PDCD2_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Programmed cell death protein 2, C-terminal putative domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBV5_LEIBR

TriTrypDb:

LbrM.21.1180 , LBRM2903_210016400

Length:

403

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HBV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	365	369	PF00656	0.623
CLV_NRD_NRD_1	33	35	PF00675	0.552
CLV_NRD_NRD_1	346	348	PF00675	0.437
CLV_NRD_NRD_1	378	380	PF00675	0.635
CLV_PCSK_KEX2_1	33	35	PF00082	0.552
CLV_PCSK_KEX2_1	346	348	PF00082	0.449
CLV_PCSK_KEX2_1	4	6	PF00082	0.667
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.667
CLV_PCSK_SKI1_1	226	230	PF00082	0.418
CLV_PCSK_SKI1_1	379	383	PF00082	0.698
CLV_PCSK_SKI1_1	384	388	PF00082	0.712
DEG_SPOP_SBC_1	284	288	PF00917	0.223
DOC_CYCLIN_RxL_1	379	391	PF00134	0.629
DOC_MAPK_DCC_7	221	230	PF00069	0.475
DOC_MAPK_gen_1	234	241	PF00069	0.420
DOC_MAPK_gen_1	346	352	PF00069	0.363
DOC_PP4_FxxP_1	229	232	PF00568	0.344
DOC_USP7_MATH_1	137	141	PF00917	0.601
DOC_USP7_MATH_1	284	288	PF00917	0.474
DOC_USP7_MATH_1	300	304	PF00917	0.438
DOC_USP7_MATH_1	72	76	PF00917	0.407
DOC_USP7_MATH_1	82	86	PF00917	0.381
DOC_USP7_UBL2_3	155	159	PF12436	0.572
DOC_WW_Pin1_4	14	19	PF00397	0.479
DOC_WW_Pin1_4	50	55	PF00397	0.434
LIG_14-3-3_CanoR_1	162	170	PF00244	0.730
LIG_14-3-3_CanoR_1	33	40	PF00244	0.470
LIG_14-3-3_CanoR_1	379	384	PF00244	0.570
LIG_APCC_ABBA_1	21	26	PF00400	0.356
LIG_BIR_II_1	1	5	PF00653	0.688
LIG_BIR_III_2	136	140	PF00653	0.621
LIG_EH1_1	42	50	PF00400	0.412
LIG_FHA_1	113	119	PF00498	0.697
LIG_FHA_1	174	180	PF00498	0.586
LIG_FHA_1	214	220	PF00498	0.464
LIG_FHA_1	250	256	PF00498	0.404
LIG_FHA_1	313	319	PF00498	0.333
LIG_FHA_1	324	330	PF00498	0.315
LIG_FHA_1	347	353	PF00498	0.449
LIG_FHA_1	376	382	PF00498	0.718
LIG_FHA_2	145	151	PF00498	0.570
LIG_FHA_2	162	168	PF00498	0.536
LIG_FHA_2	290	296	PF00498	0.367
LIG_FHA_2	306	312	PF00498	0.475
LIG_FHA_2	355	361	PF00498	0.671
LIG_FHA_2	380	386	PF00498	0.753
LIG_LIR_Apic_2	17	23	PF02991	0.574
LIG_LIR_Gen_1	185	196	PF02991	0.327
LIG_LIR_Gen_1	268	278	PF02991	0.365
LIG_LIR_Nem_3	185	191	PF02991	0.327
LIG_LIR_Nem_3	19	24	PF02991	0.490
LIG_LIR_Nem_3	268	273	PF02991	0.365
LIG_LIR_Nem_3	323	327	PF02991	0.363
LIG_NRBOX	382	388	PF00104	0.714
LIG_PDZ_Class_1	398	403	PF00595	0.542
LIG_PTAP_UEV_1	55	60	PF05743	0.591
LIG_SH2_CRK	270	274	PF00017	0.413
LIG_SH2_CRK	52	56	PF00017	0.571
LIG_SH2_PTP2	132	135	PF00017	0.520
LIG_SH2_SRC	132	135	PF00017	0.582
LIG_SH2_SRC	264	267	PF00017	0.449
LIG_SH2_STAP1	270	274	PF00017	0.449
LIG_SH2_STAT5	132	135	PF00017	0.520
LIG_SH2_STAT5	20	23	PF00017	0.525
LIG_SH2_STAT5	264	267	PF00017	0.315
LIG_SH2_STAT5	270	273	PF00017	0.321
LIG_SH2_STAT5	330	333	PF00017	0.392
LIG_SH2_STAT5	69	72	PF00017	0.361
LIG_SH2_STAT5	77	80	PF00017	0.402
LIG_SH3_3	114	120	PF00018	0.578
LIG_SH3_3	124	130	PF00018	0.450
LIG_SH3_3	140	146	PF00018	0.550
LIG_SH3_3	236	242	PF00018	0.410
LIG_SH3_3	53	59	PF00018	0.494
LIG_TRAF2_1	105	108	PF00917	0.683
LIG_TRAF2_1	166	169	PF00917	0.667
LIG_TYR_ITIM	262	267	PF00017	0.344
LIG_UBA3_1	153	159	PF00899	0.445
LIG_WW_1	129	132	PF00397	0.488
MOD_CK1_1	163	169	PF00069	0.728
MOD_CK1_1	217	223	PF00069	0.326
MOD_CK1_1	249	255	PF00069	0.447
MOD_CK1_1	268	274	PF00069	0.161
MOD_CK1_1	286	292	PF00069	0.306
MOD_CK1_1	301	307	PF00069	0.336
MOD_CK1_1	80	86	PF00069	0.462
MOD_CK2_1	144	150	PF00069	0.556
MOD_CK2_1	163	169	PF00069	0.581
MOD_CK2_1	305	311	PF00069	0.475
MOD_CK2_1	379	385	PF00069	0.755
MOD_GlcNHglycan	216	219	PF01048	0.427
MOD_GlcNHglycan	248	251	PF01048	0.378
MOD_GlcNHglycan	288	291	PF01048	0.417
MOD_GlcNHglycan	300	303	PF01048	0.487
MOD_GlcNHglycan	74	77	PF01048	0.453
MOD_GSK3_1	213	220	PF00069	0.264
MOD_GSK3_1	284	291	PF00069	0.375
MOD_GSK3_1	300	307	PF00069	0.446
MOD_GSK3_1	371	378	PF00069	0.721
MOD_GSK3_1	50	57	PF00069	0.488
MOD_GSK3_1	77	84	PF00069	0.477
MOD_LATS_1	388	394	PF00433	0.512
MOD_NEK2_1	285	290	PF00069	0.457
MOD_NEK2_2	325	330	PF00069	0.328
MOD_PIKK_1	27	33	PF00454	0.376
MOD_PIKK_1	77	83	PF00454	0.389
MOD_PKA_1	33	39	PF00069	0.532
MOD_PKA_1	346	352	PF00069	0.449
MOD_PKA_1	379	385	PF00069	0.488
MOD_PKA_2	161	167	PF00069	0.694
MOD_PKA_2	33	39	PF00069	0.510
MOD_PKA_2	346	352	PF00069	0.484
MOD_Plk_1	173	179	PF00069	0.598
MOD_Plk_1	268	274	PF00069	0.475
MOD_Plk_1	27	33	PF00069	0.323
MOD_Plk_1	310	316	PF00069	0.484
MOD_Plk_2-3	354	360	PF00069	0.661
MOD_Plk_4	16	22	PF00069	0.481
MOD_Plk_4	43	49	PF00069	0.498
MOD_Plk_4	82	88	PF00069	0.489
MOD_ProDKin_1	14	20	PF00069	0.481
MOD_ProDKin_1	50	56	PF00069	0.445
MOD_SUMO_rev_2	178	184	PF00179	0.618
MOD_SUMO_rev_2	6	14	PF00179	0.494
TRG_DiLeu_BaEn_4	168	174	PF01217	0.700
TRG_DiLeu_LyEn_5	114	119	PF01217	0.678
TRG_ENDOCYTIC_2	132	135	PF00928	0.520
TRG_ENDOCYTIC_2	188	191	PF00928	0.381
TRG_ENDOCYTIC_2	264	267	PF00928	0.342
TRG_ENDOCYTIC_2	270	273	PF00928	0.252
TRG_ENDOCYTIC_2	52	55	PF00928	0.533
TRG_ER_diArg_1	191	194	PF00400	0.328
TRG_ER_diArg_1	32	34	PF00400	0.545
TRG_ER_diArg_1	345	347	PF00400	0.449
TRG_NES_CRM1_1	168	181	PF08389	0.603
TRG_NES_CRM1_1	256	269	PF08389	0.363

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTP0	Leptomonas seymouri	66%	90%
A0A0S4JIG4	Bodo saltans	35%	100%
A0A1X0NZ44	Trypanosomatidae	46%	100%
A0A3Q8IC20	Leishmania donovani	78%	93%
A0A3S5IS34	Trypanosoma rangeli	44%	100%
D0A195	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AGW3	Leishmania infantum	80%	94%
E9AV79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	95%
Q4QCA1	Leishmania major	81%	99%
V5AR10	Trypanosoma cruzi	46%	100%