1	407	413	PF00454	0.379
MOD_PIKK_1	535	541	PF00454	0.617
MOD_PIKK_1	568	574	PF00454	0.730
MOD_PIKK_1	651	657	PF00454	0.499
MOD_PKA_1	249	255	PF00069	0.683
MOD_PKA_1	587	593	PF00069	0.483
MOD_PKA_2	165	171	PF00069	0.528
MOD_PKA_2	232	238	PF00069	0.567
MOD_PKA_2	249	255	PF00069	0.659
MOD_PKA_2	587	593	PF00069	0.530
MOD_PKA_2	599	605	PF00069	0.348
MOD_Plk_1	434	440	PF00069	0.615
MOD_Plk_4	28	34	PF00069	0.510
MOD_Plk_4	445	451	PF00069	0.572
MOD_Plk_4	551	557	PF00069	0.526
MOD_Plk_4	72	78	PF00069	0.772
MOD_ProDKin_1	339	345	PF00069	0.715
MOD_ProDKin_1	70	76	PF00069	0.716
MOD_ProDKin_1	9	15	PF00069	0.687
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.384
TRG_DiLeu_BaLyEn_6	334	339	PF01217	0.750
TRG_DiLeu_BaLyEn_6	341	346	PF01217	0.715
TRG_DiLeu_BaLyEn_6	4	9	PF01217	0.477
TRG_DiLeu_BaLyEn_6	409	414	PF01217	0.381
TRG_DiLeu_BaLyEn_6	470	475	PF01217	0.482
TRG_DiLeu_BaLyEn_6	608	613	PF01217	0.551
TRG_DiLeu_LyEn_5	505	510	PF01217	0.576
TRG_ENDOCYTIC_2	18	21	PF00928	0.408
TRG_ENDOCYTIC_2	186	189	PF00928	0.576
TRG_ENDOCYTIC_2	581	584	PF00928	0.527
TRG_ER_diArg_1	171	173	PF00400	0.509
TRG_ER_diArg_1	248	251	PF00400	0.496
TRG_ER_diArg_1	378	381	PF00400	0.559
TRG_ER_diArg_1	517	520	PF00400	0.669
TRG_ER_diArg_1	599	601	PF00400	0.413
TRG_NES_CRM1_1	397	411	PF08389	0.371
TRG_NES_CRM1_1	94	106	PF08389	0.605
TRG_NLS_MonoExtC_3	516	521	PF00514	0.630
TRG_NLS_MonoExtC_3	585	591	PF00514	0.546
TRG_NLS_MonoExtN_4	517	522	PF00514	0.638
TRG_Pf-PMV_PEXEL_1	412	416	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.591
TRG_Pf-PMV_PEXEL_1	611	616	PF00026	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P8	Leptomonas seymouri	50%	100%
A0A3S5IS33	Trypanosoma rangeli	38%	100%
A0A3S7WWN7	Leishmania donovani	72%	98%
D0A197	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AGW5	Leishmania infantum	72%	93%
E9AV81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	67%	99%
Q4QC99	Leishmania major	70%	99%
V5BFI7	Trypanosoma cruzi	37%	100%